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The effect of the creatine analogue beta-guanidinopropionic acid on energy metabolism: a systematic review.
Oudman I, Clark JF, Brewster LM. Oudman I, et al. PLoS One. 2013;8(1):e52879. doi: 10.1371/journal.pone.0052879. Epub 2013 Jan 9. PLoS One. 2013. PMID: 23326362 Free PMC article. Review.
Cellular creatine uptake is competitively inhibited by beta-guanidinopropionic acid. ...Beta-guanidinopropionic acid decreased intracellular creatine and phosphocreatine in all tissues studied. ...
Cellular creatine uptake is competitively inhibited by beta-guanidinopropionic acid. ...Beta-guanidinopropionic
The acute effect of beta-guanidinopropionic acid versus creatine or placebo in healthy men (ABC Trial): study protocol for a randomized controlled trial.
Karamat FA, Horjus DL, Haan YC, van der Woude L, Oudman I, van Montfrans GA, Clark JF, Brewster LM. Karamat FA, et al. Trials. 2015 Feb 22;16:56. doi: 10.1186/s13063-015-0581-9. Trials. 2015. PMID: 25888414 Free PMC article. Clinical Trial.
In line with this, we found that plasma CK activity after rest, a surrogate measure of tissue activity, is the main predictor of blood pressure levels and failure of antihypertensive therapy in the general population. In addition, the creatine analog and competitive oral …
In line with this, we found that plasma CK activity after rest, a surrogate measure of tissue activity, is the main predictor of blood press …
Effects of the creatine analogue beta-guanidinopropionic acid on skeletal muscles of mice deficient in muscle creatine kinase.
van Deursen J, Jap P, Heerschap A, ter Laak H, Ruitenbeek W, Wieringa B. van Deursen J, et al. Biochim Biophys Acta. 1994 May 18;1185(3):327-35. doi: 10.1016/0005-2728(94)90248-8. Biochim Biophys Acta. 1994. PMID: 8180237
To evaluate the effects of phosphocreatine (PCr) and creatine (Cr) depletion on skeletal muscles of mice deficient in muscle creatine kinase (M-CK), we have fed mutant mice a diet containing the creatine analogue beta-guanidinopropionic acid
To evaluate the effects of phosphocreatine (PCr) and creatine (Cr) depletion on skeletal muscles of mice deficient in muscle creat
Effects of creatine and its analog, beta-guanidinopropionic acid, on the differentiation of and nucleoli in myoblasts.
Ohira Y, Matsuoka Y, Kawano F, Ogura A, Higo Y, Ohira T, Terada M, Oke Y, Nakai N. Ohira Y, et al. Biosci Biotechnol Biochem. 2011;75(6):1085-9. doi: 10.1271/bbb.100901. Epub 2011 Jun 13. Biosci Biotechnol Biochem. 2011. PMID: 21670531 Free article.
The effects of supplementation with creatine (Cr) and its analog, beta-guanidinopropionic acid (beta-GPA), on the differentiation of myoblasts and the numbers of nucleoli were studied in C2C12 cells. ...
The effects of supplementation with creatine (Cr) and its analog, beta-guanidinopropionic acid (beta-GPA), on the diffe …
Creatine kinase, energy reserve, and hypertension: from bench to bedside.
Brewster LM. Brewster LM. Ann Transl Med. 2018 Aug;6(15):292. doi: 10.21037/atm.2018.07.15. Ann Transl Med. 2018. PMID: 30211180 Free PMC article. Review.
We hypothesized that human variation in the activity of the ATP regenerating enzyme creatine kinase (CK) activity affects hypertension and cardiovascular disease risk. ...In subsequent intervention studies, the oral competitive CK inhibitor beta-guanidinopropioni
We hypothesized that human variation in the activity of the ATP regenerating enzyme creatine kinase (CK) activity affects hype …
Creatine kinase kinetics, ATP turnover, and cardiac performance in hearts depleted of creatine with the substrate analogue beta-guanidinopropionic acid.
Shoubridge EA, Jeffry FM, Keogh JM, Radda GK, Seymour AM. Shoubridge EA, et al. Biochim Biophys Acta. 1985 Oct 30;847(1):25-32. doi: 10.1016/0167-4889(85)90148-x. Biochim Biophys Acta. 1985. PMID: 4052460
Rats were fed a diet containing 1% of the creatine substrate analogue beta-guanidinopropionic acid for 6-10 weeks. 31P-NMR investigation of isolated, glucose-perfused working hearts showed a 90% reduction in [phosphocreatine] from 22.2 to 2.5 mumol/g dry wt i …
Rats were fed a diet containing 1% of the creatine substrate analogue beta-guanidinopropionic acid for 6-10 weeks. 31P- …
Actions of the creatine analogue beta-guanidinopropionic acid on rat heart mitochondria.
Clark JF, Khuchua Z, Kuznetsov AV, Vassil'eva E, Boehm E, Radda GK, Saks V. Clark JF, et al. Biochem J. 1994 May 15;300 ( Pt 1)(Pt 1):211-6. doi: 10.1042/bj3000211. Biochem J. 1994. PMID: 8198536 Free PMC article.
The action of the creatine analogue beta-guanidinopropionic acid (beta-GPA) was examined in rat heart mitochondria and in isolated cardiomyocytes or fibres which were permeabilized with the non-ionic detergent saponin to determine the kinetics of mitochondria …
The action of the creatine analogue beta-guanidinopropionic acid (beta-GPA) was examined in rat heart mitochondria and …
The acute effect of beta-guanidinopropionic acid versus creatine or placebo in healthy men (ABC-Trial): A randomized controlled first-in-human trial.
Karamat FA, Horjus DL, Haan YC, van der Woude L, Schaap MC, Oudman I, van Montfrans GA, Nieuwland R, Salomons GS, Clark JF, Brewster LM. Karamat FA, et al. Br J Clin Pharmacol. 2017 Dec;83(12):2626-2635. doi: 10.1111/bcp.13390. Epub 2017 Sep 20. Br J Clin Pharmacol. 2017. PMID: 28795416 Free PMC article. Clinical Trial.
AIMS: Increasing evidence indicates that the ATP-generating enzyme creatine kinase (CK) is involved in hypertension. CK rapidly regenerates ATP from creatine phosphate and ADP. Recently, it has been shown that beta-guanidinopropionic acid (GPA), …
AIMS: Increasing evidence indicates that the ATP-generating enzyme creatine kinase (CK) is involved in hypertension. CK rapidl …
beta-Guanidinopropionic acid extends the lifespan of Drosophila melanogaster via an AMP-activated protein kinase-dependent increase in autophagy.
Yang S, Long LH, Li D, Zhang JK, Jin S, Wang F, Chen JG. Yang S, et al. Aging Cell. 2015 Dec;14(6):1024-33. doi: 10.1111/acel.12371. Epub 2015 Jun 29. Aging Cell. 2015. PMID: 26120775 Free PMC article.
Previous studies have demonstrated that AMP-activated protein kinase (AMPK) controls autophagy through the mammalian target of rapamycin (mTOR) and Unc-51 like kinase 1 (ULK1/Atg1) signaling, which augments the quality of cellular housekeeping, and that beta-guan
Previous studies have demonstrated that AMP-activated protein kinase (AMPK) controls autophagy through the mammalian target of rapamy …
Effects of creatine and beta-guanidinopropionic acid and alterations in creatine transporter and creatine kinases expression in acute seizure and chronic epilepsy models.
Kim DW, Yeo SI, Ryu HJ, Kim JE, Song HK, Kwon OS, Choi SY, Kang TC. Kim DW, et al. BMC Neurosci. 2010 Oct 28;11:141. doi: 10.1186/1471-2202-11-141. BMC Neurosci. 2010. PMID: 20979657 Free PMC article.
BACKGROUND: In order to confirm the roles of creatine (Cr) in epilepsy, we investigated the anti-convulsive effects of Cr, creatine transporter (CRT) and creatine kinases (CKs) against chemical-induced acute seizure activity and chronic epileptic seizure acti …
BACKGROUND: In order to confirm the roles of creatine (Cr) in epilepsy, we investigated the anti-convulsive effects of Cr, creatin
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