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89 results

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Page 1
Gosha-Jinki-Gan Reduces Inflammation in Chronic Ischemic Stroke Mouse Models by Suppressing the Infiltration of Macrophages.
Xu M, Suyama K, Nagahori K, Kiyoshima D, Miyakawa S, Deguchi H, Katahira Y, Mizoguchi I, Terayama H, Hayashi S, Yoshimoto T, Qu N. Xu M, et al. Biomolecules. 2025 Aug 6;15(8):1136. doi: 10.3390/biom15081136. Biomolecules. 2025. PMID: 40867580 Free PMC article.
In this study, we investigated the therapeutic effect of an oriental medicine, Gosha-jinki-gan (TJ107), on improving chronic ischemic stroke using the mouse model with middle cerebral artery occlusion (MCAO). ...On the other hand, the administration of TJ107 …
In this study, we investigated the therapeutic effect of an oriental medicine, Gosha-jinki-gan (TJ107), on improving ch …
Gosha-Jinki-Gan Improved Erectile Dysfunction Caused by Anti-Cancer Agent Oxaliplatin by Decreasing Transcriptional Expression of Phosphodiesterase-5 in Rats.
Kataoka T, Kawaki Y, Kito Y, Suzuki J, Mori T, Hotta Y, Sanagawa A, Kawade Y, Maeda Y, Furukawa-Hibi Y, Kimura K. Kataoka T, et al. Sex Med. 2022 Apr;10(2):100484. doi: 10.1016/j.esxm.2021.100484. Epub 2022 Jan 19. Sex Med. 2022. PMID: 35065470 Free PMC article.
BACKGROUND: A platinum-containing anti-cancer agent, oxaliplatin (L-OHP), is known to induce peripheral neuropathy, including erectile dysfunction (ED) as a side effect, while Gosha-jinki-gan (GJG) is a traditional Japanese herbal medicine mainly used for per …
BACKGROUND: A platinum-containing anti-cancer agent, oxaliplatin (L-OHP), is known to induce peripheral neuropathy, including erectile dysfu …
Gosha-Jinki-Gan Recovers Spermatogenesis in Mice with Busulfan-Induced Aspermatogenesis.
Qu N, Kuramasu M, Hirayanagi Y, Nagahori K, Hayashi S, Ogawa Y, Terayama H, Suyama K, Naito M, Sakabe K, Itoh M. Qu N, et al. Int J Mol Sci. 2018 Sep 3;19(9):2606. doi: 10.3390/ijms19092606. Int J Mol Sci. 2018. PMID: 30177609 Free PMC article.
Some traditional herbal medicines have been administered to improve spermatogenesis. In the present study, we administered Gosha-jinki-gan (TJ107; Tsumura Co., Ltd., Tokyo, Japan) to mice suffering from severe aspermatogenesis after busulfan treatment to dete …
Some traditional herbal medicines have been administered to improve spermatogenesis. In the present study, we administered Gosha-j …
Effect of Gosha-jinki-gan, a blended herbal medicine, on bladder activity in rats.
Nishijima S, Sugaya K, Miyazato M, Ogawa Y. Nishijima S, et al. J Urol. 2007 Feb;177(2):762-5. doi: 10.1016/j.juro.2006.09.077. J Urol. 2007. PMID: 17222677
PURPOSE: We investigated the effect of the blended herbal medicine Gosha-jinki-gan on bladder activity and the autonomic nervous system in rats. MATERIALS AND METHODS: A total of 42 female rats were divided into a control diet group of 21 and a Gosha- …
PURPOSE: We investigated the effect of the blended herbal medicine Gosha-jinki-gan on bladder activity and the autonomi …
Effects of gosha-jinki-gan, a kampo medicine, on peripheral tissue blood flow in streptozotocin-induced diabetic rats.
Suzuki Y, Goto K, Ishige A, Komatsu Y, Kamei J. Suzuki Y, et al. Methods Find Exp Clin Pharmacol. 1998 May;20(4):321-8. doi: 10.1358/mf.1998.20.4.485687. Methods Find Exp Clin Pharmacol. 1998. PMID: 9658382 Free article.
Levels of aortic guanosine 3',5'-cyclic monophosphate were dose-dependently increased by administration of Gosha-jinki-gan (0.3, 1.5 g/kg, p.o). These results suggest that Gosha-jinki-gan has vasodilating effects via increases in nitric o …
Levels of aortic guanosine 3',5'-cyclic monophosphate were dose-dependently increased by administration of Gosha-jinki-gan …
Gosha-jinki-gan reduces transmitter proteins and sensory receptors associated with C fiber activation induced by acetic acid in rat urinary bladder.
Imamura T, Ishizuka O, Aizawa N, Zhong C, Ogawa T, Nakayama T, Tanabe T, Nishizawa O. Imamura T, et al. Neurourol Urodyn. 2008;27(8):832-7. doi: 10.1002/nau.20559. Neurourol Urodyn. 2008. PMID: 18551569
However, with the instillation of acetic acid, the tachykinins and the TRPV1 and P2X3 receptors of Gosha-jinki-gan pretreated rats decreased compared with standard diet fed rats. The mRNA expression levels of neurokinin A, substance P, and the TRPV1 receptor …
However, with the instillation of acetic acid, the tachykinins and the TRPV1 and P2X3 receptors of Gosha-jinki-gan pret …
Effect of Gosha-Jinki-Gan on Levels of Specific mRNA Transcripts in Mouse Testes after Busulfan Treatment.
Qu N, Nagahori K, Kuramasu M, Ogawa Y, Suyama K, Hayashi S, Sakabe K, Itoh M. Qu N, et al. Biomedicines. 2020 Oct 19;8(10):432. doi: 10.3390/biomedicines8100432. Biomedicines. 2020. PMID: 33086656 Free PMC article.
Some studies have suggested that Sertoli cells play a key role in mediating testicular immunology in busulfan-induced aspermatogenesis. We recently demonstrated that Gosha-jinki-gan (TJ107), a traditional Japanese medicine, can completely recover injured sper …
Some studies have suggested that Sertoli cells play a key role in mediating testicular immunology in busulfan-induced aspermatogenesis. We r …
Gosha-jinki-gan (a Herbal Complex) Corrects Abnormal Insulin Signaling.
Qin B, Nagasaki M, Ren M, Bajotto G, Oshida Y, Sato Y. Qin B, et al. Evid Based Complement Alternat Med. 2004 Dec;1(3):269-276. doi: 10.1093/ecam/neh028. Epub 2004 Jul 21. Evid Based Complement Alternat Med. 2004. PMID: 15841260 Free PMC article.
Previous studies have shown that the traditional herbal complex Gosha-jinki-gan (GJG) improves diabetic neuropathy and insulin resistance. The present study was undertaken to elucidate the molecular mechanisms related with the long-term effects of GJG adminis …
Previous studies have shown that the traditional herbal complex Gosha-jinki-gan (GJG) improves diabetic neuropathy and …
Gosha-jinki-gan (herbal medicine) in streptozocin-induced diabetic neuropathy.
Nishizawa M, Sutherland WH, Nukada H. Nishizawa M, et al. J Neurol Sci. 1995 Oct;132(2):177-81. doi: 10.1016/0022-510x(95)00141-n. J Neurol Sci. 1995. PMID: 8543945
Herbal medicine should be investigated as a potential regimen for diabetic neuropathy for the following reasons: (1) diabetic neuropathy remains an important clinical problem affecting a significant proportion of diabetic subjects without satisfactory treatment; (2) there are mul …
Herbal medicine should be investigated as a potential regimen for diabetic neuropathy for the following reasons: (1) diabetic neuropathy rem …
89 results