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Year Number of Results
1980 2
1981 2
1982 1
1984 1
1995 1
1997 1
1999 3
2000 1
2001 2
2002 2
2003 2
2004 1
2005 3
2006 5
2007 1
2008 2
2009 3
2010 2
2011 5
2012 5
2013 10
2014 9
2015 9
2016 3
2017 6
2018 6
2019 6
2020 7
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2022 3
2023 1

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94 results

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Page 1
Attenuation of peripheral serotonin inhibits tumor growth and enhances immune checkpoint blockade therapy in murine tumor models.
Schneider MA, Heeb L, Beffinger MM, Pantelyushin S, Linecker M, Roth L, Lehmann K, Ungethüm U, Kobold S, Graf R, van den Broek M, Vom Berg J, Gupta A, Clavien PA. Schneider MA, et al. Among authors: graf r. Sci Transl Med. 2021 Sep 15;13(611):eabc8188. doi: 10.1126/scitranslmed.abc8188. Epub 2021 Sep 15. Sci Transl Med. 2021. PMID: 34524861
Peripheral serotonin-deficient (Tph1(/)) mice displayed reduced growth of subcutaneous and orthotopically injected syngeneic murine pancreatic and colorectal cancers with enhanced accumulation of functional CD8(+) T cells compared to control C57BL/6 mice, resulting in exte …
Peripheral serotonin-deficient (Tph1(/)) mice displayed reduced growth of subcutaneous and orthotopically injected syngeneic murine pancr …
Alogliptin after acute coronary syndrome in patients with type 2 diabetes.
White WB, Cannon CP, Heller SR, Nissen SE, Bergenstal RM, Bakris GL, Perez AT, Fleck PR, Mehta CR, Kupfer S, Wilson C, Cushman WC, Zannad F; EXAMINE Investigators. White WB, et al. N Engl J Med. 2013 Oct 3;369(14):1327-35. doi: 10.1056/NEJMoa1305889. Epub 2013 Sep 2. N Engl J Med. 2013. PMID: 23992602 Free article. Clinical Trial.
Glycated hemoglobin levels were significantly lower with alogliptin than with placebo (mean difference, -0.36 percentage points; P<0.001). Incidences of hypoglycemia, cancer, pancreatitis, and initiation of dialysis were similar with alogliptin and placebo. ...
Glycated hemoglobin levels were significantly lower with alogliptin than with placebo (mean difference, -0.36 percentage points; P<0.001) …
Pancreatic stone protein - sepsis and the riddles of the exocrine pancreas.
Graf R. Graf R. Pancreatology. 2020 Apr;20(3):301-304. doi: 10.1016/j.pan.2020.01.016. Epub 2020 Feb 1. Pancreatology. 2020. PMID: 32037128 Review.
Pancreatic stone protein (PSP), discovered in the 1970ies, was first associated with stone formation during chronic pancreatitis. ...We conclude that the true functional properties of this fascinating pancreatic protein still remain an enigma....
Pancreatic stone protein (PSP), discovered in the 1970ies, was first associated with stone formation during chronic pancreatitis …
Ibuprofen and diclofenac treatments reduce proliferation of pancreatic acinar cells upon inflammatory injury and mitogenic stimulation.
Bombardo M, Malagola E, Chen R, Rudnicka A, Graf R, Sonda S. Bombardo M, et al. Among authors: graf r. Br J Pharmacol. 2018 Jan;175(2):335-347. doi: 10.1111/bph.13867. Epub 2017 Jun 16. Br J Pharmacol. 2018. PMID: 28542719 Free PMC article.
Here, we evaluated whether NSAIDs inhibit the proliferation of pancreatic acinar cells during the development of acute pancreatitis. ...Ibuprofen also reduced acinar cell proliferation induced by mitogenic stimulation with T3, a treatment that does not elicit pan …
Here, we evaluated whether NSAIDs inhibit the proliferation of pancreatic acinar cells during the development of acute pancreatiti …
Exocrine meets endocrine: pancreatic stone protein and regenerating protein--two sides of the same coin.
Graf R, Schiesser M, Reding T, Appenzeller P, Sun LK, Fortunato F, Perren A, Bimmler D. Graf R, et al. J Surg Res. 2006 Jun 15;133(2):113-20. doi: 10.1016/j.jss.2005.09.030. Epub 2005 Dec 19. J Surg Res. 2006. PMID: 16360171 Review.
BACKGROUND: Regenerating protein (reg) and pancreatic stone protein (PSP) have been discovered independently in the fields of diabetes and pancreatitis. ...A hitherto insufficiently understood phenomenon is the massive up-regulation of PSP/reg in pancreatic t …
BACKGROUND: Regenerating protein (reg) and pancreatic stone protein (PSP) have been discovered independently in the fields of diabete …
PSP/reg inhibits cultured pancreatic stellate cell and regulates MMP/ TIMP ratio.
Li L, Bimmler D, Graf R, Zhou S, Sun Z, Chen J, Siech M, Bachem MG. Li L, et al. Among authors: graf r. Eur J Clin Invest. 2011 Feb;41(2):151-8. doi: 10.1111/j.1365-2362.2010.02390.x. Epub 2010 Sep 23. Eur J Clin Invest. 2011. PMID: 20860757
BACKGROUND: Pancreatic stellate cells (PSC) play a central role in fibrogenesis associated with acute and chronic pancreatitis. Pancreatic stone protein/regenerating protein (PSP/reg) belongs to a family of secretory stress proteins (SSP) that are constitutiv …
BACKGROUND: Pancreatic stellate cells (PSC) play a central role in fibrogenesis associated with acute and chronic pancreatitis …
The pancreas responds to remote damage and systemic stress by secretion of the pancreatic secretory proteins PSP/regI and PAP/regIII.
Reding T, Palmiere C, Pazhepurackel C, Schiesser M, Bimmler D, Schlegel A, Süss U, Steiner S, Mancina L, Seleznik G, Graf R. Reding T, et al. Among authors: graf r. Oncotarget. 2017 May 2;8(18):30162-30174. doi: 10.18632/oncotarget.16282. Oncotarget. 2017. PMID: 28415799 Free PMC article.
The origin of PSP during these conditions is presumably the pancreas, however, an intestinal origin cannot be excluded. Similarly, pancreatitis-associated protein (PAP) was identified in the pancreas. ...RESULTS: PSP and PAP responded to remote lesions in rat …
The origin of PSP during these conditions is presumably the pancreas, however, an intestinal origin cannot be excluded. Similarly, …
The role of lymphotoxin signaling in the development of autoimmune pancreatitis and associated secondary extra-pancreatic pathologies.
Seleznik GM, Zoller J, O'Connor T, Graf R, Heikenwalder M. Seleznik GM, et al. Among authors: graf r. Cytokine Growth Factor Rev. 2014 Apr;25(2):125-37. doi: 10.1016/j.cytogfr.2014.01.003. Epub 2014 Jan 10. Cytokine Growth Factor Rev. 2014. PMID: 24508087 Review.
The pathogenic mechanisms of autoimmune pancreatitis (AIP), an increasingly recognized, immune-mediated form of chronic pancreatitis, have so far remained elusive. ...We have recently demonstrated that pancreata derived from human AIP patients display overexpression …
The pathogenic mechanisms of autoimmune pancreatitis (AIP), an increasingly recognized, immune-mediated form of chronic pancreatit …
Identification and Validation of a Biomarker Signature in Patients With Resectable Pancreatic Cancer via Genome-Wide Screening for Functional Genetic Variants.
Dimitrakopoulos C, Vrugt B, Flury R, Schraml P, Knippschild U, Wild P, Hoerstrup S, Henne-Bruns D, Wuerl P, Graf R, Breitenstein S, Bond G, Beerenwinkel N, Grochola LF. Dimitrakopoulos C, et al. Among authors: graf r. JAMA Surg. 2019 Jun 1;154(6):e190484. doi: 10.1001/jamasurg.2019.0484. Epub 2019 Jun 19. JAMA Surg. 2019. PMID: 30942874 Free PMC article.
IMPORTANCE: Surgery currently offers the only chance for a cure in pancreatic ductal adenocarcinoma (PDAC), but it carries a significant morbidity and mortality risk and results in varying oncologic outcomes. ...Data analysis occurred from November 2017 to May 2018. EXPOSU …
IMPORTANCE: Surgery currently offers the only chance for a cure in pancreatic ductal adenocarcinoma (PDAC), but it carries a signific …
Pancreatic stone protein (PSP) and pancreatitis-associated protein (PAP): a protocol of a cohort study on the diagnostic efficacy and prognostic value of PSP and PAP as postoperative markers of septic complications in patients undergoing abdominal surgery (PSP study).
Fisher OM, Oberkofler CE, Raptis DA, Soll C, Béchir M, Schiesser M, Graf R. Fisher OM, et al. Among authors: graf r. BMJ Open. 2014 Mar 6;4(3):e004914. doi: 10.1136/bmjopen-2014-004914. BMJ Open. 2014. PMID: 24604486 Free PMC article.
At present, physicians have to rely on their clinical experience to differentiate between the two. Pancreatic stone protein (PSP) and pancreatitis-associated protein (PAP), both secretory proteins produced by the pancreas, are dramatically increased during …
At present, physicians have to rely on their clinical experience to differentiate between the two. Pancreatic stone protein (PSP) and …
94 results