gut microbiome autism - Search Results

Year	Number of Results
2011	1
2012	1
2013	14
2014	17
2015	30
2016	48
2017	59
2018	79
2019	104
2020	121
2021	151
2022	143
2023	120
2024	49

1

Autism-related dietary preferences mediate autism-gut microbiome associations.

Yap CX, Henders AK, Alvares GA, Wood DLA, Krause L, Tyson GW, Restuadi R, Wallace L, McLaren T, Hansell NK, Cleary D, Grove R, Hafekost C, Harun A, Holdsworth H, Jellett R, Khan F, Lawson LP, Leslie J, Frenk ML, Masi A, Mathew NE, Muniandy M, Nothard M, Miller JL, Nunn L, Holtmann G, Strike LT, de Zubicaray GI, Thompson PM, McMahon KL, Wright MJ, Visscher PM, Dawson PA, Dissanayake C, Eapen V, Heussler HS, McRae AF, Whitehouse AJO, Wray NR, Gratten J. Yap CX, et al. Cell. 2021 Nov 24;184(24):5916-5931.e17. doi: 10.1016/j.cell.2021.10.015. Epub 2021 Nov 11. Cell. 2021. PMID: 34767757 Free article.

There is increasing interest in the potential contribution of the gut microbiome to autism spectrum disorder (ASD). However, previous studies have been underpowered and have not been designed to address potential confounding factors in a comprehensive …

There is increasing interest in the potential contribution of the gut microbiome to autism spectrum disorder (AS …

2

Autism Spectrum Disorder as a Brain-Gut-Microbiome Axis Disorder.

Saurman V, Margolis KG, Luna RA. Saurman V, et al. Dig Dis Sci. 2020 Mar;65(3):818-828. doi: 10.1007/s10620-020-06133-5. Dig Dis Sci. 2020. PMID: 32056091 Free PMC article. Review.

Recent findings continue to support the relationship between the gut microbiome and both GI symptoms and behavior, but the heterogeneity within the autism spectrum requires in-depth clinical characterization of these clinical cohorts. Large, diverse, well-con …

Recent findings continue to support the relationship between the gut microbiome and both GI symptoms and behavior, but the het …

3

Role of Gut Microbiome in Autism Spectrum Disorder and Its Therapeutic Regulation.

Taniya MA, Chung HJ, Al Mamun A, Alam S, Aziz MA, Emon NU, Islam MM, Hong SS, Podder BR, Ara Mimi A, Aktar Suchi S, Xiao J. Taniya MA, et al. Front Cell Infect Microbiol. 2022 Jul 22;12:915701. doi: 10.3389/fcimb.2022.915701. eCollection 2022. Front Cell Infect Microbiol. 2022. PMID: 35937689 Free PMC article. Review.

Most autistic patients suffer from gastrointestinal (GI) symptoms. Many studies have shown that early colonization, mode of delivery, and antibiotic usage significantly affect the gut microbiome and the onset of autism. Microbial fermentation of …

Most autistic patients suffer from gastrointestinal (GI) symptoms. Many studies have shown that early colonization, mode of de …

4

The Human Gut Microbiome as a Potential Factor in Autism Spectrum Disorder.

Alharthi A, Alhazmi S, Alburae N, Bahieldin A. Alharthi A, et al. Int J Mol Sci. 2022 Jan 25;23(3):1363. doi: 10.3390/ijms23031363. Int J Mol Sci. 2022. PMID: 35163286 Free PMC article. Review.

The high prevalence of gastrointestinal (GI) disorders among autism spectrum disorder (ASD) patients has prompted scientists to look into the gut microbiota as a putative trigger in ASD pathogenesis. ...This present review highlights the potential role …

The high prevalence of gastrointestinal (GI) disorders among autism spectrum disorder (ASD) patients has prompted scien …

5

The Brain-Gut-Microbiome System: Pathways and Implications for Autism Spectrum Disorder.

Chernikova MA, Flores GD, Kilroy E, Labus JS, Mayer EA, Aziz-Zadeh L. Chernikova MA, et al. Nutrients. 2021 Dec 16;13(12):4497. doi: 10.3390/nu13124497. Nutrients. 2021. PMID: 34960049 Free PMC article. Review.

Gastrointestinal dysfunction is one of the most prevalent physiological symptoms of autism spectrum disorder (ASD). ...Specifically, we review the brain-gut-microbiome system and discuss findings from current animal and human studies as they rel …

Gastrointestinal dysfunction is one of the most prevalent physiological symptoms of autism spectrum disorder (ASD). ... …

6

The gut microbiome in neurological disorders.

Cryan JF, O'Riordan KJ, Sandhu K, Peterson V, Dinan TG. Cryan JF, et al. Lancet Neurol. 2020 Feb;19(2):179-194. doi: 10.1016/S1474-4422(19)30356-4. Epub 2019 Nov 18. Lancet Neurol. 2020. PMID: 31753762 Review.

Research into the role of the gut microbiome in modulating brain function has rapidly increased over the past 10 years, albeit chiefly in animal models. Increasing clinical and preclinical evidence implicates the microbiome as a possible key susceptibility fa …

Research into the role of the gut microbiome in modulating brain function has rapidly increased over the past 10 years, albeit …

7

A Comprehensive Review on the Role of the Gut Microbiome in Human Neurological Disorders.

Sorboni SG, Moghaddam HS, Jafarzadeh-Esfehani R, Soleimanpour S. Sorboni SG, et al. Clin Microbiol Rev. 2022 Jan 19;35(1):e0033820. doi: 10.1128/CMR.00338-20. Epub 2022 Jan 5. Clin Microbiol Rev. 2022. PMID: 34985325 Free PMC article. Review.

Novel preclinical and clinical research on interventions related to the gut microbiome for treating neurological conditions, including autism spectrum disorders, Parkinson's disease, schizophrenia, multiple sclerosis, Alzheimer's disease, epilepsy, and stroke …

Novel preclinical and clinical research on interventions related to the gut microbiome for treating neurological conditions, i …

8

Comparing the Gut Microbiome in Autism and Preclinical Models: A Systematic Review.

Alamoudi MU, Hosie S, Shindler AE, Wood JL, Franks AE, Hill-Yardin EL. Alamoudi MU, et al. Front Cell Infect Microbiol. 2022 Jul 1;12:905841. doi: 10.3389/fcimb.2022.905841. eCollection 2022. Front Cell Infect Microbiol. 2022. PMID: 35846755 Free PMC article. Review.

Many individuals diagnosed with autism spectrum disorder (ASD) experience gastrointestinal (GI) dysfunction and show microbial dysbiosis. ...Several preclinical models of autism also demonstrate microbial dysbiosis. Given that much pre-clinical researc …

Many individuals diagnosed with autism spectrum disorder (ASD) experience gastrointestinal (GI) dysfunction and show mi …

9

The Microbiome-Gut-Brain Axis in Health and Disease.

Dinan TG, Cryan JF. Dinan TG, et al. Gastroenterol Clin North Am. 2017 Mar;46(1):77-89. doi: 10.1016/j.gtc.2016.09.007. Epub 2017 Jan 4. Gastroenterol Clin North Am. 2017. PMID: 28164854 Review.

Evidence is accumulating to support the view that gut microbes influence central neurochemistry and behavior. Irritable bowel syndrome is regarded as the prototypic disorder of the brain-gut-microbiota axis that can be responsive to probiotic therapy. Transla …

Evidence is accumulating to support the view that gut microbes influence central neurochemistry and behavior. Irritable bowel syndrom …

10

The Microbiota-Gut-Brain Axis in Psychiatric Disorders.

Góralczyk-Bińkowska A, Szmajda-Krygier D, Kozłowska E. Góralczyk-Bińkowska A, et al. Int J Mol Sci. 2022 Sep 24;23(19):11245. doi: 10.3390/ijms231911245. Int J Mol Sci. 2022. PMID: 36232548 Free PMC article. Review.

Modulating the gut microbiome and its influence on human health is the subject of intense research. ...We review the microbiota alterations and their results in the development of psychiatric disorders, including major depressive disorder (MDD), schizophrenia …

Modulating the gut microbiome and its influence on human health is the subject of intense research. ...We review the microbiot …

11

Autism, Gastrointestinal Symptoms and Modulation of Gut Microbiota by Nutritional Interventions.

Ristori MV, Quagliariello A, Reddel S, Ianiro G, Vicari S, Gasbarrini A, Putignani L. Ristori MV, et al. Nutrients. 2019 Nov 18;11(11):2812. doi: 10.3390/nu11112812. Nutrients. 2019. PMID: 31752095 Free PMC article. Review.

Autism spectrum disorder (ASD) is a complex behavioral syndrome that is characterized by speech and language disorders, intellectual impairment, learning and motor dysfunctions. ...GI disorders are associated with an altered composition of the gut microbiota. …

Autism spectrum disorder (ASD) is a complex behavioral syndrome that is characterized by speech and language disorders, intell …

12

Gut microbiota in autism and mood disorders.

Mangiola F, Ianiro G, Franceschi F, Fagiuoli S, Gasbarrini G, Gasbarrini A. Mangiola F, et al. World J Gastroenterol. 2016 Jan 7;22(1):361-8. doi: 10.3748/wjg.v22.i1.361. World J Gastroenterol. 2016. PMID: 26755882 Free PMC article. Review.

In the last few years, the importance of gut microbiota impairment in the etiopathogenesis of pathology such as autism, dementia and mood disorder, has been raised. ...A deeper assessment of the role of gut microbiota in the development of autism …

In the last few years, the importance of gut microbiota impairment in the etiopathogenesis of pathology such as autism, dement …

13

Human Gut Microbiota from Autism Spectrum Disorder Promote Behavioral Symptoms in Mice.

Sharon G, Cruz NJ, Kang DW, Gandal MJ, Wang B, Kim YM, Zink EM, Casey CP, Taylor BC, Lane CJ, Bramer LM, Isern NG, Hoyt DW, Noecker C, Sweredoski MJ, Moradian A, Borenstein E, Jansson JK, Knight R, Metz TO, Lois C, Geschwind DH, Krajmalnik-Brown R, Mazmanian SK. Sharon G, et al. Cell. 2019 May 30;177(6):1600-1618.e17. doi: 10.1016/j.cell.2019.05.004. Cell. 2019. PMID: 31150625 Free PMC article.

Autism spectrum disorder (ASD) manifests as alterations in complex human behaviors including social communication and stereotypies. In addition to genetic risks, the gut microbiome differs between typically developing (TD) and ASD individuals, though i …

Autism spectrum disorder (ASD) manifests as alterations in complex human behaviors including social communication and stereoty …

14

The Central Nervous System and the Gut Microbiome.

Sharon G, Sampson TR, Geschwind DH, Mazmanian SK. Sharon G, et al. Cell. 2016 Nov 3;167(4):915-932. doi: 10.1016/j.cell.2016.10.027. Cell. 2016. PMID: 27814521 Free PMC article. Review.

While historically studied by researching the brain, inputs from the periphery impact many neurological conditions. Indeed, emerging data suggest communication between the gut and the brain in anxiety, depression, cognition, and autism spectrum disorder (ASD) …

While historically studied by researching the brain, inputs from the periphery impact many neurological conditions. Indeed, emerging data su …

15

Autism Spectrum Disorders and the Gut Microbiota.

Fattorusso A, Di Genova L, Dell'Isola GB, Mencaroni E, Esposito S. Fattorusso A, et al. Nutrients. 2019 Feb 28;11(3):521. doi: 10.3390/nu11030521. Nutrients. 2019. PMID: 30823414 Free PMC article. Review.

In recent years, there has been an emerging interest in the possible role of the gut microbiota as a co-factor in the development of autism spectrum disorders (ASDs), as many studies have highlighted the bidirectional communication between the gut and brain ( …

In recent years, there has been an emerging interest in the possible role of the gut microbiota as a co-factor in the development of …

16

Targeting gut microbiome: A novel and potential therapy for autism.

Yang Y, Tian J, Yang B. Yang Y, et al. Life Sci. 2018 Feb 1;194:111-119. doi: 10.1016/j.lfs.2017.12.027. Epub 2017 Dec 23. Life Sci. 2018. PMID: 29277311 Review.

Children with neurodevelopmental disorder, including ASD, are regularly affected by gastrointestinal problems and dysbiosis of gut microbiota. ...It also discusses the possible mechanisms by which gut microbiome influences the etiology of ASD vi …

Children with neurodevelopmental disorder, including ASD, are regularly affected by gastrointestinal problems and dysbiosis of …

17

Role of the Gut Microbiome in Autism Spectrum Disorders.

Pulikkan J, Mazumder A, Grace T. Pulikkan J, et al. Adv Exp Med Biol. 2019;1118:253-269. doi: 10.1007/978-3-030-05542-4_13. Adv Exp Med Biol. 2019. PMID: 30747427 Review.

Autism spectrum disorder (ASD) is a severe neurodevelopmental or neuropsychiatric disorder with elusive etiology and obscure pathophysiology. ...A gut disorder akin to Crohn's disease is, sometimes, reported in autistic children, an extre …

Autism spectrum disorder (ASD) is a severe neurodevelopmental or neuropsychiatric disorder with elusive etiology and ob …

18

Current Evidence on the Role of the Gut Microbiome in ADHD Pathophysiology and Therapeutic Implications.

Checa-Ros A, Jeréz-Calero A, Molina-Carballo A, Campoy C, Muñoz-Hoyos A. Checa-Ros A, et al. Nutrients. 2021 Jan 16;13(1):249. doi: 10.3390/nu13010249. Nutrients. 2021. PMID: 33467150 Free PMC article. Review.

Studies suggest that the bidirectional relationship existent between the gut microbiome (GM) and the central nervous system (CNS), or so-called the microbiome-gut-brain axis (MGBA), is involved in diverse neuropsychiatric diseases in children and adult …

Studies suggest that the bidirectional relationship existent between the gut microbiome (GM) and the central nervous system (C …

19

Microbiota Transfer Therapy alters gut ecosystem and improves gastrointestinal and autism symptoms: an open-label study.

Kang DW, Adams JB, Gregory AC, Borody T, Chittick L, Fasano A, Khoruts A, Geis E, Maldonado J, McDonough-Means S, Pollard EL, Roux S, Sadowsky MJ, Lipson KS, Sullivan MB, Caporaso JG, Krajmalnik-Brown R. Kang DW, et al. Microbiome. 2017 Jan 23;5(1):10. doi: 10.1186/s40168-016-0225-7. Microbiome. 2017. PMID: 28122648 Free PMC article. Clinical Trial.

Several previous studies have reported abnormal gut bacteria in children with ASD. The gut microbiome-ASD connection has been tested in a mouse model of ASD, where the microbiome was mechanistically linked to abnormal metabolites and behavior. ...CONCL …

Several previous studies have reported abnormal gut bacteria in children with ASD. The gut microbiome-ASD connection ha …

20

Gut microbiome and autism spectrum disorder.

Kotsiliti E. Kotsiliti E. Nat Rev Gastroenterol Hepatol. 2022 Jan;19(1):6. doi: 10.1038/s41575-021-00564-9. Nat Rev Gastroenterol Hepatol. 2022. PMID: 34857938 No abstract available.

21

Long-term benefit of Microbiota Transfer Therapy on autism symptoms and gut microbiota.

Kang DW, Adams JB, Coleman DM, Pollard EL, Maldonado J, McDonough-Means S, Caporaso JG, Krajmalnik-Brown R. Kang DW, et al. Sci Rep. 2019 Apr 9;9(1):5821. doi: 10.1038/s41598-019-42183-0. Sci Rep. 2019. PMID: 30967657 Free PMC article. Clinical Trial.

Many studies have reported abnormal gut microbiota in individuals with Autism Spectrum Disorders (ASD), suggesting a link between gut microbiome and autism-like behaviors. Modifying the gut microbiome is a potential route to improv …

Many studies have reported abnormal gut microbiota in individuals with Autism Spectrum Disorders (ASD), suggesting a link betw …

22

The microbiota-gut-brain axis and neurodevelopmental disorders.

Wang Q, Yang Q, Liu X. Wang Q, et al. Protein Cell. 2023 Oct 25;14(10):762-775. doi: 10.1093/procel/pwad026. Protein Cell. 2023. PMID: 37166201 Free PMC article. Review.

The gut microbiota has been found to interact with the brain through the microbiota-gut-brain axis, regulating various physiological processes. ...Accumulating studies have identified the role of the microbiota-gut-brain axis in neurodevelopmental disorders i …

The gut microbiota has been found to interact with the brain through the microbiota-gut-brain axis, regulating various physiol …

23

The Possible Role of the Microbiota-Gut-Brain-Axis in Autism Spectrum Disorder.

Srikantha P, Mohajeri MH. Srikantha P, et al. Int J Mol Sci. 2019 Apr 29;20(9):2115. doi: 10.3390/ijms20092115. Int J Mol Sci. 2019. PMID: 31035684 Free PMC article. Review.

New research points to a possible link between autism spectrum disorder (ASD) and the gut microbiota as many autistic children have co-occurring gastrointestinal problems. This review focuses on specific alterations of gut microbiota most …

New research points to a possible link between autism spectrum disorder (ASD) and the gut microbiota as many autisti …

24

The progress of gut microbiome research related to brain disorders.

Zhu S, Jiang Y, Xu K, Cui M, Ye W, Zhao G, Jin L, Chen X. Zhu S, et al. J Neuroinflammation. 2020 Jan 17;17(1):25. doi: 10.1186/s12974-020-1705-z. J Neuroinflammation. 2020. PMID: 31952509 Free PMC article. Review.

However, it is now becoming clear that many non-nervous system factors, including the gut-resident bacteria of the gastrointestinal tract, regulate and influence cognitive dysfunction as well as the process of neurodegeneration and cerebrovascular diseases. ...In th …

However, it is now becoming clear that many non-nervous system factors, including the gut-resident bacteria of the gastrointestina …

25

Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease.

Agus A, Planchais J, Sokol H. Agus A, et al. Cell Host Microbe. 2018 Jun 13;23(6):716-724. doi: 10.1016/j.chom.2018.05.003. Cell Host Microbe. 2018. PMID: 29902437 Free article. Review.

The gut microbiota is a crucial actor in human physiology. Many of these effects are mediated by metabolites that are either produced by the microbes or derived from the transformation of environmental or host molecules. Among the array of metabolites at the interface betw …

The gut microbiota is a crucial actor in human physiology. Many of these effects are mediated by metabolites that are either produced …

26

The Perturbance of Microbiome and Gut-Brain Axis in Autism Spectrum Disorders.

Fowlie G, Cohen N, Ming X. Fowlie G, et al. Int J Mol Sci. 2018 Aug 1;19(8):2251. doi: 10.3390/ijms19082251. Int J Mol Sci. 2018. PMID: 30071612 Free PMC article. Review.

Gastrointestinal problems have been documented in Autism Spectrum Disorder (ASD). Studies have found that these disturbances may be associated with an altered gut microbiome in ASD. Furthermore, in ASD, these alterations are implicated in increa …

Gastrointestinal problems have been documented in Autism Spectrum Disorder (ASD). Studies have found that these disturb …

27

Psychological comorbidity in gastrointestinal diseases: Update on the brain-gut-microbiome axis.

Person H, Keefer L. Person H, et al. Prog Neuropsychopharmacol Biol Psychiatry. 2021 Apr 20;107:110209. doi: 10.1016/j.pnpbp.2020.110209. Epub 2020 Dec 14. Prog Neuropsychopharmacol Biol Psychiatry. 2021. PMID: 33326819 Free PMC article. Review.

There is increasing evidence that the gut microbiome is a key part of this system, and dysregulation of the brain-gut-microbiome axis (BGMA) has been implicated in disorders of brain-gut interaction, including irritable bowel syndrome, and in ne …

There is increasing evidence that the gut microbiome is a key part of this system, and dysregulation of the brain-gut- …

28

Psychobiotics and fecal microbial transplantation for autism and attention-deficit/hyperactivity disorder: microbiome modulation and therapeutic mechanisms.

Kwak MJ, Kim SH, Kim HH, Tanpure R, Kim JI, Jeon BH, Park HK. Kwak MJ, et al. Front Cell Infect Microbiol. 2023 Jul 24;13:1238005. doi: 10.3389/fcimb.2023.1238005. eCollection 2023. Front Cell Infect Microbiol. 2023. PMID: 37554355 Free PMC article. Review.

Dysbiosis of the gut microbiome is thought to be the developmental origins of the host's health and disease through the microbiota-gut-brain (MGB) axis: such as immune-mediated, metabolic, neurodegenerative, and neurodevelopmental diseases. Autism spec …

Dysbiosis of the gut microbiome is thought to be the developmental origins of the host's health and disease through the microb …

29

Altering the gut microbiome to potentially modulate behavioral manifestations in autism spectrum disorders: A systematic review.

Davies C, Mishra D, Eshraghi RS, Mittal J, Sinha R, Bulut E, Mittal R, Eshraghi AA. Davies C, et al. Neurosci Biobehav Rev. 2021 Sep;128:549-557. doi: 10.1016/j.neubiorev.2021.07.001. Epub 2021 Jul 13. Neurosci Biobehav Rev. 2021. PMID: 34271306 Review.

There is a potential association between gastrointestinal (GI) symptoms and the severity of autism spectrum disorder (ASD). Given this correlation, the possible impact of probiotics and prebiotics have been explored in research studies to modify the gut …

There is a potential association between gastrointestinal (GI) symptoms and the severity of autism spectrum disorder (A …

30

The role of microbiota-gut-brain axis in neuropsychiatric and neurological disorders.

Socała K, Doboszewska U, Szopa A, Serefko A, Włodarczyk M, Zielińska A, Poleszak E, Fichna J, Wlaź P. Socała K, et al. Pharmacol Res. 2021 Oct;172:105840. doi: 10.1016/j.phrs.2021.105840. Epub 2021 Aug 24. Pharmacol Res. 2021. PMID: 34450312 Free article. Review.

Emerging evidence indicates that the gut microbiota play a crucial role in the bidirectional communication between the gut and the brain suggesting that the gut microbes may shape neural development, modulate neurotransmission and affect behavior, and thereby …

Emerging evidence indicates that the gut microbiota play a crucial role in the bidirectional communication between the gut and …

31

The Gastrointestinal Microbiome: A Review.

Barko PC, McMichael MA, Swanson KS, Williams DA. Barko PC, et al. J Vet Intern Med. 2018 Jan;32(1):9-25. doi: 10.1111/jvim.14875. Epub 2017 Nov 24. J Vet Intern Med. 2018. PMID: 29171095 Free PMC article. Review.

The gastrointestinal microbiome is a diverse consortium of bacteria, archaea, fungi, protozoa, and viruses that inhabit the gut of all mammals. ...Changes in the gastrointestinal microbiome are associated with diseases in humans and animals incl …

The gastrointestinal microbiome is a diverse consortium of bacteria, archaea, fungi, protozoa, and viruses that inhabit the …

32

The Gut Microbiome and Mental Health: What Should We Tell Our Patients?: Le microbiote Intestinal et la Sante Mentale : que Devrions-Nous dire a nos Patients?

Butler MI, Mörkl S, Sandhu KV, Cryan JF, Dinan TG. Butler MI, et al. Can J Psychiatry. 2019 Nov;64(11):747-760. doi: 10.1177/0706743719874168. Epub 2019 Sep 17. Can J Psychiatry. 2019. PMID: 31530002 Free PMC article. Review.

The gut microbiome as a potential therapeutic target for mental illness is a hot topic in psychiatry. ...Patients with various psychiatric disorders including depression, bipolar disorder, schizophrenia, and autism spectrum disorder have been sh …

The gut microbiome as a potential therapeutic target for mental illness is a hot topic in psychiatry. ...Patients with various …

33

The gut microbiome: a new frontier in autism research.

Mulle JG, Sharp WG, Cubells JF. Mulle JG, et al. Curr Psychiatry Rep. 2013 Feb;15(2):337. doi: 10.1007/s11920-012-0337-0. Curr Psychiatry Rep. 2013. PMID: 23307560 Free PMC article. Review.

Advances in high-throughput DNA sequencing methods have led to rapidly expanding knowledge about this gut microbiome. Here, we review fundamental emerging data on the human gut microbiome, with a focus on potential interactions between the microbiom …

Advances in high-throughput DNA sequencing methods have led to rapidly expanding knowledge about this gut microbiome. Here, we …

34

Role of diet and its effects on the gut microbiome in the pathophysiology of mental disorders.

Horn J, Mayer DE, Chen S, Mayer EA. Horn J, et al. Transl Psychiatry. 2022 Apr 20;12(1):164. doi: 10.1038/s41398-022-01922-0. Transl Psychiatry. 2022. PMID: 35443740 Free PMC article. Review.

There is emerging evidence that diet has a major modulatory influence on brain-gut-microbiome (BGM) interactions with important implications for brain health, and for several brain disorders. The BGM system is made up of neuroendocrine, neural, and immune communicat …

There is emerging evidence that diet has a major modulatory influence on brain-gut-microbiome (BGM) interactions with importan …

35

Emerging Roles for the Gut Microbiome in Autism Spectrum Disorder.

Vuong HE, Hsiao EY. Vuong HE, et al. Biol Psychiatry. 2017 Mar 1;81(5):411-423. doi: 10.1016/j.biopsych.2016.08.024. Epub 2016 Aug 26. Biol Psychiatry. 2017. PMID: 27773355 Free PMC article. Review.

Autism spectrum disorder (ASD) is a serious neurodevelopmental disorder that affects one in 45 children in the United States, with a similarly striking prevalence in countries around the world. ...Although ASD is diagnosed based on the presence and severity o …

Autism spectrum disorder (ASD) is a serious neurodevelopmental disorder that affects one in 45 children in the United S …

36

Could the gut microbiome be linked to autism?

Svoboda E. Svoboda E. Nature. 2020 Jan;577(7792):S14-S15. doi: 10.1038/d41586-020-00198-y. Nature. 2020. PMID: 31996829 No abstract available.

37

Microglia and Neurodevelopmental Disorders.

Lukens JR, Eyo UB. Lukens JR, et al. Annu Rev Neurosci. 2022 Jul 8;45:425-445. doi: 10.1146/annurev-neuro-110920-023056. Epub 2022 Apr 18. Annu Rev Neurosci. 2022. PMID: 35436413 Free PMC article. Review.

This evidence has ultimately led to growing speculation that microglial dysfunction may play a role in neurodevelopmental disorder (NDD) pathoetiology. In this review, we first provide an overview of how microglia mechanistically contribute to the sculpting of the developi …

This evidence has ultimately led to growing speculation that microglial dysfunction may play a role in neurodevelopmental disorder (N …

38

Multi-level analysis of the gut-brain axis shows autism spectrum disorder-associated molecular and microbial profiles.

Morton JT, Jin DM, Mills RH, Shao Y, Rahman G, McDonald D, Zhu Q, Balaban M, Jiang Y, Cantrell K, Gonzalez A, Carmel J, Frankiensztajn LM, Martin-Brevet S, Berding K, Needham BD, Zurita MF, David M, Averina OV, Kovtun AS, Noto A, Mussap M, Wang M, Frank DN, Li E, Zhou W, Fanos V, Danilenko VN, Wall DP, Cárdenas P, Baldeón ME, Jacquemont S, Koren O, Elliott E, Xavier RJ, Mazmanian SK, Knight R, Gilbert JA, Donovan SM, Lawley TD, Carpenter B, Bonneau R, Taroncher-Oldenburg G. Morton JT, et al. Nat Neurosci. 2023 Jul;26(7):1208-1217. doi: 10.1038/s41593-023-01361-0. Epub 2023 Jun 26. Nat Neurosci. 2023. PMID: 37365313 Free PMC article.

Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by heterogeneous cognitive, behavioral and communication impairments. Disruption of the gut-brain axis (GBA) has been implicated in ASD although with limited reproducibility …

Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by heterogeneous cognitive, behavioral an …

39

Gastrointestinal involvement of autism spectrum disorder: focus on gut microbiota.

Settanni CR, Bibbò S, Ianiro G, Rinninella E, Cintoni M, Mele MC, Cammarota G, Gasbarrini A. Settanni CR, et al. Expert Rev Gastroenterol Hepatol. 2021 Jun;15(6):599-622. doi: 10.1080/17474124.2021.1869938. Epub 2021 Jan 5. Expert Rev Gastroenterol Hepatol. 2021. PMID: 33356668 Review.

INTRODUCTION: Autism spectrum disorder (ASD) is a neurodevelopmental disorder typical of early age, characterized by impaired communication, social interaction, and repetitive behaviors. ASD patients frequently suffer from gastrointestinal (GI) symptom …

INTRODUCTION: Autism spectrum disorder (ASD) is a neurodevelopmental disorder typical of early age, characterized by im …

40

Serotonin as a link between the gut-brain-microbiome axis in autism spectrum disorders.

Israelyan N, Margolis KG. Israelyan N, et al. Pharmacol Res. 2018 Jun;132:1-6. doi: 10.1016/j.phrs.2018.03.020. Epub 2018 Mar 31. Pharmacol Res. 2018. PMID: 29614380 Free PMC article. Review.

Autism-spectrum disorder (ASD) is a neurodevelopmental disorder characterized by persistent deficits in social communication and repetitive patterns of behavior. ...Brain-gut abnormalities have been increasingly implicated in several disease processes, …

Autism-spectrum disorder (ASD) is a neurodevelopmental disorder characterized by persistent deficits in social communic …

41

Composition of Gut Microbiota in Children with Autism Spectrum Disorder: A Systematic Review and Meta-Analysis.

Iglesias-Vázquez L, Van Ginkel Riba G, Arija V, Canals J. Iglesias-Vázquez L, et al. Nutrients. 2020 Mar 17;12(3):792. doi: 10.3390/nu12030792. Nutrients. 2020. PMID: 32192218 Free PMC article.

BACKGROUND: Autism spectrum disorder (ASD) is a public health problem and has a prevalence of 0.6%-1.7% in children. As well as psychiatric symptoms, dysbiosis and gastrointestinal comorbidities are also frequently reported. The gut-brain microbiota ax …

BACKGROUND: Autism spectrum disorder (ASD) is a public health problem and has a prevalence of 0.6%-1.7% in children. As well a …

42

Childhood Development and the Microbiome-The Intestinal Microbiota in Maintenance of Health and Development of Disease During Childhood Development.

Ronan V, Yeasin R, Claud EC. Ronan V, et al. Gastroenterology. 2021 Jan;160(2):495-506. doi: 10.1053/j.gastro.2020.08.065. Epub 2020 Dec 8. Gastroenterology. 2021. PMID: 33307032 Free PMC article. Review.

The gut microbiome is constantly changing, from birth throughout adulthood, and several variables affect its development and content. ...The gut microbiome should be thought of as an organ system that has important effects on childhood development. ...

The gut microbiome is constantly changing, from birth throughout adulthood, and several variables affect its development and c …

43

Regulation of Neurotransmitters by the Gut Microbiota and Effects on Cognition in Neurological Disorders.

Chen Y, Xu J, Chen Y. Chen Y, et al. Nutrients. 2021 Jun 19;13(6):2099. doi: 10.3390/nu13062099. Nutrients. 2021. PMID: 34205336 Free PMC article. Review.

Emerging evidence indicates that gut microbiota is important in the regulation of brain activity and cognitive functions. Microbes mediate communication among the metabolic, peripheral immune, and central nervous systems via the microbiota-gut-brain axis. However, i …

Emerging evidence indicates that gut microbiota is important in the regulation of brain activity and cognitive functions. Microbes me …

44

The Role of Microbiome, Dietary Supplements, and Probiotics in Autism Spectrum Disorder.

Sivamaruthi BS, Suganthy N, Kesika P, Chaiyasut C. Sivamaruthi BS, et al. Int J Environ Res Public Health. 2020 Apr 12;17(8):2647. doi: 10.3390/ijerph17082647. Int J Environ Res Public Health. 2020. PMID: 32290635 Free PMC article. Review.

Autism spectrum disorder (ASD) is a serious neurodevelopmental disorder characterized by the impairment of the cognitive function of a child. ...An in-depth literature survey suggested that the maternal diet and lifestyle are greatly associated with the devel …

Autism spectrum disorder (ASD) is a serious neurodevelopmental disorder characterized by the impairment of the cognitiv …

45

Overview of the Recent Advances in Pathophysiology and Treatment for Autism.

Famitafreshi H, Karimian M. Famitafreshi H, et al. CNS Neurol Disord Drug Targets. 2018;17(8):590-594. doi: 10.2174/1871527317666180706141654. CNS Neurol Disord Drug Targets. 2018. PMID: 29984672 Review.

BACKGROUND & OBJECTIVE: Autism is a developmental disorder that manifests itself in early childhood. Autism is characterized by inability to acquire social skills, repetitive behaviors and failure of speech and nonverbal communication development. ...

BACKGROUND & OBJECTIVE: Autism is a developmental disorder that manifests itself in early childhood. Autism is char …

46

Potential of gut microbiome for detection of autism spectrum disorder.

Wu T, Wang H, Lu W, Zhai Q, Zhang Q, Yuan W, Gu Z, Zhao J, Zhang H, Chen W. Wu T, et al. Microb Pathog. 2020 Dec;149:104568. doi: 10.1016/j.micpath.2020.104568. Epub 2020 Oct 20. Microb Pathog. 2020. PMID: 33096147

Autism spectrum disorder (ASD) is a neuro developmental disorder characterized by a series of abnormal social behaviors. ...Besides, the validation performance of RF model after RF selection could be 0.75(0.01) on external cohort collected by our laboratory. …

Autism spectrum disorder (ASD) is a neuro developmental disorder characterized by a series of abnormal social behaviors …

47

The gut microbiota regulates autism-like behavior by mediating vitamin B(6) homeostasis in EphB6-deficient mice.

Li Y, Luo ZY, Hu YY, Bi YW, Yang JM, Zou WJ, Song YL, Li S, Shen T, Li SJ, Huang L, Zhou AJ, Gao TM, Li JM. Li Y, et al. Microbiome. 2020 Aug 20;8(1):120. doi: 10.1186/s40168-020-00884-z. Microbiome. 2020. PMID: 32819434 Free PMC article.

BACKGROUND: Autism spectrum disorder (ASD) is a developmental disorder, and the effective pharmacological treatments for the core autistic symptoms are currently limited. ...Nonetheless, the role and mechanism of EPHB6 in regulating the gut micr …

BACKGROUND: Autism spectrum disorder (ASD) is a developmental disorder, and the effective pharmacological treatments fo …

48

Deviated and early unsustainable stunted development of gut microbiota in children with autism spectrum disorder.

Lou M, Cao A, Jin C, Mi K, Xiong X, Zeng Z, Pan X, Qie J, Qiu S, Niu Y, Liang H, Liu Y, Chen L, Liu Z, Zhao Q, Qiu X, Jin Y, Sheng X, Hu Z, Jin G, Liu J, Liu X, Wang Y. Lou M, et al. Gut. 2022 Aug;71(8):1588-1599. doi: 10.1136/gutjnl-2021-325115. Epub 2021 Dec 20. Gut. 2022. PMID: 34930815 Free PMC article.

OBJECTIVE: Recent studies have provided insights into the gut microbiota in autism spectrum disorder (ASD); however, these studies were restricted owing to limited sampling at the unitary stage of childhood. ...CONCLUSION: Our large cohort combined with clini …

OBJECTIVE: Recent studies have provided insights into the gut microbiota in autism spectrum disorder (ASD); however, th …

49

Anti-Inflammatory and Immunomodulatory Effects of Probiotics in Gut Inflammation: A Door to the Body.

Cristofori F, Dargenio VN, Dargenio C, Miniello VL, Barone M, Francavilla R. Cristofori F, et al. Front Immunol. 2021 Feb 26;12:578386. doi: 10.3389/fimmu.2021.578386. eCollection 2021. Front Immunol. 2021. PMID: 33717063 Free PMC article. Review.

Diet, age, BMI (body mass index), medications, and stress may confound the benefits of probiotic intake. In addition to host gut functions (permeability and physiology), all these agents have profound implications for the gut microbiome composition. The use o …

Diet, age, BMI (body mass index), medications, and stress may confound the benefits of probiotic intake. In addition to host gut func …

50

Pilot study of probiotic/colostrum supplementation on gut function in children with autism and gastrointestinal symptoms.

Sanctuary MR, Kain JN, Chen SY, Kalanetra K, Lemay DG, Rose DR, Yang HT, Tancredi DJ, German JB, Slupsky CM, Ashwood P, Mills DA, Smilowitz JT, Angkustsiri K. Sanctuary MR, et al. PLoS One. 2019 Jan 9;14(1):e0210064. doi: 10.1371/journal.pone.0210064. eCollection 2019. PLoS One. 2019. PMID: 30625189 Free PMC article. Clinical Trial.

Over half of all children with autism spectrum disorders (ASD) have gastrointestinal (GI) co-morbidities including chronic constipation, diarrhea, and irritable bowel syndrome. ...The study objective was to assess tolerability of a probiotic (Bifidobacterium infanti …

Over half of all children with autism spectrum disorders (ASD) have gastrointestinal (GI) co-morbidities including chronic con …

51

Microbiota-derived metabolites as drivers of gut-brain communication.

Ahmed H, Leyrolle Q, Koistinen V, Kärkkäinen O, Layé S, Delzenne N, Hanhineva K. Ahmed H, et al. Gut Microbes. 2022 Jan-Dec;14(1):2102878. doi: 10.1080/19490976.2022.2102878. Gut Microbes. 2022. PMID: 35903003 Free PMC article.

The bi-directional communication between brain and the microbes residing in the gut, the so-called gut-brain axis, consists of a network of immunological, neuronal, and endocrine signaling pathways. Although the full variety of mechanisms of the gut-brain cro …

The bi-directional communication between brain and the microbes residing in the gut, the so-called gut-brain axis, consists of …

52

Underdevelopment of the gut microbiota and bacteria species as non-invasive markers of prediction in children with autism spectrum disorder.

Wan Y, Zuo T, Xu Z, Zhang F, Zhan H, Chan D, Leung TF, Yeoh YK, Chan FKL, Chan R, Ng SC. Wan Y, et al. Gut. 2022 May;71(5):910-918. doi: 10.1136/gutjnl-2020-324015. Epub 2021 Jul 26. Gut. 2022. PMID: 34312160

OBJECTIVE: The gut microbiota has been suggested to play a role in autism spectrum disorder (ASD). ...Multiple neurotransmitter biosynthesis related pathways in the gut microbiome were depleted in children with ASD compared with TD children (p&l …

OBJECTIVE: The gut microbiota has been suggested to play a role in autism spectrum disorder (ASD). ...Multiple neurotra …

53

Fecal Microbiota Transplantation in Neurological Disorders.

Vendrik KEW, Ooijevaar RE, de Jong PRC, Laman JD, van Oosten BW, van Hilten JJ, Ducarmon QR, Keller JJ, Kuijper EJ, Contarino MF. Vendrik KEW, et al. Front Cell Infect Microbiol. 2020 Mar 24;10:98. doi: 10.3389/fcimb.2020.00098. eCollection 2020. Front Cell Infect Microbiol. 2020. PMID: 32266160 Free PMC article. Review.

Background: Several studies suggested an important role of the gut microbiota in the pathophysiology of neurological disorders, implying that alteration of the gut microbiota might serve as a treatment strategy. ...Clinical trials with FMT have been performed in pat …

Background: Several studies suggested an important role of the gut microbiota in the pathophysiology of neurological disorders, imply …

54

The Role of Gut Microbiota in Various Neurological and Psychiatric Disorders-An Evidence Mapping Based on Quantified Evidence.

Zang Y, Lai X, Li C, Ding D, Wang Y, Zhu Y. Zang Y, et al. Mediators Inflamm. 2023 Feb 8;2023:5127157. doi: 10.1155/2023/5127157. eCollection 2023. Mediators Inflamm. 2023. PMID: 36816743 Free PMC article. Review.

We searched for neurological diseases and psychiatric disorders, including Alzheimer's disease (AD), attention deficit hyperactivity disorder (ADHD), amyotrophic lateral sclerosis (ALS), autism spectrum disorder (ASD), anorexia nervosa (AN), bipolar disord …

We searched for neurological diseases and psychiatric disorders, including Alzheimer's disease (AD), attention deficit hyperactivity diso …

55

Multi-angle meta-analysis of the gut microbiome in Autism Spectrum Disorder: a step toward understanding patient subgroups.

West KA, Yin X, Rutherford EM, Wee B, Choi J, Chrisman BS, Dunlap KL, Hannibal RL, Hartono W, Lin M, Raack E, Sabino K, Wu Y, Wall DP, David MM, Dabbagh K, DeSantis TZ, Iwai S. West KA, et al. Sci Rep. 2022 Oct 11;12(1):17034. doi: 10.1038/s41598-022-21327-9. Sci Rep. 2022. PMID: 36220843 Free PMC article.

Observational studies have shown that the composition of the human gut microbiome in children diagnosed with Autism Spectrum Disorder (ASD) differs significantly from that of their neurotypical (NT) counterparts. ...We have performed the largest (n = 6 …

Observational studies have shown that the composition of the human gut microbiome in children diagnosed with Autism Spe …

56

The gut microbiome in social anxiety disorder: evidence of altered composition and function.

Butler MI, Bastiaanssen TFS, Long-Smith C, Morkl S, Berding K, Ritz NL, Strain C, Patangia D, Patel S, Stanton C, O'Mahony SM, Cryan JF, Clarke G, Dinan TG. Butler MI, et al. Transl Psychiatry. 2023 Mar 20;13(1):95. doi: 10.1038/s41398-023-02325-5. Transl Psychiatry. 2023. PMID: 36941248 Free PMC article.

The gut microbiota shows compositional alterations in a variety of psychiatric disorders including depression, generalised anxiety disorder (GAD), autism spectrum disorder (ASD) and schizophrenia but studies investigating the gut microbiome …

The gut microbiota shows compositional alterations in a variety of psychiatric disorders including depression, generalised anxiety …

57

The role of the microbiota-gut-brain axis in neuropsychiatric disorders.

Generoso JS, Giridharan VV, Lee J, Macedo D, Barichello T. Generoso JS, et al. Braz J Psychiatry. 2021 May-Jun;43(3):293-305. doi: 10.1590/1516-4446-2020-0987. Braz J Psychiatry. 2021. PMID: 32667590 Free PMC article. Review.

The microbiota-gut-brain axis is a bidirectional signaling mechanism between the gastrointestinal tract and the central nervous system. ...Evidence indicates that intestinal microbiota are involved in neurological and psychiatric disorders. This review covers eviden …

The microbiota-gut-brain axis is a bidirectional signaling mechanism between the gastrointestinal tract and the central nervou …

58

Intestinal Barrier Dysfunction and Microbiota-Gut-Brain Axis: Possible Implications in the Pathogenesis and Treatment of Autism Spectrum Disorder.

Dargenio VN, Dargenio C, Castellaneta S, De Giacomo A, Laguardia M, Schettini F, Francavilla R, Cristofori F. Dargenio VN, et al. Nutrients. 2023 Mar 27;15(7):1620. doi: 10.3390/nu15071620. Nutrients. 2023. PMID: 37049461 Free PMC article. Review.

Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with multifactorial etiology, characterized by impairment in two main functional areas: (1) communication and social interactions, and (2) skills, interests and activities. ASD patients o …

Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with multifactorial etiology, characterized by …

59

New evidences on the altered gut microbiota in autism spectrum disorders.

Strati F, Cavalieri D, Albanese D, De Felice C, Donati C, Hayek J, Jousson O, Leoncini S, Renzi D, Calabrò A, De Filippo C. Strati F, et al. Microbiome. 2017 Feb 22;5(1):24. doi: 10.1186/s40168-017-0242-1. Microbiome. 2017. PMID: 28222761 Free PMC article.

In addition to neurological symptoms, ASD subjects frequently suffer from gastrointestinal abnormalities, thus implying a role of the gut microbiota in ASD gastrointestinal pathophysiology. RESULTS: Here, we characterized the bacterial and fungal gut m …

In addition to neurological symptoms, ASD subjects frequently suffer from gastrointestinal abnormalities, thus implying a role of the …

60

Gut dysbiosis impairs hippocampal plasticity and behaviors by remodeling serum metabolome.

Liu G, Yu Q, Tan B, Ke X, Zhang C, Li H, Zhang T, Lu Y. Liu G, et al. Gut Microbes. 2022 Jan-Dec;14(1):2104089. doi: 10.1080/19490976.2022.2104089. Gut Microbes. 2022. PMID: 35876011 Free PMC article.

However, the cellular and molecular mechanisms underlying the association remain unknown. Here, we modified the gut microbiome with antibiotics in newborn mice, and found that gut microbial alteration induced behavioral impairment by decreasing adult neurogen …

However, the cellular and molecular mechanisms underlying the association remain unknown. Here, we modified the gut microbiome …

61

Changes to gut amino acid transporters and microbiome associated with increased E/I ratio in Chd8(+/-) mouse model of ASD-like behavior.

Yu Y, Zhang B, Ji P, Zuo Z, Huang Y, Wang N, Liu C, Liu SJ, Zhao F. Yu Y, et al. Nat Commun. 2022 Mar 3;13(1):1151. doi: 10.1038/s41467-022-28746-2. Nat Commun. 2022. PMID: 35241668 Free PMC article.

Autism spectrum disorder (ASD), a group of neurodevelopmental disorders characterized by social communication deficits and stereotyped behaviors, may be associated with changes to the gut microbiota. However, how gut commensal bacteria modulate brain f …

Autism spectrum disorder (ASD), a group of neurodevelopmental disorders characterized by social communication deficits and ste …

62

Dietary Fat Effect on the Gut Microbiome, and Its Role in the Modulation of Gastrointestinal Disorders in Children with Autism Spectrum Disorder.

Kittana M, Ahmadani A, Al Marzooq F, Attlee A. Kittana M, et al. Nutrients. 2021 Oct 27;13(11):3818. doi: 10.3390/nu13113818. Nutrients. 2021. PMID: 34836074 Free PMC article. Review.

Children with autism spectrum disorder (ASD) report a higher frequency and severity of gastrointestinal disorders (GID) than typically developing (TD) children. ...Notably, saturated fatty acids are considered to have a pronounced effect on the increase of bi …

Children with autism spectrum disorder (ASD) report a higher frequency and severity of gastrointestinal disorders (GID) …

63

Fecal Microbiota Transplantation Relieves Gastrointestinal and Autism Symptoms by Improving the Gut Microbiota in an Open-Label Study.

Li N, Chen H, Cheng Y, Xu F, Ruan G, Ying S, Tang W, Chen L, Chen M, Lv L, Ping Y, Chen D, Wei Y. Li N, et al. Front Cell Infect Microbiol. 2021 Oct 19;11:759435. doi: 10.3389/fcimb.2021.759435. eCollection 2021. Front Cell Infect Microbiol. 2021. PMID: 34737978 Free PMC article.

Autism spectrum disorder (ASD) is a severe brain development disorder that is characterized by deficits in social communication and restricted, repetitive and stereotyped behaviors. ...Here, we performed a clinical trial to evaluate the effect of FMT on ga …

Autism spectrum disorder (ASD) is a severe brain development disorder that is characterized by deficits in social commu …

64

Gut microbiota and autism spectrum disorders: a bidirectional Mendelian randomization study.

Li Z, Liu S, Liu F, Dai N, Liang R, Lv S, Bao L. Li Z, et al. Front Cell Infect Microbiol. 2023 Dec 14;13:1267721. doi: 10.3389/fcimb.2023.1267721. eCollection 2023. Front Cell Infect Microbiol. 2023. PMID: 38156319 Free PMC article.

BACKGROUND: In recent years, observational studies have provided evidence supporting a potential association between autism spectrum disorder (ASD) and gut microbiota. However, the causal effect of gut microbiota on ASD remains unknown. ...CONCLUSION: …

BACKGROUND: In recent years, observational studies have provided evidence supporting a potential association between autism spectrum …

65

Gut microbiome and serum amino acid metabolome alterations in autism spectrum disorder.

Chang X, Zhang Y, Chen X, Li S, Mei H, Xiao H, Ma X, Liu Z, Li R. Chang X, et al. Sci Rep. 2024 Feb 19;14(1):4037. doi: 10.1038/s41598-024-54717-2. Sci Rep. 2024. PMID: 38369656 Free PMC article. Clinical Trial.

Gut microbiota and their metabolic products might play important roles in regulating the pathogenesis of autism spectrum disorder (ASD). ...Our study provides novel insights into compositional and functional alterations in the gut microbiome and …

Gut microbiota and their metabolic products might play important roles in regulating the pathogenesis of autism spectrum di …

66

Systematic review: Autism spectrum disorder and the gut microbiota.

Korteniemi J, Karlsson L, Aatsinki A. Korteniemi J, et al. Acta Psychiatr Scand. 2023 Sep;148(3):242-254. doi: 10.1111/acps.13587. Epub 2023 Jul 3. Acta Psychiatr Scand. 2023. PMID: 37395517 Review.

While there are several studies focusing on the neuropsychiatric pathogenesis of ASD, its etiology remains unclear. The role of gut-brain-axis in ASD has been studied increasingly and a correlation between symptoms and the composition of gut microbiota has been docu …

While there are several studies focusing on the neuropsychiatric pathogenesis of ASD, its etiology remains unclear. The role of gut-b …

67

Topic modeling for multi-omic integration in the human gut microbiome and implications for Autism.

Tataru C, Peras M, Rutherford E, Dunlap K, Yin X, Chrisman BS, DeSantis TZ, Wall DP, Iwai S, David MM. Tataru C, et al. Sci Rep. 2023 Jul 13;13(1):11353. doi: 10.1038/s41598-023-38228-0. Sci Rep. 2023. PMID: 37443184 Free PMC article.

While healthy gut microbiomes are critical to human health, pertinent microbial processes remain largely undefined, partially due to differential bias among profiling techniques. ...In this study, we apply LDA to multi-omic microbial data (16S rRNA amplicon, shotgun metage …

While healthy gut microbiomes are critical to human health, pertinent microbial processes remain largely undefined, partially due to …

68

The intestinal barrier in disorders of the central nervous system.

Pellegrini C, Fornai M, D'Antongiovanni V, Antonioli L, Bernardini N, Derkinderen P. Pellegrini C, et al. Lancet Gastroenterol Hepatol. 2023 Jan;8(1):66-80. doi: 10.1016/S2468-1253(22)00241-2. Epub 2022 Nov 2. Lancet Gastroenterol Hepatol. 2023. PMID: 36334596 Review.

The intestinal barrier is in close contact with gut microbiota on its luminal side and with enteric neurons and glial cells on its tissue side. Mounting evidence now suggests that the intestinal barrier is compromised not only in digestive disorders, but also in disorders …

The intestinal barrier is in close contact with gut microbiota on its luminal side and with enteric neurons and glial cells on its ti …

69

Altered gut microbiome and autism like behavior are associated with parental high salt diet in male mice.

Afroz KF, Reyes N, Young K, Parikh K, Misra V, Alviña K. Afroz KF, et al. Sci Rep. 2021 Apr 16;11(1):8364. doi: 10.1038/s41598-021-87678-x. Sci Rep. 2021. PMID: 33863940 Free PMC article.

Using 16S genome sequencing of fecal samples, we first show that (1) as expected, HSD changed the maternal gut microbiome, and (2) this altered gut microbiome was shared with the offspring. ...Taken together, our data suggests that parental HSD consump …

Using 16S genome sequencing of fecal samples, we first show that (1) as expected, HSD changed the maternal gut microbiome, and …

70

Gut microbiota in various childhood disorders: Implication and indications.

Saeed NK, Al-Beltagi M, Bediwy AS, El-Sawaf Y, Toema O. Saeed NK, et al. World J Gastroenterol. 2022 May 14;28(18):1875-1901. doi: 10.3748/wjg.v28.i18.1875. World J Gastroenterol. 2022. PMID: 35664966 Free PMC article. Review.

Gut microbiota has a significant role in gut development, maturation, and immune system differentiation. ...Dysbiosis is a common finding in many childhood disorders such as autism, failure to thrive, nutritional disorders, coeliac disease, Necrotizing Entero …

Gut microbiota has a significant role in gut development, maturation, and immune system differentiation. ...Dysbiosis is a com …

71

Are changes in the gut microbiome a contributor or consequence of autism-why not both?

Özcan E, Hsiao EY. Özcan E, et al. Cell Rep Med. 2022 Jan 18;3(1):100505. doi: 10.1016/j.xcrm.2021.100505. eCollection 2022 Jan 18. Cell Rep Med. 2022. PMID: 35106514 Free PMC article.

Alterations in the gut microbiome have been associated with autism spectrum disorder (ASD), but whether they are a cause, effect, or confounder remains unclear. ...

Alterations in the gut microbiome have been associated with autism spectrum disorder (ASD), but whether they are …

72

Antibiotics, gut microbiome and obesity.

Leong KSW, Derraik JGB, Hofman PL, Cutfield WS. Leong KSW, et al. Clin Endocrinol (Oxf). 2018 Feb;88(2):185-200. doi: 10.1111/cen.13495. Epub 2017 Nov 20. Clin Endocrinol (Oxf). 2018. PMID: 29023853 Review.

The obesity pandemic continues to increase, a problem that affects both adults and children alike. Disruptions to the gut microbiome have been linked to a multitude of adverse conditions, including obesity, type 2 diabetes, inflammatory bowel diseases, anxiety, a …

The obesity pandemic continues to increase, a problem that affects both adults and children alike. Disruptions to the gut microbio …

73

Gut-Microbiota-Brain Axis and Its Effect on Neuropsychiatric Disorders With Suspected Immune Dysregulation.

Petra AI, Panagiotidou S, Hatziagelaki E, Stewart JM, Conti P, Theoharides TC. Petra AI, et al. Clin Ther. 2015 May 1;37(5):984-95. doi: 10.1016/j.clinthera.2015.04.002. Clin Ther. 2015. PMID: 26046241 Free PMC article. Review.

METHODS: Articles were identified with a search of Medline (starting in 1980) by using the key words anxiety, attention-deficit hypersensitivity disorder (ADHD), autism, cytokines, depression, gut, hypothalamic-pituitary-adrenal (HPA) axis, inflammation, immu …

METHODS: Articles were identified with a search of Medline (starting in 1980) by using the key words anxiety, attention-deficit hypersensiti …

74

Autism and Gut-Brain Axis: Role of Probiotics.

Chidambaram SB, Tuladhar S, Bhat A, Mahalakshmi AM, Ray B, Essa MM, Bishir M, Bolla SR, Nanjaiah ND, Guillemin GJ, Qoronfleh MW. Chidambaram SB, et al. Adv Neurobiol. 2020;24:587-600. doi: 10.1007/978-3-030-30402-7_21. Adv Neurobiol. 2020. PMID: 32006375 Review.

Although the real causes that lead to the development of autism are still unclear, the gastrointestinal tract has been found to play a major role in the development of autism. ...A relationship between improved gut health and decrease of symptoms in …

Although the real causes that lead to the development of autism are still unclear, the gastrointestinal tract has been found t …

75

Probiotics: Potential novel therapeutics for microbiota-gut-brain axis dysfunction across gender and lifespan.

Snigdha S, Ha K, Tsai P, Dinan TG, Bartos JD, Shahid M. Snigdha S, et al. Pharmacol Ther. 2022 Mar;231:107978. doi: 10.1016/j.pharmthera.2021.107978. Epub 2021 Sep 4. Pharmacol Ther. 2022. PMID: 34492236 Review.

In particular, there has been a growing interest and appreciation about the role that gut microbiota may play in affecting CNS-related function through the 'microbiota-gut-brain axis'. ...Probiotics may influence the ability of the gut microbiome to af …

In particular, there has been a growing interest and appreciation about the role that gut microbiota may play in affecting CNS-relate …

76

The Role of Gut Microbiota and Gut-Brain Interplay in Selected Diseases of the Central Nervous System.

Doroszkiewicz J, Groblewska M, Mroczko B. Doroszkiewicz J, et al. Int J Mol Sci. 2021 Sep 17;22(18):10028. doi: 10.3390/ijms221810028. Int J Mol Sci. 2021. PMID: 34576191 Free PMC article. Review.

The gut microbiome has attracted increasing attention from researchers in recent years. ...We present recent findings concerning the effect of the altered microbiota on neurodegeneration and neuroinflammation, including Alzheimer's and Parkinson's diseases, as well …

The gut microbiome has attracted increasing attention from researchers in recent years. ...We present recent findings concerni …

77

The Mechanism of Secretion and Metabolism of Gut-Derived 5-Hydroxytryptamine.

Liu N, Sun S, Wang P, Sun Y, Hu Q, Wang X. Liu N, et al. Int J Mol Sci. 2021 Jul 25;22(15):7931. doi: 10.3390/ijms22157931. Int J Mol Sci. 2021. PMID: 34360695 Free PMC article. Review.

Gut microbiota, nutrients, and hormones are the main factors that play a vital role in regulating 5-HT secretion by EC cells. Apart from being an important neurotransmitter and a paracrine signaling molecule in the gut, gut-derived 5-HT was also shown to exer …

Gut microbiota, nutrients, and hormones are the main factors that play a vital role in regulating 5-HT secretion by EC cells. Apart f …

78

The influence of neuroinflammation in Autism Spectrum Disorder.

Matta SM, Hill-Yardin EL, Crack PJ. Matta SM, et al. Brain Behav Immun. 2019 Jul;79:75-90. doi: 10.1016/j.bbi.2019.04.037. Epub 2019 Apr 25. Brain Behav Immun. 2019. PMID: 31029798 Review.

Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterised by deficits in social communication and restricted or repetitive behaviours. ...Whether dysregulation of glial subtypes exacerbates alterations in neural connectivity in the brain o …

Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterised by deficits in social communication and r …

79

The gut microbiome in psychiatry: A primer for clinicians.

Van Ameringen M, Turna J, Patterson B, Pipe A, Mao RQ, Anglin R, Surette MG. Van Ameringen M, et al. Depress Anxiety. 2019 Nov;36(11):1004-1025. doi: 10.1002/da.22936. Epub 2019 Jul 29. Depress Anxiety. 2019. PMID: 31356715 Review.

Research in the past decade has shown that variations in the gut microbiome may influence behavior, and vice versa. As such, interest in the role of the gut microbiome in psychiatric conditions has drawn immense interest. ...More specifically, the nume …

Research in the past decade has shown that variations in the gut microbiome may influence behavior, and vice versa. As such, i …

80

Study of the gut Microbiome Profile in Children with Autism Spectrum Disorder: a Single Tertiary Hospital Experience.

Ahmed SA, Elhefnawy AM, Azouz HG, Roshdy YS, Ashry MH, Ibrahim AE, Meheissen MA. Ahmed SA, et al. J Mol Neurosci. 2020 Jun;70(6):887-896. doi: 10.1007/s12031-020-01500-3. Epub 2020 Feb 15. J Mol Neurosci. 2020. PMID: 32062762

The role of gut microbiome was recently raised in the pathogenesis of neurodevelopmental disorders including autism spectrum disorder (ASD). The aim of this study was to elucidate changes in gut microbiome in Egyptian autistic chil …

The role of gut microbiome was recently raised in the pathogenesis of neurodevelopmental disorders including autism spe …

81

Autism-associated synaptic mutations impact the gut-brain axis in mice.

Lee CYQ, Franks AE, Hill-Yardin EL. Lee CYQ, et al. Brain Behav Immun. 2020 Aug;88:275-282. doi: 10.1016/j.bbi.2020.05.072. Epub 2020 May 30. Brain Behav Immun. 2020. PMID: 32485290 Free article. Review.

Interactions between the gut microbiome and the brain affect mood and behaviour in health and disease. ...Strikingly, these mutations additionally affect the gut microbiome in mice. This review describes the changes in gut physiology and microbi …

Interactions between the gut microbiome and the brain affect mood and behaviour in health and disease. ...Strikingly, these mu …

82

Disorders of the enteric nervous system - a holistic view.

Niesler B, Kuerten S, Demir IE, Schäfer KH. Niesler B, et al. Nat Rev Gastroenterol Hepatol. 2021 Jun;18(6):393-410. doi: 10.1038/s41575-020-00385-2. Epub 2021 Jan 29. Nat Rev Gastroenterol Hepatol. 2021. PMID: 33514916 Review.

Evidence of a disordered ENS has accumulated in neurodegenerative diseases ranging from amyotrophic lateral sclerosis, Alzheimer disease and multiple sclerosis to Parkinson disease as well as neurodevelopmental disorders such as autism. The ENS is a key modulator of gut …

Evidence of a disordered ENS has accumulated in neurodegenerative diseases ranging from amyotrophic lateral sclerosis, Alzheimer disease and …

83

Microbiota and neurodevelopmental windows: implications for brain disorders.

Borre YE, O'Keeffe GW, Clarke G, Stanton C, Dinan TG, Cryan JF. Borre YE, et al. Trends Mol Med. 2014 Sep;20(9):509-18. doi: 10.1016/j.molmed.2014.05.002. Epub 2014 Jun 20. Trends Mol Med. 2014. PMID: 24956966 Review.

Gut microbiota is essential to human health, playing a major role in the bidirectional communication between the gastrointestinal tract and the central nervous system. The microbiota undergoes a vigorous process of development throughout the lifespan and establishes …

Gut microbiota is essential to human health, playing a major role in the bidirectional communication between the gastrointestinal …

84

The many faces of microbiota-gut-brain axis in autism spectrum disorder.

Gonçalves CL, Doifode T, Rezende VL, Costa MA, Rhoads JM, Soutullo CA. Gonçalves CL, et al. Life Sci. 2024 Jan 15;337:122357. doi: 10.1016/j.lfs.2023.122357. Epub 2023 Dec 19. Life Sci. 2024. PMID: 38123016 Review.

The gut-brain axis is gaining more attention in neurodevelopmental disorders, especially autism spectrum disorder (ASD). Many factors can influence microbiota in early life, including host genetics and perinatal events (infections, mode of birth/delivery, med …

The gut-brain axis is gaining more attention in neurodevelopmental disorders, especially autism spectrum disorder (ASD) …

85

The Microbiota-Gut-Brain Axis in Neuropsychiatric Disorders: Pathophysiological Mechanisms and Novel Treatments.

Kim YK, Shin C. Kim YK, et al. Curr Neuropharmacol. 2018;16(5):559-573. doi: 10.2174/1570159X15666170915141036. Curr Neuropharmacol. 2018. PMID: 28925886 Free PMC article.

BACKGROUND: The human gut microbiome comprise a huge number of microorganisms with co-evolutionary associations with humans. ...RESULT: Recent studies have reported that diverse forms of neuropsychiatric disorders (such as autism, depression, anxiety, and sch …

BACKGROUND: The human gut microbiome comprise a huge number of microorganisms with co-evolutionary associations with humans. . …

86

Altered Autonomic Functions and Gut Microbiome in Individuals with Autism Spectrum Disorder (ASD): Implications for Assisting ASD Screening and Diagnosis.

Kong X, Liu J, Liu K, Koh M, Tian R, Hobbie C, Fong M, Chen Q, Zhao M, Budjan C, Kong J. Kong X, et al. J Autism Dev Disord. 2021 Jan;51(1):144-157. doi: 10.1007/s10803-020-04524-1. J Autism Dev Disord. 2021. PMID: 32410097

Measurements of the gut microbiome and the autonomic indices can serve as non-invasive markers of the status of the gut-brain axis in ASD. To our knowledge, no previous studies have explored the relationship between ANS and gut microbiome in ind …

Measurements of the gut microbiome and the autonomic indices can serve as non-invasive markers of the status of the gut …

87

The gut-microbiota-brain axis in autism: what Drosophila models can offer?

Salim S, Banu A, Alwa A, Gowda SBM, Mohammad F. Salim S, et al. J Neurodev Disord. 2021 Sep 15;13(1):37. doi: 10.1186/s11689-021-09378-x. J Neurodev Disord. 2021. PMID: 34525941 Free PMC article. Review.

The idea that alterations in gut-microbiome-brain axis (GUMBA)-mediated communication play a crucial role in human brain disorders like autism remains a topic of intensive research in various labs. Gastrointestinal issues are a common comorbidity in pa …

The idea that alterations in gut-microbiome-brain axis (GUMBA)-mediated communication play a crucial role in human brain disor …

88

Role of microbiota-derived short-chain fatty acids in nervous system disorders.

Mirzaei R, Bouzari B, Hosseini-Fard SR, Mazaheri M, Ahmadyousefi Y, Abdi M, Jalalifar S, Karimitabar Z, Teimoori A, Keyvani H, Zamani F, Yousefimashouf R, Karampoor S. Mirzaei R, et al. Biomed Pharmacother. 2021 Jul;139:111661. doi: 10.1016/j.biopha.2021.111661. Epub 2021 May 8. Biomed Pharmacother. 2021. PMID: 34243604 Free article. Review.

The short-chain fatty acids (SCFAs), such as butyrate, acetate, and succinate, are produced due to the fermentation process of bacteria in the gut. It has been noted remodeling in the gut microbiota metabolites associated with the pathophysiology of several neurolog …

The short-chain fatty acids (SCFAs), such as butyrate, acetate, and succinate, are produced due to the fermentation process of bacteria in t …

89

[Microbiome and psychiatry: autism as an example].

Marijnissen GM, Zwittink RD, Kuijper EJ, van Furth EF. Marijnissen GM, et al. Tijdschr Psychiatr. 2020;62(2):131-140. Tijdschr Psychiatr. 2020. PMID: 32141520 Free article. Review. Dutch.

METHOD: A narrative literature review based on searches in the PubMed and psycinfo databases with the keywords: microbiota, microbiome, microorganisms, mental disorders, psychiatric disorder, autism spectrum disorder, autistic dis …

METHOD: A narrative literature review based on searches in the PubMed and psycinfo databases with the keywords: microbiota, m …

90

Multiple Risk Factors: A Challenge in the Management of Autism.

Nadeem MS, Al-Abbasi FA, Kazmi I, Murtaza BN, Zamzami MA, Kamal MA, Arif A, Afzal M, Anwar F. Nadeem MS, et al. Curr Pharm Des. 2020;26(7):743-754. doi: 10.2174/1381612826666200226101218. Curr Pharm Des. 2020. PMID: 32101114 Review.

Autism Spectrum Disorder (ASD) is an emerging health problem involving 1 out of every 68 children. ...These risk factors may contribute to the development of autism either independently or synergistically leading to a broad spectrum of characteristics observe …

Autism Spectrum Disorder (ASD) is an emerging health problem involving 1 out of every 68 children. ...These risk factors may c …

91

Gut to brain interaction in Autism Spectrum Disorders: a randomized controlled trial on the role of probiotics on clinical, biochemical and neurophysiological parameters.

Santocchi E, Guiducci L, Fulceri F, Billeci L, Buzzigoli E, Apicella F, Calderoni S, Grossi E, Morales MA, Muratori F. Santocchi E, et al. BMC Psychiatry. 2016 Jun 4;16:183. doi: 10.1186/s12888-016-0887-5. BMC Psychiatry. 2016. PMID: 27260271 Free PMC article. Clinical Trial.

BACKGROUND: A high prevalence of a variety of gastrointestinal (GI) symptoms is frequently reported in patients with Autism Spectrum Disorders (ASD). The GI disturbances in ASD might be linked to gut dysbiosis representing the observable phenotype of a "gu …

BACKGROUND: A high prevalence of a variety of gastrointestinal (GI) symptoms is frequently reported in patients with Autism Sp …

92

Enteric nervous system and intestinal epithelial regulation of the gut-brain axis.

Dowling LR, Strazzari MR, Keely S, Kaiko GE. Dowling LR, et al. J Allergy Clin Immunol. 2022 Sep;150(3):513-522. doi: 10.1016/j.jaci.2022.07.015. J Allergy Clin Immunol. 2022. PMID: 36075637 Review.

The gut-brain axis describes a bidirectional interplay within the enteric environment between the intestinal epithelium, the mucosal immune system, and the microbiota with the enteric nervous system. ...Disruption of the intestinal microbiota is linked not only to diseases …

The gut-brain axis describes a bidirectional interplay within the enteric environment between the intestinal epithelium, the mucosal …

93

Congenitally underdeveloped intestine drives autism-related gut microbiota and behavior.

Li J, Wang H, Qing W, Liu F, Zeng N, Wu F, Shi Y, Gao X, Cheng M, Li H, Shen W, Meng F, He Y, Chen M, Li Z, Zhou H, Wang Q. Li J, et al. Brain Behav Immun. 2022 Oct;105:15-26. doi: 10.1016/j.bbi.2022.06.006. Epub 2022 Jun 14. Brain Behav Immun. 2022. PMID: 35714916

Autism spectrum disorder (ASD) is a neurological and developmental disorder accompanied by gut dysbiosis and gastrointestinal symptoms in most cases. However, the development of the autism-related gut microbiota and its relationshi …

Autism spectrum disorder (ASD) is a neurological and developmental disorder accompanied by gut dysbiosis and …

94

Gut Microbiota and Autism: Key Concepts and Findings.

Ding HT, Taur Y, Walkup JT. Ding HT, et al. J Autism Dev Disord. 2017 Feb;47(2):480-489. doi: 10.1007/s10803-016-2960-9. J Autism Dev Disord. 2017. PMID: 27882443 Review.

There is an emerging body of evidence linking the intestinal microbiota with autism spectrum disorders (ASD). Studies have demonstrated differences in the composition of gut bacteria between children with ASD and controls. ...Evidence from animal models suggest that …

There is an emerging body of evidence linking the intestinal microbiota with autism spectrum disorders (ASD). Studies have demonstrat …

95

Gut Microbiome-Based Analysis of Lipid A Biosynthesis in Individuals with Autism Spectrum Disorder: An In Silico Evaluation.

Maigoro AY, Lee S. Maigoro AY, et al. Nutrients. 2021 Feb 21;13(2):688. doi: 10.3390/nu13020688. Nutrients. 2021. PMID: 33669978 Free PMC article.

The link between autism spectrum disorder (ASD) and the gut microbiome has received much attention, with special focus on gut-brain-axis immunological imbalances. Gastrointestinal problems are one of the major symptoms of ASD and are thou …

The link between autism spectrum disorder (ASD) and the gut microbiome has received much attention, with special …

96

Gut-immune-brain dysfunction in Autism: Importance of sex.

Kopec AM, Fiorentino MR, Bilbo SD. Kopec AM, et al. Brain Res. 2018 Aug 15;1693(Pt B):214-217. doi: 10.1016/j.brainres.2018.01.009. Epub 2018 Mar 29. Brain Res. 2018. PMID: 29360468 Free PMC article. Review.

Autism Spectrum Disorder (ASD) is characterized by social behavior deficits, stereotypies, cognitive rigidity, and in some cases severe intellectual impairment and developmental delay. ...Virtually no attention has been given to the potential role of sex-specific re …

Autism Spectrum Disorder (ASD) is characterized by social behavior deficits, stereotypies, cognitive rigidity, and in some cas …

97

Gut Microbiota and Gender in Autism Spectrum Disorders.

Kushak RI, Winter HS. Kushak RI, et al. Curr Pediatr Rev. 2020;16(4):249-254. doi: 10.2174/1573396316999200727123026. Curr Pediatr Rev. 2020. PMID: 32720604 Review.

Gender dimorphism in autism spectrum disorders (ASD) is well known; however, the reasons for gender differences in autism are poorly understood. There are several hypotheses that might explain male prevalence in ASD, including increased levels of androgens, "extreme …

Gender dimorphism in autism spectrum disorders (ASD) is well known; however, the reasons for gender differences in autism are …

98

The contribution of the gut microbiome to neurodevelopment and neuropsychiatric disorders.

Warner BB. Warner BB. Pediatr Res. 2019 Jan;85(2):216-224. doi: 10.1038/s41390-018-0191-9. Epub 2018 Sep 25. Pediatr Res. 2019. PMID: 30283047 Review.

Bidirectional communication between the gut and brain is well recognized, with data now accruing for a specific role of the gut microbiota in that link, referred to as the microbiome-gut-brain axis. ...While pathways of communication between the gut …

Bidirectional communication between the gut and brain is well recognized, with data now accruing for a specific role of the gut …

99

[Intestinal flora and neurological disorders].

Tang Q, Cao L. Tang Q, et al. Sheng Wu Gong Cheng Xue Bao. 2021 Nov 25;37(11):3757-3780. doi: 10.13345/j.cjb.210253. Sheng Wu Gong Cheng Xue Bao. 2021. PMID: 34841782 Free article. Chinese.

The intestinal flora interacts with the nervous system bidirectionally in many ways through the gut-brain axis. It causes neuroimmune inflammatory response, dysfunction of gut mucosa and blood-brain barrier, direct stimulation of the vagus nerve, spinal nerve of the …

The intestinal flora interacts with the nervous system bidirectionally in many ways through the gut-brain axis. It causes neuroimmune …

100

Gut instincts: vitamin D/vitamin D receptor and microbiome in neurodevelopment disorders.

Ogbu D, Xia E, Sun J. Ogbu D, et al. Open Biol. 2020 Jul;10(7):200063. doi: 10.1098/rsob.200063. Epub 2020 Jul 8. Open Biol. 2020. PMID: 32634371 Free PMC article. Review.

The gut microbiome regulates a relationship with the brain known as the gut-microbiota-brain (GMB) axis. This interaction is influenced by immune cells, microbial metabolites and neurotransmitters. Recent findings show gut dysbiosis is prevalent in …

The gut microbiome regulates a relationship with the brain known as the gut-microbiota-brain (GMB) axis. This interacti …

101

Exploring the Association of Autism Spectrum Disorders and Constipation through Analysis of the Gut Microbiome.

Fu SC, Lee CH, Wang H. Fu SC, et al. Int J Environ Res Public Health. 2021 Jan 14;18(2):667. doi: 10.3390/ijerph18020667. Int J Environ Res Public Health. 2021. PMID: 33466802 Free PMC article.

Over the past two decades, research into the role of the gut microbiome in regulating the central nervous system has rapidly increased. Several neurodevelopmental diseases have been linked to the unbalance of gut microbiota, including autism. Children …

Over the past two decades, research into the role of the gut microbiome in regulating the central nervous system has rapidly i …

102

Plasma and Fecal Metabolite Profiles in Autism Spectrum Disorder.

Needham BD, Adame MD, Serena G, Rose DR, Preston GM, Conrad MC, Campbell AS, Donabedian DH, Fasano A, Ashwood P, Mazmanian SK. Needham BD, et al. Biol Psychiatry. 2021 Mar 1;89(5):451-462. doi: 10.1016/j.biopsych.2020.09.025. Epub 2020 Oct 10. Biol Psychiatry. 2021. PMID: 33342544 Free PMC article.

BACKGROUND: Autism spectrum disorder (ASD) is a neurodevelopmental condition with hallmark behavioral manifestations including impaired social communication and restricted repetitive behavior. In addition, many affected individuals display metabolic imbalances, immu …

BACKGROUND: Autism spectrum disorder (ASD) is a neurodevelopmental condition with hallmark behavioral manifestations including …

103

Microbiome Disturbances and Autism Spectrum Disorders.

Rosenfeld CS. Rosenfeld CS. Drug Metab Dispos. 2015 Oct;43(10):1557-71. doi: 10.1124/dmd.115.063826. Epub 2015 Apr 7. Drug Metab Dispos. 2015. PMID: 25852213 Review.

With the characterization of the human microbiome, this concept has been expanded to include the microbiota-gut-brain axis. ...The studies to date have surveyed how gut microbiome changes may affect these neurobehavioral disorders. ...

With the characterization of the human microbiome, this concept has been expanded to include the microbiota-gut-brain axis. .. …

104

The importance of nutritional management and education in the treatment of autism.

Mandecka A, Regulska-Ilow B. Mandecka A, et al. Rocz Panstw Zakl Hig. 2022;73(3):247-258. doi: 10.32394/rpzh.2022.0218. Rocz Panstw Zakl Hig. 2022. PMID: 36169265 Free article. Review.

Autism spectrum disorders (ASDs) are an early-onset neurodevelopmental disorders. ...Dietary patterns have been evidenced to be related to maternal nutritional status that might lead to different metabolic conditions, and maternal metabolic dysfunction has been observed to …

Autism spectrum disorders (ASDs) are an early-onset neurodevelopmental disorders. ...Dietary patterns have been evidenced to be relat …

105

Potential Etiologic Factors of Microbiome Disruption in Autism.

Buie T. Buie T. Clin Ther. 2015 May 1;37(5):976-83. doi: 10.1016/j.clinthera.2015.04.001. Clin Ther. 2015. PMID: 26046240 Review.

PURPOSE: The primary purpose of this article was to consider the candidate disruptors of the development of a healthy microbiome in patients with autism. The reported abnormalities in the microbiome of individuals with autism are discussed. ...Interven …

PURPOSE: The primary purpose of this article was to consider the candidate disruptors of the development of a healthy microbiome in p …

106

Gut microbiota modulate dendritic cell antigen presentation and radiotherapy-induced antitumor immune response.

Uribe-Herranz M, Rafail S, Beghi S, Gil-de-Gómez L, Verginadis I, Bittinger K, Pustylnikov S, Pierini S, Perales-Linares R, Blair IA, Mesaros CA, Snyder NW, Bushman F, Koumenis C, Facciabene A. Uribe-Herranz M, et al. J Clin Invest. 2020 Jan 2;130(1):466-479. doi: 10.1172/JCI124332. J Clin Invest. 2020. PMID: 31815742 Free PMC article.

Alterations in gut microbiota impact the pathophysiology of several diseases, including cancer. Radiotherapy (RT), an established curative and palliative cancer treatment, exerts potent immune modulatory effects, inducing tumor-associated antigen (TAA) cross-priming with a …

Alterations in gut microbiota impact the pathophysiology of several diseases, including cancer. Radiotherapy (RT), an established cur …

107

Distinct Fecal and Plasma Metabolites in Children with Autism Spectrum Disorders and Their Modulation after Microbiota Transfer Therapy.

Kang DW, Adams JB, Vargason T, Santiago M, Hahn J, Krajmalnik-Brown R. Kang DW, et al. mSphere. 2020 Oct 21;5(5):e00314-20. doi: 10.1128/mSphere.00314-20. mSphere. 2020. PMID: 33087514 Free PMC article. Clinical Trial.

We also reported modulation of the gut microbiome toward a healthy one. In this study, we report comprehensive metabolite profiles from plasma and fecal samples of the children who participated in the MTT trial. ...Based on mounting evidences that support a link bet …

We also reported modulation of the gut microbiome toward a healthy one. In this study, we report comprehensive metabolite prof …

108

The role of the gut microbiome in mediating neurotoxic outcomes to PCB exposure.

Rude KM, Keogh CE, Gareau MG. Rude KM, et al. Neurotoxicology. 2019 Dec;75:30-40. doi: 10.1016/j.neuro.2019.08.010. Epub 2019 Aug 24. Neurotoxicology. 2019. PMID: 31454514 Free PMC article. Review.

Environmental exposures, particularly in early life, can interfere with development and impact these pathways. This review will focus on the role of the microbiome and the gut in neurodevelopment and neurodegeneration as well as the impacts of environmental exposure …

Environmental exposures, particularly in early life, can interfere with development and impact these pathways. This review will focus on the …

109

Developmental vitamin D-deficiency produces autism-relevant behaviours and gut-health associated alterations in a rat model.

Tamang MK, Ali A, Pertile RN, Cui X, Alexander S, Nitert MD, Palmieri C, Eyles D. Tamang MK, et al. Transl Psychiatry. 2023 Jun 14;13(1):204. doi: 10.1038/s41398-023-02513-3. Transl Psychiatry. 2023. PMID: 37316481 Free PMC article.

Developmental vitamin D (DVD)-deficiency is an epidemiologically established risk factor for autism. Emerging studies also highlight the involvement of gut microbiome/gut physiology in autism. ...Overall, our animal model of this epidemiological …

Developmental vitamin D (DVD)-deficiency is an epidemiologically established risk factor for autism. Emerging studies also highlight …

110

The gut microbiome and neuropsychiatric disorders: implications for attention deficit hyperactivity disorder (ADHD).

Mathee K, Cickovski T, Deoraj A, Stollstorff M, Narasimhan G. Mathee K, et al. J Med Microbiol. 2020 Jan;69(1):14-24. doi: 10.1099/jmm.0.001112. J Med Microbiol. 2020. PMID: 31821133 Free PMC article. Review.

Although the presence of a gut-brain communication axis has long been established, recent studies argue that the development and regulation of this axis is dictated by the gut microbiome. Many studies involving both animals and humans have connected the gu …

Although the presence of a gut-brain communication axis has long been established, recent studies argue that the development and regu …

111

The link between autism spectrum disorder and gut microbiota: A scoping review.

Nitschke A, Deonandan R, Konkle AT. Nitschke A, et al. Autism. 2020 Aug;24(6):1328-1344. doi: 10.1177/1362361320913364. Epub 2020 Apr 28. Autism. 2020. PMID: 32340474 Review.

Gastrointestinal distress and gut microbial imbalances are commonly found in children with autism spectrum disorder, and therefore may play a key role in the development of the disorder. ...As increasing evidence of a unique autism spectr …

Gastrointestinal distress and gut microbial imbalances are commonly found in children with autism spectrum disorder …

112

A Revolutionizing Approach to Autism Spectrum Disorder Using the Microbiome.

Johnson D, Letchumanan V, Thurairajasingam S, Lee LH. Johnson D, et al. Nutrients. 2020 Jul 3;12(7):1983. doi: 10.3390/nu12071983. Nutrients. 2020. PMID: 32635373 Free PMC article. Review.

Autism spectrum disorder (ASD) is one of the neurodevelopmental disorders which has been extensively explored in relation to gut microbiome. ...The existing knowledge and research gaps call for a more expanded and resolute research efforts in establish …

Autism spectrum disorder (ASD) is one of the neurodevelopmental disorders which has been extensively explored in relation to …

113

Altered brain-gut axis in autism: comorbidity or causative mechanisms?

Mayer EA, Padua D, Tillisch K. Mayer EA, et al. Bioessays. 2014 Oct;36(10):933-9. doi: 10.1002/bies.201400075. Epub 2014 Aug 22. Bioessays. 2014. PMID: 25145752 Review.

The concept that alterated communications between the gut microbiome and the brain may play an important role in human brain disorders has recently received considerable attention. ...In addition, alteration in the composition and metabolic products of the gut …

The concept that alterated communications between the gut microbiome and the brain may play an important role in human brain d …

114

The role of the gut microbiota in development, function and disorders of the central nervous system and the enteric nervous system.

Heiss CN, Olofsson LE. Heiss CN, et al. J Neuroendocrinol. 2019 May;31(5):e12684. doi: 10.1111/jne.12684. Epub 2019 Feb 1. J Neuroendocrinol. 2019. PMID: 30614568 Review.

Furthermore, numerous studies indicate that there is a developmental window early in life during which the gut microbial composition is crucial and perturbation of the gut microbiota during this period causes long-lasting effects on the development of the CNS and th …

Furthermore, numerous studies indicate that there is a developmental window early in life during which the gut microbial composition …

115

Altered Gut Microbiota as Potential Biomarkers for Autism Spectrum Disorder in Early Childhood.

Zhao Y, Wang Y, Meng F, Chen X, Chang T, Huang H, He F, Zheng Y. Zhao Y, et al. Neuroscience. 2023 Jul 15;523:118-131. doi: 10.1016/j.neuroscience.2023.04.029. Epub 2023 Jun 3. Neuroscience. 2023. PMID: 37271221

Gastrointestinal (GI) disorders are widely recorded in autism spectrum disorder (ASD), and ASD with GI symptoms is a vital subtype of this disease. Growing evidence suggests altered gut microbiota biomarkers in ASD, but little is known about the gut …

Gastrointestinal (GI) disorders are widely recorded in autism spectrum disorder (ASD), and ASD with GI symptoms is a vi …

116

Psychobiotics: the Influence of Gut Microbiota on the Gut-Brain Axis in Neurological Disorders.

Oroojzadeh P, Bostanabad SY, Lotfi H. Oroojzadeh P, et al. J Mol Neurosci. 2022 Sep;72(9):1952-1964. doi: 10.1007/s12031-022-02053-3. Epub 2022 Jul 18. J Mol Neurosci. 2022. PMID: 35849305 Free PMC article.

Nervous system disorders are one of the common problems that affect many people around the world every year. Regarding the beneficial effects of the probiotics on the gut and the gut-brain axis, their application along with current medications has been the subject o …

Nervous system disorders are one of the common problems that affect many people around the world every year. Regarding the beneficial effect …

117

Interaction of Heavy Metal Lead with Gut Microbiota: Implications for Autism Spectrum Disorder.

Tizabi Y, Bennani S, El Kouhen N, Getachew B, Aschner M. Tizabi Y, et al. Biomolecules. 2023 Oct 19;13(10):1549. doi: 10.3390/biom13101549. Biomolecules. 2023. PMID: 37892231 Free PMC article. Review.

Autism Spectrum Disorder (ASD), a neurodevelopmental disorder characterized by persistent deficits in social interaction and communication, manifests in early childhood and is followed by restricted and stereotyped behaviors, interests, or activities in adole …

Autism Spectrum Disorder (ASD), a neurodevelopmental disorder characterized by persistent deficits in social interactio …

118

Altered Gut Microbiota and Short-chain Fatty Acids in Chinese Children with Constipated Autism Spectrum Disorder.

He J, Gong X, Hu B, Lin L, Lin X, Gong W, Zhang B, Cao M, Xu Y, Xia R, Zheng G, Wu S, Zhang Y. He J, et al. Sci Rep. 2023 Nov 4;13(1):19103. doi: 10.1038/s41598-023-46566-2. Sci Rep. 2023. PMID: 37925571 Free PMC article. Clinical Trial.

Gastrointestinal symptoms are more prevalent in children with autism spectrum disorder (ASD) than in typically developing (TD) children. Constipation is a significant gastrointestinal comorbidity of ASD, but the associations among constipated autism …

Gastrointestinal symptoms are more prevalent in children with autism spectrum disorder (ASD) than in typically developi …

119

Gut-Brain Axis and Behavior.

Martin CR, Mayer EA. Martin CR, et al. Nestle Nutr Inst Workshop Ser. 2017;88:45-53. doi: 10.1159/000461732. Epub 2017 Mar 27. Nestle Nutr Inst Workshop Ser. 2017. PMID: 28346923 Free PMC article. Review.

In the last 5 years, interest in the interactions among the gut microbiome, brain, and behavior has exploded. Preclinical evidence supports a role of the gut microbiome in behavioral responses associated with pain, emotion, social interactions, and foo …

In the last 5 years, interest in the interactions among the gut microbiome, brain, and behavior has exploded. Preclinical evid …

120

Children and adolescents with attention deficit hyperactivity disorder and autism spectrum disorder share distinct microbiota compositions.

Bundgaard-Nielsen C, Lauritsen MB, Knudsen JK, Rold LS, Larsen MH, Hindersson P, Villadsen AB, Leutscher PDC, Hagstrøm S, Nyegaard M, Sørensen S. Bundgaard-Nielsen C, et al. Gut Microbes. 2023 Jan-Dec;15(1):2211923. doi: 10.1080/19490976.2023.2211923. Gut Microbes. 2023. PMID: 37199526 Free PMC article.

An association has been suggested between altered gut microbiota, and attention deficit hyperactivity disorder (ADHD), and autism spectrum disorder (ASD), respectively. Thus, we analyzed the gut microbiota composition in children and adolescents …

An association has been suggested between altered gut microbiota, and attention deficit hyperactivity disorder (ADHD), and …

121

Food Selectivity and Its Implications Associated with Gastrointestinal Disorders in Children with Autism Spectrum Disorders.

Valenzuela-Zamora AF, Ramírez-Valenzuela DG, Ramos-Jiménez A. Valenzuela-Zamora AF, et al. Nutrients. 2022 Jun 27;14(13):2660. doi: 10.3390/nu14132660. Nutrients. 2022. PMID: 35807840 Free PMC article. Review.

Food selectivity (FS) in children with autism spectrum disorders (ASD) is common, and its impact on a nutritional level is known. However, the etiology of gastrointestinal disorders (GID) related to alterations in the intestinal microbiota in children with ASD remai …

Food selectivity (FS) in children with autism spectrum disorders (ASD) is common, and its impact on a nutritional level is known. How …

122

Crosstalk Between the Microbiome and Gestational Immunity in Autism-Related Disorders.

Paysour MJ, Bolte AC, Lukens JR. Paysour MJ, et al. DNA Cell Biol. 2019 May;38(5):405-409. doi: 10.1089/dna.2019.4653. Epub 2019 Feb 28. DNA Cell Biol. 2019. PMID: 30817175 Free PMC article. Review.

There has been growing speculation that changes in human microflora diversity contribute at some level to the recent rise in autism incidence. This has largely stemmed from reports of dysbiosis and gastrointestinal inflammation in autistic individuals. ...In …

There has been growing speculation that changes in human microflora diversity contribute at some level to the recent rise in autism i …

123

A Systematic Review of the Role of Prebiotics and Probiotics in Autism Spectrum Disorders.

Ng QX, Loke W, Venkatanarayanan N, Lim DY, Soh AYS, Yeo WS. Ng QX, et al. Medicina (Kaunas). 2019 May 10;55(5):129. doi: 10.3390/medicina55050129. Medicina (Kaunas). 2019. PMID: 31083360 Free PMC article.

Background: Autism spectrum disorder (ASD) is a complex developmental condition typically characterized by deficits in social and communicative behaviors as well as repetitive patterns of behaviors. ...Methods: Using the keywords (prebiotics OR probiotics OR microbi …

Background: Autism spectrum disorder (ASD) is a complex developmental condition typically characterized by deficits in social …

124

Children with autism show differences in the gut DNA virome compared to non-autistic children: a case control study.

Qu A, Duan B, Wang Y, Cui Z, Zhang N, Wu D. Qu A, et al. BMC Pediatr. 2023 Apr 14;23(1):174. doi: 10.1186/s12887-023-03981-8. BMC Pediatr. 2023. PMID: 37060094 Free PMC article.

BACKGROUND: Several previous studies have identified a potential role that the gut microbiome can play in autism spectrum disorder (ASD) in children, but little is known about how variations in the virome may be involved in ASD. ...This provides prelim …

BACKGROUND: Several previous studies have identified a potential role that the gut microbiome can play in autism spectr …

125

Helminth therapy for autism under gut-brain axis- hypothesis.

Arroyo-López C. Arroyo-López C. Med Hypotheses. 2019 Apr;125:110-118. doi: 10.1016/j.mehy.2019.02.042. Epub 2019 Feb 19. Med Hypotheses. 2019. PMID: 30902137

Autism is a neurodevelopmental disease included within Autism Syndrome Disorder (ASD) spectrum. ...In addition, recent publications have shown the correlation between immune dysfunctions, gut microbiota and brain with the behavioral alterations and com …

Autism is a neurodevelopmental disease included within Autism Syndrome Disorder (ASD) spectrum. ...In addition, recent …

126

Basic Definitions and Concepts: Organization of the Gut Microbiome.

Quigley EM. Quigley EM. Gastroenterol Clin North Am. 2017 Mar;46(1):1-8. doi: 10.1016/j.gtc.2016.09.002. Epub 2017 Jan 3. Gastroenterol Clin North Am. 2017. PMID: 28164844 Review.

New claims are frequently made for a role for the microbiome in a disease or disorder previously considered remote from the gut. The microbiome has been linked to such seemingly unrelated entities as depression, anorexia nervosa, autism, Parkins …

New claims are frequently made for a role for the microbiome in a disease or disorder previously considered remote from the …

127

The Gut Microbiota and Dysbiosis in Autism Spectrum Disorders.

Hughes HK, Rose D, Ashwood P. Hughes HK, et al. Curr Neurol Neurosci Rep. 2018 Sep 24;18(11):81. doi: 10.1007/s11910-018-0887-6. Curr Neurol Neurosci Rep. 2018. PMID: 30251184 Free PMC article. Review.

PURPOSE OF REVIEW: There is a growing body of evidence indicating the gut microbiota influence neurodevelopment and behavior. The purposes of this review are to provide an overview of studies analyzing the microbiota and their metabolites in autism spectrum disorder …

PURPOSE OF REVIEW: There is a growing body of evidence indicating the gut microbiota influence neurodevelopment and behavior. The pur …

128

Gut-Amygdala Interactions in Autism Spectrum Disorders: Developmental Roles via regulating Mitochondria, Exosomes, Immunity and microRNAs.

Seo M, Anderson G. Seo M, et al. Curr Pharm Des. 2019;25(41):4344-4356. doi: 10.2174/1381612825666191105102545. Curr Pharm Des. 2019. PMID: 31692435 Review.

BACKGROUND: Autism Spectrum Disorders (ASD) have long been conceived as developmental disorder. A growing body of data highlights a role for alterations in the gut in the pathoetiology and/or pathophysiology of ASD. Recent work shows alterations in the gut …

BACKGROUND: Autism Spectrum Disorders (ASD) have long been conceived as developmental disorder. A growing body of data highlig …

129

Treating autism spectrum disorder by intervening with gut microbiota.

Tu T, Zhao C. Tu T, et al. J Med Microbiol. 2021 Dec;70(12). doi: 10.1099/jmm.0.001469. J Med Microbiol. 2021. PMID: 34898421 Review.

Autism spectrum disorder (ASD) comprises a group of neurodevelopmental disorders with a high prevalence in childhood. ...For instance, FMT can improve the core symptoms of ASD and gastrointestinal symptoms. Probiotics, breastfeeding and formula feeding, and G …

Autism spectrum disorder (ASD) comprises a group of neurodevelopmental disorders with a high prevalence in childhood. ...For i …

130

Gut Microbial Regulation of Autism Spectrum Disorder Symptoms.

Panzer AR, Lynch SV. Panzer AR, et al. Trends Endocrinol Metab. 2020 Nov;31(11):809-811. doi: 10.1016/j.tem.2020.09.001. Epub 2020 Sep 21. Trends Endocrinol Metab. 2020. PMID: 32972817

Relationships between gut microbiome perturbation and autism spectrum disorder (ASD) have been observed in several human studies, but the functional implications and molecular mechanisms by which microbes may influence disease symptomology remain enigm …

Relationships between gut microbiome perturbation and autism spectrum disorder (ASD) have been observed in sever …

131

Protocol for the Gut Bugs in Autism Trial: a double-blind randomised placebo-controlled trial of faecal microbiome transfer for the treatment of gastrointestinal symptoms in autistic adolescents and adults.

Tweedie-Cullen RY, Leong K, Wilson BC, Derraik JGB, Albert BB, Monk R, Vatanen T, Creagh C, Depczynski M, Edwards T, Beck K, Thabrew H, O'Sullivan JM, Cutfield WS. Tweedie-Cullen RY, et al. BMJ Open. 2024 Feb 6;14(2):e074625. doi: 10.1136/bmjopen-2023-074625. BMJ Open. 2024. PMID: 38320845 Free PMC article.

This study aims to evaluate the efficacy of oral encapsulated faecal microbiome transfer (FMT) in improving gastrointestinal symptoms and well-being among autistic adolescents and adults. ...Other assessments include anthropometry, body composition, hair cort …

This study aims to evaluate the efficacy of oral encapsulated faecal microbiome transfer (FMT) in improving gastrointestinal s …

132

Gut microbiota signature in children with autism spectrum disorder who suffered from chronic gastrointestinal symptoms.

Wang H, Liu S, Xie L, Wang J. Wang H, et al. BMC Pediatr. 2023 Sep 20;23(1):476. doi: 10.1186/s12887-023-04292-8. BMC Pediatr. 2023. PMID: 37730588 Free PMC article.

BACKGROUND: Children diagnosed with autism spectrum disorder (ASD) frequently suffer from persistent gastrointestinal symptoms, such as constipation and diarrhea. Various studies have highlighted differences in gut microbiota composition between indivi …

BACKGROUND: Children diagnosed with autism spectrum disorder (ASD) frequently suffer from persistent gastrointestinal s …

133

Gut Microbial Dysbiosis in Indian Children with Autism Spectrum Disorders.

Pulikkan J, Maji A, Dhakan DB, Saxena R, Mohan B, Anto MM, Agarwal N, Grace T, Sharma VK. Pulikkan J, et al. Microb Ecol. 2018 Nov;76(4):1102-1114. doi: 10.1007/s00248-018-1176-2. Epub 2018 Mar 21. Microb Ecol. 2018. PMID: 29564487

The etiology of ASD is not yet completely understood; however, a disorder in the gut-brain axis is emerging as a prominent factor leading to autism. ...Our study showed prominent dysbiosis in the gut microbiome of ASD children, with higher relat …

The etiology of ASD is not yet completely understood; however, a disorder in the gut-brain axis is emerging as a prominent fac …

134

Advances in gut microbiome in metabonomics perspective: based on bibliometrics methods and visualization analysis.

Wang J, Dong P, Zheng S, Mai Y, Ding J, Pan P, Tang L, Wan Y, Liang H. Wang J, et al. Front Cell Infect Microbiol. 2023 May 30;13:1196967. doi: 10.3389/fcimb.2023.1196967. eCollection 2023. Front Cell Infect Microbiol. 2023. PMID: 37325519 Free PMC article.

Burst detection indicates that Urine, spectroscopy, metabonomic and gut microflora are long-standing hot topics in this field, while autism spectrum disorder and omics are likely to be at the forefront of research. The study of related metabolic small molecul …

Burst detection indicates that Urine, spectroscopy, metabonomic and gut microflora are long-standing hot topics in this field, while …

135

Gut microbiome in health and disease: Linking the microbiome-gut-brain axis and environmental factors in the pathogenesis of systemic and neurodegenerative diseases.

Ghaisas S, Maher J, Kanthasamy A. Ghaisas S, et al. Pharmacol Ther. 2016 Feb;158:52-62. doi: 10.1016/j.pharmthera.2015.11.012. Epub 2015 Nov 26. Pharmacol Ther. 2016. PMID: 26627987 Free PMC article. Review.

The gut microbiome comprises the collective genome of the trillions of microorganisms residing in our gastrointestinal ecosystem. ...Understanding the mechanisms behind the activity and proliferation of the gut microbiome will provide us new ins …

The gut microbiome comprises the collective genome of the trillions of microorganisms residing in our gastrointestinal …

136

The Impact of Gut Microbiota-Derived Metabolites in Autism Spectrum Disorders.

Peralta-Marzal LN, Prince N, Bajic D, Roussin L, Naudon L, Rabot S, Garssen J, Kraneveld AD, Perez-Pardo P. Peralta-Marzal LN, et al. Int J Mol Sci. 2021 Sep 17;22(18):10052. doi: 10.3390/ijms221810052. Int J Mol Sci. 2021. PMID: 34576216 Free PMC article. Review.

Autism Spectrum Disorder (ASD) is a set of neurodevelopmental disorders characterised by behavioural impairment and deficiencies in social interaction and communication. ...Since metabolism is one of the major drivers of microbiome-host interactions, this rev …

Autism Spectrum Disorder (ASD) is a set of neurodevelopmental disorders characterised by behavioural impairment and deficienci …

137

Microbiota-indole 3-propionic acid-brain axis mediates abnormal synaptic pruning of hippocampal microglia and susceptibility to ASD in IUGR offspring.

Wang T, Chen B, Luo M, Xie L, Lu M, Lu X, Zhang S, Wei L, Zhou X, Yao B, Wang H, Xu D. Wang T, et al. Microbiome. 2023 Nov 7;11(1):245. doi: 10.1186/s40168-023-01656-1. Microbiome. 2023. PMID: 37932832 Free PMC article.

BACKGROUND: Autism spectrum disorder (ASD) has been associated with intrauterine growth restriction (IUGR), but the underlying mechanisms are unclear. ...We demonstrated that the dysregulated IPA/AHR/NF-kappaB signaling caused by disturbed gut microbiota medi …

BACKGROUND: Autism spectrum disorder (ASD) has been associated with intrauterine growth restriction (IUGR), but the underlying …

138

Can we reduce autism-related gastrointestinal and behavior problems by gut microbiota based dietary modulation? A review.

Nogay NH, Nahikian-Nelms M. Nogay NH, et al. Nutr Neurosci. 2021 May;24(5):327-338. doi: 10.1080/1028415X.2019.1630894. Epub 2019 Jun 19. Nutr Neurosci. 2021. PMID: 31216957 Review.

Introduction: Autism is a neurodevelopmental disorder that negatively affects a child's interaction and communication with the environment. ...The combinations of the following terms were used for the search: 'autism' or 'autistic' and 'microbiome …

Introduction: Autism is a neurodevelopmental disorder that negatively affects a child's interaction and communication with the …

139

Prospective associations of the infant gut microbiome and microbial function with social behaviors related to autism at age 3 years.

Laue HE, Korrick SA, Baker ER, Karagas MR, Madan JC. Laue HE, et al. Sci Rep. 2020 Sep 23;10(1):15515. doi: 10.1038/s41598-020-72386-9. Sci Rep. 2020. PMID: 32968156 Free PMC article.

The hypothesized link between gut bacteria and autism spectrum disorder (ASD) has been explored through animal models and human studies with microbiome assessment after ASD presentation. We aimed to prospectively characterize the association between th …

The hypothesized link between gut bacteria and autism spectrum disorder (ASD) has been explored through animal models a …

140

Early-life differences in the gut microbiota composition and functionality of infants at elevated likelihood of developing autism spectrum disorder.

Zuffa S, Schimmel P, Gonzalez-Santana A, Belzer C, Knol J, Bölte S, Falck-Ytter T, Forssberg H, Swann J, Diaz Heijtz R. Zuffa S, et al. Transl Psychiatry. 2023 Jul 13;13(1):257. doi: 10.1038/s41398-023-02556-6. Transl Psychiatry. 2023. PMID: 37443359 Free PMC article.

Evidence from cross-sectional human studies, and preliminary microbial-based intervention studies, have implicated the microbiota-gut-brain axis in the neurobiology of autism spectrum disorder (ASD). ...Taken together, the present results reveal early life al …

Evidence from cross-sectional human studies, and preliminary microbial-based intervention studies, have implicated the microbiota-gut …

141

A systematic review of microbiome changes and impact of probiotic supplementation in children and adolescents with neuropsychiatric disorders.

Ligezka AN, Sonmez AI, Corral-Frias MP, Golebiowski R, Lynch B, Croarkin PE, Romanowicz M. Ligezka AN, et al. Prog Neuropsychopharmacol Biol Psychiatry. 2021 Jun 8;108:110187. doi: 10.1016/j.pnpbp.2020.110187. Epub 2020 Dec 1. Prog Neuropsychopharmacol Biol Psychiatry. 2021. PMID: 33271210 Free PMC article.

One study showed an increase in prosocial behavior in children with Autism Spectrum Disorder (ASD) and an increase in the Lachnospiraceae family following prebiotic supplementation. ...A study evaluating infant supplementation of prebiotics showed both a decreased l …

One study showed an increase in prosocial behavior in children with Autism Spectrum Disorder (ASD) and an increase in the Lach …

142

A Meta-analysis of Gut Microbiota in Children with Autism.

Andreo-Martínez P, Rubio-Aparicio M, Sánchez-Meca J, Veas A, Martínez-González AE. Andreo-Martínez P, et al. J Autism Dev Disord. 2022 Mar;52(3):1374-1387. doi: 10.1007/s10803-021-05002-y. Epub 2021 May 5. J Autism Dev Disord. 2022. PMID: 33948825

Previous studies have reported dysbiosis in the gut microbiota (GM) of children with autism spectrum disorders (ASD), which may be a determining factor on child development through the microbiota-gut-brain axis. ...

Previous studies have reported dysbiosis in the gut microbiota (GM) of children with autism spectrum disorders (ASD), which ma …

143

Gut microbiome-mediated epigenetic regulation of brain disorder and application of machine learning for multi-omics data analysis.

Kaur H, Singh Y, Singh S, Singh RB. Kaur H, et al. Genome. 2021 Apr;64(4):355-371. doi: 10.1139/gen-2020-0136. Epub 2020 Oct 8. Genome. 2021. PMID: 33031715 Free article. Review.

Clinical and experimental evidence suggests gut microbiota as a key regulator of the GBA. Microbes living in the gut not only interact locally with intestinal cells and the ENS but have also been found to modulate the CNS through neuroendocrine and metabolic pathway …

Clinical and experimental evidence suggests gut microbiota as a key regulator of the GBA. Microbes living in the gut not only …

144

Making Sense of the Microbiome in Psychiatry.

Bastiaanssen TFS, Cowan CSM, Claesson MJ, Dinan TG, Cryan JF. Bastiaanssen TFS, et al. Int J Neuropsychopharmacol. 2019 Jan 1;22(1):37-52. doi: 10.1093/ijnp/pyy067. Int J Neuropsychopharmacol. 2019. PMID: 30099552 Free PMC article. Review.

The collection of microorganisms associated with a certain location is called a microbiota, with its collective genetic material referred to as the microbiome. The largest population of microorganisms on the human body resides in the gastrointestinal tract; thus, it …

The collection of microorganisms associated with a certain location is called a microbiota, with its collective genetic material referred to …

145

Microbiome and nutrition in autism spectrum disorder: current knowledge and research needs.

Berding K, Donovan SM. Berding K, et al. Nutr Rev. 2016 Dec;74(12):723-736. doi: 10.1093/nutrit/nuw048. Nutr Rev. 2016. PMID: 27864534 Review.

Autism spectrum disorder (ASD) is the fastest growing neurodevelopmental disorder in the United States. ...A number of mechanisms underlying the interaction between nutrition, the gut microbiota, and ASD symptoms via the microbiota-gut-brain axi …

Autism spectrum disorder (ASD) is the fastest growing neurodevelopmental disorder in the United States. ...A number of …

146

Gut Microbiota, Inflammation, and Probiotics on Neural Development in Autism Spectrum Disorder.

Doenyas C. Doenyas C. Neuroscience. 2018 Mar 15;374:271-286. doi: 10.1016/j.neuroscience.2018.01.060. Epub 2018 Feb 8. Neuroscience. 2018. PMID: 29427656 Review.

Recent evidence implicates immune alterations and gut microbiota dysbiosis in at least some subpopulations of individuals with autism spectrum disorder (ASD). Immune and gut alterations in ASD have mostly been studied separately, and the reviews and th …

Recent evidence implicates immune alterations and gut microbiota dysbiosis in at least some subpopulations of individuals with aut …

147

The gut microbiota in neuropsychiatric disorders.

Grochowska M, Wojnar M, Radkowski M. Grochowska M, et al. Acta Neurobiol Exp (Wars). 2018;78(2):69-81. Acta Neurobiol Exp (Wars). 2018. PMID: 30019700 Review.

The gut microbiome is responsible for multiple functions, e.g. tightness of the intestine barrier, digestion and absorption. The correlation between gut dysbiosis and development of psychiatric, autoimmune and allergic diseases as well as bidirectional commun …

The gut microbiome is responsible for multiple functions, e.g. tightness of the intestine barrier, digestion and absorption. T …

148

Exercise Changes Gut Microbiota: A New Idea to Explain that Exercise Improves Autism.

Xue Y, An S, Qiu W, Zhang W, Fu L, Zhen Z. Xue Y, et al. Int J Sports Med. 2023 Jun;44(7):473-483. doi: 10.1055/a-2018-2477. Epub 2023 Jan 23. Int J Sports Med. 2023. PMID: 36690029 Free article. Review.

The effect of exercise interventions on autism spectrum disorder (ASD) has been demonstrated in many studies, and the discovery of a bidirectional relationship between the gut microbiome (GM) and the central nervous system (CNS) has led to the concept …

The effect of exercise interventions on autism spectrum disorder (ASD) has been demonstrated in many studies, and the discover …

149

Microbiome influences on neuro-immune interactions in neurodegenerative disease.

Menees KB, Otero BA, Tansey MG. Menees KB, et al. Int Rev Neurobiol. 2022;167:25-57. doi: 10.1016/bs.irn.2022.07.006. Epub 2022 Aug 27. Int Rev Neurobiol. 2022. PMID: 36427957 Review.

Mounting evidence points to a role for the gut microbiome in a wide range of central nervous system diseases and disorders including depression, multiple sclerosis, Alzheimer's disease, Parkinson's disease, and autism spectrum disorder. ...This chapter …

Mounting evidence points to a role for the gut microbiome in a wide range of central nervous system diseases and disorders inc …

150

The interplay between gut microbiota and autism spectrum disorders: A focus on immunological pathways.

Moradi K, Ashraf-Ganjouei A, Tavolinejad H, Bagheri S, Akhondzadeh S. Moradi K, et al. Prog Neuropsychopharmacol Biol Psychiatry. 2021 Mar 2;106:110091. doi: 10.1016/j.pnpbp.2020.110091. Epub 2020 Sep 4. Prog Neuropsychopharmacol Biol Psychiatry. 2021. PMID: 32891667 Review.

A remarkable proportion of ASD patients represent immune dysregulation as well as gastrointestinal complications. Hence, a novel concept has recently emerged, addressing the possible intercommunication between the brain, the immune system, the gut and its commensals …

A remarkable proportion of ASD patients represent immune dysregulation as well as gastrointestinal complications. Hence, a novel conc …

151

Multi-omics analyses demonstrate the modulating role of gut microbiota on the associations of unbalanced dietary intake with gastrointestinal symptoms in children with autism spectrum disorder.

Li H, Liu C, Huang S, Wang X, Cao M, Gu T, Ou X, Pan S, Lin Z, Wang X, Zhu Y, Jing J. Li H, et al. Gut Microbes. 2023 Dec;15(2):2281350. doi: 10.1080/19490976.2023.2281350. Epub 2023 Nov 27. Gut Microbes. 2023. PMID: 38010793 Free PMC article.

Our previous work revealed that unbalanced dietary intake was an important independent factor associated with constipation and gastrointestinal (GI) symptoms in children with autism spectrum disorder (ASD). Growing evidence has shown the alterations in the …

Our previous work revealed that unbalanced dietary intake was an important independent factor associated with constipation and gastrointe …

152

Dietary diversity contributes to microbiome associations in autism.

Johnson AJ, Howell BR. Johnson AJ, et al. Cell Metab. 2021 Dec 7;33(12):2311-2313. doi: 10.1016/j.cmet.2021.11.008. Cell Metab. 2021. PMID: 34879238 Free PMC article.

Research exploring the links between the microbiome and autism has inadequately considered the contribution of diet diversity. Recently in Cell, Yap et al. addressed the contribution of restrictive dietary patterns to microbiome diversity in autism and …

Research exploring the links between the microbiome and autism has inadequately considered the contribution of diet diversity. …

153

An anxious relationship between Autism Spectrum Disorder and Gut Microbiota: A tangled chemistry?

Vellingiri B, Aishwarya SY, Benita Jancy S, Sriram Abhishek G, Winster Suresh Babu H, Vijayakumar P, Narayanasamy A, Mariappan S, Sangeetha R, Valsala Gopalakrishnan A, Parthasarathi R, Iyer M. Vellingiri B, et al. J Clin Neurosci. 2022 May;99:169-189. doi: 10.1016/j.jocn.2022.03.003. Epub 2022 Mar 11. J Clin Neurosci. 2022. PMID: 35286970 Review.

Autism spectrum disorder (ASD) is a serious multifactorial neurodevelopmental disorder often accompanied by strained social communication, repetitive behaviour, immune dysregulation, and gastrointestinal (GI) issues. Recent studies have recorded a link …

Autism spectrum disorder (ASD) is a serious multifactorial neurodevelopmental disorder often accompanied by strained so …

154

The role of the host microbiome in autism and neurodegenerative disorders and effect of epigenetic procedures in the brain functions.

Yousefi B, Kokhaei P, Mehranfar F, Bahar A, Abdolshahi A, Emadi A, Eslami M. Yousefi B, et al. Neurosci Biobehav Rev. 2022 Jan;132:998-1009. doi: 10.1016/j.neubiorev.2021.10.046. Epub 2021 Nov 3. Neurosci Biobehav Rev. 2022. PMID: 34742725 Review.

Autism Spectrum Disorder (ASD) is a severe neurological/neurodegenerative syndrome that results in cognitive and communication disorders. The degree of dysbiosis is related to the severity of ASD signs. The gut is conferred with a variety of sensory receptors …

Autism Spectrum Disorder (ASD) is a severe neurological/neurodegenerative syndrome that results in cognitive and communication …

155

Oral microbiome activity in children with autism spectrum disorder.

Hicks SD, Uhlig R, Afshari P, Williams J, Chroneos M, Tierney-Aves C, Wagner K, Middleton FA. Hicks SD, et al. Autism Res. 2018 Sep;11(9):1286-1299. doi: 10.1002/aur.1972. Epub 2018 Aug 14. Autism Res. 2018. PMID: 30107083 Free PMC article.

Autism spectrum disorder (ASD) is associated with several oropharyngeal abnormalities, including buccal sensory sensitivity, taste and texture aversions, speech apraxia, and salivary transcriptome alterations. Furthermore, the oropharynx represents the sole entry po …

Autism spectrum disorder (ASD) is associated with several oropharyngeal abnormalities, including buccal sensory sensitivity, t …

156

Gut microbiome populations are associated with structure-specific changes in white matter architecture.

Ong IM, Gonzalez JG, McIlwain SJ, Sawin EA, Schoen AJ, Adluru N, Alexander AL, Yu JJ. Ong IM, et al. Transl Psychiatry. 2018 Jan 10;8(1):6. doi: 10.1038/s41398-017-0022-5. Transl Psychiatry. 2018. PMID: 29317592 Free PMC article.

Altered gut microbiome populations are associated with a broad range of neurodevelopmental disorders including autism spectrum disorder and mood disorders. In animal models, modulation of gut microbiome populations via dietary manipulatio …

Altered gut microbiome populations are associated with a broad range of neurodevelopmental disorders including autism s …

157

Akkermansia muciniphila in neuropsychiatric disorders: friend or foe?

Lei W, Cheng Y, Gao J, Liu X, Shao L, Kong Q, Zheng N, Ling Z, Hu W. Lei W, et al. Front Cell Infect Microbiol. 2023 Jul 10;13:1224155. doi: 10.3389/fcimb.2023.1224155. eCollection 2023. Front Cell Infect Microbiol. 2023. PMID: 37492530 Free PMC article. Review.

Recent clinical and preclinical studies have shown that A. muciniphila plays a vital role in a variety of neuropsychiatric disorders by influencing the host brain through the microbiota-gut-brain axis (MGBA). Numerous studies observed that A. muciniphila and its metabolic …

Recent clinical and preclinical studies have shown that A. muciniphila plays a vital role in a variety of neuropsychiatric disorders by infl …

158

[Gut microbiome and psyche: paradigm shift in the concept of brain-gut axis].

Konturek PC, Zopf Y. Konturek PC, et al. MMW Fortschr Med. 2016 May 25;158 Suppl 4:12-6. doi: 10.1007/s15006-016-8304-z. Epub 2016 May 25. MMW Fortschr Med. 2016. PMID: 27221556 Review. German.

The great advances in molecular medicine in recent years led to the discovery of an enormous number of microorganisms in the intestine (gut microbiome), which greatly affect the function of the brain-gut axis. METHOD: Overview RESULTS AND CONCLUSIONS: Numerou …

The great advances in molecular medicine in recent years led to the discovery of an enormous number of microorganisms in the intestine (g …

159

Correlation of Gut Microbiome Between ASD Children and Mothers and Potential Biomarkers for Risk Assessment.

Li N, Yang J, Zhang J, Liang C, Wang Y, Chen B, Zhao C, Wang J, Zhang G, Zhao D, Liu Y, Zhang L, Yang J, Li G, Gai Z, Zhang L, Zhao G. Li N, et al. Genomics Proteomics Bioinformatics. 2019 Feb;17(1):26-38. doi: 10.1016/j.gpb.2019.01.002. Epub 2019 Apr 23. Genomics Proteomics Bioinformatics. 2019. PMID: 31026579 Free PMC article.

We examined the relationships between gut microbiome profiles of ASD children and those of their mothers, and evaluated the clinical discriminatory power of discovered bacterial biomarkers. ...Significant differences were observed in the gut microbiome …

We examined the relationships between gut microbiome profiles of ASD children and those of their mothers, and evaluated the cl …

160

Gut Reactions: How Far Are We from Understanding and Manipulating the Microbiota Complexity and the Interaction with Its Host? Lessons from Autism Spectrum Disorder Studies.

Lombardi M, Troisi J. Lombardi M, et al. Nutrients. 2021 Oct 2;13(10):3492. doi: 10.3390/nu13103492. Nutrients. 2021. PMID: 34684493 Free PMC article. Review.

It is characterized by familial aggregation, suggesting that genetic factors play a role in disease development, in addition to developmentally early environmental factors. Here, we review the role of the gut microbiome in autism, as it has been characterized …

It is characterized by familial aggregation, suggesting that genetic factors play a role in disease development, in addition to developmenta …

161

The Microbiome and Host Behavior.

Vuong HE, Yano JM, Fung TC, Hsiao EY. Vuong HE, et al. Annu Rev Neurosci. 2017 Jul 25;40:21-49. doi: 10.1146/annurev-neuro-072116-031347. Epub 2017 Mar 8. Annu Rev Neurosci. 2017. PMID: 28301775 Free PMC article. Review.

We summarize effects of the microbiota on host neurophysiology, including brain microstructure, gene expression, and neurochemical metabolism across regions of the amygdala, hippocampus, frontal cortex, and hypothalamus. We further assess evidence linking dysbiosis of the gut …

We summarize effects of the microbiota on host neurophysiology, including brain microstructure, gene expression, and neurochemical metabolis …

162

The microbiota-gut-brain axis and its potential therapeutic role in autism spectrum disorder.

Li Q, Zhou JM. Li Q, et al. Neuroscience. 2016 Jun 2;324:131-9. doi: 10.1016/j.neuroscience.2016.03.013. Epub 2016 Mar 8. Neuroscience. 2016. PMID: 26964681 Review.

Autism spectrum disorder (ASD) is a series of neurodevelopmental disorders that are characterized by deficits in both social and cognitive functions. Although the exact etiology and pathology of ASD remain unclear, a disorder of the microbiota-gut-brai …

Autism spectrum disorder (ASD) is a series of neurodevelopmental disorders that are characterized by deficits in both social a …

163

Pre- and probiotics in the management of children with autism and gut issues: a review of the current evidence.

Mitchell LK, Davies PSW. Mitchell LK, et al. Eur J Clin Nutr. 2022 Jul;76(7):913-921. doi: 10.1038/s41430-021-01027-9. Epub 2021 Oct 21. Eur J Clin Nutr. 2022. PMID: 34675402 Review.

Manipulation of the gut microbiome offers a promising treatment option for children with autism spectrum disorder (ASD) for whom functional gastrointestinal disorders (FGIDs) are a common comorbidity. ...The aim of this review is to investigate …

Manipulation of the gut microbiome offers a promising treatment option for children with autism spectrum disorder …

164

Gut microbial and clinical characteristics of individuals with autism spectrum disorder differ depending on the ecological structure of the gut microbiome.

Jung Y, Lee T, Oh HS, Hyun Y, Song S, Chun J, Kim HW. Jung Y, et al. Psychiatry Res. 2024 May;335:115775. doi: 10.1016/j.psychres.2024.115775. Epub 2024 Feb 14. Psychiatry Res. 2024. PMID: 38503005

Understanding the relationship between the gut microbiome and autism spectrum disorder (ASD) is challenging due to the heterogeneous nature of ASD. ...Our study suggests that the microbial composition in individuals with ASD exhibits considerable varia …

Understanding the relationship between the gut microbiome and autism spectrum disorder (ASD) is challenging due …

165

Impact of pesticides exposure during neurodevelopmental period on autism spectrum disorders - A focus on gut microbiota.

Yang Y, Zhou S, Xing Y, Yang G, You M. Yang Y, et al. Ecotoxicol Environ Saf. 2023 Jul 15;260:115079. doi: 10.1016/j.ecoenv.2023.115079. Epub 2023 May 30. Ecotoxicol Environ Saf. 2023. PMID: 37262968 Free article. Review.

Accumulating evidence indicates exposure to pesticides during the crucial neurodevelopmental period increases susceptibility to many diseases, including the neurodevelopmental disorder known as autism spectrum disorder (ASD). In the last few years, it has bee …

Accumulating evidence indicates exposure to pesticides during the crucial neurodevelopmental period increases susceptibility to many disease …

166

Microbiome programming of brain development: implications for neurodevelopmental disorders.

Forssberg H. Forssberg H. Dev Med Child Neurol. 2019 Jul;61(7):744-749. doi: 10.1111/dmcn.14208. Epub 2019 Mar 14. Dev Med Child Neurol. 2019. PMID: 30868564 Free article. Review.

During the last decade, research on germ-free mice has discovered that the gut microbiome (i.e. the normal bacteria colonizing the gastrointestinal tract) can programme brain function and behaviour during early development. ...WHAT THIS PAPER ADDS: The gut …

During the last decade, research on germ-free mice has discovered that the gut microbiome (i.e. the normal bacteria colonizing …

167

Maternal Intake of Polyunsaturated Fatty Acids in Autism Spectrum Etiology and Its Relation to the Gut Microbiota: What Do We Know?

Rodrigues EL, Figueiredo PS, Marcelino G, de Cássia Avellaneda Guimarães R, Pott A, Santana LF, Hiane PA, do Nascimento VA, Bogo D, de Cássia Freitas K. Rodrigues EL, et al. Nutrients. 2023 Mar 23;15(7):1551. doi: 10.3390/nu15071551. Nutrients. 2023. PMID: 37049390 Free PMC article. Review.

Maternal food habits and gut microbiota composition have potential effects on fetal neurodevelopment, impacting Autism Spectrum Disorder (ASD). Our research aims to outline the relationship that ingestion of polyunsaturated fatty acids (PUFAs) and the composi …

Maternal food habits and gut microbiota composition have potential effects on fetal neurodevelopment, impacting Autism Spectru …

168

Altered Gut Microbiota in Chinese Children With Autism Spectrum Disorders.

Ma B, Liang J, Dai M, Wang J, Luo J, Zhang Z, Jing J. Ma B, et al. Front Cell Infect Microbiol. 2019 Mar 6;9:40. doi: 10.3389/fcimb.2019.00040. eCollection 2019. Front Cell Infect Microbiol. 2019. PMID: 30895172 Free PMC article.

The link between gut microbes and autism spectrum disorders (ASD) has been already observed in some studies, but some bacterial families/species were found to be inconsistently up or down regulated. ...This study provides further evidence of intestinal microbial dys …

The link between gut microbes and autism spectrum disorders (ASD) has been already observed in some studies, but some bacteria …

169

The Crosstalk between Gut Microbiota and Nervous System: A Bidirectional Interaction between Microorganisms and Metabolome.

Montagnani M, Bottalico L, Potenza MA, Charitos IA, Topi S, Colella M, Santacroce L. Montagnani M, et al. Int J Mol Sci. 2023 Jun 19;24(12):10322. doi: 10.3390/ijms241210322. Int J Mol Sci. 2023. PMID: 37373470 Free PMC article. Review.

Several studies have shown that the gut microbiota influences behavior and, in turn, changes in the immune system associated with symptoms of depression or anxiety disorder may be mirrored by corresponding changes in the gut microbiota. ...This concept, toget …

Several studies have shown that the gut microbiota influences behavior and, in turn, changes in the immune system associated with sym …

170

Characterizing the metabolomic signature of attention-deficit hyperactivity disorder in twins.

Swann JR, Diaz Heijtz R, Mayneris-Perxachs J, Arora A, Isaksson J, Bölte S, Tammimies K. Swann JR, et al. Neuropharmacology. 2023 Aug 15;234:109562. doi: 10.1016/j.neuropharm.2023.109562. Epub 2023 Apr 25. Neuropharmacology. 2023. PMID: 37100381 Free article. Review.

Emerging evidence implicate the gut microbiota as a potential susceptibility factor in attention-deficit hyperactivity disorder (ADHD), a common multifactorial neurodevelopmental condition. ...These findings suggest that metabolic disturbances in ADHD, involving com …

Emerging evidence implicate the gut microbiota as a potential susceptibility factor in attention-deficit hyperactivity disorder …

171

Ketogenic Diet: A Dietary Intervention via Gut Microbiome Modulation for the Treatment of Neurological and Nutritional Disorders (a Narrative Review).

Lim JM, Letchumanan V, Tan LT, Hong KW, Wong SH, Ab Mutalib NS, Lee LH, Law JW. Lim JM, et al. Nutrients. 2022 Aug 30;14(17):3566. doi: 10.3390/nu14173566. Nutrients. 2022. PMID: 36079829 Free PMC article. Review.

The benefits of KD further expanded to other neurological diseases, including Alzheimer's diseases, autism spectrum disorder, and nutritional disorder (obesity). Although the therapeutic efficacy of KD has been generally accepted, there is limited knowledge a …

The benefits of KD further expanded to other neurological diseases, including Alzheimer's diseases, autism spectrum disorder, …

172

Microbiome and Mental Health, Specifically as It Relates to Adolescents.

Simkin DR. Simkin DR. Curr Psychiatry Rep. 2019 Sep 2;21(9):93. doi: 10.1007/s11920-019-1075-3. Curr Psychiatry Rep. 2019. PMID: 31478105 Review.

PURPOSE OF REVIEW: This article reviews the relationship of the microbiome, the gut-brain axis, and depression. It also will review factors which can influence this relationship, such as chronic stress, medications, and the Western diet typically consumed by adolesc …

PURPOSE OF REVIEW: This article reviews the relationship of the microbiome, the gut-brain axis, and depression. It also will r …

173

Gut microbiota changes in patients with autism spectrum disorders.

Ding X, Xu Y, Zhang X, Zhang L, Duan G, Song C, Li Z, Yang Y, Wang Y, Wang X, Zhu C. Ding X, et al. J Psychiatr Res. 2020 Oct;129:149-159. doi: 10.1016/j.jpsychires.2020.06.032. Epub 2020 Jul 18. J Psychiatr Res. 2020. PMID: 32912596 Free article.

Autism spectrum disorder (ASD) has a high incidence of intestinal comorbidity, indicating a strong association with gut microbiota. The purpose of this study was to characterize gut microbiota profiles in children with ASD. Seventy-seven children with …

Autism spectrum disorder (ASD) has a high incidence of intestinal comorbidity, indicating a strong association with gut …

174

An approach to gut microbiota profile in children with autism spectrum disorder.

Andreo-Martínez P, García-Martínez N, Sánchez-Samper EP, Martínez-González AE. Andreo-Martínez P, et al. Environ Microbiol Rep. 2020 Apr;12(2):115-135. doi: 10.1111/1758-2229.12810. Epub 2019 Nov 27. Environ Microbiol Rep. 2020. PMID: 31713352 Review.

In recent years, there has been an increase in studies on the implications of gut microbiota (GM) on the behaviour of children with autism spectrum disorders (ASD) due to a dysbiosis in GM that can trigger onset, development or progression of ASD through the microbi …

In recent years, there has been an increase in studies on the implications of gut microbiota (GM) on the behaviour of children with …

175

Altered gut microbiota correlates with behavioral problems but not gastrointestinal symptoms in individuals with autism.

Chen YC, Lin HY, Chien Y, Tung YH, Ni YH, Gau SS. Chen YC, et al. Brain Behav Immun. 2022 Nov;106:161-178. doi: 10.1016/j.bbi.2022.08.015. Epub 2022 Sep 2. Brain Behav Immun. 2022. PMID: 36058421 Free article.

BACKGROUND: Despite inconsistent results across studies, emerging evidence suggests that the microbial micro-environment may be associated with autism spectrum disorder (ASD). Geographical and cultural factors highly impact microbial profiles, and there is a shortag …

BACKGROUND: Despite inconsistent results across studies, emerging evidence suggests that the microbial micro-environment may be associated w …

176

Production of Psychoactive Metabolites by Gut Bacteria.

Wiley NC, Cryan JF, Dinan TG, Ross RP, Stanton C. Wiley NC, et al. Mod Trends Psychiatry. 2021;32:74-99. doi: 10.1159/000510419. Epub 2021 May 6. Mod Trends Psychiatry. 2021. PMID: 34032647 Review.

The gut microbiome plays a vital role in numerous aspects of physiology, including functions related to metabolism, the immune system, behaviour, brain structure and function. ...An important method by which the gut microbiome can influence the gut …

The gut microbiome plays a vital role in numerous aspects of physiology, including functions related to metabolism, the immune …

177

Dietary interventions for autism spectrum disorder: New perspectives from the gut-brain axis.

Doenyas C. Doenyas C. Physiol Behav. 2018 Oct 1;194:577-582. doi: 10.1016/j.physbeh.2018.07.014. Epub 2018 Jul 20. Physiol Behav. 2018. PMID: 30036560 Review.

There is still controversy surrounding the effectiveness of dietary interventions for autism spectrum disorder (ASD), namely the gluten-free/casein free diet and the ketogenic diet. ...Some evidence has emerged with findings of the gut-microbial, inflammatory …

There is still controversy surrounding the effectiveness of dietary interventions for autism spectrum disorder (ASD), namely t …

178

[The Role of Gut Microbiota in Autism Spectrum Disorder].

Ersöz Alan B, Gülerman F. Ersöz Alan B, et al. Turk Psikiyatri Derg. 2019 Fall;30(3):210-219. Turk Psikiyatri Derg. 2019. PMID: 31613980 Free article. Review. Turkish.

Autism spectrum disorder (ASD), which is a neurodevelopmental disorder of early childhood, is one of these disorders. Most of such studies were cross-sectional and mainly investigated the bacterial species. Changes in gut microbiota composition and the …

Autism spectrum disorder (ASD), which is a neurodevelopmental disorder of early childhood, is one of these disorders. M …

179

Correlation among gut microbiota, fecal metabolites and autism-like behavior in an adolescent valproic acid-induced rat autism model.

Gu Y, Han Y, Ren S, Zhang B, Zhao Y, Wang X, Zhang S, Qin J. Gu Y, et al. Behav Brain Res. 2022 Jan 24;417:113580. doi: 10.1016/j.bbr.2021.113580. Epub 2021 Sep 20. Behav Brain Res. 2022. PMID: 34555431

This study aims to understand the relationship between fecal metabolites and gut microbiota in an adolescent valproic acid-induced rat autism model (VPA-exposed offspring). ...Based on these data, we analyzed the association among fecal metabolites, gut micro …

This study aims to understand the relationship between fecal metabolites and gut microbiota in an adolescent valproic acid-induced ra …

180

Interventions on Microbiota: Where Do We Stand on a Gut-Brain Link in Autism? A Systematic Review.

Prosperi M, Santocchi E, Guiducci L, Frinzi J, Morales MA, Tancredi R, Muratori F, Calderoni S. Prosperi M, et al. Nutrients. 2022 Jan 20;14(3):462. doi: 10.3390/nu14030462. Nutrients. 2022. PMID: 35276821 Free PMC article. Review.

The alteration of the microbiota-gut-brain axis has been recently recognized as a critical modulator of neuropsychiatric health and a possible factor in the etiopathogenesis of autism spectrum disorders (ASD). This systematic review offers practitioners an overview …

The alteration of the microbiota-gut-brain axis has been recently recognized as a critical modulator of neuropsychiatric health and a …

181

Effects of repeated lysergic acid diethylamide (LSD) on the mouse brain endocannabinoidome and gut microbiome.

Inserra A, Giorgini G, Lacroix S, Bertazzo A, Choo J, Markopolous A, Grant E, Abolghasemi A, De Gregorio D, Flamand N, Rogers G, Comai S, Silvestri C, Gobbi G, Di Marzo V. Inserra A, et al. Br J Pharmacol. 2023 Mar;180(6):721-739. doi: 10.1111/bph.15977. Epub 2022 Dec 12. Br J Pharmacol. 2023. PMID: 36316276 Free article.

Whether psychedelics affect the brain endocannabinoid system and its extended version, the endocannabinoidome (eCBome) or the gut microbiome, remains unknown. EXPERIMENTAL APPROACH: Adult C57BL/6N male mice were administered lysergic acid diethylamide (LSD) or salin …

Whether psychedelics affect the brain endocannabinoid system and its extended version, the endocannabinoidome (eCBome) or the gut …

182

The Gut Microbiota and Oxidative Stress in Autism Spectrum Disorders (ASD).

Hu T, Dong Y, He C, Zhao M, He Q. Hu T, et al. Oxid Med Cell Longev. 2020 Oct 1;2020:8396708. doi: 10.1155/2020/8396708. eCollection 2020. Oxid Med Cell Longev. 2020. PMID: 33062148 Free PMC article. Review.

Autism spectrum disorders (ASDs) are a kind of neurodevelopmental disorder with rapidly increasing morbidity. ...Additionally, the oxidative stress and GIT dysfunction in autistic children have both been reported to be related to mitochondrial dysfunction. .. …

Autism spectrum disorders (ASDs) are a kind of neurodevelopmental disorder with rapidly increasing morbidity. ...Additionally, …

183

Food and the gut: relevance to some of the autisms.

Whiteley P. Whiteley P. Proc Nutr Soc. 2017 Nov;76(4):478-483. doi: 10.1017/S0029665117002798. Epub 2017 Sep 26. Proc Nutr Soc. 2017. PMID: 28946927 Review.

The gastrointestinal (GI) tract represents an important biological system pertinent to at least some autism. The notion of a gut-brain-behaviour axis has garnered support from various findings: an overrepresentation of functional and pathological bowel states …

The gastrointestinal (GI) tract represents an important biological system pertinent to at least some autism. The notion of a …

184

The role of probiotics in children with autism spectrum disorders: A study protocol for a randomised controlled trial.

Zhang L, Xu Y, Li H, Li B, Duan G, Zhu C. Zhang L, et al. PLoS One. 2022 Feb 24;17(2):e0263109. doi: 10.1371/journal.pone.0263109. eCollection 2022. PLoS One. 2022. PMID: 35202432 Free PMC article. Clinical Trial.

BACKGROUND: Autism spectrum disorder (ASD) is a neurological and developmental condition that begins in infancy or earlier and lasts through the individual's lifetime. ...

BACKGROUND: Autism spectrum disorder (ASD) is a neurological and developmental condition that begins in infancy or earlier and …

185

Microbiota in Autism Spectrum Disorder: A Systematic Review.

Lewandowska-Pietruszka Z, Figlerowicz M, Mazur-Melewska K. Lewandowska-Pietruszka Z, et al. Int J Mol Sci. 2023 Nov 23;24(23):16660. doi: 10.3390/ijms242316660. Int J Mol Sci. 2023. PMID: 38068995 Free PMC article. Review.

Autism spectrum disorder (ASD) is a complex neurodevelopmental condition characterized by several core symptoms: restricted interests, communication difficulties, and impaired social interactions. Many ASD children experience gastrointestinal functional disor …

Autism spectrum disorder (ASD) is a complex neurodevelopmental condition characterized by several core symptoms: restricted in …

186

Maternal microbiome disturbance induces deficits in the offspring's behaviors: a systematic review and meta-analysis.

Hassib L, de Oliveira CL, Rouvier GA, Kanashiro A, Guimarães FS, Ferreira FR. Hassib L, et al. Gut Microbes. 2023 Jan-Dec;15(1):2226282. doi: 10.1080/19490976.2023.2226282. Gut Microbes. 2023. PMID: 37400971 Free PMC article. Review.

Recent evidence has suggested that changes in maternal gut microbiota in early life may generate neurobiological consequences associated with psychiatric-related abnormalities. ...

Recent evidence has suggested that changes in maternal gut microbiota in early life may generate neurobiological consequences associa …

187

Between Dysbiosis, Maternal Immune Activation and Autism: Is There a Common Pathway?

Suprunowicz M, Tomaszek N, Urbaniak A, Zackiewicz K, Modzelewski S, Waszkiewicz N. Suprunowicz M, et al. Nutrients. 2024 Feb 16;16(4):549. doi: 10.3390/nu16040549. Nutrients. 2024. PMID: 38398873 Free PMC article. Review.

Autism spectrum disorder (ASD) is a neuropsychiatric condition characterized by impaired social interactions and repetitive stereotyped behaviors. Growing evidence highlights an important role of the gut-brain-microbiome axis in the pathogenesis of ASD …

Autism spectrum disorder (ASD) is a neuropsychiatric condition characterized by impaired social interactions and repetitive st …

188

Autism spectrum disorder is associated with gut microbiota disorder in children.

Sun H, You Z, Jia L, Wang F. Sun H, et al. BMC Pediatr. 2019 Dec 27;19(1):516. doi: 10.1186/s12887-019-1896-6. BMC Pediatr. 2019. PMID: 31881951 Free PMC article.

BACKGROUND: The aim of this study was to evaluate the occurrence and clinical characteristics of autism spectrum disorder (ASD) associated to the stable state of the gut microbiota. ...These differences affect the biological function of the host. These result …

BACKGROUND: The aim of this study was to evaluate the occurrence and clinical characteristics of autism spectrum disorder (ASD …

189

Microbiota revolution: How gut microbes regulate our lives.

Colella M, Charitos IA, Ballini A, Cafiero C, Topi S, Palmirotta R, Santacroce L. Colella M, et al. World J Gastroenterol. 2023 Jul 28;29(28):4368-4383. doi: 10.3748/wjg.v29.i28.4368. World J Gastroenterol. 2023. PMID: 37576701 Free PMC article. Review.

Therefore, a dysbiosis can lead to an association of unfavourable factors which lead to a dysregulation of the physiological processes of homeostasis. Thus, it has pre-viously noted that the gut microbiota can participate in the pathogenesis of autoimmune diseases, chronic …

Therefore, a dysbiosis can lead to an association of unfavourable factors which lead to a dysregulation of the physiological processes of ho …

190

Review of microbiota gut brain axis and innate immunity in inflammatory and infective diseases.

Yuan C, He Y, Xie K, Feng L, Gao S, Cai L. Yuan C, et al. Front Cell Infect Microbiol. 2023 Oct 4;13:1282431. doi: 10.3389/fcimb.2023.1282431. eCollection 2023. Front Cell Infect Microbiol. 2023. PMID: 37868345 Free PMC article. Review.

The microbiota gut brain (MGB) axis has been shown to play a significant role in the regulation of inflammatory and infective diseases. ...This article reviews the composition, communication mechanism of MGB axis and its role in inflammatory and infective diseases, includi …

The microbiota gut brain (MGB) axis has been shown to play a significant role in the regulation of inflammatory and infective disease …

191

The mediating role of the gut microbiome in the association between ambient air pollution and autistic traits.

Kim JI, Kim BN, Lee YA, Shin CH, Hong YC, Lim YH. Kim JI, et al. Int J Hyg Environ Health. 2022 Sep;246:114047. doi: 10.1016/j.ijheh.2022.114047. Epub 2022 Oct 7. Int J Hyg Environ Health. 2022. PMID: 36215749 Free article.

Air pollution has been reported to be an environmental risk factor for autism spectrum disorder. However, the gut microbiome's role as a potential mediator has not been investigated. ...Autistic traits and gut microbiome were asses …

Air pollution has been reported to be an environmental risk factor for autism spectrum disorder. However, the gut mi …

192

Dysregulated phosphate metabolism in autism spectrum disorder: associations and insights for future research.

Brown RB. Brown RB. Expert Rev Mol Med. 2023 Jun 13;25:e20. doi: 10.1017/erm.2023.15. Expert Rev Mol Med. 2023. PMID: 37309057 Free PMC article. Review.

Studies of autism spectrum disorder (ASD) related to exposure to toxic levels of dietary phosphate are lacking. ...The rise in ASD prevalence has been suggested to originate in changes to the gut microbiome from increasing consumption of additives in p …

Studies of autism spectrum disorder (ASD) related to exposure to toxic levels of dietary phosphate are lacking. ...The rise in …

193

Introduction to the Special Issue "The Brain-Gut Axis".

Taché Y, Saavedra JM. Taché Y, et al. Cell Mol Neurobiol. 2022 Mar;42(2):311-313. doi: 10.1007/s10571-021-01155-7. Epub 2021 Oct 15. Cell Mol Neurobiol. 2022. PMID: 34652580

This special Issue presents comprehensive and state-of-the-art advances in supporting the crucial role of the bidirectional interactions between the Brain-Gut Axis in health and diseases with an emphasis on the microbiome-gut-brain axis and its implications i …

This special Issue presents comprehensive and state-of-the-art advances in supporting the crucial role of the bidirectional interactions bet …

194

Gut Dysbiosis in Animals Due to Environmental Chemical Exposures.

Rosenfeld CS. Rosenfeld CS. Front Cell Infect Microbiol. 2017 Sep 8;7:396. doi: 10.3389/fcimb.2017.00396. eCollection 2017. Front Cell Infect Microbiol. 2017. PMID: 28936425 Free PMC article. Review.

All animals, including humans, are exposed daily to various environmental chemicals that can influence the gut microbiome. Exposure to such chemicals might lead to downstream systemic effects that occur secondary to gut microbiome disturbances. Increas …

All animals, including humans, are exposed daily to various environmental chemicals that can influence the gut microbiome. Exp …

195

Our Mental Health Is Determined by an Intrinsic Interplay between the Central Nervous System, Enteric Nerves, and Gut Microbiota.

Dicks LMT. Dicks LMT. Int J Mol Sci. 2023 Dec 19;25(1):38. doi: 10.3390/ijms25010038. Int J Mol Sci. 2023. PMID: 38203207 Free PMC article. Review.

Bacteria in the gut microbiome play an intrinsic part in immune activation, intestinal permeability, enteric reflex, and entero-endocrine signaling. ...In this review, the intricate control of entero-endocrine signaling and immune responses that keep the gut …

Bacteria in the gut microbiome play an intrinsic part in immune activation, intestinal permeability, enteric reflex, and enter …

196

A snapshot of gut microbiota data from murine models of Autism Spectrum Disorder: Still a blurred picture.

Tartaglione AM, Pazienza V, Calamandrei G, Ricceri L. Tartaglione AM, et al. Neurosci Biobehav Rev. 2023 Apr;147:105105. doi: 10.1016/j.neubiorev.2023.105105. Epub 2023 Feb 18. Neurosci Biobehav Rev. 2023. PMID: 36804416 Review.

Autism Spectrum Disorder (ASD) is a heterogeneous neurodevelopmental disorder characterized by deficits in social communication and interaction and repetitive/stereotyped behaviors. In recent years, the role of microbiota-gut-brain axis in ASD pathogen …

Autism Spectrum Disorder (ASD) is a heterogeneous neurodevelopmental disorder characterized by deficits in social commu …

197

GW4064 Alters Gut Microbiota Composition and Counteracts Autism-Associated Behaviors in BTBR T+tf/J Mice.

Liu J, Liu C, Gao Z, Zhou L, Gao J, Luo Y, Liu T, Fan X. Liu J, et al. Front Cell Infect Microbiol. 2022 Jun 22;12:911259. doi: 10.3389/fcimb.2022.911259. eCollection 2022. Front Cell Infect Microbiol. 2022. PMID: 35811667 Free PMC article.

Autism spectrum disorder (ASD) is considered a heterogeneous neurodevelopmental disorder characterized by significant social, communication, and behavioral impairments. ...Farnesoid X receptor (FXR) has recently been shown to modulate the gut microbiot …

Autism spectrum disorder (ASD) is considered a heterogeneous neurodevelopmental disorder characterized by significant s …

198

Gastrointestinal alterations in autism spectrum disorder: What do we know?

Bjørklund G, Pivina L, Dadar M, Meguid NA, Semenova Y, Anwar M, Chirumbolo S. Bjørklund G, et al. Neurosci Biobehav Rev. 2020 Nov;118:111-120. doi: 10.1016/j.neubiorev.2020.06.033. Epub 2020 Jul 1. Neurosci Biobehav Rev. 2020. PMID: 32621940 Review.

There is an emerging body of evidence associating children having autism spectrum disorder (ASD) with gastrointestinal (GI) symptoms, such as abdominal pain, chronic diarrhea, constipation, vomiting, gastroesophageal reflux, intestinal infections, and increas …

There is an emerging body of evidence associating children having autism spectrum disorder (ASD) with gastrointestinal …

199

Changes in the Gut Microbiota of Children with Autism Spectrum Disorder.

Zou R, Xu F, Wang Y, Duan M, Guo M, Zhang Q, Zhao H, Zheng H. Zou R, et al. Autism Res. 2020 Sep;13(9):1614-1625. doi: 10.1002/aur.2358. Epub 2020 Aug 24. Autism Res. 2020. PMID: 32830918

Alterations in the gut microbiota may influence gastrointestinal (GI) dysbiosis frequently reported in individuals with autism spectrum disorder (ASD). ...These findings suggest that a gut microbiome-associated therapeutic intervention ma …

Alterations in the gut microbiota may influence gastrointestinal (GI) dysbiosis frequently reported in individuals with aut …

200

Determinants of Leaky Gut and Gut Microbiota Differences in Children With Autism Spectrum Disorder and Their Siblings.

Yitik Tonkaz G, Esin IS, Turan B, Uslu H, Dursun OB. Yitik Tonkaz G, et al. J Autism Dev Disord. 2023 Jul;53(7):2703-2716. doi: 10.1007/s10803-022-05540-z. Epub 2022 Apr 20. J Autism Dev Disord. 2023. PMID: 35441922

Leaky gut hypothesis is one of the well-known theory which tries to explain etiology of Autism Spectrum Disorder (ASD). ...Biological markers of bacterial translocation showed a significant difference in the sibling group, whereas the marker indicating local …

Leaky gut hypothesis is one of the well-known theory which tries to explain etiology of Autism Spectrum Disorder (ASD). …

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