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The feasibility of Miltuximab®-IRDye700DX-mediated photoimmunotherapy of solid tumors.
Polikarpov DM, Campbell DH, Lund ME, Lu Y, Lu Y, Wu J, Walsh BJ, Zvyagin AV, Gillatt DA. Polikarpov DM, et al. Photodiagnosis Photodyn Ther. 2020 Dec;32:102064. doi: 10.1016/j.pdpdt.2020.102064. Epub 2020 Oct 15. Photodiagnosis Photodyn Ther. 2020. PMID: 33069874
We aimed to investigate whether anti-GPC-1 antibody Miltuximab (Glytherix Ltd., Sydney, Australia) can be conjugated with IR700 for PIT of solid tumors. ...
We aimed to investigate whether anti-GPC-1 antibody Miltuximab (Glytherix Ltd., Sydney, Australia) can be conjugated with IR700 for P …
Pharmacokinetics and Biodistribution of 89Zr-Miltuximab and Its Antibody Fragments as Glypican-1 Targeting Immuno-PET Agents in Glioblastoma.
Ghosh S, Fletcher NL, Huda P, Houston ZH, Howard CB, Lund ME, Lu Y, Campbell DH, Walsh BJ, Thurecht KJ. Ghosh S, et al. Mol Pharm. 2023 Mar 6;20(3):1549-1563. doi: 10.1021/acs.molpharmaceut.2c00760. Epub 2023 Jan 5. Mol Pharm. 2023. PMID: 36602058
Here, we investigate zirconium-89 ((89)Zr)-conjugated Miltuximab (a clinical stage anti-GPC-1 monoclonal antibody developed by GlyTherix, Ltd.) and engineered fragments for their potential as immuno-PET tracers to detect GPC-1(positive) GBM tumors in preclinical models. .. …
Here, we investigate zirconium-89 ((89)Zr)-conjugated Miltuximab (a clinical stage anti-GPC-1 monoclonal antibody developed by GlyTherix …
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