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Page 1
The gut-joint axis in spondyloarthritis: immunological, microbial, and clinical insights.
Qaiyum Z, Lim M, Inman RD. Qaiyum Z, et al. Semin Immunopathol. 2021 Apr;43(2):173-192. doi: 10.1007/s00281-021-00845-0. Epub 2021 Feb 24. Semin Immunopathol. 2021. PMID: 33625549 Review.
The strong genetic and clinical overlaps between spondyloarthritis (SpA) and inflammatory bowel disease (IBD) have placed much needed focus on the gut-joint axis of inflammation in SpA, leading to three key hypotheses that attempt to unravel this compl …
The strong genetic and clinical overlaps between spondyloarthritis (SpA) and inflammatory bowel disease (IBD) have placed much needed …
Revisiting the gut-joint axis: links between gut inflammation and spondyloarthritis.
Gracey E, Vereecke L, McGovern D, Fröhling M, Schett G, Danese S, De Vos M, Van den Bosch F, Elewaut D. Gracey E, et al. Nat Rev Rheumatol. 2020 Aug;16(8):415-433. doi: 10.1038/s41584-020-0454-9. Epub 2020 Jul 13. Nat Rev Rheumatol. 2020. PMID: 32661321 Review.
Gut inflammation is strongly associated with spondyloarthritis (SpA), as exemplified by the high prevalence of inflammatory bowel disease (IBD) and the even higher occurrence of subclinical gut inflammation in patients with SpA. The gut-joint …
Gut inflammation is strongly associated with spondyloarthritis (SpA), as exemplified by the high prevalence of inflammatory bo …
Role of the Gut Microbiota in Osteoarthritis, Rheumatoid Arthritis, and Spondylarthritis: An Update on the Gut-Joint Axis.
Longo UG, Lalli A, Bandini B, de Sire R, Angeletti S, Lustig S, Ammendolia A, Budhiparama NC, de Sire A. Longo UG, et al. Int J Mol Sci. 2024 Mar 13;25(6):3242. doi: 10.3390/ijms25063242. Int J Mol Sci. 2024. PMID: 38542216 Free PMC article. Review.
This dysregulation is defined as the "gut-joint axis" and is based on the joint-gut interaction. It is widely recognized that the microbiota of the gut produce a variety of compounds, including enzymes, short-chain fatty acids, and metabo …
This dysregulation is defined as the "gut-joint axis" and is based on the joint-gut interaction. It is wi …
The gut-enthesis axis and the pathogenesis of Spondyloarthritis.
Mauro D, Nakamura A, Haroon N, Ciccia F. Mauro D, et al. Semin Immunol. 2021 Dec;58:101607. doi: 10.1016/j.smim.2022.101607. Epub 2022 Jul 15. Semin Immunol. 2021. PMID: 35850909 Review.
Subclinical inflammation is associated with Spondylarthritis (SpA). SpA patients show features of dysbiosis, altered gut barrier function, and local expansion of innate and innate-like cells involved in type 3 immune response. The recirculation of intestinal primed …
Subclinical inflammation is associated with Spondylarthritis (SpA). SpA patients show features of dysbiosis, altered gut barri …
Relevance of the gut/joint axis for the management of spondyloarthritis in daily clinical practice.
Cypers H, Van Praet L, Varkas G, Elewaut D. Cypers H, et al. Curr Opin Rheumatol. 2014 Jul;26(4):371-6. doi: 10.1097/BOR.0000000000000070. Curr Opin Rheumatol. 2014. PMID: 24841232 Review.
PURPOSE OF REVIEW: Thirty years ago, the concept of microscopic gut inflammation in spondyloarthritis (SpA) was established. Over the past decade, there has been tremendous progress in the earlier diagnosis of SpA. ...It is therefore necessary to re-establish the ro …
PURPOSE OF REVIEW: Thirty years ago, the concept of microscopic gut inflammation in spondyloarthritis (SpA) was established. O …
The pivotal role of Interleukin-23 in the skin-gut-joint axis.
Zabotti A, Novelli L, Luchetti Gentiloni MM, Guggino G, Biljan A, Lubrano E, McGonagle D. Zabotti A, et al. J Autoimmun. 2025 Dec;157:103500. doi: 10.1016/j.jaut.2025.103500. Epub 2025 Nov 19. J Autoimmun. 2025. PMID: 41265050 Free article. Review.
Interleukin-23 (IL-23) plays a pivotal role in the intricate interplay between the skin, gut, and joints, contributing significantly to the pathogenesis of various inflammatory diseases including psoriasis, psoriatic arthritis (PsA), inflammatory bowel disease (IBD) …
Interleukin-23 (IL-23) plays a pivotal role in the intricate interplay between the skin, gut, and joints, contributing signifi …
The role of the gut and intestinal dysbiosis in the pathogenesis of spondyloarthritis.
Mauro D, Cai B, Ciancio A, Forte G, Gandolfo S, Thomas R, Bergot AS, Ciccia F. Mauro D, et al. Joint Bone Spine. 2025 Dec;92(6):105923. doi: 10.1016/j.jbspin.2025.105923. Epub 2025 May 20. Joint Bone Spine. 2025. PMID: 40404007 Review.
Spondyloarthritis (SpA) encompasses chronic inflammatory diseases affecting both axial and peripheral joints. Emerging evidence highlights a pivotal role for the gut-joint axis in SpA pathogenesis, where intestinal dysbiosis and barrier dysfunct …
Spondyloarthritis (SpA) encompasses chronic inflammatory diseases affecting both axial and peripheral joints. Emerging evidenc …
Gut inflammation and microbiome in spondyloarthritis.
Kabeerdoss J, Sandhya P, Danda D. Kabeerdoss J, et al. Rheumatol Int. 2016 Apr;36(4):457-68. doi: 10.1007/s00296-015-3414-y. Epub 2015 Dec 30. Rheumatol Int. 2016. PMID: 26719306 Review.
Spondyloarthritis (SpA) is chronic inflammatory disease involving joints and the spine. Bowel inflammation is common in SpA, which may be classified as acute or chronic. ...The pathogenesis of gut inflammation in SpA could be explained by two factors-over-act …
Spondyloarthritis (SpA) is chronic inflammatory disease involving joints and the spine. Bowel inflammation is common in SpA, w …
58 results