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Clinical evidence that treatment of metabolic acidosis slows the progression of chronic kidney disease.
Goraya N, Wesson DE. Goraya N, et al. Curr Opin Nephrol Hypertens. 2019 May;28(3):267-277. doi: 10.1097/MNH.0000000000000491. Curr Opin Nephrol Hypertens. 2019. PMID: 30681417 Free PMC article. Review.
PURPOSE OF REVIEW: We review the growing clinical evidence that metabolic acidosis mediates chronic kidney disease (CKD) progression and that treatment to increase the associated low serum bicarbonate (HCO3) in CKD is disease-modifying. ...SUMMA …
PURPOSE OF REVIEW: We review the growing clinical evidence that metabolic acidosis mediates chronic kidney disease (CKD …
Pathophysiology of Diet-Induced Acid Stress.
Goraya N, Wesson DE. Goraya N, et al. Int J Mol Sci. 2024 Feb 16;25(4):2336. doi: 10.3390/ijms25042336. Int J Mol Sci. 2024. PMID: 38397012 Free PMC article. Review.
Acid accumulation severe enough to reduce serum bicarbonate concentration, i.e., manifesting as chronic metabolic acidosis, the most extreme end of the continuum of "acid stress", harms bones and muscles and appears to enhance the progression of chronic kidne …
Acid accumulation severe enough to reduce serum bicarbonate concentration, i.e., manifesting as chronic metabolic acidosis …
A comparison of treating metabolic acidosis in CKD stage 4 hypertensive kidney disease with fruits and vegetables or sodium bicarbonate.
Goraya N, Simoni J, Jo CH, Wesson DE. Goraya N, et al. Clin J Am Soc Nephrol. 2013 Mar;8(3):371-81. doi: 10.2215/CJN.02430312. Epub 2013 Feb 7. Clin J Am Soc Nephrol. 2013. PMID: 23393104 Free PMC article. Clinical Trial.
One-year PTCO2 was higher than baseline in the HCO3 group (21.2 1.3 versus 19.5 1.5 mM; P<0.01) and the fruits and vegetables group (19.9 1.7 versus 19.3 1.9 mM; P<0.01), consistent with improved metabolic acidosis, and was higher in the HCO3 tha …
One-year PTCO2 was higher than baseline in the HCO3 group (21.2 1.3 versus 19.5 1.5 mM; P<0.01) and the fruits and vegetables …