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Year Number of Results
2006 1
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67 results

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Page 1
Loss of tolerance precedes triggering and lifelong persistence of pathogenic type I interferon autoantibodies.
Fernbach S, Mair NK, Abela IA, Groen K, Kuratli R, Lork M, Thorball CW, Bernasconi E, Filippidis P, Leuzinger K, Notter J, Rauch A, Hirsch HH, Huber M, Günthard HF, Fellay J, Kouyos RD, Hale BG; Swiss HIV Cohort Study. Fernbach S, et al. Among authors: hale bg. J Exp Med. 2024 Sep 2;221(9):e20240365. doi: 10.1084/jem.20240365. Epub 2024 Jul 17. J Exp Med. 2024. PMID: 39017930 Free PMC article.
Type I interferon autoantibody footprints reveal neutralizing mechanisms and allow inhibitory decoy design.
Groen K, Kuratli R, Enkelmann J, Fernbach S, Wendel-Garcia PD, Staiger WI, Lejeune M, Sauras-Colón E, Roche-Campo F, Filippidis P, Rauch A; Swiss HIV Cohort Study; Trkola A, Günthard HF, Kouyos RD, Brugger SD, Hale BG. Groen K, et al. Among authors: hale bg. J Exp Med. 2025 Jun 2;222(6):e20242039. doi: 10.1084/jem.20242039. Epub 2025 Mar 20. J Exp Med. 2025. PMID: 40111224 Free PMC article.
TRIM28 is a target for paramyxovirus V proteins.
Lieber G, Kwaschik F, Lork M, Schmidt N, Hale BG. Lieber G, et al. Among authors: hale bg. PLoS Pathog. 2025 Sep 8;21(9):e1013487. doi: 10.1371/journal.ppat.1013487. eCollection 2025 Sep. PLoS Pathog. 2025. PMID: 40920817 Free PMC article.
Here, we reveal that V proteins from diverse paramyxoviruses, including Measles, Mumps, Parainfluenza, and Nipah/Hendra viruses, can all engage with TRIM28. Notably, the efficiency of engagement varies markedly between virus species, a phenotype that can be linked t …
Here, we reveal that V proteins from diverse paramyxoviruses, including Measles, Mumps, Parainfluenza, and Nipah/Hendra viruses, can …
Influenza A virus NS1 protein mimics oncogenic PI3K resulting in isoform specific cellular redistribution and activation.
Aslam S, Sánchez-Aparicio MT, Siempelkamp BD, Dornan GL, Tsolakos N, Burke JE, Hale BG, García-Sastre A, Ayllon J. Aslam S, et al. Among authors: hale bg. Proc Natl Acad Sci U S A. 2025 Aug 12;122(32):e2423066122. doi: 10.1073/pnas.2423066122. Epub 2025 Aug 4. Proc Natl Acad Sci U S A. 2025. PMID: 40758871 Free PMC article.
The nonstructural protein 1 (NS1) of influenza A virus performs a broad variety of proviral activities in the infected cell, primarily mediating evasion from the host innate immune response by being the main viral interferon antagonist. ...We found that clinically relevant …
The nonstructural protein 1 (NS1) of influenza A virus performs a broad variety of proviral activities in the infected cell, primaril …
Regulated localization of transposable element RNA during influenza A virus infection.
Lork M, Childs L, Lieber G, Kwaschik F, König R, Hale BG. Lork M, et al. Among authors: hale bg. EMBO Rep. 2025 Jul;26(14):3506-3528. doi: 10.1038/s44319-025-00498-2. Epub 2025 Jun 16. EMBO Rep. 2025. PMID: 40523985 Free PMC article.
Influenza A virus (IAV) infection triggers derepression of host transposable elements (TEs), which have the potential to form double-stranded (ds)RNAs and could enhance innate antiviral immunity. ...
Influenza A virus (IAV) infection triggers derepression of host transposable elements (TEs), which have the potential to form double- …
Antiviral immunity triggered by infection-induced host transposable elements.
Hale BG. Hale BG. Curr Opin Virol. 2022 Feb;52:211-216. doi: 10.1016/j.coviro.2021.12.006. Epub 2021 Dec 24. Curr Opin Virol. 2022. PMID: 34959082 Free article. Review.
Host silencing of transposable elements (TEs) is critical to prevent genome damage and inappropriate inflammation. However, new evidence suggests that a virus-infected host may re-activate TEs and co-opt them for antiviral defense. RNA-Seq and specialized bioinformatics ha …
Host silencing of transposable elements (TEs) is critical to prevent genome damage and inappropriate inflammation. However, new evidence sug …
Interferon system deficiencies exacerbating severe pandemic virus infections.
Stertz S, Hale BG. Stertz S, et al. Among authors: hale bg. Trends Microbiol. 2021 Nov;29(11):973-982. doi: 10.1016/j.tim.2021.03.001. Epub 2021 Mar 20. Trends Microbiol. 2021. PMID: 33757684 Free PMC article. Review.
An emerging concept is that genetic and non-genetic deficiencies in interferon system components lead to uncontrolled virus replication and severe illness in a subset of people. Intriguingly, new findings suggest that individuals with autoantibodies neutralizing the antivi …
An emerging concept is that genetic and non-genetic deficiencies in interferon system components lead to uncontrolled virus replicati …
Proteomic Approaches to Dissect Host SUMOylation during Innate Antiviral Immune Responses.
Lork M, Lieber G, Hale BG. Lork M, et al. Among authors: hale bg. Viruses. 2021 Mar 23;13(3):528. doi: 10.3390/v13030528. Viruses. 2021. PMID: 33806893 Free PMC article. Review.
SUMOylation is a highly dynamic ubiquitin-like post-translational modification that is essential for cells to respond to and resolve various genotoxic and proteotoxic stresses. Virus infections also constitute a considerable stress scenario for cells, and recent research h …
SUMOylation is a highly dynamic ubiquitin-like post-translational modification that is essential for cells to respond to and resolve various …
67 results