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Expression of HIV-1 Intron-Containing RNA in Microglia Induces Inflammatory Responses.
Akiyama H, Jalloh S, Park S, Lei M, Mostoslavsky G, Gummuluru S. Akiyama H, et al. J Virol. 2020 Dec 9;95(5):e01386-20. doi: 10.1128/JVI.01386-20. Online ahead of print. J Virol. 2020. PMID: 33298546 Free PMC article.
These studies suggest that Rev-CRM1-dependent nuclear export and cytosolic sensing of HIV-1 icRNA induces pro-inflammatory responses in productively infected microglia. Novel strategies targeting HIV icRNA expression specifically are needed to suppress HIV
These studies suggest that Rev-CRM1-dependent nuclear export and cytosolic sensing of HIV-1 icRNA induces pro-inflammatory res …
HIV-1 intron-containing RNA expression induces innate immune activation and T cell dysfunction.
Akiyama H, Miller CM, Ettinger CR, Belkina AC, Snyder-Cappione JE, Gummuluru S. Akiyama H, et al. Nat Commun. 2018 Aug 27;9(1):3450. doi: 10.1038/s41467-018-05899-7. Nat Commun. 2018. PMID: 30150664 Free PMC article.
Here, we show Rev-CRM1-dependent nuclear export and peripheral membrane association of intron-containing HIV-1 RNA, independent of primary viral sequence or viral protein expression, is subject to sensing and signaling via MAVS, resulting in IFN-I-dependent pro-infl …
Here, we show Rev-CRM1-dependent nuclear export and peripheral membrane association of intron-containing HIV-1 RNA, independen …