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Guggulsterone for Chemoprevention of Cancer.
Shishodia S, Azu N, Rosenzweig JA, Jackson DA. Shishodia S, et al. Curr Pharm Des. 2016;22(3):294-306. doi: 10.2174/1381612822666151112153117. Curr Pharm Des. 2016. PMID: 26561056 Review.
Guggulsterone [4, 17(20)-pregnadiene-3, 16-dione] is a plant sterol derived from the gum resin of the tree Commiphora wightii. ...This review describes the anti-cancer properties, molecular targets, and the apoptotic effects of gugguls …
Guggulsterone [4, 17(20)-pregnadiene-3, 16-dione] is a plant sterol derived from the gum resin of …
Guggulsterone and Its Role in Chronic Diseases.
Yamada T, Sugimoto K. Yamada T, et al. Adv Exp Med Biol. 2016;929:329-361. doi: 10.1007/978-3-319-41342-6_15. Adv Exp Med Biol. 2016. PMID: 27771932 Review.
Guggulsterone is a plant sterol derived from gum resin of Commiphora wightii. ...This review aimed to clarify the cell signal pathways targeted by guggulsterone and the bioactivities of guggulsterone in animal models and humans....
Guggulsterone is a plant sterol derived from gum resin of Commiphora wightii. ...This review aimed to clarify the cell signal pathway …
Potential therapeutic targets of Guggulsterone in cancer.
Bhat AA, Prabhu KS, Kuttikrishnan S, Krishnankutty R, Babu J, Mohammad RM, Uddin S. Bhat AA, et al. Nutr Metab (Lond). 2017 Feb 28;14:23. doi: 10.1186/s12986-017-0180-8. eCollection 2017. Nutr Metab (Lond). 2017. PMID: 28261317 Free PMC article. Review.
Many such compounds are under screening and development with their potential evolution as a clinical drug benefiting many of the cancer patients. Guggulsterone (GS), a phytosterol isolated gum resin of the tree Commiphora mukul has been widely used in Indian traditional me …
Many such compounds are under screening and development with their potential evolution as a clinical drug benefiting many of the cancer pati …
Z-guggulsterone regulates MDR1 expression mainly through the pregnane X receptor-dependent manner in human brain microvessel endothelial cells.
Xu HB, Tang ZQ, Wang J, Kong PS. Xu HB, et al. Eur J Pharmacol. 2020 May 5;874:173023. doi: 10.1016/j.ejphar.2020.173023. Epub 2020 Feb 19. Eur J Pharmacol. 2020. PMID: 32087256
Z-guggulsterone reduced the co-activator SRC-1 expression in hBDMECs, as to prevent the activation of MDR1 gene transcription. In addition, Z-guggulsterone (30 muM) at 24 h significantly inhibited the expression of human constitutive androstane receptor (CAR) protei …
Z-guggulsterone reduced the co-activator SRC-1 expression in hBDMECs, as to prevent the activation of MDR1 gene transcription. In add …
Guggulsterone-releasing microspheres direct the differentiation of human induced pluripotent stem cells into neural phenotypes.
Agbay A, De La Vega L, Nixon G, Willerth S. Agbay A, et al. Biomed Mater. 2018 Feb 28;13(3):034104. doi: 10.1088/1748-605X/aaaa77. Biomed Mater. 2018. PMID: 29368696
Recent work demonstrated that a naturally occurring steroid called guggulsterone effectively differentiated PSCs into DNs, simplifying this process. ...Guggulsterone microsphere incorporated aggregates exhibited the highest levels of TUJ1 expression as well as high …
Recent work demonstrated that a naturally occurring steroid called guggulsterone effectively differentiated PSCs into DNs, simplifyin …
Z-Guggulsterone Produces Antidepressant-Like Effects in Mice through Activation of the BDNF Signaling Pathway.
Liu FG, Hu WF, Wang JL, Wang P, Gong Y, Tong LJ, Jiang B, Zhang W, Qin YB, Chen Z, Yang RR, Huang C. Liu FG, et al. Int J Neuropsychopharmacol. 2017 Jun 1;20(6):485-497. doi: 10.1093/ijnp/pyx009. Int J Neuropsychopharmacol. 2017. PMID: 28339691 Free PMC article.
Here, we investigated the antidepressant-like effect of Z-guggulsterone in a chronic unpredictable stress mouse model of depression. METHODS: The effects of Z-guggulsterone were assessed in mice with the tail suspension test and forced swimming test. ...
Here, we investigated the antidepressant-like effect of Z-guggulsterone in a chronic unpredictable stress mouse model of depression. …
Protective effects of guggulsterone against colitis are associated with the suppression of TREM-1 and modulation of macrophages.
Che X, Park KC, Park SJ, Kang YH, Jin HA, Kim JW, Seo DH, Kim DK, Kim TI, Kim WH, Kim SW, Cheon JH. Che X, et al. Am J Physiol Gastrointest Liver Physiol. 2018 Jul 1;315(1):G128-G139. doi: 10.1152/ajpgi.00027.2018. Epub 2018 Mar 15. Am J Physiol Gastrointest Liver Physiol. 2018. PMID: 29543509 Free article.
Gene expression in macrophages was examined and wound-healing assay using HT-29 cells was performed. Colitis in wild-type and IL-10-, Toll-like receptor 4 (TLR4)-, and myeloid differentiation primary response 88 (MyD88)-deficient mice was induced via the administration of …
Gene expression in macrophages was examined and wound-healing assay using HT-29 cells was performed. Colitis in wild-type and IL-10-, Toll-l …
Z-Guggulsterone attenuates glucocorticoid-induced osteoporosis through activation of Nrf2/HO-1 signaling.
Xu Y, Guan J, Xu J, Chen S, Sun G. Xu Y, et al. Life Sci. 2019 May 1;224:58-66. doi: 10.1016/j.lfs.2019.03.051. Epub 2019 Mar 21. Life Sci. 2019. PMID: 30905781
AIMS: The present study aims to investigate the protective effect and underlying mechanism of Z-Guggulsterone (Z-GS), an active component from myrrh, on glucocorticoid-induced osteoporosis (GIO). ...
AIMS: The present study aims to investigate the protective effect and underlying mechanism of Z-Guggulsterone (Z-GS), an active compo …
Guggulsterone sensitized drug-resistant human hepatocarcinoma cells to doxorubicin through a Cox-2/P-gp dependent pathway.
Xu HB, Fu J, Huang F, Yu J. Xu HB, et al. Eur J Pharmacol. 2017 May 15;803:57-64. doi: 10.1016/j.ejphar.2017.03.045. Epub 2017 Mar 23. Eur J Pharmacol. 2017. PMID: 28342979
When doxorubicin (10M) was combined with guggulsterone (50M), the mean apoptotic population of PLC/PRF/5R cells was 20.16%. ...However, guggulsterone did not show significantly inhibitory effect on the expression of prostaglandin E receptors. ...
When doxorubicin (10M) was combined with guggulsterone (50M), the mean apoptotic population of PLC/PRF/5R cells was 20.16%. .. …
Z-guggulsterone negatively controls microglia-mediated neuroinflammation via blocking IkappaB-alpha-NF-kappaB signals.
Huang C, Wang J, Lu X, Hu W, Wu F, Jiang B, Ling Y, Yang R, Zhang W. Huang C, et al. Neurosci Lett. 2016 Apr 21;619:34-42. doi: 10.1016/j.neulet.2016.02.021. Epub 2016 Feb 12. Neurosci Lett. 2016. PMID: 26879835
Z-guggulsterone also reduced the mRNA level of iNOS, TNF-alpha, and IL-6. ...Z-guggulsterone, however, failed to reduce the LPS-induced increase in NF-kappaB phosphorylation level. ...
Z-guggulsterone also reduced the mRNA level of iNOS, TNF-alpha, and IL-6. ...Z-guggulsterone, however, failed to reduce the LP …
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