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3,710 results

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Page 1
Engineering Heart Morphogenesis.
Mandrycky CJ, Williams NP, Batalov I, El-Nachef D, de Bakker BS, Davis J, Kim DH, DeForest CA, Zheng Y, Stevens KR, Sniadecki NJ. Mandrycky CJ, et al. Trends Biotechnol. 2020 Aug;38(8):835-845. doi: 10.1016/j.tibtech.2020.01.006. Epub 2020 Mar 5. Trends Biotechnol. 2020. PMID: 32673587 Free PMC article. Review.
Here, we re-examine heart tube looping through the lens of an engineer and argue that the linear heart tube is an advantageous starting point for tissue engineering. We summarize the structures, signaling pathways, and stresses in the looping heart …
Here, we re-examine heart tube looping through the lens of an engineer and argue that the linear heart tube is an advan …
Plasticity of ventricle position after heart looping in heterotaxy with right isomerism.
Desgrange A, Perthame E, Marchiol C, Madec D, Guillemot L, Chabry MA, El Beheiry M, Masson JB, Raisky O, Bernheim S, Houyel L, Meilhac SM. Desgrange A, et al. Sci Adv. 2025 Sep 19;11(38):eads8192. doi: 10.1126/sciadv.ads8192. Epub 2025 Sep 19. Sci Adv. 2025. PMID: 40971441 Free PMC article.
In the heterotaxy syndrome, abnormal left-right patterning leads to a spectrum of severe congenital heart defects, including ventricle malposition. A postulate anchored in the clinical nomenclature assumes that the looping direction of the embryonic heart tub …
In the heterotaxy syndrome, abnormal left-right patterning leads to a spectrum of severe congenital heart defects, including ventricl …
Neural Crest.
Thattaliyath BD, Firulli AB. Thattaliyath BD, et al. Adv Exp Med Biol. 2024;1441:125-143. doi: 10.1007/978-3-031-44087-8_6. Adv Exp Med Biol. 2024. PMID: 38884708 Review.
Recently, cardiac neural crest cells have also been shown to indirectly influence the development of the secondary heart field, another derivative of the caudal pharynx, by modulating signaling in the pharynx. ...
Recently, cardiac neural crest cells have also been shown to indirectly influence the development of the secondary heart field, anoth …
Left-right asymmetry and cardiac looping: implications for cardiac development and congenital heart disease.
Kathiriya IS, Srivastava D. Kathiriya IS, et al. Am J Med Genet. 2000 Winter;97(4):271-9. doi: 10.1002/1096-8628(200024)97:4<271::aid-ajmg1277>3.0.co;2-o. Am J Med Genet. 2000. PMID: 11376438 Review.
Disorganization of LR signals can result in myriad congenital heart defects that are a consequence of abnormal looping and remodeling of the primitive heart tube into a multi-chambered organ. ...Here we review the impact of LR signaling pathways on cardiac de …
Disorganization of LR signals can result in myriad congenital heart defects that are a consequence of abnormal looping and rem …
Di-2-ethylhexyl phthalate induces heart looping disorders during zebrafish development.
Sun Y, Yang F, Liu Y, Yu M, Wu F, Wang G. Sun Y, et al. Toxicol Ind Health. 2021 Jul;37(7):391-397. doi: 10.1177/07482337211019184. Epub 2021 May 28. Toxicol Ind Health. 2021. PMID: 34047658
In the present study, we explored the effects of DEHP on heart development by using zebrafish as a model organism. DEHP (0.02 pg) was injected into the yolk sac of zebrafish embryos at the one-cell stage. ...In addition, massive pericardial edema was found in DEHP-treated …
In the present study, we explored the effects of DEHP on heart development by using zebrafish as a model organism. DEHP (0.02 pg) was …
Left-right asymmetric heart jogging increases the robustness of dextral heart looping in zebrafish.
Grimes DT, Patterson VL, Luna-Arvizu G, Schottenfeld-Roames J, Irons ZH, Burdine RD. Grimes DT, et al. Dev Biol. 2020 Mar 15;459(2):79-86. doi: 10.1016/j.ydbio.2019.11.012. Epub 2019 Nov 20. Dev Biol. 2020. PMID: 31758943 Free article.
The jogged heart then undergoes dextral (i.e. rightward) looping to correctly position the heart chambers relative to one another. ...Thus, we conclude that the role of leftward jogging is to spatially position the heart tube in a manner that promotes …
The jogged heart then undergoes dextral (i.e. rightward) looping to correctly position the heart chambers relative to o …
The Chiral Looping of the Embryonic Heart Is Formed by the Combination of Three Axial Asymmetries.
Honda H, Abe T, Fujimori T. Honda H, et al. Biophys J. 2020 Feb 4;118(3):742-752. doi: 10.1016/j.bpj.2019.11.3397. Epub 2019 Dec 18. Biophys J. 2020. PMID: 31952803 Free PMC article.
In mammals and birds, embryonic development of the heart involves conversion of a straight tubular structure into a three-dimensional helical loop, which is a chiral structure. ...Morphogenesis of chiral looping of the embryonic heart is a large-scaled event …
In mammals and birds, embryonic development of the heart involves conversion of a straight tubular structure into a three-dimensional …
Isoniazid causes heart looping disorder in zebrafish embryos by the induction of oxidative stress.
Ni J, Wang H, Wei X, Shen K, Sha Y, Dong Y, Shu Y, Wan X, Cheng J, Wang F, Liu Y. Ni J, et al. BMC Pharmacol Toxicol. 2020 Mar 12;21(1):22. doi: 10.1186/s40360-020-0399-2. BMC Pharmacol Toxicol. 2020. PMID: 32178728 Free PMC article.
The negative effects of isoniazid on the developing heart were characterized by lower heart rate and more heart looping disorders. Mechanistically, PCR showed decreased expression of heart-specific transcription factors when exposed to isoniazid …
The negative effects of isoniazid on the developing heart were characterized by lower heart rate and more heart loop …
Retinoic acid signaling in heart development.
Nakajima Y. Nakajima Y. Genesis. 2019 Jul;57(7-8):e23300. doi: 10.1002/dvg.23300. Epub 2019 Apr 25. Genesis. 2019. PMID: 31021052 Review.
Excess or defective RA signaling causes developmental defects including in the heart. The heart develops from the anterior lateral plate mesoderm. Cardiogenesis involves successive steps, including formation of the primitive heart tube, cardiac looping …
Excess or defective RA signaling causes developmental defects including in the heart. The heart develops from the anterior lat …
Heart fields and cardiac morphogenesis.
Kelly RG, Buckingham ME, Moorman AF. Kelly RG, et al. Cold Spring Harb Perspect Med. 2014 Oct 1;4(10):a015750. doi: 10.1101/cshperspect.a015750. Cold Spring Harb Perspect Med. 2014. PMID: 25274757 Free PMC article. Review.
In this review, we focus on two important steps in the formation of the embryonic heart: (i) the progressive addition of late differentiating progenitor cells from the second heart field that drives heart tube extension during looping morphogenesis, an …
In this review, we focus on two important steps in the formation of the embryonic heart: (i) the progressive addition of late differe …
3,710 results