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5' cap sequestration is required for sensing of unspliced HIV-1 RNA by MDA5.
Hughes IK, Kharytonchyk S, Ramaswamy S, Jalloh S, Hood JB, He X, Henderson AJ, Akiyama H, Telesnitsky A, Gummuluru S. Hughes IK, et al. bioRxiv [Preprint]. 2025 Aug 25:2025.08.20.671346. doi: 10.1101/2025.08.20.671346. bioRxiv. 2025. PMID: 40909469 Free PMC article. Preprint.
Heterogenous transcription start site (TSS) usage dictates the structure and function of unspliced HIV-1 RNAs (usRNA). We and others have previously reported that expression and Rev/CRM1-mediated nuclear export of HIV-1 usRNA in macrophages activates MDA5, MA …
Heterogenous transcription start site (TSS) usage dictates the structure and function of unspliced HIV-1 RNAs (usRNA). We and others …
Expression of HIV-1 Intron-Containing RNA in Microglia Induces Inflammatory Responses.
Akiyama H, Jalloh S, Park S, Lei M, Mostoslavsky G, Gummuluru S. Akiyama H, et al. J Virol. 2021 Mar 1;95(5):e01386-20. doi: 10.1128/JVI.01386-20. Epub 2020 Dec 9. J Virol. 2021. PMID: 33298546 Free PMC article.
These studies suggest that Rev-CRM1-dependent nuclear export and cytosolic sensing of HIV-1 icRNA induces pro-inflammatory responses in productively infected microglia. Novel strategies targeting HIV icRNA expression specifically are needed to suppress HIV …
These studies suggest that Rev-CRM1-dependent nuclear export and cytosolic sensing of HIV-1 icRNA induces pro-inflammatory res …
HIV-1 intron-containing RNA expression induces innate immune activation and T cell dysfunction.
Akiyama H, Miller CM, Ettinger CR, Belkina AC, Snyder-Cappione JE, Gummuluru S. Akiyama H, et al. Nat Commun. 2018 Aug 27;9(1):3450. doi: 10.1038/s41467-018-05899-7. Nat Commun. 2018. PMID: 30150664 Free PMC article.
Here, we show Rev-CRM1-dependent nuclear export and peripheral membrane association of intron-containing HIV-1 RNA, independent of primary viral sequence or viral protein expression, is subject to sensing and signaling via MAVS, resulting in IFN-I-dependent pro-infl …
Here, we show Rev-CRM1-dependent nuclear export and peripheral membrane association of intron-containing HIV-1 RNA, independen …