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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1840 2
1851 2
1862 1
1876 1
1879 1
1883 1
1884 2
1887 1
1888 2
1894 1
1898 1
1910 1
1911 1
1913 1
1946 1
1947 1
1951 2
1952 2
1954 2
1957 2
1961 1
1963 1
1964 3
1965 3
1966 2
1967 2
1968 1
1969 3
1970 3
1971 5
1972 4
1973 2
1974 4
1975 5
1976 4
1977 5
1978 1
1979 4
1980 5
1982 5
1983 1
1984 6
1985 2
1986 1
1987 3
1988 6
1989 3
1990 5
1991 2
1992 2
1993 2
1994 3
1995 2
1996 7
1997 5
1998 7
1999 3
2000 7
2001 5
2002 7
2003 4
2004 9
2005 13
2006 10
2007 9
2008 11
2009 9
2010 13
2011 6
2012 9
2013 14
2014 11
2015 19
2016 17
2017 18
2018 19
2019 43
2020 47
2021 43
2022 43
2023 38
2024 41
2025 44
2026 12

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610 results

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Page 1
Pharmacological prevention and treatment of opioid-induced constipation in cancer patients: A systematic review and meta-analysis.
Kistemaker KRJ, Sijani F, Brinkman DJ, de Graeff A, Burchell GL, Steegers MAH, van Zuylen L. Kistemaker KRJ, et al. Cancer Treat Rev. 2024 Apr;125:102704. doi: 10.1016/j.ctrv.2024.102704. Epub 2024 Mar 1. Cancer Treat Rev. 2024. PMID: 38452708 Free article.
BACKGROUND: Cancer-related pain often requires opioid treatment with opioid-induced constipation (OIC) as its most frequent gastrointestinal side-effect. Both for prevention and treatment of OIC osmotic (e.g. polyethylene glycol) and stimulant (e.g. bisacodyl) laxatives ar …
BACKGROUND: Cancer-related pain often requires opioid treatment with opioid-induced constipation (OIC) as its most frequent gastroint …
Opioid complications and side effects.
Benyamin R, Trescot AM, Datta S, Buenaventura R, Adlaka R, Sehgal N, Glaser SE, Vallejo R. Benyamin R, et al. Pain Physician. 2008 Mar;11(2 Suppl):S105-20. Pain Physician. 2008. PMID: 18443635 Free article. Review.
Common side effects of opioid administration include sedation, dizziness, nausea, vomiting, constipation, physical dependence, tolerance, and respiratory depression. Physical dependence and addiction are clinical concerns that may prevent proper prescribing and in turn ina …
Common side effects of opioid administration include sedation, dizziness, nausea, vomiting, constipation, physical dependence, tolera …
A brain-to-small intestine circuit mediates morphine-induced constipation in male mice.
Ma J, Peng X, Zhang M, Gao W, Yang X, Wang Z, Chai X, Zhang Z, Wang S, Cao P. Ma J, et al. Nat Commun. 2025 Dec 23;17(1):1023. doi: 10.1038/s41467-025-67765-7. Nat Commun. 2025. PMID: 41436468 Free PMC article.
Opioid-induced constipation is one of the most common and persistent side effect of opioid analgesics, yet the underlying neural mechanism(s) remain unclear. ...Chemogenetic activation of this circuit, as well as pharmacological inhibition or knockdown of the mu-opioid rec …
Opioid-induced constipation is one of the most common and persistent side effect of opioid analgesics, yet the underlying neural mech …
Naldemedine for Opioid-Induced Constipation in Patients With Cancer: A Multicenter, Double-Blind, Randomized, Placebo-Controlled Trial.
Hamano J, Higashibata T, Kessoku T, Kajiura S, Hirakawa M, Oyamada S, Ariyoshi K, Yamada T, Yamamoto Y, Takashima Y, Doki K, Homma M, Mathis BJ, Jono T, Ogata T, Tanaka K, Kasai Y, Iwaki M, Fuyuki A, Nakajima A, Hayashi R, Ando T, Izawa N, Kobayashi Y, Horie Y, Morita T. Hamano J, et al. J Clin Oncol. 2024 Dec 10;42(35):4206-4217. doi: 10.1200/JCO.24.00381. Epub 2024 Sep 10. J Clin Oncol. 2024. PMID: 39255425 Free PMC article. Clinical Trial.
PURPOSE: Opioid-induced constipation is the most frequent and non-self-limiting adverse effect of opioid analgesia, reducing adherence and interfering with pain relief. ...The frequency of SBM, QOL, and the severity of OINV were nominally significant in the naldemedine gro …
PURPOSE: Opioid-induced constipation is the most frequent and non-self-limiting adverse effect of opioid analgesia, reducing adherenc …
Habitual constipation.
MEISELAS DA. MEISELAS DA. Rev Gastroenterol. 1947 Aug;14(8):558-62. Rev Gastroenterol. 1947. PMID: 20253379 No abstract available.
Effects of Electroacupuncture for Opioid-Induced Constipation in Patients With Cancer in China: A Randomized Clinical Trial.
Wang W, Liu Y, Yang X, Sun J, Yue Z, Lu D, Zhou K, Sun Y, Hou A, Zang Z, Jin X, Liu C, Wang Y, Yu J, Zhu L, Liu Z. Wang W, et al. JAMA Netw Open. 2023 Feb 1;6(2):e230310. doi: 10.1001/jamanetworkopen.2023.0310. JAMA Netw Open. 2023. PMID: 36811861 Free PMC article. Clinical Trial.
IMPORTANCE: Opioid-induced constipation (OIC) is prevalent among patients treated with opioids for cancer pain. Safe and effective therapies for OIC in patients with cancer remain an unmet need. ...
IMPORTANCE: Opioid-induced constipation (OIC) is prevalent among patients treated with opioids for cancer pain. Safe and effective th …
Exploring Community Perspectives on Functional Paediatric Habitual Constipation.
Al Khashram N, Al Abdulqader AA, Alarfaj HM, Bu Bshait MS, Kamal AH, Zakaria OM, Albarqi MN, Almulhim MA, Almousa MA, Almaqhawi A. Al Khashram N, et al. Int J Environ Res Public Health. 2024 Aug 2;21(8):1017. doi: 10.3390/ijerph21081017. Int J Environ Res Public Health. 2024. PMID: 39200628 Free PMC article.
(1) Background: Functional habitual constipation (FC) in children is a common gastrointestinal problem. This study aimed to explore the local community's view on this problem, emphasising the challenges that parents face in managing the condition and its impact on t …
(1) Background: Functional habitual constipation (FC) in children is a common gastrointestinal problem. This study aimed to ex …
Preventing Opioid-Induced Constipation.
Ben Salem C, Ben Abdelkrim A, Ouni B. Ben Salem C, et al. JAMA Intern Med. 2021 May 1;181(5):726. doi: 10.1001/jamainternmed.2020.8894. JAMA Intern Med. 2021. PMID: 33616603 No abstract available.
[Habitual constipation].
Otrebski T. Otrebski T. Pieleg Polozna. 1974 Aug;0(8):7, 23. Pieleg Polozna. 1974. PMID: 4498339 Polish. No abstract available.
[Habitual constipation].
VASCONCELLOS D. VASCONCELLOS D. Hospital (Rio J). 1954 Sep;46(3):249-70. Hospital (Rio J). 1954. PMID: 13201100 Portuguese. No abstract available.
610 results