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Page 1
Mitochondrion as a Target of Astaxanthin Therapy in Heart Failure.
Krestinina O, Baburina Y, Krestinin R. Krestinina O, et al. Int J Mol Sci. 2021 Jul 26;22(15):7964. doi: 10.3390/ijms22157964. Int J Mol Sci. 2021. PMID: 34360729 Free PMC article. Review.
Mitochondria are considered to be important organelles in the cell and play a key role in the physiological function of the heart, as well as in the pathogenesis and development of various heart diseases. Under certain pathological conditions, such as cardiovascular …
Mitochondria are considered to be important organelles in the cell and play a key role in the physiological function of the heart, as …
Astaxanthin Reduces Heart Rate and Carbohydrate Oxidation Rates During Exercise in Overweight Individuals.
Wika AA, Reason KW, Green JM, Killen LG, McAllister MJ, Waldman HS. Wika AA, et al. Int J Exerc Sci. 2023 Feb 1;16(2):252-266. doi: 10.70252/FPGA5839. eCollection 2023. Int J Exerc Sci. 2023. PMID: 37114194 Free PMC article.
Astaxanthin (AX) is an antioxidant which may spare endogenous carbohydrates and improve fat oxidation rates, thus improving metabolic flexibility. ...Further, the AX group demonstrated a 7% decrease in heart rate across the graded exercise test. These findings sugge …
Astaxanthin (AX) is an antioxidant which may spare endogenous carbohydrates and improve fat oxidation rates, thus improving metabolic …
Astaxanthin Prevented Oxidative Stress in Heart and Kidneys of Isoproterenol-Administered Aged Rats.
Alam MN, Hossain MM, Rahman MM, Subhan N, Mamun MAA, Ulla A, Reza HM, Alam MA. Alam MN, et al. J Diet Suppl. 2018 Jan 2;15(1):42-54. doi: 10.1080/19390211.2017.1321078. Epub 2017 May 10. J Diet Suppl. 2018. PMID: 28489954
Group II (ISO group) was administered ISO at a dose of 50 mg/kg subcutaneously (SC) twice a week for two weeks. Group III (Astaxanthin + ISO group) was treated with astaxanthin (25 mg/kg) orally every day and ISO 50 mg/kg SC twice a week for two weeks. ...Moreover, …
Group II (ISO group) was administered ISO at a dose of 50 mg/kg subcutaneously (SC) twice a week for two weeks. Group III (Astaxanthin …
The Effect of Astaxanthin on Mitochondrial Dynamics in Rat Heart Mitochondria under ISO-Induced Injury.
Krestinin R, Baburina Y, Odinokova I, Kruglov A, Sotnikova L, Krestinina O. Krestinin R, et al. Antioxidants (Basel). 2023 Jun 9;12(6):1247. doi: 10.3390/antiox12061247. Antioxidants (Basel). 2023. PMID: 37371979 Free PMC article.
Mitochondria are involved not only in a healthy heart but also in the development of heart disease. Therefore, attempts should be made to enhance the body's defense response against oxidative stress with the help of various antioxidants in order to decrease mitochon …
Mitochondria are involved not only in a healthy heart but also in the development of heart disease. Therefore, attempts should …
Astaxanthin Inhibits Mitochondrial Permeability Transition Pore Opening in Rat Heart Mitochondria.
Baburina Y, Krestinin R, Odinokova I, Sotnikova L, Kruglov A, Krestinina O. Baburina Y, et al. Antioxidants (Basel). 2019 Nov 21;8(12):576. doi: 10.3390/antiox8120576. Antioxidants (Basel). 2019. PMID: 31766490 Free PMC article.
AST treatment changed the level of mPTP regulatory proteins in isolated rat heart mitochondria. Consequently, AST can protect mitochondria from changes in the induced permeability of the inner membrane. ...Since AST improves the resistance of rat heart mitochondria …
AST treatment changed the level of mPTP regulatory proteins in isolated rat heart mitochondria. Consequently, AST can protect mitocho …
Impact of astaxanthin on oxidative markers, uric acid, and clinical symptoms in heart failure: a randomized clinical trial.
Mohammadi SG, Shafie D, Feizi A, Bagherniya M, Ahmadi AR, Kafeshani M. Mohammadi SG, et al. BMC Cardiovasc Disord. 2025 Oct 29;25(1):779. doi: 10.1186/s12872-025-05260-z. BMC Cardiovasc Disord. 2025. PMID: 41162864 Free PMC article. Clinical Trial.
BACKGROUND AND AIMS: Chronic heart failure (HF) is often linked to increased oxidative stress and metabolic issues like high uric acid, which can worsen outcomes. Astaxanthin (ASX), a strong antioxidant, may help reduce these harmful effects. This study aimed to inv …
BACKGROUND AND AIMS: Chronic heart failure (HF) is often linked to increased oxidative stress and metabolic issues like high uric aci …
Astaxanthin alleviates PM(2.5)-induced cardiomyocyte injury via inhibiting ferroptosis.
Ren J, Yin B, Guo Z, Sun X, Pei H, Wen R, Wang Z, Zhu S, Zuo J, Zhang Y, Ma Y. Ren J, et al. Cell Mol Biol Lett. 2023 Nov 25;28(1):95. doi: 10.1186/s11658-023-00513-1. Cell Mol Biol Lett. 2023. PMID: 38007415 Free PMC article.
BACKGROUND: Long-term exposure of humans to air pollution is associated with an increasing risk of cardiovascular diseases (CVDs). Astaxanthin (AST), a naturally occurring red carotenoid pigment, was proved to have multiple health benefits. ...
BACKGROUND: Long-term exposure of humans to air pollution is associated with an increasing risk of cardiovascular diseases (CVDs). Astaxa …
Nutraceutical activation of Sirt1: a review.
DiNicolantonio JJ, McCarty MF, O'Keefe JH. DiNicolantonio JJ, et al. Open Heart. 2022 Dec;9(2):e002171. doi: 10.1136/openhrt-2022-002171. Open Heart. 2022. PMID: 36522127 Free PMC article. Review.
Nutraceuticals reported to enhance Sirt1 synthesis or protein expression include ferulic acid, tetrahydrocurcumin, urolithin A, melatonin, astaxanthin, carnosic acid and neochlorogenic acid. The half-life of Sirt1 protein can be enhanced with the natural nicotinamide catab …
Nutraceuticals reported to enhance Sirt1 synthesis or protein expression include ferulic acid, tetrahydrocurcumin, urolithin A, melatonin, …
The Improvement of Functional State of Brain Mitochondria with Astaxanthin in Rats after Heart Failure.
Baburina Y, Krestinin R, Fedorov D, Odinokova I, Pershina E, Sotnikova L, Krestinina O. Baburina Y, et al. Int J Mol Sci. 2022 Dec 20;24(1):31. doi: 10.3390/ijms24010031. Int J Mol Sci. 2022. PMID: 36613474 Free PMC article.
Astaxanthin (AST), a marine-derived xanthophyll carotenoid, has multiple functions and its effects have been shown in both experimental and clinical studies. We investigated the effects of AST on the functional state of brain mitochondria in rats after heart failure …
Astaxanthin (AST), a marine-derived xanthophyll carotenoid, has multiple functions and its effects have been shown in both experiment …
The effect of astaxanthin supplementation on inflammatory markers, oxidative stress indices, lipid profile, uric acid level, blood pressure, endothelial function, quality of life, and disease symptoms in heart failure subjects.
Mohammadi SG, Feizi A, Bagherniya M, Shafie D, Ahmadi AR, Kafeshani M. Mohammadi SG, et al. Trials. 2024 Aug 1;25(1):518. doi: 10.1186/s13063-024-08339-8. Trials. 2024. PMID: 39090754 Free PMC article.
Oxidative stress and inflammation are key elements in the development and progression of heart failure. Astaxanthin, a carotenoid, has strong anti-inflammatory and antioxidant effects that may protect the cardiovascular system. ...This RCT contributes to the expandi …
Oxidative stress and inflammation are key elements in the development and progression of heart failure. Astaxanthin, a caroten …
144 results