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100 results

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Page 1
Attenuation of peripheral serotonin inhibits tumor growth and enhances immune checkpoint blockade therapy in murine tumor models.
Schneider MA, Heeb L, Beffinger MM, Pantelyushin S, Linecker M, Roth L, Lehmann K, Ungethüm U, Kobold S, Graf R, van den Broek M, Vom Berg J, Gupta A, Clavien PA. Schneider MA, et al. Among authors: graf r. Sci Transl Med. 2021 Sep 15;13(611):eabc8188. doi: 10.1126/scitranslmed.abc8188. Epub 2021 Sep 15. Sci Transl Med. 2021. PMID: 34524861
Peripheral serotonin-deficient (Tph1(/)) mice displayed reduced growth of subcutaneous and orthotopically injected syngeneic murine pancreatic and colorectal cancers with enhanced accumulation of functional CD8(+) T cells compared to control C57BL/6 mice, resulting in exte …
Peripheral serotonin-deficient (Tph1(/)) mice displayed reduced growth of subcutaneous and orthotopically injected syngeneic murine pancr …
Pancreatic stone protein - sepsis and the riddles of the exocrine pancreas.
Graf R. Graf R. Pancreatology. 2020 Apr;20(3):301-304. doi: 10.1016/j.pan.2020.01.016. Epub 2020 Feb 1. Pancreatology. 2020. PMID: 32037128 Review.
Pancreatic stone protein (PSP), discovered in the 1970ies, was first associated with stone formation during chronic pancreatitis. ...In this review, written in connection with receiving the Lifetime Achievement Award of the European Pancreatic Club, the evolu …
Pancreatic stone protein (PSP), discovered in the 1970ies, was first associated with stone formation during chronic pancreatitis …
Exocrine meets endocrine: pancreatic stone protein and regenerating protein--two sides of the same coin.
Graf R, Schiesser M, Reding T, Appenzeller P, Sun LK, Fortunato F, Perren A, Bimmler D. Graf R, et al. J Surg Res. 2006 Jun 15;133(2):113-20. doi: 10.1016/j.jss.2005.09.030. Epub 2005 Dec 19. J Surg Res. 2006. PMID: 16360171 Review.
BACKGROUND: Regenerating protein (reg) and pancreatic stone protein (PSP) have been discovered independently in the fields of diabetes and pancreatitis. ...A hitherto insufficiently understood phenomenon is the massive up-regulation of PSP/reg in pancreatic t …
BACKGROUND: Regenerating protein (reg) and pancreatic stone protein (PSP) have been discovered independently in the fields of diabete …
Ibuprofen and diclofenac treatments reduce proliferation of pancreatic acinar cells upon inflammatory injury and mitogenic stimulation.
Bombardo M, Malagola E, Chen R, Rudnicka A, Graf R, Sonda S. Bombardo M, et al. Among authors: graf r. Br J Pharmacol. 2018 Jan;175(2):335-347. doi: 10.1111/bph.13867. Epub 2017 Jun 16. Br J Pharmacol. 2018. PMID: 28542719 Free PMC article.
Here, we evaluated whether NSAIDs inhibit the proliferation of pancreatic acinar cells during the development of acute pancreatitis. EXPERIMENTAL APPROACH: The NSAIDs ibuprofen and diclofenac were administered to C57BL/6 mice after induction of pancreatitis w …
Here, we evaluated whether NSAIDs inhibit the proliferation of pancreatic acinar cells during the development of acute pancreatiti …
Discriminative performance of pancreatic stone protein in predicting ICU mortality and infection severity in adult patients with infection: a systematic review and individual patient level meta-analysis.
Zuercher P, Moser A, Garcia de Guadiana-Romualdo L, Llewelyn MJ, Graf R, Reding T, Eggimann P, Que YA, Prazak J. Zuercher P, et al. Among authors: graf r. Infection. 2023 Dec;51(6):1797-1807. doi: 10.1007/s15010-023-02093-w. Epub 2023 Sep 14. Infection. 2023. PMID: 37707744 Free PMC article.
BACKGROUND: Several studies suggested pancreatic stone protein (PSP) as a promising biomarker to predict mortality among patients with severe infection. ...METHODS: A systematic search across Cochrane Central Register of Controlled Trials and MEDLINE databases (1966 to Feb …
BACKGROUND: Several studies suggested pancreatic stone protein (PSP) as a promising biomarker to predict mortality among patients wit …
The role of lymphotoxin signaling in the development of autoimmune pancreatitis and associated secondary extra-pancreatic pathologies.
Seleznik GM, Zoller J, O'Connor T, Graf R, Heikenwalder M. Seleznik GM, et al. Among authors: graf r. Cytokine Growth Factor Rev. 2014 Apr;25(2):125-37. doi: 10.1016/j.cytogfr.2014.01.003. Epub 2014 Jan 10. Cytokine Growth Factor Rev. 2014. PMID: 24508087 Review.
The pathogenic mechanisms of autoimmune pancreatitis (AIP), an increasingly recognized, immune-mediated form of chronic pancreatitis, have so far remained elusive. ...We have recently demonstrated that pancreata derived from human AIP patients display overexpression …
The pathogenic mechanisms of autoimmune pancreatitis (AIP), an increasingly recognized, immune-mediated form of chronic pancreatit …
PSP/reg inhibits cultured pancreatic stellate cell and regulates MMP/ TIMP ratio.
Li L, Bimmler D, Graf R, Zhou S, Sun Z, Chen J, Siech M, Bachem MG. Li L, et al. Among authors: graf r. Eur J Clin Invest. 2011 Feb;41(2):151-8. doi: 10.1111/j.1365-2362.2010.02390.x. Epub 2010 Sep 23. Eur J Clin Invest. 2011. PMID: 20860757
BACKGROUND: Pancreatic stellate cells (PSC) play a central role in fibrogenesis associated with acute and chronic pancreatitis. Pancreatic stone protein/regenerating protein (PSP/reg) belongs to a family of secretory stress proteins (SSP) that are constitutiv …
BACKGROUND: Pancreatic stellate cells (PSC) play a central role in fibrogenesis associated with acute and chronic pancreatitis …
The pancreas responds to remote damage and systemic stress by secretion of the pancreatic secretory proteins PSP/regI and PAP/regIII.
Reding T, Palmiere C, Pazhepurackel C, Schiesser M, Bimmler D, Schlegel A, Süss U, Steiner S, Mancina L, Seleznik G, Graf R. Reding T, et al. Among authors: graf r. Oncotarget. 2017 May 2;8(18):30162-30174. doi: 10.18632/oncotarget.16282. Oncotarget. 2017. PMID: 28415799 Free PMC article.
INTRODUCTION: In patients with infection and sepsis serum levels of Pancreatic Stone protein/regenerating protein I (PSP) are highly elevated. The origin of PSP during these conditions is presumably the pancreas, however, an intestinal origin cannot be excluded. Sim …
INTRODUCTION: In patients with infection and sepsis serum levels of Pancreatic Stone protein/regenerating protein I (PSP) are highly …
Pancreatic stone protein (PSP) and pancreatitis-associated protein (PAP): a protocol of a cohort study on the diagnostic efficacy and prognostic value of PSP and PAP as postoperative markers of septic complications in patients undergoing abdominal surgery (PSP study).
Fisher OM, Oberkofler CE, Raptis DA, Soll C, Béchir M, Schiesser M, Graf R. Fisher OM, et al. Among authors: graf r. BMJ Open. 2014 Mar 6;4(3):e004914. doi: 10.1136/bmjopen-2014-004914. BMJ Open. 2014. PMID: 24604486 Free PMC article.
At present, physicians have to rely on their clinical experience to differentiate between the two. Pancreatic stone protein (PSP) and pancreatitis-associated protein (PAP), both secretory proteins produced by the pancreas, are dramatically increased during …
At present, physicians have to rely on their clinical experience to differentiate between the two. Pancreatic stone protein (PSP) and …
Response of routine inflammatory biomarkers and novel Pancreatic Stone Protein to inhalation injury and its interference with sepsis detection in severely burned patients.
Klein HJ, Rittirsch D, Buehler PK, Schweizer R, Giovanoli P, Cinelli P, Plock JA, Reding T, Graf R. Klein HJ, et al. Among authors: graf r. Burns. 2021 Mar;47(2):338-348. doi: 10.1016/j.burns.2020.04.039. Epub 2020 May 3. Burns. 2021. PMID: 33272743
Inhalation injury related kinetics of currently available inflammatory biomarkers and novel Pancreatic Stone Protein (PSP) as well as their interference with septic events has not been addressed to literature yet. ...
Inhalation injury related kinetics of currently available inflammatory biomarkers and novel Pancreatic Stone Protein (PSP) as well as …
100 results