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Harzianic Acid Activity against Staphylococcus aureus and Its Role in Calcium Regulation.
Staropoli A, Cuomo P, Salvatore MM, De Tommaso G, Iuliano M, Andolfi A, Tenore GC, Capparelli R, Vinale F. Staropoli A, et al. Toxins (Basel). 2023 Mar 24;15(4):237. doi: 10.3390/toxins15040237. Toxins (Basel). 2023. PMID: 37104175 Free PMC article.
Then, we demonstrate that harzianic acid significantly modulates Ca(2+) increase in HaCaT (human keratinocytes) cells incubated with S. aureus. In conclusion, this study suggests harzianic acid as a promising therapeutical alternative against diseases associated wit …
Then, we demonstrate that harzianic acid significantly modulates Ca(2+) increase in HaCaT (human keratinocytes) cells incubated with …
Harzianic acids and oxazolidinone from the endophytic fungus Ilyonectria sp. and their cytotoxicity activity.
Tong SY, Ye K, Wang WX, Ai HL. Tong SY, et al. Fitoterapia. 2024 Jun;175:105941. doi: 10.1016/j.fitote.2024.105941. Epub 2024 Apr 2. Fitoterapia. 2024. PMID: 38575089
Four undescribed compounds including three harzianic acids (1, 3 and 4) and one oxazolidinone (2), along with three known ones (5-7) were isolated from the solid fermented product of endophytic fungus Ilyonectria sp., their structures were elucidated as 1-amino-harziani …
Four undescribed compounds including three harzianic acids (1, 3 and 4) and one oxazolidinone (2), along with three known ones (5-7) …
Harzianic acid exerts antimicrobial activity against Gram-positive bacteria and targets the cell membrane.
Ouyang X, Hoeksma J, Beenker WAG, van der Beek S, den Hertog J. Ouyang X, et al. Front Microbiol. 2024 Jan 29;15:1332774. doi: 10.3389/fmicb.2024.1332774. eCollection 2024. Front Microbiol. 2024. PMID: 38348189 Free PMC article.
Here, we identified a Gram-positive bacteria-selective antimicrobial secondary metabolite from this fungal species, harzianic acid (HA). Using Bacillus subtilis strain 168 combined with dynamic bacterial morphology imaging, we found that HA targeted the cell membrane. ...
Here, we identified a Gram-positive bacteria-selective antimicrobial secondary metabolite from this fungal species, harzianic acid (H …
Antimicrobial activity of harzianic acid against Staphylococcus pseudintermedius.
De Filippis A, Nocera FP, Tafuri S, Ciani F, Staropoli A, Comite E, Bottiglieri A, Gioia L, Lorito M, Woo SL, Vinale F, De Martino L. De Filippis A, et al. Nat Prod Res. 2021 Dec;35(23):5440-5445. doi: 10.1080/14786419.2020.1779714. Epub 2020 Jun 15. Nat Prod Res. 2021. PMID: 32538678
Bioassay-guided fractionation of E45 and ET45 extracts allowed to isolate harzianic acid as the major compound responsible for biological activities (e.g. antimicrobial, antibiofilm formation and biofilm disaggregation)....
Bioassay-guided fractionation of E45 and ET45 extracts allowed to isolate harzianic acid as the major compound responsible for biolog …
Harzianic Acid from Trichoderma afroharzianum Is a Natural Product Inhibitor of Acetohydroxyacid Synthase.
Xie L, Zang X, Cheng W, Zhang Z, Zhou J, Chen M, Tang Y. Xie L, et al. J Am Chem Soc. 2021 Jun 30;143(25):9575-9584. doi: 10.1021/jacs.1c03988. Epub 2021 Jun 16. J Am Chem Soc. 2021. PMID: 34132537 Free PMC article.
Acetohydroxyacid synthase (AHAS) is the first enzyme in the branched-chain amino acid biosynthetic pathway and is a validated target for herbicide and fungicide development. Here we report harzianic acid (HA, 1) produced by the biocontrol fungus Trichoderma afroharzianum t …
Acetohydroxyacid synthase (AHAS) is the first enzyme in the branched-chain amino acid biosynthetic pathway and is a validated target for her …
Harzianic acid: a novel siderophore from Trichoderma harzianum.
Vinale F, Nigro M, Sivasithamparam K, Flematti G, Ghisalberti EL, Ruocco M, Varlese R, Marra R, Lanzuise S, Eid A, Woo SL, Lorito M. Vinale F, et al. FEMS Microbiol Lett. 2013 Oct;347(2):123-9. doi: 10.1111/1574-6968.12231. Epub 2013 Sep 10. FEMS Microbiol Lett. 2013. PMID: 23909277
Many different strains of the genus Trichoderma, in addition to a direct activity against phytopathogens, are well-known producers of secondary metabolites and compounds that substantially affect the metabolism of the host plant. Harzianic acid is a Trichoderma secondary m …
Many different strains of the genus Trichoderma, in addition to a direct activity against phytopathogens, are well-known producers of second …
Harzianic acid, an antifungal and plant growth promoting metabolite from Trichoderma harzianum.
Vinale F, Flematti G, Sivasithamparam K, Lorito M, Marra R, Skelton BW, Ghisalberti EL. Vinale F, et al. J Nat Prod. 2009 Nov;72(11):2032-5. doi: 10.1021/np900548p. J Nat Prod. 2009. PMID: 19894739
The structure and absolute configuration of the fungal compound, harzianic acid (1), were determined by X-ray diffraction studies. Harzianic acid showed antibiotic activity against Pythium irregulare, Sclerotinia sclerotiorum, and Rhizoctonia solani. ...
The structure and absolute configuration of the fungal compound, harzianic acid (1), were determined by X-ray diffraction studies. …
Interaction of the Fungal Metabolite Harzianic Acid with Rare-Earth Cations (Pr(3+), Eu(3+), Ho(3+), Tm(3+)).
Salvatore MM, Siciliano A, Staropoli A, Vinale F, Nicoletti R, DellaGreca M, Guida M, Salvatore F, Iuliano M, Andolfi A, De Tommaso G. Salvatore MM, et al. Molecules. 2022 Oct 1;27(19):6468. doi: 10.3390/molecules27196468. Molecules. 2022. PMID: 36235005 Free PMC article.
Therefore, in the current study, HPLC-ESI-HRMS experiments, circular dichroism (CD), and UV-Vis spectrophotometric absorption data, as well as accurate pH measurements, were applied to characterize bonding interactions between harzianic acid and Pr(3+), Eu(3+), Ho(3+), and …
Therefore, in the current study, HPLC-ESI-HRMS experiments, circular dichroism (CD), and UV-Vis spectrophotometric absorption data, as well …
Interaction of the Fungal Metabolite Harzianic Acid with Rare-Earth Cations (La(3+), Nd(3+), Sm(3+), Gd(3+)).
De Tommaso G, Salvatore MM, Siciliano A, Staropoli A, Vinale F, Nicoletti R, DellaGreca M, Guida M, Salvatore F, Iuliano M, Andolfi A. De Tommaso G, et al. Molecules. 2022 Mar 17;27(6):1959. doi: 10.3390/molecules27061959. Molecules. 2022. PMID: 35335320 Free PMC article.
Within this framework, coordination by harzianic acid (H(2)L), a Trichoderma secondary metabolite, of a selection of tripositive rare-earth cations Ln(3+) (Ln(3+) = La(3+), Nd(3+), Sm(3+,) and Gd(3+)) was investigated at 25 C, and in a CH(3)OH/0.1 M NaClO(4) (50/50 w/w) s …
Within this framework, coordination by harzianic acid (H(2)L), a Trichoderma secondary metabolite, of a selection of tripositive rare …
Bivalent Metal-Chelating Properties of Harzianic Acid Produced by Trichoderma pleuroticola Associated to the Gastropod Melarhaphe neritoides.
De Tommaso G, Salvatore MM, Nicoletti R, DellaGreca M, Vinale F, Bottiglieri A, Staropoli A, Salvatore F, Lorito M, Iuliano M, Andolfi A. De Tommaso G, et al. Molecules. 2020 May 4;25(9):2147. doi: 10.3390/molecules25092147. Molecules. 2020. PMID: 32375327 Free PMC article.
Harzianic acid is a secondary metabolite of Trichoderma, structurally belonging to the dienyltetramic acid subgroup of the tetramic acids. Biological activities of harzianic acid are of great interest for its antimicrobial and plant growth-promoting activities, whic …
Harzianic acid is a secondary metabolite of Trichoderma, structurally belonging to the dienyltetramic acid subgroup of the tetramic a …
33 results