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114 results

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Page 1
Hyperoside modulates bile acid and fatty acid metabolism, presenting a potentially promising treatment for non-alcoholic fatty liver disease.
Wang S, Jia Q, Liu X, Ma Y, Yang Y, Rong X, Wang Y, Wang H, Liu F, Yang S, Li Y, Han L. Wang S, et al. J Adv Res. 2026 Feb;80:759-773. doi: 10.1016/j.jare.2025.05.014. Epub 2025 May 9. J Adv Res. 2026. PMID: 40349961 Free PMC article.
Hyperoside, a natural flavone glycoside found in Cuscuta chinensis Lam, Forsythia suspensa, and Crataegus pinnatifida Bge, has been shown to effectively mitigate NAFLD in rats. However, the underlying mechanism through which hyperoside alleviates NAFLD remains uncle …
Hyperoside, a natural flavone glycoside found in Cuscuta chinensis Lam, Forsythia suspensa, and Crataegus pinnatifida Bge, has been s …
Uncovering the Mechanism of Chinese Hawthorn Leaf on Myocardial Ischemia Based on Network Pharmacology, Molecular Docking Verification, and In Vitro Studies.
Gao J, Wang Y, Xiong H, Zhao S, He M, He M, Pan H. Gao J, et al. Cardiovasc Toxicol. 2024 Feb;24(2):171-183. doi: 10.1007/s12012-024-09825-w. Epub 2024 Feb 20. Cardiovasc Toxicol. 2024. PMID: 38376772
Hawthorn leaf has shown therapeutic effects in the patients with myocardial ischemia. Our study combines network pharmacology, molecular docking techniques, and in vitro experiment with the aim of revealing the mechanism of hawthorn leaves in the treatment of …
Hawthorn leaf has shown therapeutic effects in the patients with myocardial ischemia. Our study combines network pharmacology, molecu …
Hyperoside induces ferroptosis in chronic myeloid leukemia cells by targeting NRF2.
Wei J, Chai Q, Qin Y, Li L, Guo C, Lu Z, Liu H. Wei J, et al. Mol Med. 2024 Nov 21;30(1):224. doi: 10.1186/s10020-024-01002-7. Mol Med. 2024. PMID: 39573995 Free PMC article.
BACKGROUND: Hyperoside (quercetin-3-O-beta-D-galactopyranoside) is a flavonol glycoside compound derived from plants in the Hypericum and Crataegus genera that reportedly exhibits an array of anti-inflammatory, antioxidant, and antitumor properties such that it has …
BACKGROUND: Hyperoside (quercetin-3-O-beta-D-galactopyranoside) is a flavonol glycoside compound derived from plants in the Hypericum and …
Structural characterisation of hawthorn polysaccharide and its mechanisms of action against non-alcoholic fatty liver disease.
Zhang Y, Sun J, Zhang X, Zhong Q, Hao P, Yin W, Chen B, Wei Q, Shen H, Zhang Y, Yang X, Yu X, Wu X, Qu W, Wu Y. Zhang Y, et al. Int J Biol Macromol. 2025 Aug;319(Pt 4):145713. doi: 10.1016/j.ijbiomac.2025.145713. Epub 2025 Jul 2. Int J Biol Macromol. 2025. PMID: 40614996
Non-alcoholic fatty liver disease (NAFLD) represents a significant health risk to humans; however, effective pharmacological treatments are currently unavailable. Hawthorn polysaccharide (HP) possesses a range of beneficial properties that enhance cardiovascular health, di …
Non-alcoholic fatty liver disease (NAFLD) represents a significant health risk to humans; however, effective pharmacological treatments are …
Hawthorn fruit attenuates atherosclerosis by improving the hypolipidemic and antioxidant activities in apolipoprotein e-deficient mice.
Zhang Y, Zhang L, Geng Y, Geng Y. Zhang Y, et al. J Atheroscler Thromb. 2014;21(2):119-28. doi: 10.5551/jat.19174. Epub 2013 Oct 11. J Atheroscler Thromb. 2014. PMID: 24126122 Free article.
AIMS: The protective effects of hawthorn fruit against atherosclerosis and the potential underlying mechanisms of this fruit in improving the hypolipidemic and antioxidant activities were investigated in apolipoprotein E-deficient(apoE(-/-)) mice. ...CONCLUSI …
AIMS: The protective effects of hawthorn fruit against atherosclerosis and the potential underlying mechanisms of this fruit i …
Hawthorn leaf flavonoids alleviate the deterioration of atherosclerosis by inhibiting SCAP-SREBP2-LDLR pathway through sPLA2- A signaling in macrophages in mice.
Bai X, Wang S, Shu L, Cao Q, Hu H, Zhu Y, Chen C. Bai X, et al. J Ethnopharmacol. 2024 Jun 12;327:118006. doi: 10.1016/j.jep.2024.118006. Epub 2024 Mar 3. J Ethnopharmacol. 2024. PMID: 38442806
ETHNOPHARMACOLOGICAL RELEVANCE: Hawthorn leaves are a combination of the dried leaves of the Rosaceae plants, i.e., Crataegus pinnatifida Bge. or Crataegus pinnatifida Bge. var. major N. ...Br., is primarily cultivated in East Asia, North America, and Europe. …
ETHNOPHARMACOLOGICAL RELEVANCE: Hawthorn leaves are a combination of the dried leaves of the Rosaceae plants, i.e., Crataegus …
Study on the hypotensive effect and mechanism of hawthorn (Crataegus pinnatifida) fruits and hyperoside in spontaneously hypertensive rats.
Chi B, Zhang M, Sun L, Liu H, Tian Z. Chi B, et al. Food Funct. 2024 May 20;15(10):5627-5640. doi: 10.1039/d3fo02641h. Food Funct. 2024. PMID: 38722076
However, their hypotensive effects and potential mechanisms of anti-hypertension still need to be elucidated. This study aims to explore the antihypertensive effect of hawthorn and its monomer hyperoside on spontaneously hypertensive rats through pharmacodynamics, s …
However, their hypotensive effects and potential mechanisms of anti-hypertension still need to be elucidated. This study aims to expl …
UPLC-ESI-QTRAP-MS/MS identification and antioxidant activity of hawthorn with different infestation levels.
Cheng Y, Liu Z, Yang J, Chao Z. Cheng Y, et al. BMC Chem. 2025 Aug 31;19(1):256. doi: 10.1186/s13065-025-01611-1. BMC Chem. 2025. PMID: 40887638 Free PMC article.
This study employed UPLC-ESI-QTRAP-MS/MS metabolomics technology (MRM mode) to analyze two hawthorn varieties infested by Plodia interpunctella (Hub.) and Tribolium castaneum (Hbst.) at different infestation levels (3 biological replicates per treatment), aiming to investi …
This study employed UPLC-ESI-QTRAP-MS/MS metabolomics technology (MRM mode) to analyze two hawthorn varieties infested by Plodia inte …
Vitexin alleviates MNNG-induced chronic atrophic gastritis via inhibiting NLRP3 inflammasome.
Liu J, Chen Y, Zhang J, Zheng Y, An Y, Xia C, Chen Y, Huang S, Hou S, Deng D. Liu J, et al. J Ethnopharmacol. 2025 Jan 31;340:119272. doi: 10.1016/j.jep.2024.119272. Epub 2024 Dec 21. J Ethnopharmacol. 2025. PMID: 39716512
ETHNOPHARMACOLOGICAL RELEVANCE: The dried fruit of Crataegus pinnatifida Bunge (Hawthorn in Chinese) is a traditional medicine used in China, Japan and Korea for thousands of years. ...Vitexin, a flavonoid glycoside, is an important biologically active compound deri …
ETHNOPHARMACOLOGICAL RELEVANCE: The dried fruit of Crataegus pinnatifida Bunge (Hawthorn in Chinese) is a traditional medicine …
Hyperoside extends lifespan in Caenorhabditis elegans through SEK-1/PMK-1/SKN-1 pathway.
Yu XT, Shi L, Huang Q, Li B, Li YQ, Ou LL, Luo HR, Wu GS. Yu XT, et al. Biogerontology. 2025 Sep 19;26(5):180. doi: 10.1007/s10522-025-10322-y. Biogerontology. 2025. PMID: 40973886
Hyperoside, a flavonoid abundant in edible plants such as hawthorn, possesses various pharmacological activities, but its specific role and molecular mechanisms in geroprotection remain poorly understood. This study aimed to elucidate the anti-aging effects of hyper …
Hyperoside, a flavonoid abundant in edible plants such as hawthorn, possesses various pharmacological activities, but its specific ro …
114 results