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71 results

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Page 1
Topical phage therapy in a mouse model of Cutibacterium acnes-induced acne-like lesions.
Rimon A, Rakov C, Lerer V, Sheffer-Levi S, Oren SA, Shlomov T, Shasha L, Lubin R, Zubeidat K, Jaber N, Mujahed M, Wilensky A, Coppenhagen-Glazer S, Molho-Pessach V, Hazan R. Rimon A, et al. Among authors: hazan r. Nat Commun. 2023 Feb 22;14(1):1005. doi: 10.1038/s41467-023-36694-8. Nat Commun. 2023. PMID: 36813793 Free PMC article.
For decades, antibiotics have been widely employed to treat acne vulgaris, inevitably resulting in increased bacterial antibiotic resistance. Phage therapy is a promising strategy to combat the growing challenge of antibiotic-resistant bacteria, utilizing viruses th …
For decades, antibiotics have been widely employed to treat acne vulgaris, inevitably resulting in increased bacterial antibiotic resistance …
Alternative antimicrobial approach: nano-antimicrobial materials.
Beyth N, Houri-Haddad Y, Domb A, Khan W, Hazan R. Beyth N, et al. Among authors: hazan r. Evid Based Complement Alternat Med. 2015;2015:246012. doi: 10.1155/2015/246012. Epub 2015 Mar 16. Evid Based Complement Alternat Med. 2015. PMID: 25861355 Free PMC article. Review.
The present review discusses the activities of nanoparticles as an antimicrobial means, their mode of action, nanoparticle effect on drug-resistant bacteria, and the risks attendant on their use as antibacterial agents. Factors contributing to nanoparticle performance in t …
The present review discusses the activities of nanoparticles as an antimicrobial means, their mode of action, nanoparticle effect on drug-re …
Phage Therapy: A New Horizon in the Antibacterial Treatment of Oral Pathogens.
Shlezinger M, Khalifa L, Houri-Haddad Y, Coppenhagen-Glazer S, Resch G, Que YA, Beyth S, Dorfman E, Hazan R, Beyth N. Shlezinger M, et al. Among authors: hazan r. Curr Top Med Chem. 2017;17(10):1199-1211. doi: 10.2174/1568026616666160930145649. Curr Top Med Chem. 2017. PMID: 27770768 Review.
A promising alternative approach is bacteriophage (phage) therapy. Phages play a key role in the natural balance in a predator-prey relationship with bacteria and thus have the potential to be efficient anti-bacterial agents. Phages are highly e …
A promising alternative approach is bacteriophage (phage) therapy. Phages play a key role in the natural balance in a p …
Phage Therapy in Israel, Past, Present, and Future.
Rimon A, Gelman D, Yerushalmy O, Coppenhagen-Glazer S, Katvan E, Nir-Paz R, Hazan R. Rimon A, et al. Among authors: hazan r. Phage (New Rochelle). 2022 Jun 1;3(2):85-94. doi: 10.1089/phage.2022.0010. Epub 2022 Jun 16. Phage (New Rochelle). 2022. PMID: 36157284 Free PMC article. Review.
The fascinating scientific history of phage therapy has been documented in numerous publications. In this study, however, we focus on an angle of the story that hitherto has remained relatively neglected, namely, phage therapy treatments, and the protagonists that c …
The fascinating scientific history of phage therapy has been documented in numerous publications. In this study, however, we focus on …
Clinical Phage Microbiology: a suggested framework and recommendations for the in-vitro matching steps of phage therapy.
Gelman D, Yerushalmy O, Alkalay-Oren S, Rakov C, Ben-Porat S, Khalifa L, Adler K, Abdalrhman M, Coppenhagen-Glazer S, Aslam S, Schooley RT, Nir-Paz R, Hazan R. Gelman D, et al. Among authors: hazan r. Lancet Microbe. 2021 Oct;2(10):e555-e563. doi: 10.1016/S2666-5247(21)00127-0. Epub 2021 Aug 16. Lancet Microbe. 2021. PMID: 35544180 Free article. Review.
In this Personal View, we suggest a framework aimed to match appropriate bacteriophage-based treatments in clinical microbiology laboratories. This framework, which we have termed Clinical Phage Microbiology, is based on the current research on phag …
In this Personal View, we suggest a framework aimed to match appropriate bacteriophage-based treatments in clinical microbiology …
The Israeli Phage Bank (IPB).
Yerushalmy O, Khalifa L, Gold N, Rakov C, Alkalay-Oren S, Adler K, Ben-Porat S, Kraitman R, Gronovich N, Shulamit Ginat K, Abdalrhman M, Coppenhagen-Glazer S, Nir-Paz R, Hazan R. Yerushalmy O, et al. Among authors: hazan r. Antibiotics (Basel). 2020 May 21;9(5):269. doi: 10.3390/antibiotics9050269. Antibiotics (Basel). 2020. PMID: 32455557 Free PMC article.
These phage banks serve for both research and clinical purposes. Phage banks are also a key element in clinical phage microbiology, the prior treatment matching of phages and antibiotics to specific bacterial targets. A worldwide network of p …
These phage banks serve for both research and clinical purposes. Phage banks are also a key element in clinical phage …
Towards Standardization of Phage Susceptibility Testing: The Israeli Phage Therapy Center "Clinical Phage Microbiology"-A Pipeline Proposal.
Yerushalmy O, Braunstein R, Alkalay-Oren S, Rimon A, Coppenhagn-Glazer S, Onallah H, Nir-Paz R, Hazan R. Yerushalmy O, et al. Among authors: hazan r. Clin Infect Dis. 2023 Nov 2;77(Suppl 5):S337-S351. doi: 10.1093/cid/ciad514. Clin Infect Dis. 2023. PMID: 37932122 Review.
Given the high specificity of phages, selecting the suitable phage(s) targeting the causative bacteria becomes critical for achieving treatment success. ...This review discusses and compares published methods for clinical phage microbiology …
Given the high specificity of phages, selecting the suitable phage(s) targeting the causative bacteria becomes c …
Successful phage-antibiotic therapy of P. aeruginosa implant-associated infection in a Siamese cat.
Braunstein R, Hubanic G, Yerushalmy O, Oren-Alkalay S, Rimon A, Coppenhagen-Glazer S, Niv O, Marom H, Barsheshet A, Hazan R. Braunstein R, et al. Among authors: hazan r. Vet Q. 2024 Dec;44(1):1-9. doi: 10.1080/01652176.2024.2350661. Epub 2024 May 10. Vet Q. 2024. PMID: 38726795 Free PMC article.
Antibiotic-resistant pathogens are a growing global issue, leading to untreatable infectious diseases in both humans and animals. Personalized bacteriophage (phage) therapy, the use of specific anti-bacterial viruses, is currently a leading approach to combat antibi …
Antibiotic-resistant pathogens are a growing global issue, leading to untreatable infectious diseases in both humans and animals. Personaliz …
Expanding clinical phage microbiology: simulating phage inhalation for respiratory tract infections.
Ben Porat S, Gelman D, Yerushalmy O, Alkalay-Oren S, Coppenhagen-Glazer S, Cohen-Cymberknoh M, Kerem E, Amirav I, Nir-Paz R, Hazan R. Ben Porat S, et al. Among authors: hazan r. ERJ Open Res. 2021 Nov 8;7(4):00367-2021. doi: 10.1183/23120541.00367-2021. eCollection 2021 Oct. ERJ Open Res. 2021. PMID: 34760998 Free PMC article.
Here we present an in vitro model to evaluate phage inhalation. Eight phages, most of which target pathogens common in cystic fibrosis, were aerosolised by jet nebuliser and administered to a real-scale computed tomography-derived 3D airways model with a breathing s …
Here we present an in vitro model to evaluate phage inhalation. Eight phages, most of which target pathogens common in cystic …
The history and promising future of phage therapy in the military service.
Gelman D, Eisenkraft A, Chanishvili N, Nachman D, Coppenhagem Glazer S, Hazan R. Gelman D, et al. Among authors: hazan r. J Trauma Acute Care Surg. 2018 Jul;85(1S Suppl 2):S18-S26. doi: 10.1097/TA.0000000000001809. J Trauma Acute Care Surg. 2018. PMID: 29370056 Review.
These strains, frequently isolated from military-associated environments, have created an urgent need to develop supplementary anti-infective modalities. One of the leading directions is phage therapy, which includes the administration of bacteriophages, viruses tha …
These strains, frequently isolated from military-associated environments, have created an urgent need to develop supplementary anti-infectiv …
71 results