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A reproductive screening test of goldenseal.
Yao M, Ritchie HE, Brown-Woodman PD. Yao M, et al. Birth Defects Res B Dev Reprod Toxicol. 2005 Oct;74(5):399-404. doi: 10.1002/bdrb.20055. Birth Defects Res B Dev Reprod Toxicol. 2005. PMID: 16193497
BACKGROUND: Goldenseal (Hydrastis canadensis L) is a multi-purpose herb (Hobbs, 1990: Pharm Hist 32:79-82) widely used for its antibiotic properties. ...Goldenseal induced toxicity when GD10.5 embryos were cultured for 26 hr in rat serum to which extra …
BACKGROUND: Goldenseal (Hydrastis canadensis L) is a multi-purpose herb (Hobbs, 1990: Pharm Hist 32:79-82) widely used for its …
Effect of goldenseal (Hydrastis canadensis) and kava kava (Piper methysticum) supplementation on digoxin pharmacokinetics in humans.
Gurley BJ, Swain A, Barone GW, Williams DK, Breen P, Yates CR, Stuart LB, Hubbard MA, Tong Y, Cheboyina S. Gurley BJ, et al. Drug Metab Dispos. 2007 Feb;35(2):240-5. doi: 10.1124/dmd.106.012708. Epub 2006 Nov 1. Drug Metab Dispos. 2007. PMID: 17079360 Free PMC article. Clinical Trial.
Serial plasma concentration-time profiles of the P-gp substrate, digoxin, were used to determine whether supplementation with goldenseal or kava kava modified P-gp activity in vivo. Twenty healthy volunteers were randomly assigned to receive a standardized goldenseal
Serial plasma concentration-time profiles of the P-gp substrate, digoxin, were used to determine whether supplementation with goldenseal
Supplementation with goldenseal (Hydrastis canadensis), but not kava kava (Piper methysticum), inhibits human CYP3A activity in vivo.
Gurley BJ, Swain A, Hubbard MA, Hartsfield F, Thaden J, Williams DK, Gentry WB, Tong Y. Gurley BJ, et al. Clin Pharmacol Ther. 2008 Jan;83(1):61-9. doi: 10.1038/sj.clpt.6100222. Epub 2007 May 9. Clin Pharmacol Ther. 2008. PMID: 17495878 Clinical Trial.
The effects of goldenseal (Hydrastis canadensis) and kava kava (Piper methysticum) supplementation on human CYP3A activity were evaluated using midazolam (MDZ) as a phenotypic probe. ...These findings suggest that significant herb-drug interactions may result from t …
The effects of goldenseal (Hydrastis canadensis) and kava kava (Piper methysticum) supplementation on human CYP3A activity wer …
Biochemometrics to Identify Synergists and Additives from Botanical Medicines: A Case Study with Hydrastis canadensis (Goldenseal).
Britton ER, Kellogg JJ, Kvalheim OM, Cech NB. Britton ER, et al. J Nat Prod. 2018 Mar 23;81(3):484-493. doi: 10.1021/acs.jnatprod.7b00654. Epub 2017 Nov 1. J Nat Prod. 2018. PMID: 29091439 Free PMC article.
To demonstrate this approach, an extract of the botanical goldenseal ( Hydrastis canadensis) was fractionated and tested for its ability to enhance the antimicrobial activity of the alkaloid berberine (4) against the pathogenic bacterium Staphylococcus aureus. ...
To demonstrate this approach, an extract of the botanical goldenseal ( Hydrastis canadensis) was fractionated and tested for i …
Quorum quenching and antimicrobial activity of goldenseal (Hydrastis canadensis) against methicillin-resistant Staphylococcus aureus (MRSA).
Cech NB, Junio HA, Ackermann LW, Kavanaugh JS, Horswill AR. Cech NB, et al. Planta Med. 2012 Sep;78(14):1556-61. doi: 10.1055/s-0032-1315042. Epub 2012 Jul 18. Planta Med. 2012. PMID: 22814821 Free PMC article.
The popular herbal remedy goldenseal (Hydrastis canadensis L.) is traditionally used to treat skin infections. ...LC-MS detected alkaloids and efflux-pump inhibitory flavonoids in the extract, and the latter may explain the enhanced efficacy of the extract compared …
The popular herbal remedy goldenseal (Hydrastis canadensis L.) is traditionally used to treat skin infections. ...LC-MS detect …
Goldenseal (Hydrastis canadensis L.) extracts synergistically enhance the antibacterial activity of berberine via efflux pump inhibition.
Ettefagh KA, Burns JT, Junio HA, Kaatz GW, Cech NB. Ettefagh KA, et al. Planta Med. 2011 May;77(8):835-40. doi: 10.1055/s-0030-1250606. Epub 2010 Dec 14. Planta Med. 2011. PMID: 21157683 Free PMC article.
Goldenseal (Hydrastis canadensis L.) is used to combat inflammation and infection. ...The aerial extract inhibited ethidium bromide efflux from wild-type S. aureus but had no effect on the expulsion of this compound from an isogenic derivative deleted for nor
Goldenseal (Hydrastis canadensis L.) is used to combat inflammation and infection. ...The aerial extract inhibited ethidium br
Prevalence of antibiotic-resistant bacteria in herbal products.
Brown JC, Jiang X. Brown JC, et al. J Food Prot. 2008 Jul;71(7):1486-90. doi: 10.4315/0362-028x-71.7.1486. J Food Prot. 2008. PMID: 18680952
Total bacterial counts were determined by pour plate and surface spreading on tryptic soy agar (TSA). ...Traditional and organic onion powder samples contained tetracycline-resistant bacteria at 17 and 28 CFU/g and ceftriaxone-resistant bacteria at 35 and 2.0 x 10(3) CFU/g …
Total bacterial counts were determined by pour plate and surface spreading on tryptic soy agar (TSA). ...Traditional and organic onio …
Antimicrobial constituents from goldenseal (the Rhizomes of Hydrastis canadensis) against selected oral pathogens.
Hwang BY, Roberts SK, Chadwick LR, Wu CD, Kinghorn AD. Hwang BY, et al. Planta Med. 2003 Jul;69(7):623-7. doi: 10.1055/s-2003-41115. Planta Med. 2003. PMID: 12898417
Two new C-methyl flavonoids, 6,8-di- C-methylluteolin 7-methyl ether (1) and 6- C-methylluteolin 7-methyl ether (2), were isolated from a commercially available sample of the roots of Hydrastis canadensis, along with seven known compounds, berberine (3), beta-hydrastine (4 …
Two new C-methyl flavonoids, 6,8-di- C-methylluteolin 7-methyl ether (1) and 6- C-methylluteolin 7-methyl ether (2), were isolated from a co …
Progress and prospects in the management of bacterial infections and developments in Phytotherapeutic modalities.
Akram M, Riaz M, Munir N, Rasul A, Daniyal M, Ali Shah SM, Shariati MA, Shaheen G, Akhtar N, Parveen F, Akhter N, Owais Ghauri A, Chishti AW, Usman Sarwar M, Said Khan F. Akram M, et al. Clin Exp Pharmacol Physiol. 2020 Jul;47(7):1107-1119. doi: 10.1111/1440-1681.13282. Epub 2020 Mar 15. Clin Exp Pharmacol Physiol. 2020. PMID: 32064656 Review.
The advent of antibiotics revolutionized medical care resulting in significantly reduced mortality and morbidity caused by infectious diseases. However, excessive use of antibiotics has led to the development of antibiotic resistance and indeed, the incidence …
The advent of antibiotics revolutionized medical care resulting in significantly reduced mortality and morbidity caused by infectious …
Extracts of Canadian first nations medicinal plants, used as natural products, inhibit neisseria gonorrhoeae isolates with different antibiotic resistance profiles.
Cybulska P, Thakur SD, Foster BC, Scott IM, Leduc RI, Arnason JT, Dillon JA. Cybulska P, et al. Sex Transm Dis. 2011 Jul;38(7):667-71. doi: 10.1097/OLQ.0b013e31820cb166. Sex Transm Dis. 2011. PMID: 21301385
BACKGROUND: Neisseria gonorrhoeae (Ng) has developed resistance to most antimicrobial agents and the antibiotics recommended for therapy are restricted, for the most part, to third generation cephalosporins. ...RESULTS: Extracts of Arctostaphylos uva ursi (kinnikinn …
BACKGROUND: Neisseria gonorrhoeae (Ng) has developed resistance to most antimicrobial agents and the antibiotics recommended f …
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