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Association between antibiotics and gut microbiome dysbiosis in children: systematic review and meta-analysis.
McDonnell L, Gilkes A, Ashworth M, Rowland V, Harries TH, Armstrong D, White P. McDonnell L, et al. Gut Microbes. 2021 Jan-Dec;13(1):1-18. doi: 10.1080/19490976.2020.1870402. Gut Microbes. 2021. PMID: 33651651 Free PMC article.
The underlying mechanisms are thought related to dysbiosis of the gut microbiome. We conducted a systematic review of the association between antibiotics and disruption of the pediatric gut microbiome. Searches used MEDLINE, EMBASE and Web of Sc …
The underlying mechanisms are thought related to dysbiosis of the gut microbiome. We conducted a systematic review of the asso …
A review of antibiotics, depression, and the gut microbiome.
Hao WZ, Li XJ, Zhang PW, Chen JX. Hao WZ, et al. Psychiatry Res. 2020 Feb;284:112691. doi: 10.1016/j.psychres.2019.112691. Epub 2019 Nov 14. Psychiatry Res. 2020. PMID: 31791704 Review.
Emerging evidence indicates that disruption of the intestinal flora play an important role in the pathogenesis of depression. As one of the causes of such disturbances, the role of antibiotics in depression risk is gradually being revealed. Herein, we review recent finding …
Emerging evidence indicates that disruption of the intestinal flora play an important role in the pathogenesis of depression. As one of the …
Effects of early-life antibiotics on the developing infant gut microbiome and resistome: a randomized trial.
Reyman M, van Houten MA, Watson RL, Chu MLJN, Arp K, de Waal WJ, Schiering I, Plötz FB, Willems RJL, van Schaik W, Sanders EAM, Bogaert D. Reyman M, et al. Nat Commun. 2022 Feb 16;13(1):893. doi: 10.1038/s41467-022-28525-z. Nat Commun. 2022. PMID: 35173154 Free PMC article. Clinical Trial.
Broad-spectrum antibiotics for suspected early-onset neonatal sepsis (sEONS) may have pronounced effects on gut microbiome development and selection of antimicrobial resistance when administered in the first week of life, during the assembly phase of the neon …
Broad-spectrum antibiotics for suspected early-onset neonatal sepsis (sEONS) may have pronounced effects on gut microbiome …
Gut Microbiome and Antibiotics.
Iizumi T, Battaglia T, Ruiz V, Perez Perez GI. Iizumi T, et al. Arch Med Res. 2017 Nov;48(8):727-734. doi: 10.1016/j.arcmed.2017.11.004. Epub 2017 Dec 6. Arch Med Res. 2017. PMID: 29221800 Review.
This site is highly susceptible to the effects of many external factors that may affect in the quality and the quantity of the microbiome. Specific factors such as diet, personal hygiene, pharmacological drugs and the use of antibiotics can produce a significant imp …
This site is highly susceptible to the effects of many external factors that may affect in the quality and the quantity of the microbiome …
Antibiotics, gut microbiome and obesity.
Leong KSW, Derraik JGB, Hofman PL, Cutfield WS. Leong KSW, et al. Clin Endocrinol (Oxf). 2018 Feb;88(2):185-200. doi: 10.1111/cen.13495. Epub 2017 Nov 20. Clin Endocrinol (Oxf). 2018. PMID: 29023853 Review.
The obesity pandemic continues to increase, a problem that affects both adults and children alike. Disruptions to the gut microbiome have been linked to a multitude of adverse conditions, including obesity, type 2 diabetes, inflammatory bowel diseases, anxiety, auti …
The obesity pandemic continues to increase, a problem that affects both adults and children alike. Disruptions to the gut microbio …
Antibiotics, gut microbiota, and Alzheimer's disease.
Angelucci F, Cechova K, Amlerova J, Hort J. Angelucci F, et al. J Neuroinflammation. 2019 May 22;16(1):108. doi: 10.1186/s12974-019-1494-4. J Neuroinflammation. 2019. PMID: 31118068 Free PMC article. Review.
Thus, the action of antibiotics in AD could be wide and even opposite, depending on the type of antibiotic and on the specific role of the microbiome in AD pathogenesis.Alteration of the gut microbiota can induce changes in brain activity, which raise …
Thus, the action of antibiotics in AD could be wide and even opposite, depending on the type of antibiotic and on the specific …
Effects of Antibiotics on Gut Microbiota.
Lange K, Buerger M, Stallmach A, Bruns T. Lange K, et al. Dig Dis. 2016;34(3):260-8. doi: 10.1159/000443360. Epub 2016 Mar 30. Dig Dis. 2016. PMID: 27028893 Review.
Short-term antibiotic treatment is able to shift the gut microbiota to long-term alternative dysbiotic states, which may promote the development and aggravation of disease. ...This review summarizes the antibiotic-related changes of the gut microbiota …
Short-term antibiotic treatment is able to shift the gut microbiota to long-term alternative dysbiotic states, which may promo …
Antibiotic perturbations to the gut microbiome.
Fishbein SRS, Mahmud B, Dantas G. Fishbein SRS, et al. Nat Rev Microbiol. 2023 Dec;21(12):772-788. doi: 10.1038/s41579-023-00933-y. Epub 2023 Jul 25. Nat Rev Microbiol. 2023. PMID: 37491458 Review.
Antibiotic-mediated perturbation of the gut microbiome is associated with numerous infectious and autoimmune diseases of the gastrointestinal tract. Yet, as the gut microbiome is a complex ecological network of microorganisms, the effects …
Antibiotic-mediated perturbation of the gut microbiome is associated with numerous infectious and autoimmune diseases o …
The gut microbiome.
Sidhu M, van der Poorten D. Sidhu M, et al. Aust Fam Physician. 2017;46(4):206-211. Aust Fam Physician. 2017. PMID: 28376573 Free article.
OBJECTIVE: This article provides an overview of the gut microbiome in health and disease, highlighting conditions such as Clostridium difficile infection, inflammatory bowel disease, irritable bowel syndrome, obesity and non-alcoholic fatty liver disease, with which …
OBJECTIVE: This article provides an overview of the gut microbiome in health and disease, highlighting conditions such as Clos …
Gut microbiome and type 2 diabetes: where we are and where to go?
Sharma S, Tripathi P. Sharma S, et al. J Nutr Biochem. 2019 Jan;63:101-108. doi: 10.1016/j.jnutbio.2018.10.003. Epub 2018 Oct 11. J Nutr Biochem. 2019. PMID: 30366260 Review.
We reviewed the published literature for better understanding of the dynamics of gut microbiota, factors that potentially induce gut microbiome dysbiosis and their relation to the progression of T2D. Special emphasis was also given to understand the gut …
We reviewed the published literature for better understanding of the dynamics of gut microbiota, factors that potentially induce g …
THE EFFECTS OF ANTIBIOTICS ON THE GUT MICROBIOME AND THE IMMUNE SYSTEM (Review).
Nurgaziyev M, Sergazy S, Chulenbayeva L, Nurgozhina A, Gulyayev A, Kozhakhmetov S, Kartbayeva G, Kushugulova A. Nurgaziyev M, et al. Georgian Med News. 2020 Jun;(303):167-173. Georgian Med News. 2020. PMID: 32841200 Review.
Studies have shown that treatment with antibiotics leads to dramatic changes in composition and function of gut microbiome. This review focuses on the association between antibiotics use and its impact on gut microbiome of adults and chil …
Studies have shown that treatment with antibiotics leads to dramatic changes in composition and function of gut microbiome …
The impact of maternal exposure to antibiotics on the development of child gut microbiome.
Miyoshi J, Hisamatsu T. Miyoshi J, et al. Immunol Med. 2022 Jun;45(2):63-68. doi: 10.1080/25785826.2021.1963189. Epub 2021 Aug 15. Immunol Med. 2022. PMID: 34392799 Review.
The maternal microbiome, particularly the gut microbiome, is transmitted to their neonates and is one of the major sources that shape the child's gut microbiome. The gut microbiome early in life plays a crucial role in the developm …
The maternal microbiome, particularly the gut microbiome, is transmitted to their neonates and is one of the major sour …
Emerging frontiers of antibiotics use and their impacts on the human gut microbiome.
Kumari R, Yadav Y, Misra R, Das U, Das Adhikari U, Malakar P, Dubey GP. Kumari R, et al. Microbiol Res. 2022 Oct;263:127127. doi: 10.1016/j.micres.2022.127127. Epub 2022 Jul 15. Microbiol Res. 2022. PMID: 35914416 Free article. Review.
Human gut microbiome (GM), known to play an important role in various physiological processes, consists of pool of diverse microbes. ...Here, we discuss the recent developments that have given insights into the effects of antibiotics on the homeostatic balanc …
Human gut microbiome (GM), known to play an important role in various physiological processes, consists of pool of diverse mic …
Antibiotics as both friends and foes of the human gut microbiome: The microbial community approach.
Nogueira T, David PHC, Pothier J. Nogueira T, et al. Drug Dev Res. 2019 Feb;80(1):86-97. doi: 10.1002/ddr.21466. Epub 2018 Oct 28. Drug Dev Res. 2019. PMID: 30370682 Review.
The exposure of the human gut to antibiotics can have a great impact on human health. Antibiotics pertain to the preservation of human health and are useful tools for fighting bacterial infections. ...They can shape, and even disrupt, the composition and func …
The exposure of the human gut to antibiotics can have a great impact on human health. Antibiotics pertain to the preser …
Gut microbiome stability and resilience: elucidating the response to perturbations in order to modulate gut health.
Fassarella M, Blaak EE, Penders J, Nauta A, Smidt H, Zoetendal EG. Fassarella M, et al. Gut. 2021 Mar;70(3):595-605. doi: 10.1136/gutjnl-2020-321747. Epub 2020 Oct 13. Gut. 2021. PMID: 33051190 Review.
The human gut microbiome is a complex ecosystem, densely colonised by thousands of microbial species. It varies among individuals and depends on host genotype and environmental factors, such as diet and antibiotics. In this review, we focus on stability and r …
The human gut microbiome is a complex ecosystem, densely colonised by thousands of microbial species. It varies among individu …
Sepsis and the Microbiome: A Vicious Cycle.
Miller WD, Keskey R, Alverdy JC. Miller WD, et al. J Infect Dis. 2021 Jun 16;223(12 Suppl 2):S264-S269. doi: 10.1093/infdis/jiaa682. J Infect Dis. 2021. PMID: 33330900 Free PMC article. Review.
Alterations in the gut microbiome resulting from sepsis and its treatment have been implicated in organ dysfunction typical of sepsis across multiple tissues including the lung, kidney, and brain. ...The emerging evidence shows that the gut microbiome …
Alterations in the gut microbiome resulting from sepsis and its treatment have been implicated in organ dysfunction typical of …
Horizontal transfer of antibiotic resistance genes in the human gut microbiome.
McInnes RS, McCallum GE, Lamberte LE, van Schaik W. McInnes RS, et al. Curr Opin Microbiol. 2020 Feb;53:35-43. doi: 10.1016/j.mib.2020.02.002. Epub 2020 Mar 3. Curr Opin Microbiol. 2020. PMID: 32143027 Review.
HGT is a common event in the human gut microbiome, that is, the microbial ecosystem of the human intestinal tract. ...Insights from studies into HGT in the gut microbiome may lead to the development of novel interventions to minimise the spread of a …
HGT is a common event in the human gut microbiome, that is, the microbial ecosystem of the human intestinal tract. ...Insights …
Do Antibiotics Cause Obesity Through Long-term Alterations in the Gut Microbiome? A Review of Current Evidence.
Vallianou N, Dalamaga M, Stratigou T, Karampela I, Tsigalou C. Vallianou N, et al. Curr Obes Rep. 2021 Sep;10(3):244-262. doi: 10.1007/s13679-021-00438-w. Epub 2021 May 4. Curr Obes Rep. 2021. PMID: 33945146 Free PMC article. Review.
PURPOSE OF REVIEW: In this review, we summarize current evidence on the association between antibiotics and the subsequent development of obesity through modulation of the gut microbiome. Particular emphasis is given on (i) animal and human studies and their …
PURPOSE OF REVIEW: In this review, we summarize current evidence on the association between antibiotics and the subsequent developmen …
Modulation of gut microbiome in nonalcoholic fatty liver disease: pro-, pre-, syn-, and antibiotics.
Cho MS, Kim SY, Suk KT, Kim BY. Cho MS, et al. J Microbiol. 2018 Dec;56(12):855-867. doi: 10.1007/s12275-018-8346-2. Epub 2018 Oct 25. J Microbiol. 2018. PMID: 30377993 Review.
Therefore, the gut-microbiome and microbial products have been actively studied as likely key factors in NAFLD pathophysiology. Hence, dysbiosis of the gut microbiome and therapeutic manipulation of the gut-liver axis are being investigated. ...
Therefore, the gut-microbiome and microbial products have been actively studied as likely key factors in NAFLD pathophysiology …
Maternal exposures and the infant gut microbiome: a systematic review with meta-analysis.
Grech A, Collins CE, Holmes A, Lal R, Duncanson K, Taylor R, Gordon A. Grech A, et al. Gut Microbes. 2021 Jan-Dec;13(1):1-30. doi: 10.1080/19490976.2021.1897210. Gut Microbes. 2021. PMID: 33978558 Free PMC article.
Postnatal factors affecting the microbiome, including mode of delivery, feeding type, and antibiotic exposure have been widely investigated, but questions remain regarding the influence of exposures in utero on infant gut microbiome assembly. ...Eleven …
Postnatal factors affecting the microbiome, including mode of delivery, feeding type, and antibiotic exposure have been widely …
Impact of antibiotics on gut microbiome composition and resistome in the first years of life in low- to middle-income countries: A systematic review.
Luchen CC, Chibuye M, Spijker R, Simuyandi M, Chisenga C, Bosomprah S, Chilengi R, Schultsz C, Mende DR, Harris VC. Luchen CC, et al. PLoS Med. 2023 Jun 27;20(6):e1004235. doi: 10.1371/journal.pmed.1004235. eCollection 2023 Jun. PLoS Med. 2023. PMID: 37368871 Free PMC article.
The included studies were all randomized control trials (RCTs) and were assessed for risk of bias using the Cochrane risk-of-bias for randomized studies tool. Overall, antibiotics reduced gut microbiome diversity and increased antibiotic-specific resis …
The included studies were all randomized control trials (RCTs) and were assessed for risk of bias using the Cochrane risk-of-bias for random …
Gut microbiota in autism and mood disorders.
Mangiola F, Ianiro G, Franceschi F, Fagiuoli S, Gasbarrini G, Gasbarrini A. Mangiola F, et al. World J Gastroenterol. 2016 Jan 7;22(1):361-8. doi: 10.3748/wjg.v22.i1.361. World J Gastroenterol. 2016. PMID: 26755882 Free PMC article. Review.
The hypothesis of an important role of gut microbiota in the maintenance of physiological state into the gastrointestinal (GI) system is supported by several studies that have shown a qualitative and quantitative alteration of the intestinal flora in a number of …
The hypothesis of an important role of gut microbiota in the maintenance of physiological state into the gastrointestinal (GI) …
Birth Mode, Breastfeeding, Pet Exposure, and Antibiotic Use: Associations With the Gut Microbiome and Sensitization in Children.
Kim H, Sitarik AR, Woodcroft K, Johnson CC, Zoratti E. Kim H, et al. Curr Allergy Asthma Rep. 2019 Mar 11;19(4):22. doi: 10.1007/s11882-019-0851-9. Curr Allergy Asthma Rep. 2019. PMID: 30859338 Free PMC article. Review.
This review will focus on specific factors (pet keeping, breastfeeding, antibiotic use, and mode of delivery) that influence the infant gut microbiome and atopy. RECENT FINDINGS: This is a review of recent literature describing how pet keeping, breastfeeding, …
This review will focus on specific factors (pet keeping, breastfeeding, antibiotic use, and mode of delivery) that influence the infa …
Gut Microbiome Modulation by Antibiotics in Adult Asthma: A Human Proof-of-Concept Intervention Trial.
Van Engelen TSR, Yang J, Haak BW, Bonta PI, Van Der Poll T, Wiersinga WJ; CAST study group. Van Engelen TSR, et al. Clin Gastroenterol Hepatol. 2022 Jun;20(6):1404-1407.e4. doi: 10.1016/j.cgh.2021.07.030. Epub 2021 Jul 22. Clin Gastroenterol Hepatol. 2022. PMID: 34303860 Free article. Clinical Trial.
Although the pathophysiology of asthma is complex, perturbation of the gut microbiota has been associated with an increased risk of asthma development in childhood.(1) Disruption and subsequent dysregulation of gut microbiota-related immunologic processes have also …
Although the pathophysiology of asthma is complex, perturbation of the gut microbiota has been associated with an increased risk of a …
Gut microbiota promote liver regeneration through hepatic membrane phospholipid biosynthesis.
Yin Y, Sichler A, Ecker J, Laschinger M, Liebisch G, Höring M, Basic M, Bleich A, Zhang XJ, Kübelsbeck L, Plagge J, Scherer E, Wohlleber D, Wang J, Wang Y, Steffani M, Stupakov P, Gärtner Y, Lohöfer F, Mogler C, Friess H, Hartmann D, Holzmann B, Hüser N, Janssen KP. Yin Y, et al. J Hepatol. 2023 Apr;78(4):820-835. doi: 10.1016/j.jhep.2022.12.028. Epub 2023 Jan 18. J Hepatol. 2023. PMID: 36681162
We therefore hypothesized that dysbiotic insults like antibiotic treatment not only affect gut microbiota, but also impair hepatic lipid synthesis and liver regeneration. ...Perturbations of the gut microbiome, e.g. by antibiotics, impair the pr …
We therefore hypothesized that dysbiotic insults like antibiotic treatment not only affect gut microbiota, but also impair hep …
The Gut Microbiota and Ageing.
Maynard C, Weinkove D. Maynard C, et al. Subcell Biochem. 2018;90:351-371. doi: 10.1007/978-981-13-2835-0_12. Subcell Biochem. 2018. PMID: 30779015 Review.
Understanding how the human gut microbiota might influence ageing is challenging. The gut microbiota is a hugely complex ecology of organisms that varies greatly with individuals and time, making age-related changes difficult to measure. ...Antibiotics also e …
Understanding how the human gut microbiota might influence ageing is challenging. The gut microbiota is a hugely complex ecolo …
Alzheimer's disease and gut microbiota.
Hu X, Wang T, Jin F. Hu X, et al. Sci China Life Sci. 2016 Oct;59(10):1006-1023. doi: 10.1007/s11427-016-5083-9. Epub 2016 Aug 26. Sci China Life Sci. 2016. PMID: 27566465 Review.
Alzheimer's disease (AD) is a most common neurodegenerative disorder, which associates with impaired cognition. Gut microbiota can modulate host brain function and behavior via microbiota-gut-brain axis, including cognitive behavior. Germ-free animals, antibiotic …
Alzheimer's disease (AD) is a most common neurodegenerative disorder, which associates with impaired cognition. Gut microbiota can mo …
Understanding the impact of antibiotic perturbation on the human microbiome.
Schwartz DJ, Langdon AE, Dantas G. Schwartz DJ, et al. Genome Med. 2020 Sep 28;12(1):82. doi: 10.1186/s13073-020-00782-x. Genome Med. 2020. PMID: 32988391 Free PMC article. Review.
The human gut microbiome is a dynamic collection of bacteria, archaea, fungi, and viruses that performs essential functions for immune development, pathogen colonization resistance, and food metabolism. Perturbation of the gut microbiome's ecological b …
The human gut microbiome is a dynamic collection of bacteria, archaea, fungi, and viruses that performs essential functions fo …
Antibiotic Resistance and Microbiota Response.
Santacroce L, Di Domenico M, Montagnani M, Jirillo E. Santacroce L, et al. Curr Pharm Des. 2023;29(5):356-364. doi: 10.2174/1381612829666221219093450. Curr Pharm Des. 2023. PMID: 36537602 Review.
Use of antibiotics has dramatically eradicated bacterial infections in humans and animals. ...There is evidence that antibiotic treatment decreases the diversity of gut microbiota species, also provoking metabolic changes, increased susceptibility to coloniza …
Use of antibiotics has dramatically eradicated bacterial infections in humans and animals. ...There is evidence that antibiotic …
Antibiotic-Induced Changes in the Intestinal Microbiota and Disease.
Becattini S, Taur Y, Pamer EG. Becattini S, et al. Trends Mol Med. 2016 Jun;22(6):458-478. doi: 10.1016/j.molmed.2016.04.003. Epub 2016 May 10. Trends Mol Med. 2016. PMID: 27178527 Free PMC article. Review.
The gut microbiota is a key player in many physiological and pathological processes occurring in humans. ...The emergence of multidrug-resistant pathogens raises concerns about the common, and at times inappropriate, use of antimicrobial agents. Here we review the m …
The gut microbiota is a key player in many physiological and pathological processes occurring in humans. ...The emergence of multidru …
Extensive impact of non-antibiotic drugs on human gut bacteria.
Maier L, Pruteanu M, Kuhn M, Zeller G, Telzerow A, Anderson EE, Brochado AR, Fernandez KC, Dose H, Mori H, Patil KR, Bork P, Typas A. Maier L, et al. Nature. 2018 Mar 29;555(7698):623-628. doi: 10.1038/nature25979. Epub 2018 Mar 19. Nature. 2018. PMID: 29555994 Free PMC article.
A few commonly used non-antibiotic drugs have recently been associated with changes in gut microbiome composition, but the extent of this phenomenon is unknown. ...The potential risk of non-antibiotics promoting antibiotic resistance warrants fu …
A few commonly used non-antibiotic drugs have recently been associated with changes in gut microbiome composition, but …
Natural history of the infant gut microbiome and impact of antibiotic treatment on bacterial strain diversity and stability.
Yassour M, Vatanen T, Siljander H, Hämäläinen AM, Härkönen T, Ryhänen SJ, Franzosa EA, Vlamakis H, Huttenhower C, Gevers D, Lander ES, Knip M; DIABIMMUNE Study Group; Xavier RJ. Yassour M, et al. Sci Transl Med. 2016 Jun 15;8(343):343ra81. doi: 10.1126/scitranslmed.aad0917. Sci Transl Med. 2016. PMID: 27306663 Free PMC article.
However, little is known about the impact of environmental factors on the developing human gut microbiome. We report a longitudinal study of the gut microbiome based on DNA sequence analysis of monthly stool samples and clinical information from 39 chi …
However, little is known about the impact of environmental factors on the developing human gut microbiome. We report a longitu …
Scheduled Empiric Antibiotics May Alter the Gut Microbiome and Nutrition Outcomes in Pediatric Intestinal Failure.
Talathi S, Wilkinson L, Meloni K, Shroyer M, Eipers P, Van Der Pol WJ, Martin C, Dimmitt R, Yi N, Morrow C, Galloway D. Talathi S, et al. Nutr Clin Pract. 2021 Dec;36(6):1230-1239. doi: 10.1002/ncp.10594. Epub 2020 Oct 19. Nutr Clin Pract. 2021. PMID: 33078427
BACKGROUND: In this study, we aim to determine the effect of scheduled antibiotics on gut microbiome in pediatric intestinal failure (IF) and to evaluate the effect of the gut microbiome on nutrition outcomes in IF. ...Gut microbiome …
BACKGROUND: In this study, we aim to determine the effect of scheduled antibiotics on gut microbiome in pediatric intes …
Fluoroquinolone antibiotics disturb the defense system, gut microbiome, and antibiotic resistance genes of Enchytraeus crypticus.
Jin MK, Zhang Q, Zhao WL, Li ZH, Qian HF, Yang XR, Zhu YG, Liu HJ. Jin MK, et al. J Hazard Mater. 2022 Feb 15;424(Pt C):127509. doi: 10.1016/j.jhazmat.2021.127509. Epub 2021 Oct 21. J Hazard Mater. 2022. PMID: 34736185
In this study, the toxicological effects of fluoroquinolone antibiotics on Enchytraeus crypticus, including defence response, gut microbiome, and antibiotic resistance genes (ARGs), were studied. ...The superoxide dismutase and glutathione S-transferas …
In this study, the toxicological effects of fluoroquinolone antibiotics on Enchytraeus crypticus, including defence response, gut …
Phage therapy in gut microbiome.
Chen X, Mendes BG, Alves BS, Duan Y. Chen X, et al. Prog Mol Biol Transl Sci. 2023;201:93-118. doi: 10.1016/bs.pmbts.2023.04.005. Epub 2023 May 2. Prog Mol Biol Transl Sci. 2023. PMID: 37770177 Review.
Phage therapy, the use of bacteriophage viruses for bacterial infection treatment, has been around for almost a century, but with the increase in antibiotic use, its importance has declined rapidly. There has been renewed interest in revisiting this practice due to the gen …
Phage therapy, the use of bacteriophage viruses for bacterial infection treatment, has been around for almost a century, but with the increa …
Evolution of Plasmid-Mediated Antibiotic Resistance in the Clinical Context.
San Millan A. San Millan A. Trends Microbiol. 2018 Dec;26(12):978-985. doi: 10.1016/j.tim.2018.06.007. Epub 2018 Jul 23. Trends Microbiol. 2018. PMID: 30049587 Free article. Review.
Antibiotic-resistant infections are an urgent problem in clinical settings because they sharply increase mortality risk in critically ill patients. The horizontal spread of antibiotic resistance genes among bacteria is driven by bacterial plasmids, promoting the evo …
Antibiotic-resistant infections are an urgent problem in clinical settings because they sharply increase mortality risk in critically …
Role of Microbiome and Antibiotics in Autoimmune Diseases.
Vangoitsenhoven R, Cresci GAM. Vangoitsenhoven R, et al. Nutr Clin Pract. 2020 Jun;35(3):406-416. doi: 10.1002/ncp.10489. Epub 2020 Apr 22. Nutr Clin Pract. 2020. PMID: 32319703 Review.
The global rise in the incidence of autoimmune diseases has paralleled the widespread use of antibiotics. Recently, the gut microbiome has been shown to be key in the development and maturation of a normal immune system, and a range of microbial disturbances …
The global rise in the incidence of autoimmune diseases has paralleled the widespread use of antibiotics. Recently, the gut …
Environmental concentrations of antibiotics alter the zebrafish gut microbiome structure and potential functions.
Kayani MUR, Yu K, Qiu Y, Shen Y, Gao C, Feng R, Zeng X, Wang W, Chen L, Su HL. Kayani MUR, et al. Environ Pollut. 2021 Jun 1;278:116760. doi: 10.1016/j.envpol.2021.116760. Epub 2021 Feb 22. Environ Pollut. 2021. PMID: 33725532
Long term exposure of environmental concentrations of oxytetracycline and sulfamethoxazole significantly impacted the taxonomic composition and metabolic pathways of zebrafish gut microbiome. The antibiotic exposed samples exhibited significant enrichment of …
Long term exposure of environmental concentrations of oxytetracycline and sulfamethoxazole significantly impacted the taxonomic composition …
Broad-spectrum antibiotics associated gut microbiome disturbance impairs T cell immunity and promotes lung cancer metastasis: a retrospective study.
Xu K, Cai J, Xing J, Li X, Wu B, Zhu Z, Zhang Z. Xu K, et al. BMC Cancer. 2022 Nov 17;22(1):1182. doi: 10.1186/s12885-022-10307-x. BMC Cancer. 2022. PMID: 36384523 Free PMC article.
BACKGROUND: Gut microbiome has been linked to a regulatory role in cancer progression. However, whether broad-spectrum antibiotics (ATB) associated gut microbiome dysbiosis contributes to an impaired T cell immune function, and ultimately promot …
BACKGROUND: Gut microbiome has been linked to a regulatory role in cancer progression. However, whether broad-spectrum anti …
Vertical Transmission of Gut Microbiome and Antimicrobial Resistance Genes in Infants Exposed to Antibiotics at Birth.
Li W, Tapiainen T, Brinkac L, Lorenzi HA, Moncera K, Tejesvi MV, Salo J, Nelson KE. Li W, et al. J Infect Dis. 2021 Oct 13;224(7):1236-1246. doi: 10.1093/infdis/jiaa155. J Infect Dis. 2021. PMID: 32239170 Free PMC article.
Vertical transmission of maternal microbes is a major route for establishing the gut microbiome in newborns. The impact of perinatal antibiotics on vertical transmission of microbes and antimicrobial resistance is not well understood. Using a metagenomic appr …
Vertical transmission of maternal microbes is a major route for establishing the gut microbiome in newborns. The impact of per …
Antibiotic discovery: history, methods and perspectives.
Durand GA, Raoult D, Dubourg G. Durand GA, et al. Int J Antimicrob Agents. 2019 Apr;53(4):371-382. doi: 10.1016/j.ijantimicag.2018.11.010. Epub 2018 Nov 23. Int J Antimicrob Agents. 2019. PMID: 30472287 Review.
Antibiotics are natural products of soil-living organisms. Actinobacteria and fungi are the source of approximately two-thirds of the antimicrobial agents currently used in human medicine; they were mainly discovered during the golden age of antibiotic discov …
Antibiotics are natural products of soil-living organisms. Actinobacteria and fungi are the source of approximately two-thirds of the …
Protection of the Human Gut Microbiome From Antibiotics.
de Gunzburg J, Ghozlane A, Ducher A, Le Chatelier E, Duval X, Ruppé E, Armand-Lefevre L, Sablier-Gallis F, Burdet C, Alavoine L, Chachaty E, Augustin V, Varastet M, Levenez F, Kennedy S, Pons N, Mentré F, Andremont A. de Gunzburg J, et al. J Infect Dis. 2018 Jan 30;217(4):628-636. doi: 10.1093/infdis/jix604. J Infect Dis. 2018. PMID: 29186529 Free PMC article. Clinical Trial.
BACKGROUND: Antibiotics are life-saving drugs but severely affect the gut microbiome with short-term consequences including diarrhea and selection of antibiotic-resistant bacteria. ...In addition, DAV132 efficiently adsorbed a wide range of clinically …
BACKGROUND: Antibiotics are life-saving drugs but severely affect the gut microbiome with short-term consequences inclu …
Cross-omics analysis revealed gut microbiome-related metabolic pathways underlying atherosclerosis development after antibiotics treatment.
Kappel BA, De Angelis L, Heiser M, Ballanti M, Stoehr R, Goettsch C, Mavilio M, Artati A, Paoluzi OA, Adamski J, Mingrone G, Staels B, Burcelin R, Monteleone G, Menghini R, Marx N, Federici M. Kappel BA, et al. Mol Metab. 2020 Jun;36:100976. doi: 10.1016/j.molmet.2020.100976. Epub 2020 Mar 13. Mol Metab. 2020. PMID: 32251665 Free PMC article.
The aim of this study was to explore the interaction between gut dysbiosis by antibiotics and metabolic pathways with the impact on atherosclerosis development. ...These pathways were related to the reduction of certain members of Bacteroidetes and Clostridia by …
The aim of this study was to explore the interaction between gut dysbiosis by antibiotics and metabolic pathways with the impa …
Antibiotics, the microbiome and gastrointestinal cancers: A causal interference?
Ramai D, Salati M, Pomati G, Amoroso C, Facciorusso A, Botticelli A, Ghidini M. Ramai D, et al. Curr Opin Pharmacol. 2022 Dec;67:102315. doi: 10.1016/j.coph.2022.102315. Epub 2022 Nov 6. Curr Opin Pharmacol. 2022. PMID: 36351361 Review.
Advances in the analysis of the gut microbiome continues to reveal complex microbial communities and discoveries about their role in health and diseases, including cancer development, are continuously growing. In addition, research has demonstrated that the use of …
Advances in the analysis of the gut microbiome continues to reveal complex microbial communities and discoveries about their r …
Effect of antibiotics on the human microbiome: a systematic review.
Nel Van Zyl K, Matukane SR, Hamman BL, Whitelaw AC, Newton-Foot M. Nel Van Zyl K, et al. Int J Antimicrob Agents. 2022 Feb;59(2):106502. doi: 10.1016/j.ijantimicag.2021.106502. Epub 2021 Dec 18. Int J Antimicrob Agents. 2022. PMID: 34929293 Review.
BACKGROUND: Global antibiotic use has been increasing for decades. The gut microbiome, a key contributor to health, can be altered by antibiotics, which have been associated with both short- and long-term effects on the intestinal microbiome. .. …
BACKGROUND: Global antibiotic use has been increasing for decades. The gut microbiome, a key contributor to health, can …
Capacity of a Microbial Synbiotic To Rescue the In Vitro Metabolic Activity of the Gut Microbiome following Perturbation with Alcohol or Antibiotics.
Tierney BT, Van den Abbeele P, Al-Ghalith GA, Verstrepen L, Ghyselinck J, Calatayud M, Marzorati M, Gadir AA, Daisley B, Reid G, Bron PA, Gevers D, Dhir R, Simmons SL. Tierney BT, et al. Appl Environ Microbiol. 2023 Mar 29;89(3):e0188022. doi: 10.1128/aem.01880-22. Epub 2023 Feb 22. Appl Environ Microbiol. 2023. PMID: 36840551 Free PMC article.
The human gut microbiome contributes crucial bioactive metabolites that support human health and is sensitive to perturbations from the ingestion of alcohol and antibiotics. ...In this study, we used an in vitro system modeling the gut microbiome …
The human gut microbiome contributes crucial bioactive metabolites that support human health and is sensitive to perturbations …
The Gut Microbiome and Ozone-induced Airway Hyperresponsiveness. Mechanisms and Therapeutic Prospects.
Tashiro H, Shore SA. Tashiro H, et al. Am J Respir Cell Mol Biol. 2021 Mar;64(3):283-291. doi: 10.1165/rcmb.2020-0288TR. Am J Respir Cell Mol Biol. 2021. PMID: 33091322 Review.
The gut microbiome has important roles in human health and disease, and a growing body of evidence indicates a link between the gut microbiome and asthma. ...Finally, we discuss future prospects for gut microbiome-targeted therapies such …
The gut microbiome has important roles in human health and disease, and a growing body of evidence indicates a link between th …
Unveiling and harnessing the human gut microbiome in the rising burden of non-communicable diseases during urbanization.
Huang Z, Li Y, Park H, Ho M, Bhardwaj K, Sugimura N, Lee HW, Meng H, Ebert MP, Chao K, Burgermeister E, Bhatt AP, Shetty SA, Li K, Wen W, Zuo T. Huang Z, et al. Gut Microbes. 2023 Jan-Dec;15(1):2237645. doi: 10.1080/19490976.2023.2237645. Gut Microbes. 2023. PMID: 37498052 Free PMC article. Review.
Concomitantly, the global burden of non-communicable diseases (NCDs) is rising, markedly associated with the changing landscape of lifestyle and environment during urbanization. Accumulating studies have revealed the role of the gut microbiome in regulating the immu …
Concomitantly, the global burden of non-communicable diseases (NCDs) is rising, markedly associated with the changing landscape of lifestyle …
The Local Defender and Functional Mediator: Gut Microbiome.
Yang H, Duan Z. Yang H, et al. Digestion. 2018;97(2):137-145. doi: 10.1159/000484687. Epub 2018 Jan 8. Digestion. 2018. PMID: 29310114 Free article. Review.
BACKGROUND: The gut microbiome has been developing and making adaption all the time, which is consistent with their host from the initial colonization at birth or earlier. ...SUMMARY: In the review, we will conclude the recent researches related to the influence of …
BACKGROUND: The gut microbiome has been developing and making adaption all the time, which is consistent with their host from …
Disruption of the Gut Ecosystem by Antibiotics.
Yoon MY, Yoon SS. Yoon MY, et al. Yonsei Med J. 2018 Jan;59(1):4-12. doi: 10.3349/ymj.2018.59.1.4. Yonsei Med J. 2018. PMID: 29214770 Free PMC article. Review.
Here, we illustrate how antibiotics are associated with an increased risk of antibiotic-associated diseases by driving intestinal environment changes that favor the proliferation and virulence of pathogens. Understanding the pathogenesis caused by antibiotics …
Here, we illustrate how antibiotics are associated with an increased risk of antibiotic-associated diseases by driving intesti …
Delivery mode and perinatal antibiotics influence the predicted metabolic pathways of the gut microbiome.
Vänni P, Tejesvi MV, Ainonen S, Renko M, Korpela K, Salo J, Paalanne N, Tapiainen T. Vänni P, et al. Sci Rep. 2021 Sep 1;11(1):17483. doi: 10.1038/s41598-021-97007-x. Sci Rep. 2021. PMID: 34471207 Free PMC article.
Delivery mode and perinatal antibiotics influence gut microbiome composition in children. Most microbiome studies have used the sequencing of the bacterial 16S marker gene but have not reported the metabolic function of the gut microbiome …
Delivery mode and perinatal antibiotics influence gut microbiome composition in children. Most microbiome studie …
Diarrheal disease and gut microbiome.
Ramamurthy T, Kumari S, Ghosh A. Ramamurthy T, et al. Prog Mol Biol Transl Sci. 2022;192(1):149-177. doi: 10.1016/bs.pmbts.2022.08.002. Epub 2022 Sep 9. Prog Mol Biol Transl Sci. 2022. PMID: 36280318
Enteric infections caused by several viral, bacterial and parasitic species not only affect the host, but also alter the gut microbiome. The host physiology dictates the intestinal milieu and decides the composition and richness of gut microbiota, which forms …
Enteric infections caused by several viral, bacterial and parasitic species not only affect the host, but also alter the gut micro …
Impact of commonly used drugs on the composition and metabolic function of the gut microbiota.
Vich Vila A, Collij V, Sanna S, Sinha T, Imhann F, Bourgonje AR, Mujagic Z, Jonkers DMAE, Masclee AAM, Fu J, Kurilshikov A, Wijmenga C, Zhernakova A, Weersma RK. Vich Vila A, et al. Nat Commun. 2020 Jan 17;11(1):362. doi: 10.1038/s41467-019-14177-z. Nat Commun. 2020. PMID: 31953381 Free PMC article.
The human gut microbiota has now been associated with drug responses and efficacy, while chemical compounds present in these drugs can also impact the gut bacteria. ...Here, we report relations between commonly used drugs and the gut microbiome. We per …
The human gut microbiota has now been associated with drug responses and efficacy, while chemical compounds present in these drugs ca …
Gut microbiome signatures and host colonization with multidrug-resistant bacteria.
Isles NS, Mu A, Kwong JC, Howden BP, Stinear TP. Isles NS, et al. Trends Microbiol. 2022 Sep;30(9):853-865. doi: 10.1016/j.tim.2022.01.013. Epub 2022 Feb 18. Trends Microbiol. 2022. PMID: 35184972 Review.
Antibiotic use, medications, health conditions, and lifestyle factors can alter the composition of the gut microbiota in such a way that results in loss of colonization resistance and increased susceptibility to invading pathogenic antibiotic-resistant bacter …
Antibiotic use, medications, health conditions, and lifestyle factors can alter the composition of the gut microbiota in such …
Antibiotics reduce genetic diversity of core species in the honeybee gut microbiome.
Raymann K, Bobay LM, Moran NA. Raymann K, et al. Mol Ecol. 2018 Apr;27(8):2057-2066. doi: 10.1111/mec.14434. Epub 2017 Dec 14. Mol Ecol. 2018. PMID: 29164717 Free PMC article.
The gut microbiome plays a key role in animal health, and perturbing it can have detrimental effects. One major source of perturbation to microbiomes, in humans and human-associated animals, is exposure to antibiotics. Most studies of how antibiotics a …
The gut microbiome plays a key role in animal health, and perturbing it can have detrimental effects. One major source of pert …
Unintended Consequences of Antibiotic Therapy on the Microbiome Delivers a Gut Punch in Ovarian Cancer.
Hawkins SM, Nephew KP. Hawkins SM, et al. Cancer Res. 2022 Dec 16;82(24):4511-4512. doi: 10.1158/0008-5472.CAN-22-3013. Cancer Res. 2022. PMID: 36524345
The study by Chambers and colleagues in this issue of Cancer Research provides mechanistic insights into how disrupting the gut microbiome with broad-spectrum antibiotics negatively influences the survival of patients with ovarian cancer and highlights the im …
The study by Chambers and colleagues in this issue of Cancer Research provides mechanistic insights into how disrupting the gut mi …
Acute and persistent effects of commonly used antibiotics on the gut microbiome and resistome in healthy adults.
Anthony WE, Wang B, Sukhum KV, D'Souza AW, Hink T, Cass C, Seiler S, Reske KA, Coon C, Dubberke ER, Burnham CD, Dantas G, Kwon JH. Anthony WE, et al. Cell Rep. 2022 Apr 12;39(2):110649. doi: 10.1016/j.celrep.2022.110649. Cell Rep. 2022. PMID: 35417701 Free PMC article.
To understand acute and persistent effects of antibiotics on the gut microbiota of healthy adult volunteers, we quantify microbiome dynamics before, during, and 6 months after exposure to 4 commonly used antibiotic regimens. ...These results improve ou …
To understand acute and persistent effects of antibiotics on the gut microbiota of healthy adult volunteers, we quantify mi …
Gut microbiome perturbation, antibiotic resistance, and Escherichia coli strain dynamics associated with international travel: a metagenomic analysis.
Worby CJ, Sridhar S, Turbett SE, Becker MV, Kogut L, Sanchez V, Bronson RA, Rao SR, Oliver E, Walker AT, Walters MS, Kelly P, Leung DT, Knouse MC, Hagmann SHF, Harris JB, Ryan ET, Earl AM, LaRocque RC. Worby CJ, et al. Lancet Microbe. 2023 Oct;4(10):e790-e799. doi: 10.1016/S2666-5247(23)00147-7. Epub 2023 Sep 13. Lancet Microbe. 2023. PMID: 37716364 Free PMC article.
We aimed to identify (1) whether the gut microbiome provided colonisation resistance against antimicrobial-resistant organism acquisition, (2) the effect of travel and travel behaviours on the gut microbiome, and (3) the scale and global heterogeneity …
We aimed to identify (1) whether the gut microbiome provided colonisation resistance against antimicrobial-resistant organism …
Antibiotics Associated Disorders and Post-biotics Induced Rescue in Gut Health.
Paul D, Manna S, Mandal SM. Paul D, et al. Curr Pharm Des. 2018;24(7):821-829. doi: 10.2174/1381612824666171227221731. Curr Pharm Des. 2018. PMID: 29283050 Review.
In this article, we assessed the differences in microbial colonization and immune function of the intestinal tract in infants, adults, and the aged people and also examined the recent reports describing the impacts of antibiotics on infant microbiome assembly and fu …
In this article, we assessed the differences in microbial colonization and immune function of the intestinal tract in infants, adults, and t …
Helicobacter pylori and oral-gut microbiome: clinical implications.
Elghannam MT, Hassanien MH, Ameen YA, Turky EA, ELattar GM, ELRay AA, ELTalkawy MD. Elghannam MT, et al. Infection. 2024 Apr;52(2):289-300. doi: 10.1007/s15010-023-02115-7. Epub 2023 Nov 2. Infection. 2024. PMID: 37917397 Free PMC article. Review.
Therefore, therapy regimens integrated with probiotics may abolish the negative effects of antibiotic therapy on the gut microbiota. These eradication therapies combined with probiotics have also higher rates of eradication, when compared to standard treatments, and …
Therefore, therapy regimens integrated with probiotics may abolish the negative effects of antibiotic therapy on the gut micro …
Gastrointestinal involvement of autism spectrum disorder: focus on gut microbiota.
Settanni CR, Bibbò S, Ianiro G, Rinninella E, Cintoni M, Mele MC, Cammarota G, Gasbarrini A. Settanni CR, et al. Expert Rev Gastroenterol Hepatol. 2021 Jun;15(6):599-622. doi: 10.1080/17474124.2021.1869938. Epub 2021 Jan 5. Expert Rev Gastroenterol Hepatol. 2021. PMID: 33356668 Review.
INTRODUCTION: Autism spectrum disorder (ASD) is a neurodevelopmental disorder typical of early age, characterized by impaired communication, social interaction, and repetitive behaviors. ASD patients frequently suffer from gastrointestinal (GI) symptoms. Neuro-psychologica …
INTRODUCTION: Autism spectrum disorder (ASD) is a neurodevelopmental disorder typical of early age, characterized by impaired communication, …
Microbiome-related metabolite changes in gut tissue, cecum content and feces of rats treated with antibiotics.
Behr C, Sperber S, Jiang X, Strauss V, Kamp H, Walk T, Herold M, Beekmann K, Rietjens IMCM, van Ravenzwaay B. Behr C, et al. Toxicol Appl Pharmacol. 2018 Sep 15;355:198-210. doi: 10.1016/j.taap.2018.06.028. Epub 2018 Jul 6. Toxicol Appl Pharmacol. 2018. PMID: 30008377
Omics technologies could facilitate unraveling metabolism by the gut microbiota. In this study, we performed metabolite profiling of different matrices of the gut, after antibiotic treatment of rats in order to evaluate metabolite changes observed at differen …
Omics technologies could facilitate unraveling metabolism by the gut microbiota. In this study, we performed metabolite profiling of …
Early exposure to antibiotics in the neonatal intensive care unit alters the taxonomic and functional infant gut microbiome.
Bender JM, Li F, Purswani H, Capretz T, Cerini C, Zabih S, Hung L, Francis N, Chin S, Pannaraj PS, Aldrovandi G. Bender JM, et al. J Matern Fetal Neonatal Med. 2021 Oct;34(20):3335-3343. doi: 10.1080/14767058.2019.1684466. Epub 2019 Nov 19. J Matern Fetal Neonatal Med. 2021. PMID: 31744351 Free PMC article.
INTRODUCTION: The infant gut microbiome is thought to play a key role in developing metabolic and immunologic pathways. ...Through this study, we further characterize the effect antibiotics have on the gut microbiome of infants by looking at met …
INTRODUCTION: The infant gut microbiome is thought to play a key role in developing metabolic and immunologic pathways. ...Thr …
The Effect of Antibiotics Treatment on the Maternal Immune Response and Gut Microbiome in Pregnant and Non-Pregnant Mice.
Faas MM, Liu Y, Wekema L, Weiss GA, van Loo-Bouwman CA, Silva Lagos L. Faas MM, et al. Nutrients. 2023 Jun 12;15(12):2723. doi: 10.3390/nu15122723. Nutrients. 2023. PMID: 37375627 Free PMC article.
Thus, pregnant mice received antibiotics from day 9 to day 16 to disturb the maternal gut microbiome. ...Correlation of immune cells with bacterial genera showed various correlations between immune cells in the PP, MLN and peripheral circulation (blood and sp …
Thus, pregnant mice received antibiotics from day 9 to day 16 to disturb the maternal gut microbiome. ...Correlation of …
Global landscape of gut microbiome diversity and antibiotic resistomes across vertebrates.
Huang G, Qu Q, Wang M, Huang M, Zhou W, Wei F. Huang G, et al. Sci Total Environ. 2022 Sep 10;838(Pt 2):156178. doi: 10.1016/j.scitotenv.2022.156178. Epub 2022 May 23. Sci Total Environ. 2022. PMID: 35618126 Review.
Multiple factors influence gut microbiome diversity in vertebrate hosts. Most previous studies have only investigated specific factors and certain host species or taxa. ...Among wild vertebrates, diet was most significantly associated with gut microbiome …
Multiple factors influence gut microbiome diversity in vertebrate hosts. Most previous studies have only investigated specific …
Microbiome, antibiotics and irritable bowel syndrome.
Ahmad OF, Akbar A. Ahmad OF, et al. Br Med Bull. 2016 Dec;120(1):91-99. doi: 10.1093/bmb/ldw038. Epub 2016 Oct 13. Br Med Bull. 2016. PMID: 27737852 Review.
INTRODUCTION: Irritable bowel syndrome (IBS) is the most prevalent functional gastrointestinal (GI) disorder. Increasing evidence implicates the GI microbiota in IBS pathogenesis and its modulation represents an emerging therapeutic strategy. SOURCES OF DATA: Original and …
INTRODUCTION: Irritable bowel syndrome (IBS) is the most prevalent functional gastrointestinal (GI) disorder. Increasing evidence imp …
Antibiotics as deep modulators of gut microbiota: between good and evil.
Ianiro G, Tilg H, Gasbarrini A. Ianiro G, et al. Gut. 2016 Nov;65(11):1906-1915. doi: 10.1136/gutjnl-2016-312297. Epub 2016 Aug 16. Gut. 2016. PMID: 27531828 Review.
Both drug-related factors (such as antibiotic class, timing of exposure or route of administration) and host-related factors appear to influence the alterations of human gut microbiota produced by antibiotics. ...Moreover, some antibiotics can also act …
Both drug-related factors (such as antibiotic class, timing of exposure or route of administration) and host-related factors appear t …
Differential responses of the gut microbiome and resistome to antibiotic exposures in infants and adults.
Li X, Brejnrod A, Thorsen J, Zachariasen T, Trivedi U, Russel J, Vestergaard GA, Stokholm J, Rasmussen MA, Sørensen SJ. Li X, et al. Nat Commun. 2023 Dec 22;14(1):8526. doi: 10.1038/s41467-023-44289-6. Nat Commun. 2023. PMID: 38135681 Free PMC article.
The effects of antibiotic treatments on the gut microbiome last longer in adults than in infants, and different antibiotics are associated with distinct impacts. Overall, this study broadens our current understanding of gut resistome dynamics an …
The effects of antibiotic treatments on the gut microbiome last longer in adults than in infants, and different anti …
Impact of intrapartum and postnatal antibiotics on the gut microbiome and emergence of antimicrobial resistance in infants.
Tapiainen T, Koivusaari P, Brinkac L, Lorenzi HA, Salo J, Renko M, Pruikkonen H, Pokka T, Li W, Nelson K, Pirttilä AM, Tejesvi MV. Tapiainen T, et al. Sci Rep. 2019 Jul 23;9(1):10635. doi: 10.1038/s41598-019-46964-5. Sci Rep. 2019. PMID: 31337807 Free PMC article.
Caesarean section has a long-term impact on the intestinal microbiome but the effects of perinatal antibiotics on gut microbiome in vaginally delivered infants are not well known. We compared the impact of IAP, postnatal antibiotics, or their co …
Caesarean section has a long-term impact on the intestinal microbiome but the effects of perinatal antibiotics on gut …
The effect of antibiotics on the gut microbiome: a metagenomics analysis of microbial shift and gut antibiotic resistance in antibiotic treated mice.
Xu L, Surathu A, Raplee I, Chockalingam A, Stewart S, Walker L, Sacks L, Patel V, Li Z, Rouse R. Xu L, et al. BMC Genomics. 2020 Mar 30;21(1):263. doi: 10.1186/s12864-020-6665-2. BMC Genomics. 2020. PMID: 32228448 Free PMC article.
BACKGROUND: Emergence of antibiotic resistance is a global public health concern. The relationships between antibiotic use, the gut community composition, normal physiology and metabolism, and individual and public health are still being defined. ...RESULTS: …
BACKGROUND: Emergence of antibiotic resistance is a global public health concern. The relationships between antibiotic use, th …
Manipulating the neonatal gut microbiome: current understanding and future perspectives.
Wong E, Lui K, Day AS, Leach ST. Wong E, et al. Arch Dis Child Fetal Neonatal Ed. 2022 Jul;107(4):346-350. doi: 10.1136/archdischild-2021-321922. Epub 2021 Aug 25. Arch Dis Child Fetal Neonatal Ed. 2022. PMID: 34433586 Free PMC article. Review.
Aberrant microbiome development may be a key factor in the increasing incidence of inflammatory and gut diseases. This review will summarise the current understanding of how modern birth practices may contribute to deficiencies in neonatal gut microbiome …
Aberrant microbiome development may be a key factor in the increasing incidence of inflammatory and gut diseases. This review …
Antimicrobial Resistance Genes (ARGs), the Gut Microbiome, and Infant Nutrition.
Theophilus RJ, Taft DH. Theophilus RJ, et al. Nutrients. 2023 Jul 18;15(14):3177. doi: 10.3390/nu15143177. Nutrients. 2023. PMID: 37513595 Free PMC article. Review.
The spread of antimicrobial resistance genes (ARGs) is a major public health crisis, with the ongoing spread of ARGs leading to reduced efficacy of antibiotic treatments. The gut microbiome is a key reservoir for ARGs, and because diet shapes the gut …
The spread of antimicrobial resistance genes (ARGs) is a major public health crisis, with the ongoing spread of ARGs leading to reduced effi …
Protecting the Microbiota.
Rooney CM, Ahmed S, Wilcox MH. Rooney CM, et al. J Infect Dis. 2021 Jun 16;223(12 Suppl 2):S290-S295. doi: 10.1093/infdis/jiab143. J Infect Dis. 2021. PMID: 33838031
We examine 3 different approaches to protecting the gut microbiome: highly targeted antibiotics, antibiotic destruction, and antibiotic binding. Each approach shows promise to prevent the off-target effects of antibiotics on the gut …
We examine 3 different approaches to protecting the gut microbiome: highly targeted antibiotics, antibiotic dest …
Gut microbiome alterations in the crustacean Pacifastacus leniusculus exposed to environmental concentrations of antibiotics and effects on susceptibility to bacteria challenges.
Hernández-Pérez A, Zamora-Briseño JA, Söderhäll K, Söderhäll I. Hernández-Pérez A, et al. Dev Comp Immunol. 2022 Jan;126:104181. doi: 10.1016/j.dci.2021.104181. Epub 2021 Jun 24. Dev Comp Immunol. 2022. PMID: 34175331 Free article.
In the present study, we used high-throughput 16S rRNA sequencing technology to study the composition of gut-associated microbiota of the crayfish Pacifastacus leniusculus after exposure to environmentally-relevant concentrations of an antibiotic, namely sulfamethox …
In the present study, we used high-throughput 16S rRNA sequencing technology to study the composition of gut-associated microbiota of …
The intestinal microbiota: Antibiotics, colonization resistance, and enteric pathogens.
Kim S, Covington A, Pamer EG. Kim S, et al. Immunol Rev. 2017 Sep;279(1):90-105. doi: 10.1111/imr.12563. Immunol Rev. 2017. PMID: 28856737 Free PMC article. Review.
This is a particularly relevant concern in the hospital setting, where antibiotic use and antibiotic-resistant pathogen exposure are more frequent. Many nosocomial infections arise from gastrointestinal colonization. Due to their resistance to antibiotics …
This is a particularly relevant concern in the hospital setting, where antibiotic use and antibiotic-resistant pathogen exposu …
Systematic profiling of the chicken gut microbiome reveals dietary supplementation with antibiotics alters expression of multiple microbial pathways with minimal impact on community structure.
Zou A, Nadeau K, Xiong X, Wang PW, Copeland JK, Lee JY, Pierre JS, Ty M, Taj B, Brumell JH, Guttman DS, Sharif S, Korver D, Parkinson J. Zou A, et al. Microbiome. 2022 Aug 15;10(1):127. doi: 10.1186/s40168-022-01319-7. Microbiome. 2022. PMID: 35965349 Free PMC article.
AGPs are thought to operate through modulating the gut microbiome to limit opportunities for colonization by pathogens, increase nutrient utilization, and reduce inflammation. ...Previous studies investigating the effects of AGPs on the poultry gut microbi …
AGPs are thought to operate through modulating the gut microbiome to limit opportunities for colonization by pathogens, increa …
Impact of antimicrobial therapy on the gut microbiome.
Bhalodi AA, van Engelen TSR, Virk HS, Wiersinga WJ. Bhalodi AA, et al. J Antimicrob Chemother. 2019 Jan 1;74(Suppl 1):i6-i15. doi: 10.1093/jac/dky530. J Antimicrob Chemother. 2019. PMID: 30690540 Free PMC article. Review.
The gut microbiome is now considered an organ unto itself and plays an important role in health maintenance and recovery from critical illness. The commensal organisms responsible for the framework of the gut microbiome are valuable in protection again …
The gut microbiome is now considered an organ unto itself and plays an important role in health maintenance and recovery from …
Antibiotics at birth and later antibiotic courses: effects on gut microbiota.
Ainonen S, Tejesvi MV, Mahmud MR, Paalanne N, Pokka T, Li W, Nelson KE, Salo J, Renko M, Vänni P, Pirttilä AM, Tapiainen T. Ainonen S, et al. Pediatr Res. 2022 Jan;91(1):154-162. doi: 10.1038/s41390-021-01494-7. Epub 2021 Apr 6. Pediatr Res. 2022. PMID: 33824448 Free PMC article.
Here, we compared the impacts of perinatal antibiotic exposure and later courses of antibiotic courses on gut microbiota. ...Impact of the perinatal antibiotics on the gut microbiota composition was greater than that of the later courses of a …
Here, we compared the impacts of perinatal antibiotic exposure and later courses of antibiotic courses on gut microbiot …
The Human Gut Microbiome in Liver Diseases.
Davis BC, Bajaj JS. Davis BC, et al. Semin Liver Dis. 2017 May;37(2):128-140. doi: 10.1055/s-0037-1602763. Epub 2017 May 31. Semin Liver Dis. 2017. PMID: 28564721 Review. No abstract available.
Probiotic supplementation during antibiotic treatment is unjustified in maintaining the gut microbiome diversity: a systematic review and meta-analysis.
Éliás AJ, Barna V, Patoni C, Demeter D, Veres DS, Bunduc S, Erőss B, Hegyi P, Földvári-Nagy L, Lenti K. Éliás AJ, et al. BMC Med. 2023 Jul 19;21(1):262. doi: 10.1186/s12916-023-02961-0. BMC Med. 2023. PMID: 37468916 Free PMC article.
We aimed to investigate the effects of concurrent probiotic supplementation on gut microbiome composition during antibiotic therapy. METHODS: We performed a systematic review and meta-analysis of randomized controlled trials reporting the differences in gu …
We aimed to investigate the effects of concurrent probiotic supplementation on gut microbiome composition during antibiotic …
Sexual dimorphism in glucose metabolism is shaped by androgen-driven gut microbiome.
Gao A, Su J, Liu R, Zhao S, Li W, Xu X, Li D, Shi J, Gu B, Zhang J, Li Q, Wang X, Zhang Y, Xu Y, Lu J, Ning G, Hong J, Bi Y, Gu W, Wang J, Wang W. Gao A, et al. Nat Commun. 2021 Dec 6;12(1):7080. doi: 10.1038/s41467-021-27187-7. Nat Commun. 2021. PMID: 34873153 Free PMC article.
However, the underlying mechanisms remain to be determined. Here, we revealed that gut microbiome depletion abolished sexual dimorphism in glucose metabolism. ...More importantly, the effects of androgen on glucose metabolism were largely abolished when the gut …
However, the underlying mechanisms remain to be determined. Here, we revealed that gut microbiome depletion abolished sexual d …
Antibiotic perturbation of the preterm infant gut microbiome and resistome.
Gasparrini AJ, Crofts TS, Gibson MK, Tarr PI, Warner BB, Dantas G. Gasparrini AJ, et al. Gut Microbes. 2016 Sep 2;7(5):443-9. doi: 10.1080/19490976.2016.1218584. Epub 2016 Jul 29. Gut Microbes. 2016. PMID: 27472377 Free PMC article. Review.
Because antibiotics are heavily administered during the first critical years of gut microbiota development, it is important to understand the effects of these interventions. Infants, particularly those born prematurely, represent an interesting population because th …
Because antibiotics are heavily administered during the first critical years of gut microbiota development, it is important to …
Microbial modulation of the gut microbiome for treating autoimmune diseases.
Balakrishnan B, Taneja V. Balakrishnan B, et al. Expert Rev Gastroenterol Hepatol. 2018 Oct;12(10):985-996. doi: 10.1080/17474124.2018.1517044. Epub 2018 Sep 3. Expert Rev Gastroenterol Hepatol. 2018. PMID: 30146910 Review.
Many studies have shown the relationship between autoimmune diseases and the gut microbiome in humans: those with autoimmune conditions display gut microbiome dysbiosis. ...We searched for genetically modified and potential probiotics for diseases and …
Many studies have shown the relationship between autoimmune diseases and the gut microbiome in humans: those with autoimmune c …
Gut microbiome in the emergence of antibiotic-resistant bacterial pathogens.
Paul D, Das B. Paul D, et al. Prog Mol Biol Transl Sci. 2022;192(1):1-31. doi: 10.1016/bs.pmbts.2022.07.009. Epub 2022 Sep 3. Prog Mol Biol Transl Sci. 2022. PMID: 36280316
Both the commensal and pathogenic members of the gut microbiome serve as reservoirs of antimicrobial-resistance genes (ARG), which can cause potential health threats to the host and can transfer the ARGs to the susceptible microbes and into the environment. Antimicr …
Both the commensal and pathogenic members of the gut microbiome serve as reservoirs of antimicrobial-resistance genes (ARG), w …
Drug and gut microbe relationships: Moving beyond antibiotics.
Kumbhare SV, Pedroso I, Ugalde JA, Márquez-Miranda V, Sinha R, Almonacid DE. Kumbhare SV, et al. Drug Discov Today. 2023 Nov;28(11):103797. doi: 10.1016/j.drudis.2023.103797. Epub 2023 Oct 6. Drug Discov Today. 2023. PMID: 37806386 Review.
Our understanding of drug-microbe relationships has evolved from viewing microbes as mere drug producers to a dynamic, modifiable system where they can serve as drugs or targets of precision pharmacology. This review highlights recent findings on the gut microbiome, …
Our understanding of drug-microbe relationships has evolved from viewing microbes as mere drug producers to a dynamic, modifiable system whe …
Modelling microbiome recovery after antibiotics using a stability landscape framework.
Shaw LP, Bassam H, Barnes CP, Walker AS, Klein N, Balloux F. Shaw LP, et al. ISME J. 2019 Jul;13(7):1845-1856. doi: 10.1038/s41396-019-0392-1. Epub 2019 Mar 15. ISME J. 2019. PMID: 30877283 Free PMC article.
Treatment with antibiotics is one of the most extreme perturbations to the human microbiome. ...We fit this model in a Bayesian framework to data from a previous study of the year-long effects of short courses of four common antibiotics on the gut and …
Treatment with antibiotics is one of the most extreme perturbations to the human microbiome. ...We fit this model in a Bayesia …
Gut microbiome and antibiotic resistance effects during travelers' diarrhea treatment and prevention.
Blake KS, Schwartz DJ, Paruthiyil S, Wang B, Ning J, Isidean SD, Burns DS, Whiteson H, Lalani T, Fraser JA, Connor P, Troth T, Porter CK, Tribble DR, Riddle MS, Gutiérrez RL, Simons MP, Dantas G. Blake KS, et al. mBio. 2024 Jan 16;15(1):e0279023. doi: 10.1128/mbio.02790-23. Epub 2023 Dec 12. mBio. 2024. PMID: 38085102 Free PMC article.
The travelers' gut microbiome is potentially assaulted by acute and chronic perturbations (e.g., diarrhea, antibiotic use, and different environments). ...Our findings indicate that the antibiotic treatment regimens that were studied generally do not l …
The travelers' gut microbiome is potentially assaulted by acute and chronic perturbations (e.g., diarrhea, antibiotic u …
Antibiotics and the developing infant gut microbiota and resistome.
Gibson MK, Crofts TS, Dantas G. Gibson MK, et al. Curr Opin Microbiol. 2015 Oct;27:51-6. doi: 10.1016/j.mib.2015.07.007. Epub 2015 Aug 1. Curr Opin Microbiol. 2015. PMID: 26241507 Free PMC article. Review.
While the mature adult gut microbiota is believed to be relatively stable, the developing infant gut microbiota (IGM) is highly dynamic and prone to disruption by external factors, including antibiotic exposure. Studies have revealed both transient and persis …
While the mature adult gut microbiota is believed to be relatively stable, the developing infant gut microbiota (IGM) is highl …
Iron-containing micronutrient powders modify the effect of oral antibiotics on the infant gut microbiome and increase post-antibiotic diarrhoea risk: a controlled study in Kenya.
Paganini D, Uyoga MA, Kortman GAM, Cercamondi CI, Winkler HC, Boekhorst J, Moretti D, Lacroix C, Karanja S, Zimmermann MB. Paganini D, et al. Gut. 2019 Apr;68(4):645-653. doi: 10.1136/gutjnl-2018-317399. Epub 2018 Nov 17. Gut. 2019. PMID: 30448776
In this study, we evaluated the effect of antibiotics on the infant gut microbiome and diarrhoea when given with or without iron-containing micronutrient powders (MNPs). ...We collected a faecal sample before the first antibiotic dose (D0) and after 5, …
In this study, we evaluated the effect of antibiotics on the infant gut microbiome and diarrhoea when given with or wit …
[Role of the gut microbiome in the development and transfer of antibiotic resistances].
Appel TM, Vehreschild MJ. Appel TM, et al. Inn Med (Heidelb). 2022 Oct;63(10):1043-1050. doi: 10.1007/s00108-022-01400-1. Epub 2022 Sep 1. Inn Med (Heidelb). 2022. PMID: 36048186 Review. German.
Under these circumstances, the risk of the development of invasive infections increases. Antibiotic stewardship programs, the use of narrow-spectrum antibiotics, and the administration of substances that protect the intestinal microbiome from antibiotic …
Under these circumstances, the risk of the development of invasive infections increases. Antibiotic stewardship programs, the use of …
The Role of Antibiotics in Gut Microbiota Modulation: The Eubiotic Effects of Rifaximin.
Ponziani FR, Scaldaferri F, Petito V, Paroni Sterbini F, Pecere S, Lopetuso LR, Palladini A, Gerardi V, Masucci L, Pompili M, Cammarota G, Sanguinetti M, Gasbarrini A. Ponziani FR, et al. Dig Dis. 2016;34(3):269-78. doi: 10.1159/000443361. Epub 2016 Mar 30. Dig Dis. 2016. PMID: 27027301 Review.
Antibiotics are mainly used in clinical practice for their activity against pathogens, but they also alter the composition of commensal gut microbial community. Rifaximin is a non-absorbable antibiotic with additional effects on the gut microbiota abou …
Antibiotics are mainly used in clinical practice for their activity against pathogens, but they also alter the composition of commens …
Human microbiome restoration and safety.
Daliri EB, Tango CN, Lee BH, Oh DH. Daliri EB, et al. Int J Med Microbiol. 2018 Jul;308(5):487-497. doi: 10.1016/j.ijmm.2018.05.002. Epub 2018 May 9. Int J Med Microbiol. 2018. PMID: 29773467 Review.
The human gut microbiome consists of many bacteria which are in symbiotic relationship with human beings. ...Factors such as diet, antibiotic use and lifestyle have been associated with alterations in the gut microbial community and may result in sever …
The human gut microbiome consists of many bacteria which are in symbiotic relationship with human beings. ...Factors such as d …
The initial state of the human gut microbiome determines its reshaping by antibiotics.
Raymond F, Ouameur AA, Déraspe M, Iqbal N, Gingras H, Dridi B, Leprohon P, Plante PL, Giroux R, Bérubé È, Frenette J, Boudreau DK, Simard JL, Chabot I, Domingo MC, Trottier S, Boissinot M, Huletsky A, Roy PH, Ouellette M, Bergeron MG, Corbeil J. Raymond F, et al. ISME J. 2016 Mar;10(3):707-20. doi: 10.1038/ismej.2015.148. Epub 2015 Sep 11. ISME J. 2016. PMID: 26359913 Free PMC article.
Microbiome studies have demonstrated the high inter-individual diversity of the gut microbiota. ...On average, 15 billion nucleotides were sequenced for each sample. We show that standard antibiotic treatment can alter the gut microbiome in a sp …
Microbiome studies have demonstrated the high inter-individual diversity of the gut microbiota. ...On average, 15 billion nucl …
The resistance within: Antibiotic disruption of the gut microbiome and resistome dynamics in infancy.
Thänert R, Sawhney SS, Schwartz DJ, Dantas G. Thänert R, et al. Cell Host Microbe. 2022 May 11;30(5):675-683. doi: 10.1016/j.chom.2022.03.013. Cell Host Microbe. 2022. PMID: 35550670 Free PMC article. Review.
Furthermore, antibiotics increase the abundance of resistant bacteria and enrich the resistome-the compendium of antibiotic resistance genes-within the gut microbiota. Here, we discuss acute and persistent impacts of antibiotic exposure during infancy …
Furthermore, antibiotics increase the abundance of resistant bacteria and enrich the resistome-the compendium of antibiotic re …
Population-level impacts of antibiotic usage on the human gut microbiome.
Lee K, Raguideau S, Sirén K, Asnicar F, Cumbo F, Hildebrand F, Segata N, Cha CJ, Quince C. Lee K, et al. Nat Commun. 2023 Mar 2;14(1):1191. doi: 10.1038/s41467-023-36633-7. Nat Commun. 2023. PMID: 36864029 Free PMC article.
However, the impact on the wider community of commensal microbes associated with the human body, the microbiome, is less well understood. Small-scale studies have determined the transient impacts of antibiotic consumption but we conduct an extensive survey of ARGs i …
However, the impact on the wider community of commensal microbes associated with the human body, the microbiome, is less well underst …
Links Between the Microbiome and Bone.
Hernandez CJ, Guss JD, Luna M, Goldring SR. Hernandez CJ, et al. J Bone Miner Res. 2016 Sep;31(9):1638-46. doi: 10.1002/jbmr.2887. Epub 2016 Jul 26. J Bone Miner Res. 2016. PMID: 27317164 Free PMC article. Review.
The gut microbiome is the largest reservoir of microbial organisms in the body and consists of more than a thousand different species interacting with one another in a stable, dynamic equilibrium. ...In addition, alteration of the gut microbiome has th …
The gut microbiome is the largest reservoir of microbial organisms in the body and consists of more than a thousand different …
Therapeutic Advances in Gut Microbiome Modulation in Patients with Inflammatory Bowel Disease from Pediatrics to Adulthood.
Eindor-Abarbanel A, Healey GR, Jacobson K. Eindor-Abarbanel A, et al. Int J Mol Sci. 2021 Nov 19;22(22):12506. doi: 10.3390/ijms222212506. Int J Mol Sci. 2021. PMID: 34830388 Free PMC article. Review.
For the past decade, high throughput sequencing-based gut microbiome research has identified characteristic shifts in the composition of the intestinal microbiota in patients with IBD, suggesting that IBD results from alterations in the interactions between intestin …
For the past decade, high throughput sequencing-based gut microbiome research has identified characteristic shifts in the comp …
Antibiotics-induced monodominance of a novel gut bacterial order.
Hildebrand F, Moitinho-Silva L, Blasche S, Jahn MT, Gossmann TI, Huerta-Cepas J, Hercog R, Luetge M, Bahram M, Pryszlak A, Alves RJ, Waszak SM, Zhu A, Ye L, Costea PI, Aalvink S, Belzer C, Forslund SK, Sunagawa S, Hentschel U, Merten C, Patil KR, Benes V, Bork P. Hildebrand F, et al. Gut. 2019 Oct;68(10):1781-1790. doi: 10.1136/gutjnl-2018-317715. Epub 2019 Jan 18. Gut. 2019. PMID: 30658995 Free PMC article.
OBJECTIVE: The composition of the healthy human adult gut microbiome is relatively stable over prolonged periods, and representatives of the most highly abundant and prevalent species have been cultured and described. ...DESIGN: Analysing gut microbial time-s …
OBJECTIVE: The composition of the healthy human adult gut microbiome is relatively stable over prolonged periods, and represen …
Recent advances in modulating the microbiome.
Quigley EMM, Gajula P. Quigley EMM, et al. F1000Res. 2020 Jan 27;9:F1000 Faculty Rev-46. doi: 10.12688/f1000research.20204.1. eCollection 2020. F1000Res. 2020. PMID: 32047611 Free PMC article. Review.
We are in the midst of "the microbiome revolution"-not a day goes by without some new revelation on the potential role of the gut microbiome in some disease or disorder. ...From all of the extant studies of interventions targeted at the gut microbio …
We are in the midst of "the microbiome revolution"-not a day goes by without some new revelation on the potential role of the gut …
Determinants of microbial colonization in the premature gut.
Chen X, Shi Y. Chen X, et al. Mol Med. 2023 Jul 5;29(1):90. doi: 10.1186/s10020-023-00689-4. Mol Med. 2023. PMID: 37407941 Free PMC article. Review.
Abnormal microbial colonization in the gut at an early stage of life affects growth, development, and health, resulting in short- and long-term adverse effects. Microbial colonization patterns of preterm infants differ from those of full-term infants in that preterm babies …
Abnormal microbial colonization in the gut at an early stage of life affects growth, development, and health, resulting in short- and …
Animal gut microbiome mediates the effects of antibiotic pollution on an artificial freshwater system.
Zhu W, Yang D, Chang L, Zhang M, Zhu L, Jiang J. Zhu W, et al. J Hazard Mater. 2022 Mar 5;425:127968. doi: 10.1016/j.jhazmat.2021.127968. Epub 2021 Dec 1. J Hazard Mater. 2022. PMID: 34894514 Free article.
Moreover, changes of tadpole gut microbiome (i.e., Cyanobacteria and Basidiomycota OTUs) partly explained the variations of water parameters. In contrast, environmental microbiota and metagenome stayed relatively stable, and didn't contribute to the environmental va …
Moreover, changes of tadpole gut microbiome (i.e., Cyanobacteria and Basidiomycota OTUs) partly explained the variations of wa …
Antibiotic Therapy and the Gut Microbiome: Investigating the Effect of Delivery Route on Gut Pathogens.
Kelly SA, Nzakizwanayo J, Rodgers AM, Zhao L, Weiser R, Tekko IA, McCarthy HO, Ingram RJ, Jones BV, Donnelly RF, Gilmore BF. Kelly SA, et al. ACS Infect Dis. 2021 May 14;7(5):1283-1296. doi: 10.1021/acsinfecdis.1c00081. Epub 2021 Apr 12. ACS Infect Dis. 2021. PMID: 33843198
The contribution of the gut microbiome to human health has long been established, with normal gut microbiota conferring protection against invasive pathogens. ...We have profiled the rat gut microbiome following treatment with commonly prescribe …
The contribution of the gut microbiome to human health has long been established, with normal gut microbiota conferring …
Characteristics of Gut Microbiome After Traumatic Brain Injury.
Mahajan C, Khurana S, Kapoor I, Sokhal S, Kumar S, Prabhakar H, Mathur P, Mani K. Mahajan C, et al. J Neurosurg Anesthesiol. 2023 Jan 1;35(1):86-90. doi: 10.1097/ANA.0000000000000789. Epub 2021 Jul 8. J Neurosurg Anesthesiol. 2023. PMID: 34238913
BACKGROUND: Preclinical studies have reported significant changes in the gut microbiome after traumatic brain injury (TBI). We hypothesized that TBI induces the growth of Proteobacteria in the human gut. ...Samples from rectal swabs obtained on days 0, 3, and …
BACKGROUND: Preclinical studies have reported significant changes in the gut microbiome after traumatic brain injury (TBI). We …
Suppression of the gut microbiome ameliorates age-related arterial dysfunction and oxidative stress in mice.
Brunt VE, Gioscia-Ryan RA, Richey JJ, Zigler MC, Cuevas LM, Gonzalez A, Vázquez-Baeza Y, Battson ML, Smithson AT, Gilley AD, Ackermann G, Neilson AP, Weir T, Davy KP, Knight R, Seals DR. Brunt VE, et al. J Physiol. 2019 May;597(9):2361-2378. doi: 10.1113/JP277336. Epub 2019 Feb 27. J Physiol. 2019. PMID: 30714619 Free PMC article.
The present study aimed to determine whether the gut microbiome modulates arterial function with ageing. We measured arterial function in young and older mice after 3-4 weeks of treatment with broad-spectrum, poorly-absorbed antibiotics to suppress the gut …
The present study aimed to determine whether the gut microbiome modulates arterial function with ageing. We measured arterial …
Antibiotics and probiotics impact gut antimicrobial resistance gene reservoir in COVID-19 patients.
Su Q, Liu Q, Zhang L, Xu Z, Liu C, Lu W, Ching JY, Li A, Mak JWY, Lui GCY, Ng SSS, Chow KM, Hui DS, Chan PK, Chan FKL, Ng SC. Su Q, et al. Gut Microbes. 2022 Jan-Dec;14(1):2128603. doi: 10.1080/19490976.2022.2128603. Gut Microbes. 2022. PMID: 36201636 Free PMC article.
Here, we performed longitudinal fecal metagenomic profiling of 142 patients with COVID-19, characterized the dynamics of resistome from diagnosis to 6 months after viral clearance, and reported the impact of antibiotics or probiotics on the ARGs reservoir. Antibiotic …
Here, we performed longitudinal fecal metagenomic profiling of 142 patients with COVID-19, characterized the dynamics of resistome from diag …
The impact of mass drug administration of antibiotics on the gut microbiota of target populations.
Gough EK. Gough EK. Infect Dis Poverty. 2022 Jun 30;11(1):76. doi: 10.1186/s40249-022-00999-5. Infect Dis Poverty. 2022. PMID: 35773678 Free PMC article. Review.
The importance of the gut microbiota to human metabolism and physiology is now well established, and antibiotic exposure may impact host health via collateral effects on the microbiota and its functions. To gain further insight into how gut microbiota respond …
The importance of the gut microbiota to human metabolism and physiology is now well established, and antibiotic exposure may i …
Effects of short- and long-course antibiotics on the lower intestinal microbiome as they relate to traveller's diarrhea.
McDonald LC. McDonald LC. J Travel Med. 2017 Apr 1;24(suppl_1):S35-S38. doi: 10.1093/jtm/taw084. J Travel Med. 2017. PMID: 28520993 Free PMC article. Review.
BACKGROUND: Antibiotics have profound and lasting effects on the lower intestinal (gut) microbiome that can both promote resistance and increase susceptibility to colonization and infection; knowledge of these changes is important to the prevention and treatm …
BACKGROUND: Antibiotics have profound and lasting effects on the lower intestinal (gut) microbiome that can both promot …
Diet, commensal microbiota-derived extracellular vesicles, and host immunity.
Taitz JJ, Tan JK, Potier-Villette C, Ni D, King NJ, Nanan R, Macia L. Taitz JJ, et al. Eur J Immunol. 2023 Jul;53(7):e2250163. doi: 10.1002/eji.202250163. Epub 2023 May 17. Eur J Immunol. 2023. PMID: 37137164 Review.
The production of gut microbiota-derived BEVs is regulated by host factors such as diet and antibiotic usage. ...This review summarizes current knowledge of the powerful links between nutrition, antibiotics, gut microbiota-derived BEV, and their effect …
The production of gut microbiota-derived BEVs is regulated by host factors such as diet and antibiotic usage. ...This review s …
Does Dietary Consumption of Antibiotics by Humans Promote Antibiotic Resistance in the Gut Microbiome?
Subirats J, Domingues A, Topp E. Subirats J, et al. J Food Prot. 2019 Oct;82(10):1636-1642. doi: 10.4315/0362-028X.JFP-19-158. J Food Prot. 2019. PMID: 31512932 Free article.
Dietary exposure was estimated either using published measured antibiotic concentrations in foodstuffs or using ADI values or food MRLs and a conservative diet. Using the ADI, the estimated antibiotic residue concentrations in the human colon of all antibiotics …
Dietary exposure was estimated either using published measured antibiotic concentrations in foodstuffs or using ADI values or food MR …
Sublethal antibiotics collapse gut bacterial populations by enhancing aggregation and expulsion.
Schlomann BH, Wiles TJ, Wall ES, Guillemin K, Parthasarathy R. Schlomann BH, et al. Proc Natl Acad Sci U S A. 2019 Oct 22;116(43):21392-21400. doi: 10.1073/pnas.1907567116. Epub 2019 Oct 7. Proc Natl Acad Sci U S A. 2019. PMID: 31591228 Free PMC article.
Antibiotics induce large and highly variable changes in the intestinal microbiome even at sublethal concentrations, through mechanisms that remain elusive. ...Intestinal mechanics therefore amplify the effects of antibiotics on resident bacteria. Microbial dy …
Antibiotics induce large and highly variable changes in the intestinal microbiome even at sublethal concentrations, through me …
Fiber supplementation protects from antibiotic-induced gut microbiome dysbiosis by modulating gut redox potential.
Penumutchu S, Korry BJ, Hewlett K, Belenky P. Penumutchu S, et al. Nat Commun. 2023 Aug 24;14(1):5161. doi: 10.1038/s41467-023-40553-x. Nat Commun. 2023. PMID: 37620319 Free PMC article.
Antibiotic-induced gut dysbiosis (AID) is a frequent and serious side effect of antibiotic use and mitigating this dysbiosis is a critical therapeutic target. We propose that the host diet can modulate the chemical environment of the gut resulting in c …
Antibiotic-induced gut dysbiosis (AID) is a frequent and serious side effect of antibiotic use and mitigating this dysb …
Antibiotics, gut bugs and the young.
Browne H. Browne H. Nat Rev Microbiol. 2016 Jun;14(6):336. doi: 10.1038/nrmicro.2016.73. Epub 2016 May 3. Nat Rev Microbiol. 2016. PMID: 27140687
Two recent studies have investigated the effects of antibiotic use on the intestinal microbiota of preterm infants and young children....
Two recent studies have investigated the effects of antibiotic use on the intestinal microbiota of preterm infants and young children …
The effect of modulation of gut microbiome profile on radiation-induced carcinogenesis and survival.
Cook JA, Sowers AL, Choudhuri R, Gadisetti C, Edmondson EF, Gohain S, Krishna MC, Mitchell JB. Cook JA, et al. J Radiat Res. 2023 Jan 20;64(1):24-32. doi: 10.1093/jrr/rrac062. J Radiat Res. 2023. PMID: 36253079 Free PMC article.
Means of protecting against carcinogenesis are lacking. We questioned the role of the gut microbiome in IR-induced carcinogenesis. The gut microbiome was modulated by administering broad spectrum antibiotics (Ab) in the drinking water. ...In con …
Means of protecting against carcinogenesis are lacking. We questioned the role of the gut microbiome in IR-induced carcinogene …
The gut microbiome and antibiotic resistome of chronic diarrhea rhesus macaques (Macaca mulatta) and its similarity to the human gut microbiome.
Yang S, Liu Y, Yang N, Lan Y, Lan W, Feng J, Yue B, He M, Zhang L, Zhang A, Price M, Li J, Fan Z. Yang S, et al. Microbiome. 2022 Feb 9;10(1):29. doi: 10.1186/s40168-021-01218-3. Microbiome. 2022. PMID: 35139923 Free PMC article.
The metabolic pathways of chronic diarrhea RM gut microbiome were enriched in aerobactin biosynthesis, while the metabolic pathways of asymptomatic RM gut microbiome were enriched in the production of short-chain fatty acids (SCFAs). ...CONCLUSIONS: Ou …
The metabolic pathways of chronic diarrhea RM gut microbiome were enriched in aerobactin biosynthesis, while the metabolic pat …
Antibiotic-contaminated wastewater irrigated vegetables pose resistance selection risks to the gut microbiome.
Gudda FO, Waigi MG, Odinga ES, Yang B, Carter L, Gao Y. Gudda FO, et al. Environ Pollut. 2020 Sep;264:114752. doi: 10.1016/j.envpol.2020.114752. Epub 2020 May 7. Environ Pollut. 2020. PMID: 32417582 Review.
However, there is limited attention on the relationship of sub-lethal antibiotic levels in vegetables and resistance selection. Most risk assessment studies show non-significant toxicity, but overlook the link between antibiotics in crops and propagation of gut …
However, there is limited attention on the relationship of sub-lethal antibiotic levels in vegetables and resistance selection. Most …
Gut microbiota suppress feeding induced by palatable foods.
Ousey J, Boktor JC, Mazmanian SK. Ousey J, et al. Curr Biol. 2023 Jan 9;33(1):147-157.e7. doi: 10.1016/j.cub.2022.10.066. Epub 2022 Nov 29. Curr Biol. 2023. PMID: 36450285 Free PMC article.
Feeding behaviors depend on intrinsic and extrinsic factors including genetics, food palatability, and the environment.(1)(,)(2)(,)(3)(,)(4)(,)(5) The gut microbiota is a major environmental contributor to host physiology and impacts feeding behavior.(6)(,)(7)(,)(8)(,)(9)( …
Feeding behaviors depend on intrinsic and extrinsic factors including genetics, food palatability, and the environment.(1)(,)(2)(,)(3)(,)(4) …
Gut Microbiota-Mediated Drug-Antibiotic Interactions.
Kim DH. Kim DH. Drug Metab Dispos. 2015 Oct;43(10):1581-9. doi: 10.1124/dmd.115.063867. Epub 2015 Apr 29. Drug Metab Dispos. 2015. PMID: 25926432 Review.
Antibiotic treatment might influence xenobiotic metabolisms more extensively and potently than previously recognized and reduce gut microbiota-mediated transformation of orally administered drugs, thereby altering the systemic concentrations of intact drugs, their m …
Antibiotic treatment might influence xenobiotic metabolisms more extensively and potently than previously recognized and reduce gu …
Characterisation and therapeutic manipulation of the gut microbiome in inflammatory bowel disease.
Schulberg J, De Cruz P. Schulberg J, et al. Intern Med J. 2016 Mar;46(3):266-73. doi: 10.1111/imj.13003. Intern Med J. 2016. PMID: 26968595 Review.
Inflammatory bowel diseases are thought to develop as a result of dysregulation of the relationship that exists between the gut microbiota, host genetics and the immune system. The advent of culture-independent techniques has revolutionised the ability to characterise the …
Inflammatory bowel diseases are thought to develop as a result of dysregulation of the relationship that exists between the gut micro …
Interaction of drugs with gut microbiota modulators.
Kim DH. Kim DH. Drug Metab Rev. 2023 Aug;55(3):181-194. doi: 10.1080/03602532.2023.2197178. Epub 2023 Apr 4. Drug Metab Rev. 2023. PMID: 36999361 Review.
Although these metabolic reactions typically inactivate drugs (ranitidine, digoxin, and amlodipine), some activate them (sulfasalazine). The composition and quantity of gut microbiota are variable across individuals and fluctuated by gut microbiota modulators such a …
Although these metabolic reactions typically inactivate drugs (ranitidine, digoxin, and amlodipine), some activate them (sulfasalazine). The …
Impact of Intrapartum Antibiotic Prophylaxis for Group B Streptococcus on the Term Infant Gut Microbiome: A State of the Science Review.
Garcia VR. Garcia VR. J Midwifery Womens Health. 2021 May;66(3):351-359. doi: 10.1111/jmwh.13245. Epub 2021 Jun 11. J Midwifery Womens Health. 2021. PMID: 34114318 Review.
Research on antibiotic administration to pregnant individuals during labor for GBS colonization and its potential impact on the developing gut microbiome of term infants is now emerging. Despite the growing body of evidence of the negative impact of antibi …
Research on antibiotic administration to pregnant individuals during labor for GBS colonization and its potential impact on the devel …
The gut microbiome may influence post-prandial nitrogen handling in an elasmobranch, the Pacific spiny dogfish (Squalus suckleyi).
MacPherson J, Weinrauch AM, Anderson WG, Bucking C. MacPherson J, et al. Comp Biochem Physiol A Mol Integr Physiol. 2022 Oct;272:111269. doi: 10.1016/j.cbpa.2022.111269. Epub 2022 Jul 9. Comp Biochem Physiol A Mol Integr Physiol. 2022. PMID: 35820643
Nitrogen recycling through the gut microbiome is an important mechanism used throughout vertebrates to reclaim valuable nitrogen trapped in urea. Evidence suggests it may be especially important in nitrogen limited animals, yet little is known about its role in mari …
Nitrogen recycling through the gut microbiome is an important mechanism used throughout vertebrates to reclaim valuable nitrog …
Antibiotic effect and microbiome persistence vary along the European seabass gut.
Kokou F, Sasson G, Mizrahi I, Cnaani A. Kokou F, et al. Sci Rep. 2020 Jun 19;10(1):10003. doi: 10.1038/s41598-020-66622-5. Sci Rep. 2020. PMID: 32561815 Free PMC article.
Hence, we evaluated the effect of feed-administrated antibiotics on the composition and metabolic potential of the gut microbiome in the European seabass, an economically important aquaculture species. ...Moreover, we found an increase in abundance of predict …
Hence, we evaluated the effect of feed-administrated antibiotics on the composition and metabolic potential of the gut micr …
Neonatal development of intestinal neuroimmune interactions.
Schill EM, Floyd AN, Newberry RD. Schill EM, et al. Trends Neurosci. 2022 Dec;45(12):928-941. doi: 10.1016/j.tins.2022.10.002. Epub 2022 Oct 28. Trends Neurosci. 2022. PMID: 36404456 Free PMC article. Review.
In early life, these interactions are dynamic, because the mucosal immune system, microbiota, and the ENS are developing and influencing each other. Moreover, disrupting gut microbiota and gut immune system development, and potentially ENS development, by early-life …
In early life, these interactions are dynamic, because the mucosal immune system, microbiota, and the ENS are developing and influencing eac …
Early microbiota, antibiotics and health.
Nogacka AM, Salazar N, Arboleya S, Suárez M, Fernández N, Solís G, de Los Reyes-Gavilán CG, Gueimonde M. Nogacka AM, et al. Cell Mol Life Sci. 2018 Jan;75(1):83-91. doi: 10.1007/s00018-017-2670-2. Epub 2017 Oct 7. Cell Mol Life Sci. 2018. PMID: 28988290 Review.
However, we are still far from understanding the impact of early antibiotics and their long-term effects. Increased risk of non-communicable diseases, such as allergies or obesity, has been observed in individuals exposed to antibiotics during early infancy. Moreove …
However, we are still far from understanding the impact of early antibiotics and their long-term effects. Increased risk of non-commu …
Resistome expansion in disease-associated human gut microbiomes.
Fredriksen S, de Warle S, van Baarlen P, Boekhorst J, Wells JM. Fredriksen S, et al. Microbiome. 2023 Jul 29;11(1):166. doi: 10.1186/s40168-023-01610-1. Microbiome. 2023. PMID: 37507809 Free PMC article.
BACKGROUND: The resistome, the collection of antibiotic resistance genes (ARGs) in a microbiome, is increasingly recognised as relevant to the development of clinically relevant antibiotic resistance. ...In this study, we re-analysed human gut micro …
BACKGROUND: The resistome, the collection of antibiotic resistance genes (ARGs) in a microbiome, is increasingly recognised as …
The microbiome and systemic lupus erythematosus.
Katz-Agranov N, Zandman-Goddard G. Katz-Agranov N, et al. Immunol Res. 2017 Apr;65(2):432-437. doi: 10.1007/s12026-017-8906-2. Immunol Res. 2017. PMID: 28233089 Review.
Various parameters of health and disease have been found to be associated with the variation in the human gut microbiome. In recent years, many studies have demonstrated an important role of gut microbes in the development of various illnesses including autoi …
Various parameters of health and disease have been found to be associated with the variation in the human gut microbiome. In r …
Antibiotics in early life: dysbiosis and the damage done.
Neuman H, Forsythe P, Uzan A, Avni O, Koren O. Neuman H, et al. FEMS Microbiol Rev. 2018 Jul 1;42(4):489-499. doi: 10.1093/femsre/fuy018. FEMS Microbiol Rev. 2018. PMID: 29945240 Review.
While use of antibiotics has transformed previously lethal infections into relatively minor diseases, antibiotic treatments can have adverse effects as well. It has been shown in children, adults and animal models that antibiotics dramatically alter the gu …
While use of antibiotics has transformed previously lethal infections into relatively minor diseases, antibiotic treatments ca …
Temporal development of the infant gut microbiome.
Moore RE, Townsend SD. Moore RE, et al. Open Biol. 2019 Sep 27;9(9):190128. doi: 10.1098/rsob.190128. Epub 2019 Sep 11. Open Biol. 2019. PMID: 31506017 Free PMC article.
In a balanced microbiome, symbiotic and commensal species outcompete pathogens for resources. ...In this targeted review we will describe factors that influence the temporal development of the infant microbiome, including the mode of delivery and gestational age at …
In a balanced microbiome, symbiotic and commensal species outcompete pathogens for resources. ...In this targeted review we will desc …
Improved gut microbiome recovery following drug therapy is linked to abundance and replication of probiotic strains.
FitzGerald J, Patel S, Eckenberger J, Guillemard E, Veiga P, Schäfer F, Walter J, Claesson MJ, Derrien M. FitzGerald J, et al. Gut Microbes. 2022 Jan-Dec;14(1):2094664. doi: 10.1080/19490976.2022.2094664. Gut Microbes. 2022. PMID: 35916669 Free PMC article. Clinical Trial.
Collectively, our findings show a small but measurable benefit of a fermented milk product on microbiome recovery after antibiotics, which was linked to the detection and replication of specific probiotic strains. Such functional insight can form the basis for the d …
Collectively, our findings show a small but measurable benefit of a fermented milk product on microbiome recovery after antibiotic …
Antibiotics in early life alter the gut microbiome and increase disease incidence in a spontaneous mouse model of autoimmune insulin-dependent diabetes.
Candon S, Perez-Arroyo A, Marquet C, Valette F, Foray AP, Pelletier B, Milani C, Ventura M, Bach JF, Chatenoud L. Candon S, et al. PLoS One. 2015 May 13;10(5):e0125448. doi: 10.1371/journal.pone.0125448. eCollection 2015. PLoS One. 2015. PMID: 25970503 Free PMC article.
Administration of the antibiotic mixture resulted in near complete ablation of the gut microbiota. ...These results show that a directed even partial ablation of the gut microbiota, as induced by vancomycin, significantly increases type 1 diabetes incidence i …
Administration of the antibiotic mixture resulted in near complete ablation of the gut microbiota. ...These results show that …
Collateral Damage in the Human Gut Microbiome - Blastocystis Is Significantly Less Prevalent in an Antibiotic-Treated Adult Population Compared to Non-Antibiotic Treated Controls.
Jeffery IB, Cotter PD, Scanlan PD. Jeffery IB, et al. Front Cell Infect Microbiol. 2022 Feb 25;12:822475. doi: 10.3389/fcimb.2022.822475. eCollection 2022. Front Cell Infect Microbiol. 2022. PMID: 35281435 Free PMC article.
To date, studies have largely focused on how antibiotics affect the bacterial fraction of the gut microbiome and their impact on non-bacterial members, including prevalent eukaryal species, such as Blastocystis, remains largely unknown. ...Given that antib …
To date, studies have largely focused on how antibiotics affect the bacterial fraction of the gut microbiome and their …
The Impact of the Microbiome on Immunity to Vaccination in Humans.
de Jong SE, Olin A, Pulendran B. de Jong SE, et al. Cell Host Microbe. 2020 Aug 12;28(2):169-179. doi: 10.1016/j.chom.2020.06.014. Cell Host Microbe. 2020. PMID: 32791110 Free PMC article. Review.
Although the factors that are associated with intra- and inter-population variation in vaccine responses are manifold, emerging evidence points to a key role for the gut microbiome in controlling immune responses to vaccination. Much of this evidence comes from stud …
Although the factors that are associated with intra- and inter-population variation in vaccine responses are manifold, emerging evidence poi …
Antibiotics in IBD: Still a Role in the Biological Era?
Ledder O, Turner D. Ledder O, et al. Inflamm Bowel Dis. 2018 Jul 12;24(8):1676-1688. doi: 10.1093/ibd/izy067. Inflamm Bowel Dis. 2018. PMID: 29722812 Review.
Despite compelling evidence pointing to a critical role of gut microflora in inflammatory bowel disease (IBD) pathogenesis, the role of antibiotics in clinical practice remains limited, largely due to heterogeneous trials with often conflicting evidence. ...Similarl …
Despite compelling evidence pointing to a critical role of gut microflora in inflammatory bowel disease (IBD) pathogenesis, the role …
Prenatal Maternal Antibiotics Treatment Alters the Gut Microbiota and Immune Function of Post-Weaned Prepubescent Offspring.
Madany AM, Hughes HK, Ashwood P. Madany AM, et al. Int J Mol Sci. 2022 Oct 25;23(21):12879. doi: 10.3390/ijms232112879. Int J Mol Sci. 2022. PMID: 36361666 Free PMC article.
This study aimed to investigate the immediate and continual perturbation to the gut microbiota of offspring in the weeks post-weaning and how these may be modulated by treating pregnant C57BL/6J dams with antibiotics (ABX). ...Lower levels of chemokines and inflamma …
This study aimed to investigate the immediate and continual perturbation to the gut microbiota of offspring in the weeks post-weaning …
The TaxUMAP atlas: Efficient display of large clinical microbiome data reveals ecological competition in protection against bacteremia.
Schluter J, Djukovic A, Taylor BP, Yan J, Duan C, Hussey GA, Liao C, Sharma S, Fontana E, Amoretti LA, Wright RJ, Dai A, Peled JU, Taur Y, Perales MA, Siranosian BA, Bhatt AS, van den Brink MRM, Pamer EG, Xavier JB. Schluter J, et al. Cell Host Microbe. 2023 Jul 12;31(7):1126-1139.e6. doi: 10.1016/j.chom.2023.05.027. Epub 2023 Jun 16. Cell Host Microbe. 2023. PMID: 37329880
To address these limitations, we present TaxUMAP, a taxonomically informed visualization for displaying microbiome states in large clinical microbiome datasets. We used TaxUMAP to chart a microbiome atlas of 1,870 patients with cancer during therapy-induced p …
To address these limitations, we present TaxUMAP, a taxonomically informed visualization for displaying microbiome states in large cl …
In situ, in vivo, and in vitro approaches for studying AMR plasmid conjugation in the gut microbiome.
Kessler C, Hou J, Neo O, Buckner MMC. Kessler C, et al. FEMS Microbiol Rev. 2023 Jan 16;47(1):fuac044. doi: 10.1093/femsre/fuac044. FEMS Microbiol Rev. 2023. PMID: 36341518 Free PMC article. Review.
The human gut microbiome is a known 'melting pot' for plasmid conjugation, with ARG transfer in this environment widely documented. ...Each has brought unique insights to our understanding of conjugation in the gut. The use and development of these systems, a …
The human gut microbiome is a known 'melting pot' for plasmid conjugation, with ARG transfer in this environment widely docume …
Triclosan targeting of gut microbiome ameliorates hepatic steatosis in high fat diet-fed mice.
Sun D, Zuo C, Huang W, Wang J, Zhang Z. Sun D, et al. J Antibiot (Tokyo). 2022 Jun;75(6):341-353. doi: 10.1038/s41429-022-00522-w. Epub 2022 Apr 19. J Antibiot (Tokyo). 2022. PMID: 35440769
Triclosan, a widely used antibiotic, may improve gut microbiome dysbiosis associated with NAFLD through the suppression of pathogenic gram-negative bacteria. ...In conclusion, our results suggest that triclosan can alleviate liver steatosis in HFD-fed mice by …
Triclosan, a widely used antibiotic, may improve gut microbiome dysbiosis associated with NAFLD through the suppression …
Manipulation of the Gut Microbiome Alters Acetaminophen Biodisposition in Mice.
Malfatti MA, Kuhn EA, Murugesh DK, Mendez ME, Hum N, Thissen JB, Jaing CJ, Loots GG. Malfatti MA, et al. Sci Rep. 2020 Mar 12;10(1):4571. doi: 10.1038/s41598-020-60982-8. Sci Rep. 2020. PMID: 32165665 Free PMC article.
To determine how changes in the gut microbiome can alter drug disposition, the pharmacokinetics (PK), and biodistribution of acetaminophen were assessed in C57Bl/6 mice after treatment with the antibiotics ciprofloxacin, amoxicillin, or a cocktail of ampicill …
To determine how changes in the gut microbiome can alter drug disposition, the pharmacokinetics (PK), and biodistribution of a …
Gut microbiota response to antibiotics is personalized and depends on baseline microbiota.
Rashidi A, Ebadi M, Rehman TU, Elhusseini H, Nalluri H, Kaiser T, Holtan SG, Khoruts A, Weisdorf DJ, Staley C. Rashidi A, et al. Microbiome. 2021 Oct 27;9(1):211. doi: 10.1186/s40168-021-01170-2. Microbiome. 2021. PMID: 34702350 Free PMC article.
BACKGROUND: The magnitude of microbiota perturbations after exposure to antibiotics varies among individuals. It has been suggested that the composition of pre-treatment microbiota underpins personalized responses to antibiotics. ...Penalized generalized estimating …
BACKGROUND: The magnitude of microbiota perturbations after exposure to antibiotics varies among individuals. It has been suggested t …
Probiotics in the next-generation sequencing era.
Suez J, Zmora N, Elinav E. Suez J, et al. Gut Microbes. 2020;11(1):77-93. doi: 10.1080/19490976.2019.1586039. Epub 2019 Apr 5. Gut Microbes. 2020. PMID: 30951391 Free PMC article. Review.
We have recently demonstrated that even during probiotic supplementation, resident gut bacteria in a subset of individuals resist the mucosal presence of probiotic strains, limiting their modulatory effect on the microbiome and on the host gut transcriptional …
We have recently demonstrated that even during probiotic supplementation, resident gut bacteria in a subset of individuals resist the …
Clinically relevant antibiotic resistance genes are linked to a limited set of taxa within gut microbiome worldwide.
Diebold PJ, Rhee MW, Shi Q, Trung NV, Umrani F, Ahmed S, Kulkarni V, Deshpande P, Alexander M, Thi Hoa N, Christakis NA, Iqbal NT, Ali SA, Mathad JS, Brito IL. Diebold PJ, et al. Nat Commun. 2023 Nov 14;14(1):7366. doi: 10.1038/s41467-023-42998-6. Nat Commun. 2023. PMID: 37963868 Free PMC article.
Even cfiA, the most common carbapenemase gene within the human gut microbiome, remains tightly restricted to Bacteroides, despite being found on a mobilizable plasmid. We confirmed these findings in gut microbiome samples from India, Honduras, Pakistan …
Even cfiA, the most common carbapenemase gene within the human gut microbiome, remains tightly restricted to Bacteroides, desp …
Exposure to antibiotics during pregnancy alters offspring outcomes.
Qu W, Liu L, Miao L. Qu W, et al. Expert Opin Drug Metab Toxicol. 2021 Oct;17(10):1165-1174. doi: 10.1080/17425255.2021.1974000. Epub 2021 Sep 6. Expert Opin Drug Metab Toxicol. 2021. PMID: 34435921 Review.
INTRODUCTION: The composition of microorganisms is closely related to human health. Antibiotic use during pregnancy may have adverse effects on the neonatal gut microbiome and subsequently affect infant health development, leading to childhood atopy and aller …
INTRODUCTION: The composition of microorganisms is closely related to human health. Antibiotic use during pregnancy may have adverse …
Alteration of gut microbiota in acute pancreatitis and associated therapeutic strategies.
Zhu Y, Mei Q, Fu Y, Zeng Y. Zhu Y, et al. Biomed Pharmacother. 2021 Sep;141:111850. doi: 10.1016/j.biopha.2021.111850. Epub 2021 Jun 30. Biomed Pharmacother. 2021. PMID: 34214727 Free article. Review.
Gut microbiome is considered as a crucial regulator of human health. ...This review summarizes the role of gut microbiome in AP, lists possible mechanisms associated with it and offers an overview of current treatments based on gut microbiome …
Gut microbiome is considered as a crucial regulator of human health. ...This review summarizes the role of gut micro …
Microbial Metabolism Modulates Antibiotic Susceptibility within the Murine Gut Microbiome.
Cabral DJ, Penumutchu S, Reinhart EM, Zhang C, Korry BJ, Wurster JI, Nilson R, Guang A, Sano WH, Rowan-Nash AD, Li H, Belenky P. Cabral DJ, et al. Cell Metab. 2019 Oct 1;30(4):800-823.e7. doi: 10.1016/j.cmet.2019.08.020. Epub 2019 Sep 12. Cell Metab. 2019. PMID: 31523007 Free PMC article.
Although antibiotics disturb the structure of the gut microbiota, factors that modulate these perturbations are poorly understood. ...We applied a metagenomic and metatranscriptomic approach to link antibiotic-induced taxonomic and transcriptional responses w …
Although antibiotics disturb the structure of the gut microbiota, factors that modulate these perturbations are poorly underst …
Interactions Between the Gastrointestinal Microbiome and Clostridium difficile.
Theriot CM, Young VB. Theriot CM, et al. Annu Rev Microbiol. 2015;69:445-61. doi: 10.1146/annurev-micro-091014-104115. Annu Rev Microbiol. 2015. PMID: 26488281 Free PMC article. Review.
By altering the community structure of the gut microbiome, antibiotics alter the intestinal metabolome, which includes both host- and microbe-derived metabolites. ...This review focuses on how antibiotics alter the structure of the gut microbiot …
By altering the community structure of the gut microbiome, antibiotics alter the intestinal metabolome, which includes …
Impact of Antibiotic Treatment on the Gut Microbiome and its Resistome in Hematopoietic Stem Cell Transplant Recipients.
Nørgaard JC, Jørgensen M, Moestrup KS, Ilett EE, Zucco AG, Marandi RZ, Julian MN, Paredes R, Lundgren JD, Sengeløv H, MacPherson C. Nørgaard JC, et al. J Infect Dis. 2023 Jun 28;228(1):28-36. doi: 10.1093/infdis/jiad033. J Infect Dis. 2023. PMID: 36751730
How antibiotic treatment impacts antibiotic resistance in the human gut microbiome remains poorly understood in vivo. ...Here, we highlight the need for a high-resolution approach in understanding the development of antibiotic resistance in the …
How antibiotic treatment impacts antibiotic resistance in the human gut microbiome remains poorly understood in …
Pharmacomicrobiomics in Pediatric Oncology: The Complex Interplay between Commonly Used Drugs and Gut Microbiome.
Leardini D, Venturelli F, Baccelli F, Cerasi S, Muratore E, Brigidi P, Pession A, Prete A, Masetti R. Leardini D, et al. Int J Mol Sci. 2022 Dec 6;23(23):15387. doi: 10.3390/ijms232315387. Int J Mol Sci. 2022. PMID: 36499714 Free PMC article. Review.
The gut microbiome (GM) has emerged in the last few years as a main character in several diseases. ...The therapeutic course for most pediatric cancer influences the GM due to dietary modifications and several administrated drugs, including chemotherapies, antibi …
The gut microbiome (GM) has emerged in the last few years as a main character in several diseases. ...The therapeutic course f …
The role of antimicrobial treatment during pregnancy on the neonatal gut microbiome and the development of atopy, asthma, allergy and obesity in childhood.
Milliken S, Allen RM, Lamont RF. Milliken S, et al. Expert Opin Drug Saf. 2019 Mar;18(3):173-185. doi: 10.1080/14740338.2019.1579795. Epub 2019 Feb 22. Expert Opin Drug Saf. 2019. PMID: 30739516 Review.
INTRODUCTION: The use of antibiotics prenatally, during pregnancy, or neonatally may have adverse effects on the neonatal gut microbiome, and adversely affect the development of the infant immune system, leading to childhood atopy, asthma, allergy and obesity …
INTRODUCTION: The use of antibiotics prenatally, during pregnancy, or neonatally may have adverse effects on the neonatal gut …
The impact of modulating the gastrointestinal microbiota in cancer patients.
Morkūnas E, Skiecevičienė J, Kupčinskas J. Morkūnas E, et al. Best Pract Res Clin Gastroenterol. 2020 Oct-Dec;48-49:101700. doi: 10.1016/j.bpg.2020.101700. Epub 2020 Oct 19. Best Pract Res Clin Gastroenterol. 2020. PMID: 33317795 Review.
Recent preclinical and clinical studies demonstrate different mechanisms and outcomes of deregulation of gut microbiome, and investigate effects of modulating gastrointestinal microbiota in cancer patients. This paper reviews effects of altered microbiome …
Recent preclinical and clinical studies demonstrate different mechanisms and outcomes of deregulation of gut microbiome, and i …
Disruption of the Gut Microbiota With Antibiotics Exacerbates Acute Vascular Rejection.
Rey K, Manku S, Enns W, Van Rossum T, Bushell K, Morin RD, Brinkman FSL, Choy JC. Rey K, et al. Transplantation. 2018 Jul;102(7):1085-1095. doi: 10.1097/TP.0000000000002169. Transplantation. 2018. PMID: 29538261 Free PMC article.
BACKGROUND: The gut microbiota influences many immunological processes but how its disruption affects transplant rejection is poorly understood. METHODS: Interposition grafting of aortic segments was used to examine vascular rejection. The gut microbiota was disrupt …
BACKGROUND: The gut microbiota influences many immunological processes but how its disruption affects transplant rejection is poorly …
Sex-specific association between the gut microbiome and high-fat diet-induced metabolic disorders in mice.
Peng C, Xu X, Li Y, Li X, Yang X, Chen H, Zhu Y, Lu N, He C. Peng C, et al. Biol Sex Differ. 2020 Jan 20;11(1):5. doi: 10.1186/s13293-020-0281-3. Biol Sex Differ. 2020. PMID: 31959230 Free PMC article.
Alterations in the gut microbiota in response to antibiotics followed by HFD were different between males and females, indicating sex-dependent sensitivity to antibiotics. CONCLUSIONS: We identified that sex had a greater impact on the composition of gut …
Alterations in the gut microbiota in response to antibiotics followed by HFD were different between males and females, indicat …
Detrimental Effect of Broad-spectrum Antibiotics on Intestinal Microbiome Diversity in Patients After Allogeneic Stem Cell Transplantation: Lack of Commensal Sparing Antibiotics.
Weber D, Hiergeist A, Weber M, Dettmer K, Wolff D, Hahn J, Herr W, Gessner A, Holler E. Weber D, et al. Clin Infect Dis. 2019 Apr 8;68(8):1303-1310. doi: 10.1093/cid/ciy711. Clin Infect Dis. 2019. PMID: 30124813
Based on antibiotic activity, we formed 3 subgroups (Rifaximin without systemic antibiotics, Rifaximin with systemic antibiotics, and Ciprofloxacin/Metronidazole with/without systemic antibiotics). ...CONCLUSIONS: Different types of antibiotic t …
Based on antibiotic activity, we formed 3 subgroups (Rifaximin without systemic antibiotics, Rifaximin with systemic antibi …
Impact of antibiotics on off-target infant gut microbiota and resistance genes in cohort studies.
Lebeaux RM, Madan JC, Nguyen QP, Coker MO, Dade EF, Moroishi Y, Palys TJ, Ross BD, Pettigrew MM, Morrison HG, Karagas MR, Hoen AG. Lebeaux RM, et al. Pediatr Res. 2022 Dec;92(6):1757-1766. doi: 10.1038/s41390-022-02104-w. Epub 2022 May 14. Pediatr Res. 2022. PMID: 35568730 Free PMC article. Clinical Trial.
BACKGROUND: Young children are frequently exposed to antibiotics, with the potential for collateral consequences to the gut microbiome. ...Thus, our study design and approach have important implications for future studies evaluating the unintended impacts of …
BACKGROUND: Young children are frequently exposed to antibiotics, with the potential for collateral consequences to the gut …
Antibiotic effects on gut microbiota, metabolism, and beyond.
Mu C, Zhu W. Mu C, et al. Appl Microbiol Biotechnol. 2019 Dec;103(23-24):9277-9285. doi: 10.1007/s00253-019-10165-x. Epub 2019 Nov 7. Appl Microbiol Biotechnol. 2019. PMID: 31701196 Review.
As a microbiota-targeted approach, the use of antibiotics has been widely adopted to explore the role of gut microbiota in vivo. ...Additionally, antibiotic interventions enable to identify novel roles of gut microbiota in gut-liver axis and …
As a microbiota-targeted approach, the use of antibiotics has been widely adopted to explore the role of gut microbiota in viv …
Antibiotics-induced dysbiosis in gut microbiota affects bumblebee health via regulating host amino acid metabolism.
Chen R, Li L, Zhao W. Chen R, et al. Amino Acids. 2023 Apr;55(4):519-528. doi: 10.1007/s00726-023-03247-8. Epub 2023 Feb 7. Amino Acids. 2023. PMID: 36749379
In this study, we specifically examined the important roles of free amino acids in the gut microbiota-host interaction. Bumblebees were treated with different concentrations of antibiotics (ampicillin combined with low/high concentrations of tetracycline). Then the …
In this study, we specifically examined the important roles of free amino acids in the gut microbiota-host interaction. Bumblebees we …
Gut microbiome-depleting antibiotic regimens are not tolerated by all mouse strains: learn from (our) bitter experience.
Almonte AA, Cavic G, Neeman T, Enders A, Fahrer AM. Almonte AA, et al. J Immunother Cancer. 2022 Nov;10(11):e005575. doi: 10.1136/jitc-2022-005575. J Immunother Cancer. 2022. PMID: 36323432 Free PMC article.
Why the gut microbiome is critical for the success of checkpoint inhibitor cancer therapy is a question that remains unanswered, but progress has slowed. We argue that this lack of advancement is due to an unappreciated biological detail. Here, we show that the a …
Why the gut microbiome is critical for the success of checkpoint inhibitor cancer therapy is a question that remains unanswere …
Multiple micronutrient deficiencies in early life cause multi-kingdom alterations in the gut microbiome and intrinsic antibiotic resistance genes in mice.
Littlejohn PT, Metcalfe-Roach A, Cardenas Poire E, Holani R, Bar-Yoseph H, Fan YM, Woodward SE, Finlay BB. Littlejohn PT, et al. Nat Microbiol. 2023 Dec;8(12):2392-2405. doi: 10.1038/s41564-023-01519-3. Epub 2023 Nov 16. Nat Microbiol. 2023. PMID: 37973864
Here we used a postnatal mouse model that is deficient in multiple micronutrients (that is, zinc, folate, iron, vitamin A and vitamin B12 deficient) and shotgun metagenomic sequencing of faecal samples to characterize gut microbiome structure and functional potentia …
Here we used a postnatal mouse model that is deficient in multiple micronutrients (that is, zinc, folate, iron, vitamin A and vitamin B12 de …
Non-responder phenotype reveals apparent microbiome-wide antibiotic tolerance in the murine gut.
Diener C, Hoge ACH, Kearney SM, Kusebauch U, Patwardhan S, Moritz RL, Erdman SE, Gibbons SM. Diener C, et al. Commun Biol. 2021 Mar 9;4(1):316. doi: 10.1038/s42003-021-01841-8. Commun Biol. 2021. PMID: 33750910 Free PMC article.
Broad spectrum antibiotics cause both transient and lasting damage to the ecology of the gut microbiome. Antibiotic-induced loss of gut bacterial diversity has been linked to susceptibility to enteric infections. ...
Broad spectrum antibiotics cause both transient and lasting damage to the ecology of the gut microbiome. Antibiotic …
The Microbiome That Shapes Us: Can It Cause Obesity?
Omer E, Atassi H. Omer E, et al. Curr Gastroenterol Rep. 2017 Oct 27;19(12):59. doi: 10.1007/s11894-017-0600-y. Curr Gastroenterol Rep. 2017. PMID: 29080046 Review.
PURPOSE OF REVIEW: We sought to examine the effects of the gut microbial makeup on weight gain and obesity. We wanted to find out what the current research on this topic was and what the effect of the gut microbiota on energy metabolism is, as well the effects of di …
PURPOSE OF REVIEW: We sought to examine the effects of the gut microbial makeup on weight gain and obesity. We wanted to find out wha …
Oxytetracycline reduces the diversity of tetracycline-resistance genes in the Galleria mellonella gut microbiome.
Ignasiak K, Maxwell A. Ignasiak K, et al. BMC Microbiol. 2018 Dec 29;18(1):228. doi: 10.1186/s12866-018-1377-3. BMC Microbiol. 2018. PMID: 30594143 Free PMC article.
RESULTS: Here we investigate the impact of antibiotics on the insect gut microbiome by identifying tetracycline-resistance genes in the gut bacteria of greater wax moth (Galleria mellonella) larvae, feeding on artificial food containing oxytetracycline …
RESULTS: Here we investigate the impact of antibiotics on the insect gut microbiome by identifying tetracycline-resista …
The implication of gut microbiota in recovery from gastrointestinal surgery.
Zheng Z, Hu Y, Tang J, Xu W, Zhu W, Zhang W. Zheng Z, et al. Front Cell Infect Microbiol. 2023 Feb 28;13:1110787. doi: 10.3389/fcimb.2023.1110787. eCollection 2023. Front Cell Infect Microbiol. 2023. PMID: 36926517 Free PMC article. Review.
Recovery from gastrointestinal (GI) surgery is often interrupted by the unpredictable occurrence of postoperative complications, including infections, anastomotic leak, GI dysmotility, malabsorption, cancer development, and cancer recurrence, in which the implication of …
Recovery from gastrointestinal (GI) surgery is often interrupted by the unpredictable occurrence of postoperative complications, incl …
Do your gut microbes affect your brain dopamine?
González-Arancibia C, Urrutia-Piñones J, Illanes-González J, Martinez-Pinto J, Sotomayor-Zárate R, Julio-Pieper M, Bravo JA. González-Arancibia C, et al. Psychopharmacology (Berl). 2019 May;236(5):1611-1622. doi: 10.1007/s00213-019-05265-5. Epub 2019 May 17. Psychopharmacology (Berl). 2019. PMID: 31098656 Review.
Increasing evidence shows changes in gut microbiota composition in association with psychiatric disorders, including anxiety and depression. ...For this, we reviewed evidence from studies carried out on germ-free animals, or in rodents subjected to intestinal dysbiosis usi …
Increasing evidence shows changes in gut microbiota composition in association with psychiatric disorders, including anxiety and depr …
Recovery of the gut microbiome following enteric infection and persistence of antimicrobial resistance genes in specific microbial hosts.
Hansen ZA, Vasco K, Rudrik JT, Scribner KT, Zhang L, Manning SD. Hansen ZA, et al. Sci Rep. 2023 Sep 19;13(1):15524. doi: 10.1038/s41598-023-42822-7. Sci Rep. 2023. PMID: 37726374 Free PMC article.
Enteric pathogens cause widespread foodborne illness and are increasingly resistant to important antibiotics yet their ecological impact on the gut microbiome and resistome is not fully understood. ...Because of the increasing incidence of disease caused by f …
Enteric pathogens cause widespread foodborne illness and are increasingly resistant to important antibiotics yet their ecological imp …
Commensal antimicrobial resistance mediates microbiome resilience to antibiotic disruption.
Bhattarai SK, Du M, Zeamer AL, M Morzfeld B, Kellogg TD, Firat K, Benjamin A, Bean JM, Zimmerman M, Mardi G, Vilbrun SC, Walsh KF, Fitzgerald DW, Glickman MS, Bucci V. Bhattarai SK, et al. Sci Transl Med. 2024 Jan 17;16(730):eadi9711. doi: 10.1126/scitranslmed.adi9711. Epub 2024 Jan 17. Sci Transl Med. 2024. PMID: 38232140 Free PMC article.
Here, we investigate gut microbiome dynamics over 20 months of multidrug-resistant tuberculosis (TB) and 6 months of drug-sensitive TB treatment in humans. We find that gut microbiome dynamics and TB clearance are shared predictive cofactors of the res …
Here, we investigate gut microbiome dynamics over 20 months of multidrug-resistant tuberculosis (TB) and 6 months of drug-sens …
Gut Check Time: Antibiotic Delivery Strategies to Reduce Antimicrobial Resistance.
Kelly SA, Rodgers AM, O'Brien SC, Donnelly RF, Gilmore BF. Kelly SA, et al. Trends Biotechnol. 2020 Apr;38(4):447-462. doi: 10.1016/j.tibtech.2019.10.008. Epub 2019 Nov 19. Trends Biotechnol. 2020. PMID: 31757410 Review.
Antimicrobial resistance (AMR) has developed into a huge threat to global health, and reducing it is an urgent priority for public health authorities. The importance of a healthy and balanced gut microbiome has been identified as a key protective factor against AMR …
Antimicrobial resistance (AMR) has developed into a huge threat to global health, and reducing it is an urgent priority for public health au …
Gut microbiota: Implications in Parkinson's disease.
Parashar A, Udayabanu M. Parashar A, et al. Parkinsonism Relat Disord. 2017 May;38:1-7. doi: 10.1016/j.parkreldis.2017.02.002. Epub 2017 Feb 7. Parkinsonism Relat Disord. 2017. PMID: 28202372 Free PMC article. Review.
Gut microbiota (GM) can influence various neurological outcomes, like cognition, learning, and memory. ...
Gut microbiota (GM) can influence various neurological outcomes, like cognition, learning, and memory. ...
Signal Versus Noise: How to Analyze the Microbiome and Make Progress on Antimicrobial Resistance.
Golob JL, Rao K. Golob JL, et al. J Infect Dis. 2021 Jun 16;223(12 Suppl 2):S214-S221. doi: 10.1093/infdis/jiab184. J Infect Dis. 2021. PMID: 33880565 Free PMC article. Review.
Despite these extraordinary measures, the challenge of AROs continues to grow. The gut microbiome, the ecosystem of microbes (ie, the microbiota) and metabolites present upon and within all humans, is an emerging target for both the risk for colonization and defense …
Despite these extraordinary measures, the challenge of AROs continues to grow. The gut microbiome, the ecosystem of microbes ( …
The impact of gut microbiota manipulation with antibiotics on colon tumorigenesis in a murine model.
Lee JG, Eun CS, Jo SV, Lee AR, Park CH, Han DS. Lee JG, et al. PLoS One. 2019 Dec 20;14(12):e0226907. doi: 10.1371/journal.pone.0226907. eCollection 2019. PLoS One. 2019. PMID: 31860645 Free PMC article.
It has been suggested that manipulation of gut microbiota using antibiotics can inhibit colitis-associated colorectal cancer (CAC) in a mouse model. ...Principal coordinate analysis showed similar gut microbial community structures among the full-time, early, …
It has been suggested that manipulation of gut microbiota using antibiotics can inhibit colitis-associated colorectal cancer ( …
The gut microbiome and resistome of conventionally vs. pasture-raised pigs.
Holman DB, Gzyl KE, Kommadath A. Holman DB, et al. Microb Genom. 2023 Jul;9(7):mgen001061. doi: 10.1099/mgen.0.001061. Microb Genom. 2023. PMID: 37439777 Free PMC article.
In this study, we used shotgun metagenomic sequencing to compare the gut microbiomes and resistomes of pigs raised indoors on a conventional farm with those raised outdoors on pasture. ...Overall, the study provides insights into the differences between the gut micr …
In this study, we used shotgun metagenomic sequencing to compare the gut microbiomes and resistomes of pigs raised indoors on a conve …
Role of the gut microbiota in nutrient competition and protection against intestinal pathogen colonization.
Horrocks V, King OG, Yip AYG, Marques IM, McDonald JAK. Horrocks V, et al. Microbiology (Reading). 2023 Aug;169(8):001377. doi: 10.1099/mic.0.001377. Microbiology (Reading). 2023. PMID: 37540126 Free PMC article. Review.
However, antibiotic treatment can kill members of the gut microbiota ('gut commensals') and reduce competition for nutrients, making these nutrients available to support the growth of pathogens. This disturbance can lead to the growth and expansion of pathoge …
However, antibiotic treatment can kill members of the gut microbiota ('gut commensals') and reduce competition for nutr …
Protective effects of konjac glucomannan on gut microbiome with antibiotic perturbation in mice.
Mao YH, Xu Y, Song F, Wang ZM, Li YH, Zhao M, He F, Tian Z, Yang Y. Mao YH, et al. Carbohydr Polym. 2022 Aug 15;290:119476. doi: 10.1016/j.carbpol.2022.119476. Epub 2022 Apr 12. Carbohydr Polym. 2022. PMID: 35550768
This study assessed the protective effects of konjac glucomannan (KGM) on gut microbiome against the antibiotic perturbation in C57BL/6J mice. ...These results have demonstrated the protective effects of KGM with high MW on gut microbiome agains …
This study assessed the protective effects of konjac glucomannan (KGM) on gut microbiome against the antibiotic perturb …
Urbanization and the gut microbiota in health and inflammatory bowel disease.
Zuo T, Kamm MA, Colombel JF, Ng SC. Zuo T, et al. Nat Rev Gastroenterol Hepatol. 2018 Jul;15(7):440-452. doi: 10.1038/s41575-018-0003-z. Nat Rev Gastroenterol Hepatol. 2018. PMID: 29670252 Review.
The disparate patterns of the gut microbiota composition in rural and urban areas offer an opportunity to understand the contribution of a 'rural microbiome' in potentially protecting against the development of IBD. This Perspective discusses the effect of urbanizat …
The disparate patterns of the gut microbiota composition in rural and urban areas offer an opportunity to understand the contribution …
Impact of lincosamides antibiotics on the composition of the rat gut microbiota and the metabolite profile of plasma and feces.
Behr C, Ramírez-Hincapié S, Cameron HJ, Strauss V, Walk T, Herold M, Beekmann K, Rietjens IMCM, van Ravenzwaay B. Behr C, et al. Toxicol Lett. 2018 Oct 15;296:139-151. doi: 10.1016/j.toxlet.2018.08.002. Epub 2018 Aug 10. Toxicol Lett. 2018. PMID: 30102961
In this study, lincomycin and clindamycin were used to modulate microbial communities of Wistar rats to gain a comprehensive understanding of the implications of microbiome alterations. A metabolomics approach and taxonomic profiling were applied to characterize the effect …
In this study, lincomycin and clindamycin were used to modulate microbial communities of Wistar rats to gain a comprehensive understanding o …
Effects of Antibiotic Treatment on Gut Microbiota and How to Overcome Its Negative Impacts on Human Health.
Ribeiro CFA, Silveira GGOS, Cândido ES, Cardoso MH, Espínola Carvalho CM, Franco OL. Ribeiro CFA, et al. ACS Infect Dis. 2020 Oct 9;6(10):2544-2559. doi: 10.1021/acsinfecdis.0c00036. Epub 2020 Sep 2. ACS Infect Dis. 2020. PMID: 32786282 Review.
The impact of antibiotics on gut microbiota homeostasis is alarming, compromising its microbial community and leading to changes in host health. ...Thus, this Review will address a new perspective on antimicrobial therapies through pathogen-selective antibiotics …
The impact of antibiotics on gut microbiota homeostasis is alarming, compromising its microbial community and leading to chang …
Gut microbiota interspecies interactions shape the response of Clostridioides difficile to clinically relevant antibiotics.
Hromada S, Venturelli OS. Hromada S, et al. PLoS Biol. 2023 May 11;21(5):e3002100. doi: 10.1371/journal.pbio.3002100. eCollection 2023 May. PLoS Biol. 2023. PMID: 37167201 Free PMC article.
In the human gut, the growth of the pathogen Clostridioides difficile is impacted by a complex web of interspecies interactions with members of human gut microbiota. We investigate the contribution of interspecies interactions on the antibiotic response of C. …
In the human gut, the growth of the pathogen Clostridioides difficile is impacted by a complex web of interspecies interactions with …
Gut microbiome-targeted therapies in nonalcoholic fatty liver disease: a systematic review, meta-analysis, and meta-regression.
Sharpton SR, Maraj B, Harding-Theobald E, Vittinghoff E, Terrault NA. Sharpton SR, et al. Am J Clin Nutr. 2019 Jul 1;110(1):139-149. doi: 10.1093/ajcn/nqz042. Am J Clin Nutr. 2019. PMID: 31124558 Free PMC article.
BACKGROUND: Preclinical evidence suggests that modulation of the gut microbiome could represent a new therapeutic target in nonalcoholic fatty liver disease (NAFLD). ...MTT was defined as antibiotics, probiotics, synbiotics, or fecal microbiota transplantatio …
BACKGROUND: Preclinical evidence suggests that modulation of the gut microbiome could represent a new therapeutic target in no …
Antibiotic-induced gut microbiota dysbiosis altered host metabolism.
He M, Shi J, Liu A, Xu YJ, Liu Y. He M, et al. Mol Omics. 2023 May 9;19(4):330-339. doi: 10.1039/d2mo00284a. Mol Omics. 2023. PMID: 36852671
The goal of this study was to determine whether antibiotics alter the metabolic phenotype of the host. We found that taking antibiotics reduced the diversity and richness of gut microbiota and affected the composition of the microbiome, which in turn a …
The goal of this study was to determine whether antibiotics alter the metabolic phenotype of the host. We found that taking antibi …
[The human gut microbiota to find new antibiotics].
Herrou C, Mom J, Nasri I, Turrini E, Aussel L. Herrou C, et al. Med Sci (Paris). 2022 May;38(5):487-492. doi: 10.1051/medsci/2022059. Epub 2022 May 24. Med Sci (Paris). 2022. PMID: 35608474 Free article. French.
Individualized recovery of gut microbial strains post antibiotics.
Koo H, Hakim JA, Crossman DK, Kumar R, Lefkowitz EJ, Morrow CD. Koo H, et al. NPJ Biofilms Microbiomes. 2019 Oct 11;5(1):30. doi: 10.1038/s41522-019-0103-8. eCollection 2019. NPJ Biofilms Microbiomes. 2019. PMID: 31632686 Free PMC article.
To further understand the impact of antibiotics on the gastrointestinal tract microbial community, the intra-individual recovery pattern of specific microbial strains was determined using metagenomic sequencing coupled with strain-tracking analyses. ...The presence …
To further understand the impact of antibiotics on the gastrointestinal tract microbial community, the intra-individual recove …
Sulfur Cycling and the Intestinal Microbiome.
Barton LL, Ritz NL, Fauque GD, Lin HC. Barton LL, et al. Dig Dis Sci. 2017 Sep;62(9):2241-2257. doi: 10.1007/s10620-017-4689-5. Epub 2017 Aug 1. Dig Dis Sci. 2017. PMID: 28766244 Review.
In this review, we focus on the activities transpiring in the anaerobic segment of the sulfur cycle occurring in the gut environment where hydrogen sulfide is produced. While sulfate-reducing bacteria are considered as the principal agents for hydrogen sulfide produ …
In this review, we focus on the activities transpiring in the anaerobic segment of the sulfur cycle occurring in the gut environment …
Dynamics of the Gut Microbiome and Transcriptome in Korea Native Ricefish (Oryzias latipes) during Chronic Antibiotic Exposure.
Yoon JB, Hwang S, Yang JH, Lee S, Bang WY, Moon KH. Yoon JB, et al. Genes (Basel). 2022 Jul 14;13(7):1243. doi: 10.3390/genes13071243. Genes (Basel). 2022. PMID: 35886026 Free PMC article.
Antibiotics have been widely used to inhibit microbial growth and to control bacterial infection; however, they can trigger an imbalance in the gut flora of the host and dysregulate the host gene regulatory system when discharged into the aquatic environment. We inv …
Antibiotics have been widely used to inhibit microbial growth and to control bacterial infection; however, they can trigger an imbala …
Differential response to prolonged amoxicillin treatment: long-term resilience of the microbiome versus long-lasting perturbations in the gut resistome.
Dhariwal A, Haugli Bråten LC, Sturød K, Salvadori G, Bargheet A, Åmdal H, Junges R, Berild D, Zwart JA, Storheim K, Petersen FC. Dhariwal A, et al. Gut Microbes. 2023 Jan-Dec;15(1):2157200. doi: 10.1080/19490976.2022.2157200. Gut Microbes. 2023. PMID: 36576106 Free PMC article.
The collateral impact of antibiotics on the microbiome has attained increasing attention. However, the ecological consequences of long-term antibiotic exposure on the gut microbiome, including antibiotic resistance, are still limited. Her …
The collateral impact of antibiotics on the microbiome has attained increasing attention. However, the ecological consequences …
Gut microbiota and bipolar disorder: a review of mechanisms and potential targets for adjunctive therapy.
Gondalia S, Parkinson L, Stough C, Scholey A. Gondalia S, et al. Psychopharmacology (Berl). 2019 May;236(5):1433-1443. doi: 10.1007/s00213-019-05248-6. Epub 2019 Apr 30. Psychopharmacology (Berl). 2019. PMID: 31041459 Review.
There is increasing evidence that connections formed between microbiome, the gut, and the brain play a role in health and well-being. ...Further in this review, we explore links between bipolar disorder, inflammation and gut microbiome with a focus on …
There is increasing evidence that connections formed between microbiome, the gut, and the brain play a role in health and well …
Impact of the gut microbiome on immune checkpoint inhibitor efficacy-a systematic review.
Pierrard J, Seront E. Pierrard J, et al. Curr Oncol. 2019 Dec;26(6):395-403. doi: 10.3747/co.26.5177. Epub 2019 Dec 1. Curr Oncol. 2019. PMID: 31896938 Free PMC article.
Preclinical models showed significant interaction between the gut microbiome (gm) and response to icis. However, that interaction remains unclear in clinical practice. ...In 2 cases, fecal microbiota transplantation was reported to reduce immune colitis. CONCLUSIONS …
Preclinical models showed significant interaction between the gut microbiome (gm) and response to icis. However, that interact …
The effect of microbiome composition on impulsive and violent behavior: A systematic review.
Langmajerová M, Roubalová R, Šebela A, Vevera J. Langmajerová M, et al. Behav Brain Res. 2023 Feb 25;440:114266. doi: 10.1016/j.bbr.2022.114266. Epub 2022 Dec 20. Behav Brain Res. 2023. PMID: 36549572 Review.
We searched for a link between the gut microbiome and impulsive and violent behavior. We focused on critical factors influencing the microbiome establishment that may affect human health later in life, i.e., delivery mode, early-life feeding, and early ant …
We searched for a link between the gut microbiome and impulsive and violent behavior. We focused on critical factors influenci …
The altered gut virome community in rhesus monkeys is correlated with the gut bacterial microbiome and associated metabolites.
Li H, Li H, Wang J, Guo L, Fan H, Zheng H, Yang Z, Huang X, Chu M, Yang F, He Z, Li N, Yang J, Wu Q, Shi H, Liu L. Li H, et al. Virol J. 2019 Aug 19;16(1):105. doi: 10.1186/s12985-019-1211-z. Virol J. 2019. PMID: 31426820 Free PMC article.
Examination of the interactions between the gut bacterial microbiome and virome of rhesus monkey would significantly contribute to revealing the gut microbiome composition. METHODS: Here, we conducted a metagenomic analysis of the gut microbi …
Examination of the interactions between the gut bacterial microbiome and virome of rhesus monkey would significantly contribut …
The infant gut resistome associates with E. coli, environmental exposures, gut microbiome maturity, and asthma-associated bacterial composition.
Li X, Stokholm J, Brejnrod A, Vestergaard GA, Russel J, Trivedi U, Thorsen J, Gupta S, Hjelmsø MH, Shah SA, Rasmussen MA, Bisgaard H, Sørensen SJ. Li X, et al. Cell Host Microbe. 2021 Jun 9;29(6):975-987.e4. doi: 10.1016/j.chom.2021.03.017. Epub 2021 Apr 21. Cell Host Microbe. 2021. PMID: 33887206 Free article.
Antimicrobial resistance (AMR) is an accelerating global threat, yet the nature of AMR in the gut microbiome and how AMR is acquired during early life remain largely unknown. ...Among these factors, the importance of antibiotics diminished with time since tre …
Antimicrobial resistance (AMR) is an accelerating global threat, yet the nature of AMR in the gut microbiome and how AMR is ac …
Temporal development and potential interactions between the gut microbiome and resistome in early childhood.
Zhao L, Yang X, Liang Y, Zhang Z, Ding Y, Wang Y, Chen B, Wu J, Jin C, Zhao G, Li Z, Zhang L. Zhao L, et al. Microbiol Spectr. 2024 Feb 6;12(2):e0317723. doi: 10.1128/spectrum.03177-23. Epub 2024 Jan 9. Microbiol Spectr. 2024. PMID: 38193687 Free PMC article.
Moreover, the potential interactions between gut microbiome and resistome still need to be further explored. In this study, we found that antibiotic treatment led to destabilization of the gut microbiome and resistome structural communities, exh …
Moreover, the potential interactions between gut microbiome and resistome still need to be further explored. In this study, we …
An Alternative Explanation for Alzheimer's Disease and Parkinson's Disease Initiation from Specific Antibiotics, Gut Microbiota Dysbiosis and Neurotoxins.
Roe K. Roe K. Neurochem Res. 2022 Mar;47(3):517-530. doi: 10.1007/s11064-021-03467-y. Epub 2021 Oct 20. Neurochem Res. 2022. PMID: 34669122 Review.
Two major barriers to neurotoxin entry into the central nervous system are the blood-brain barrier and the intestinal wall, in the absence of gut dysbiosis. Inflammation from gut dysbiosis, induced by antibiotic usage, can increase the intestinal wall permeab …
Two major barriers to neurotoxin entry into the central nervous system are the blood-brain barrier and the intestinal wall, in the absence o …
An RNA biology perspective on species-specific programmable RNA antibiotics.
Vogel J. Vogel J. Mol Microbiol. 2020 Mar;113(3):550-559. doi: 10.1111/mmi.14476. Mol Microbiol. 2020. PMID: 32185839 Free article. Review.
These ASOs are coupled to small peptides that carry them inside the bacteria to silence mRNAs of essential genes, for example, to target antibiotic-resistant pathogens as an alternative to standard antibiotics. There is already proof-of-principle with diverse bacter …
These ASOs are coupled to small peptides that carry them inside the bacteria to silence mRNAs of essential genes, for example, to target …
Stereotypes About Enterotype: the Old and New Ideas.
Cheng M, Ning K. Cheng M, et al. Genomics Proteomics Bioinformatics. 2019 Feb;17(1):4-12. doi: 10.1016/j.gpb.2018.02.004. Epub 2019 Apr 23. Genomics Proteomics Bioinformatics. 2019. PMID: 31026581 Free PMC article. Review.
In 2011, the term "enterotype" first appeared to the general public in Nature, which refers to stratification of human gut microbiota. However, with more studies on enterotypes conducted nowadays, doubts about the existence and robustness of enterotypes have also emerged. …
In 2011, the term "enterotype" first appeared to the general public in Nature, which refers to stratification of human gut microbiota …
Critical windows of early-life microbiota disruption on behaviour, neuroimmune function, and neurodevelopment.
Lynch CMK, Cowan CSM, Bastiaanssen TFS, Moloney GM, Theune N, van de Wouw M, Florensa Zanuy E, Ventura-Silva AP, Codagnone MG, Villalobos-Manríquez F, Segalla M, Koc F, Stanton C, Ross P, Dinan TG, Clarke G, Cryan JF. Lynch CMK, et al. Brain Behav Immun. 2023 Feb;108:309-327. doi: 10.1016/j.bbi.2022.12.008. Epub 2022 Dec 17. Brain Behav Immun. 2023. PMID: 36535610 Free article.
Numerous studies have emphasised the importance of the gut microbiota during early life and its role in modulating neurodevelopment and behaviour. ...Our results demonstrate that targeted microbiota disruption during early life has enduring effects into adolescence on the …
Numerous studies have emphasised the importance of the gut microbiota during early life and its role in modulating neurodevelopment a …
Phylogenetic diversity analysis of shotgun metagenomic reads describes gut microbiome development and treatment effects in the post-weaned pig.
Gaio D, DeMaere MZ, Anantanawat K, Eamens GJ, Falconer L, Chapman TA, Djordjevic S, Darling AE. Gaio D, et al. PLoS One. 2022 Jun 24;17(6):e0270372. doi: 10.1371/journal.pone.0270372. eCollection 2022. PLoS One. 2022. PMID: 35749534 Free PMC article.
To counteract dysbiotic effects, numerous studies in the past two decades sought to understand whether probiotics are a valid tool to help re-establish a healthy gut microbial community after antibiotic treatment. Although dysbiotic effects of antibiotics are …
To counteract dysbiotic effects, numerous studies in the past two decades sought to understand whether probiotics are a valid tool to help r …
Distinct consequences of amoxicillin and ertapenem exposure in the porcine gut microbiome.
Connelly S, Subramanian P, Hasan NA, Colwell RR, Kaleko M. Connelly S, et al. Anaerobe. 2018 Oct;53:82-93. doi: 10.1016/j.anaerobe.2018.04.012. Epub 2018 Apr 22. Anaerobe. 2018. PMID: 29689301
The gut microbiome influences many, if not all, aspects of human health. ...Here, porcine models were developed to evaluate changes to the gut microbiome caused by two distinct types of beta-lactam antibiotics delivered via common administration …
The gut microbiome influences many, if not all, aspects of human health. ...Here, porcine models were developed to evaluate ch …
Influence of Fluconazole Administration on Gut Microbiome, Intestinal Barrier, and Immune Response in Mice.
Heng X, Jiang Y, Chu W. Heng X, et al. Antimicrob Agents Chemother. 2021 May 18;65(6):e02552-20. doi: 10.1128/AAC.02552-20. Print 2021 May 18. Antimicrob Agents Chemother. 2021. PMID: 33722893 Free PMC article.
For example, antibiotics use may affect the host's immune system by altering the gut microbiota. ...These results suggest that the administration of fluconazole can influence the gut microbiota and that a healthy gut microbiome is important for …
For example, antibiotics use may affect the host's immune system by altering the gut microbiota. ...These results suggest that …
Do common antibiotic treatments influence emotional processing?
Johnson KV, Steenbergen L. Johnson KV, et al. Physiol Behav. 2022 Oct 15;255:113900. doi: 10.1016/j.physbeh.2022.113900. Epub 2022 Jul 8. Physiol Behav. 2022. PMID: 35810835 Free article.
Since studies in both humans and animal models have revealed that the gut microbiome can affect the brain, influencing emotion and cognition, here we investigate whether antibiotic treatment is associated with changes in emotional processing and mood with a b …
Since studies in both humans and animal models have revealed that the gut microbiome can affect the brain, influencing emotion …
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