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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1987 2
1988 1
1989 1
1991 3
1996 2
1997 3
1998 4
1999 3
2000 3
2001 2
2002 2
2003 5
2004 5
2005 6
2006 1
2007 6
2008 2
2009 3
2010 4
2011 8
2012 2
2013 11
2014 4
2015 1
2016 3
2018 4
2019 3
2020 4
2021 7
2022 5
2023 3

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107 results

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Page 1
RNF168 regulates R-loop resolution and genomic stability in BRCA1/2-deficient tumors.
Patel PS, Abraham KJ, Guturi KKN, Halaby MJ, Khan Z, Palomero L, Ho B, Duan S, St-Germain J, Algouneh A, Mateo F, El Ghamrasni S, Barbour H, Barnes DR, Beesley J, Sanchez O, Berman HK, Brown GW, Affar EB, Chenevix-Trench G, Antoniou AC, Arrowsmith CH, Raught B, Pujana MA, Mekhail K, Hakem A, Hakem R. Patel PS, et al. Among authors: hakem r. J Clin Invest. 2021 Feb 1;131(3):e140105. doi: 10.1172/JCI140105. J Clin Invest. 2021. PMID: 33529165 Free PMC article.
The metabolic enzyme hexokinase 2 localizes to the nucleus in AML and normal haematopoietic stem and progenitor cells to maintain stemness.
Thomas GE, Egan G, García-Prat L, Botham A, Voisin V, Patel PS, Hoff FW, Chin J, Nachmias B, Kaufmann KB, Khan DH, Hurren R, Wang X, Gronda M, MacLean N, O'Brien C, Singh RP, Jones CL, Harding SM, Raught B, Arruda A, Minden MD, Bader GD, Hakem R, Kornblau S, Dick JE, Schimmer AD. Thomas GE, et al. Among authors: hakem r. Nat Cell Biol. 2022 Jun;24(6):872-884. doi: 10.1038/s41556-022-00925-9. Epub 2022 Jun 6. Nat Cell Biol. 2022. PMID: 35668135 Free PMC article.
Ptpn6 inhibits caspase-8- and Ripk3/Mlkl-dependent inflammation.
Speir M, Nowell CJ, Chen AA, O'Donnell JA, Shamie IS, Lakin PR, D'Cruz AA, Braun RO, Babon JJ, Lewis RS, Bliss-Moreau M, Shlomovitz I, Wang S, Cengia LH, Stoica AI, Hakem R, Kelliher MA, O'Reilly LA, Patsiouras H, Lawlor KE, Weller E, Lewis NE, Roberts AW, Gerlic M, Croker BA. Speir M, et al. Among authors: hakem r. Nat Immunol. 2020 Jan;21(1):54-64. doi: 10.1038/s41590-019-0550-7. Epub 2019 Dec 9. Nat Immunol. 2020. PMID: 31819256 Free PMC article.
Nucleolar RNA polymerase II drives ribosome biogenesis.
Abraham KJ, Khosraviani N, Chan JNY, Gorthi A, Samman A, Zhao DY, Wang M, Bokros M, Vidya E, Ostrowski LA, Oshidari R, Pietrobon V, Patel PS, Algouneh A, Singhania R, Liu Y, Yerlici VT, De Carvalho DD, Ohh M, Dickson BC, Hakem R, Greenblatt JF, Lee S, Bishop AJR, Mekhail K. Abraham KJ, et al. Among authors: hakem r. Nature. 2020 Sep;585(7824):298-302. doi: 10.1038/s41586-020-2497-0. Epub 2020 Jul 15. Nature. 2020. PMID: 32669707 Free PMC article.
Emerging roles of DNA topoisomerases in the regulation of R-loops.
Patel PS, Krishnan R, Hakem R. Patel PS, et al. Among authors: hakem r. Mutat Res Genet Toxicol Environ Mutagen. 2022 Apr-May;876-877:503450. doi: 10.1016/j.mrgentox.2022.503450. Epub 2022 Jan 20. Mutat Res Genet Toxicol Environ Mutagen. 2022. PMID: 35483781 Review.
Modification of BRCA1-associated breast cancer risk by HMMR overexpression.
Mateo F, He Z, Mei L, de Garibay GR, Herranz C, García N, Lorentzian A, Baiges A, Blommaert E, Gómez A, Mirallas O, Garrido-Utrilla A, Palomero L, Espín R, Extremera AI, Soler-Monsó MT, Petit A, Li R, Brunet J, Chen K, Tan S, Eaves CJ, McCloskey C, Hakem R, Khokha R, Lange PF, Lázaro C, Maxwell CA, Pujana MA. Mateo F, et al. Among authors: hakem r. Nat Commun. 2022 Apr 7;13(1):1895. doi: 10.1038/s41467-022-29335-z. Nat Commun. 2022. PMID: 35393420 Free PMC article.
BRCA1 and Metastasis: Outcome of Defective DNA Repair.
Krishnan R, Patel PS, Hakem R. Krishnan R, et al. Among authors: hakem r. Cancers (Basel). 2021 Dec 27;14(1):108. doi: 10.3390/cancers14010108. Cancers (Basel). 2021. PMID: 35008272 Free PMC article. Review.
Immune Cell Associations with Cancer Risk.
Palomero L, Galván-Femenía I, de Cid R, Espín R, Barnes DR, Cimba, Blommaert E, Gil-Gil M, Falo C, Stradella A, Ouchi D, Roso-Llorach A, Violan C, Peña-Chilet M, Dopazo J, Extremera AI, García-Valero M, Herranz C, Mateo F, Mereu E, Beesley J, Chenevix-Trench G, Roux C, Mak T, Brunet J, Hakem R, Gorrini C, Antoniou AC, Lázaro C, Pujana MA. Palomero L, et al. Among authors: hakem r. iScience. 2020 Jul 24;23(7):101296. doi: 10.1016/j.isci.2020.101296. Epub 2020 Jun 20. iScience. 2020. PMID: 32622267 Free PMC article.
Animal models of tumor-suppressor genes.
Hakem R, Mak TW. Hakem R, et al. Annu Rev Genet. 2001;35:209-41. doi: 10.1146/annurev.genet.35.102401.090432. Annu Rev Genet. 2001. PMID: 11700283 Review.
107 results