Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1911 1
1935 1
1938 1
1940 2
1946 2
1947 1
1948 1
1949 2
1950 1
1951 2
1952 4
1953 7
1954 6
1955 5
1956 7
1957 8
1958 8
1959 7
1960 7
1961 14
1962 7
1963 11
1964 20
1965 11
1966 15
1967 31
1968 27
1969 32
1970 27
1971 30
1972 23
1973 34
1974 41
1975 57
1976 37
1977 20
1978 32
1979 31
1980 28
1981 29
1982 49
1983 39
1984 37
1985 63
1986 46
1987 35
1988 46
1989 52
1990 67
1991 48
1992 71
1993 61
1994 63
1995 73
1996 76
1997 92
1998 78
1999 92
2000 84
2001 109
2002 156
2003 223
2004 290
2005 338
2006 403
2007 408
2008 440
2009 463
2010 580
2011 610
2012 688
2013 770
2014 912
2015 966
2016 969
2017 1018
2018 1083
2019 1046
2020 1149
2021 1154
2022 1030
2023 1018
2024 1007
2025 649

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

17,243 results

Results by year

Filters applied: . Clear all
Page 1
Regeneration of the heart.
Steinhauser ML, Lee RT. Steinhauser ML, et al. EMBO Mol Med. 2011 Dec;3(12):701-12. doi: 10.1002/emmm.201100175. Epub 2011 Sep 23. EMBO Mol Med. 2011. PMID: 22095736 Free PMC article. Review.
The death of cardiac myocytes diminishes the heart's pump function and is a major cause of heart failure, one of the dominant causes of death worldwide. ...These achievements challenge our conceptions of what is possible in terms of heart regenerati …
The death of cardiac myocytes diminishes the heart's pump function and is a major cause of heart failure, one of the do …
Heart regeneration: 20 years of progress and renewed optimism.
Garbern JC, Lee RT. Garbern JC, et al. Dev Cell. 2022 Feb 28;57(4):424-439. doi: 10.1016/j.devcel.2022.01.012. Dev Cell. 2022. PMID: 35231426 Free PMC article. Review.
Cardiovascular disease is a leading cause of death worldwide, and thus there remains great interest in regenerative approaches to treat heart failure. In the past 20 years, the field of heart regeneration has entered a renaissance period with remarkable progr …
Cardiovascular disease is a leading cause of death worldwide, and thus there remains great interest in regenerative approaches to treat h …
Heart regeneration.
Laflamme MA, Murry CE. Laflamme MA, et al. Nature. 2011 May 19;473(7347):326-35. doi: 10.1038/nature10147. Nature. 2011. PMID: 21593865 Free PMC article. Review.
It usually results from a deficiency of specialized cardiac muscle cells known as cardiomyocytes, and a robust therapy to regenerate lost myocardium could help millions of patients every year. Heart regeneration is well documented in amphibia and fish and in …
It usually results from a deficiency of specialized cardiac muscle cells known as cardiomyocytes, and a robust therapy to regenerate …
Heart regeneration in zebrafish.
Poss KD, Wilson LG, Keating MT. Poss KD, et al. Science. 2002 Dec 13;298(5601):2188-90. doi: 10.1126/science.1077857. Science. 2002. PMID: 12481136
Cardiac injury in mammals and amphibians typically leads to scarring, with minimal regeneration of heart muscle. Here, we demonstrate histologically that zebrafish fully regenerate hearts within 2 months of 20% ventricular resection. ...The hearts …
Cardiac injury in mammals and amphibians typically leads to scarring, with minimal regeneration of heart muscle. Here, we demo …
Wnt Signaling in Heart Development and Regeneration.
Li D, Sun J, Zhong TP. Li D, et al. Curr Cardiol Rep. 2022 Oct;24(10):1425-1438. doi: 10.1007/s11886-022-01756-8. Epub 2022 Aug 4. Curr Cardiol Rep. 2022. PMID: 35925512 Review.
PURPOSE OF REVIEW: Cardiovascular diseases are the leading cause of death worldwide, largely due to the limited regenerative capacity of the adult human heart. In contrast, teleost zebrafish hearts possess natural regeneration capacity by proliferation of pre …
PURPOSE OF REVIEW: Cardiovascular diseases are the leading cause of death worldwide, largely due to the limited regenerative capacity of the …
Heart development and regeneration-a multi-organ effort.
Filosa A, Sawamiphak S. Filosa A, et al. FEBS J. 2023 Feb;290(4):913-930. doi: 10.1111/febs.16319. Epub 2021 Dec 18. FEBS J. 2023. PMID: 34894086 Free article. Review.
Our hearts replace dead muscles with non-contractile fibrotic scars. We have learned from animal models capable of scarless repair that regenerative capability of the heart does not depend only on competency of the myocardium and cardiac-intrinsic factors but also o …
Our hearts replace dead muscles with non-contractile fibrotic scars. We have learned from animal models capable of scarless repair th …
Macrophages are required for neonatal heart regeneration.
Aurora AB, Porrello ER, Tan W, Mahmoud AI, Hill JA, Bassel-Duby R, Sadek HA, Olson EN. Aurora AB, et al. J Clin Invest. 2014 Mar;124(3):1382-92. doi: 10.1172/JCI72181. Epub 2014 Feb 24. J Clin Invest. 2014. PMID: 24569380 Free PMC article.
In neonatal mice, the heart can regenerate fully without scarring following MI; however, this regenerative capacity is lost by P7. ...Our findings suggest that macrophages provide necessary signals to drive angiogenesis and regeneration of the neonatal mouse …
In neonatal mice, the heart can regenerate fully without scarring following MI; however, this regenerative capacity is lost by …
Heart regeneration using pluripotent stem cells.
Kadota S, Tanaka Y, Shiba Y. Kadota S, et al. J Cardiol. 2020 Nov;76(5):459-463. doi: 10.1016/j.jjcc.2020.03.013. Epub 2020 Jul 18. J Cardiol. 2020. PMID: 32690435 Free article. Review.
However, transient ventricular arrhythmias were detected after injection into non-human primates and swine ischemic hearts; as engrafted PSC-CMs form an electrical coupling between host and graft, the immature characteristics of PSC-CMs may serve as an ectopic pacemaker. . …
However, transient ventricular arrhythmias were detected after injection into non-human primates and swine ischemic hearts; as engraf …
Innate Mechanisms of Heart Regeneration.
Yin HM, Burns CG, Burns CE. Yin HM, et al. Cold Spring Harb Perspect Biol. 2021 Nov 1;13(11):a040766. doi: 10.1101/cshperspect.a040766. Cold Spring Harb Perspect Biol. 2021. PMID: 34187805 Free PMC article. Review.
Heart regeneration is a remarkable process whereby regrowth of damaged cardiac tissue rehabilitates organ anatomy and function. ...Luckily, a detailed blueprint for achieving therapeutic heart regeneration already exists in nature because several lower …
Heart regeneration is a remarkable process whereby regrowth of damaged cardiac tissue rehabilitates organ anatomy and function …
Mending broken hearts: cardiac development as a basis for adult heart regeneration and repair.
Xin M, Olson EN, Bassel-Duby R. Xin M, et al. Nat Rev Mol Cell Biol. 2013 Aug;14(8):529-41. doi: 10.1038/nrm3619. Epub 2013 Jul 10. Nat Rev Mol Cell Biol. 2013. PMID: 23839576 Free PMC article. Review.
As the adult mammalian heart has limited potential for regeneration and repair, the loss of cardiomyocytes during injury and disease can result in heart failure and death. ...Stimulating cardiomyocyte dedifferentiation and proliferation by activating mitotic …
As the adult mammalian heart has limited potential for regeneration and repair, the loss of cardiomyocytes during injury and d …
Model organisms at the heart of regeneration.
Price EL, Vieira JM, Riley PR. Price EL, et al. Dis Model Mech. 2019 Sep 27;12(10):dmm040691. doi: 10.1242/dmm.040691. Dis Model Mech. 2019. PMID: 31562250 Free PMC article. Review.
Heart failure is a major cause of death worldwide owing to the inability of the adult human heart to regenerate after a heart attack. ...We compare across different species, highlighting evolutionarily conserved mechanisms of regeneration and de …
Heart failure is a major cause of death worldwide owing to the inability of the adult human heart to regenerate after a …
Origin and function of activated fibroblast states during zebrafish heart regeneration.
Hu B, Lelek S, Spanjaard B, El-Sammak H, Simões MG, Mintcheva J, Aliee H, Schäfer R, Meyer AM, Theis F, Stainier DYR, Panáková D, Junker JP. Hu B, et al. Nat Genet. 2022 Aug;54(8):1227-1237. doi: 10.1038/s41588-022-01129-5. Epub 2022 Jul 21. Nat Genet. 2022. PMID: 35864193 Free PMC article.
The adult zebrafish heart has a high capacity for regeneration following injury. However, the composition of the regenerative niche has remained largely elusive. ...In summary, our work identifies specialized activated fibroblast cell states that contribute to he …
The adult zebrafish heart has a high capacity for regeneration following injury. However, the composition of the regenerative …
Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation.
Jopling C, Sleep E, Raya M, Martí M, Raya A, Izpisúa Belmonte JC. Jopling C, et al. Nature. 2010 Mar 25;464(7288):606-9. doi: 10.1038/nature08899. Nature. 2010. PMID: 20336145 Free PMC article.
In contrast to mammals, several non-mammalian vertebrate species are able to regenerate their hearts, including the zebrafish, which can fully regenerate its heart after amputation of up to 20% of the ventricle. ...Here we use this system to show that …
In contrast to mammals, several non-mammalian vertebrate species are able to regenerate their hearts, including the zebrafish, …
Mechanisms of Neonatal Heart Regeneration.
Cardoso AC, Pereira AHM, Sadek HA. Cardoso AC, et al. Curr Cardiol Rep. 2020 Apr 24;22(5):33. doi: 10.1007/s11886-020-01282-5. Curr Cardiol Rep. 2020. PMID: 32333123 Review.
RECENT FINDINGS: We present recent advances in the understanding of the molecular mechanisms of neonatal cardiac regeneration and the implications for the development of new cardiac regenerative therapies. During the early postnatal period, several cell types and pathways …
RECENT FINDINGS: We present recent advances in the understanding of the molecular mechanisms of neonatal cardiac regeneration and the …
Heart valve regeneration.
Rabkin-Aikawa E, Mayer JE Jr, Schoen FJ. Rabkin-Aikawa E, et al. Adv Biochem Eng Biotechnol. 2005;94:141-79. doi: 10.1007/b100003. Adv Biochem Eng Biotechnol. 2005. PMID: 15915872 Review.
The valves of the heart cannot regenerate spontaneously. Therefore, heart valve disease generally necessitates surgical repair or replacement of the diseased tissue by mechanical or bioprosthetic valve substitutes in order to avoid potentially fatal cardiac o …
The valves of the heart cannot regenerate spontaneously. Therefore, heart valve disease generally necessitates surgical …
Leading progress in heart regeneration and repair.
Deshmukh V, Wang J, Martin JF. Deshmukh V, et al. Curr Opin Cell Biol. 2019 Dec;61:79-85. doi: 10.1016/j.ceb.2019.07.005. Epub 2019 Aug 10. Curr Opin Cell Biol. 2019. PMID: 31408771 Free PMC article. Review.
Ischemic heart disease is one of the leading causes of mortality. Myocardial infarction causes loss of cardiomyocytes in the injury area accompanied by formation of a fibrotic scar. ...Recently, multiple studies have provided substantial insights in to the molecular pathwa …
Ischemic heart disease is one of the leading causes of mortality. Myocardial infarction causes loss of cardiomyocytes in the injury a …
Cardiac Regeneration and Stem Cells.
Zhang Y, Mignone J, MacLellan WR. Zhang Y, et al. Physiol Rev. 2015 Oct;95(4):1189-204. doi: 10.1152/physrev.00021.2014. Physiol Rev. 2015. PMID: 26269526 Free PMC article. Review.
After decades of believing the heart loses the ability to regenerate soon after birth, numerous studies are now reporting that the adult heart may indeed be capable of regeneration, although the magnitude of new cardiac myocyte formation varies greatly …
After decades of believing the heart loses the ability to regenerate soon after birth, numerous studies are now reporting that …
Polyploidy in Cardiomyocytes: Roadblock to Heart Regeneration?
Derks W, Bergmann O. Derks W, et al. Circ Res. 2020 Feb 14;126(4):552-565. doi: 10.1161/CIRCRESAHA.119.315408. Epub 2020 Feb 13. Circ Res. 2020. PMID: 32078450 Free article. Review.
In the perinatal period, cardiomyocytes still proliferate, and the heart shows the capacity to regenerate upon injury. In the adult heart, however, the actual rate of cardiomyocyte renewal is too low to efficiently counteract substantial cell loss caused by c …
In the perinatal period, cardiomyocytes still proliferate, and the heart shows the capacity to regenerate upon injury. In the …
Cardiac regeneration strategies: Staying young at heart.
Tzahor E, Poss KD. Tzahor E, et al. Science. 2017 Jun 9;356(6342):1035-1039. doi: 10.1126/science.aam5894. Epub 2017 Jun 8. Science. 2017. PMID: 28596337 Free PMC article. Review.
Whereas damaged skeletal muscle has a profound capacity to regenerate, heart muscle, at least in mammals, has poor regenerative potential. This deficiency is attributable to the lack of resident cardiac stem cells, combined with roadblocks that limit adult cardiomyo …
Whereas damaged skeletal muscle has a profound capacity to regenerate, heart muscle, at least in mammals, has poor regenerativ …
Animal models to study cardiac regeneration.
Weinberger M, Riley PR. Weinberger M, et al. Nat Rev Cardiol. 2024 Feb;21(2):89-105. doi: 10.1038/s41569-023-00914-x. Epub 2023 Aug 14. Nat Rev Cardiol. 2024. PMID: 37580429 Review.
In contrast to the restricted potential for cellular and functional regeneration of the adult mammalian heart, a robust capacity for cardiac regeneration is seen during the neonatal period in mammals as well as in the adults of many fish and amphibian species …
In contrast to the restricted potential for cellular and functional regeneration of the adult mammalian heart, a robust capaci …
Thyroid hormone-dependent regulation of metabolism and heart regeneration.
Ross I, Omengan DB, Huang GN, Payumo AY. Ross I, et al. J Endocrinol. 2022 Jan 20;252(3):R71-R82. doi: 10.1530/JOE-21-0335. J Endocrinol. 2022. PMID: 34935637 Free PMC article. Review.
While adult zebrafish and newborn mice possess a robust capacity to regenerate their hearts, this ability is generally lost in adult mammals. The logic behind the diversity of cardiac regenerative capacity across the animal kingdom is not well understood. ...We prop …
While adult zebrafish and newborn mice possess a robust capacity to regenerate their hearts, this ability is generally lost in …
Improving Cardiac Reprogramming for Heart Regeneration in Translational Medicine.
Liu L, Guo Y, Li Z, Wang Z. Liu L, et al. Cells. 2021 Nov 25;10(12):3297. doi: 10.3390/cells10123297. Cells. 2021. PMID: 34943805 Free PMC article. Review.
Direct reprogramming of fibroblasts into CM-like cells has emerged as an attractive strategy to generate induced CMs (iCMs) in heart regeneration. However, low conversion rate, poor purity, and the lack of precise conversion of iCMs are still present as significant …
Direct reprogramming of fibroblasts into CM-like cells has emerged as an attractive strategy to generate induced CMs (iCMs) in heart …
Progress and Challenge of Cardiac Regeneration to Treat Heart Failure.
Isomi M, Sadahiro T, Ieda M. Isomi M, et al. J Cardiol. 2019 Feb;73(2):97-101. doi: 10.1016/j.jjcc.2018.10.002. Epub 2018 Nov 9. J Cardiol. 2019. PMID: 30420106 Free article. Review.
Thus, heart regeneration holds great potential to offer innovative therapy to treat heart failure patients. Currently, there are several strategies for heart regeneration. Transplantation of somatic stem cells was safe and modestly improved card …
Thus, heart regeneration holds great potential to offer innovative therapy to treat heart failure patients. Currently, …
Cell migration during heart regeneration in zebrafish.
Tahara N, Brush M, Kawakami Y. Tahara N, et al. Dev Dyn. 2016 Jul;245(7):774-87. doi: 10.1002/dvdy.24411. Epub 2016 May 10. Dev Dyn. 2016. PMID: 27085002 Free PMC article. Review.
Although very limited, mammalian hearts do in fact have measurable levels of cardiomyocyte regeneration. Therefore, elucidating mechanisms of zebrafish heart regeneration would provide information of naturally occurring regeneration to potential …
Although very limited, mammalian hearts do in fact have measurable levels of cardiomyocyte regeneration. Therefore, elucidatin …
Macrophages and regeneration: Lessons from the heart.
Leor J, Palevski D, Amit U, Konfino T. Leor J, et al. Semin Cell Dev Biol. 2016 Oct;58:26-33. doi: 10.1016/j.semcdb.2016.04.012. Epub 2016 Apr 23. Semin Cell Dev Biol. 2016. PMID: 27118656 Review.
The search for therapies that will improve myocardial regeneration needs a better understanding of the mechanisms of repair and regeneration. While the role of macrophages in inflammation, scar formation, and fibrosis are well defined, their role in myocardial re …
The search for therapies that will improve myocardial regeneration needs a better understanding of the mechanisms of repair and re …
Telomeres and telomerase in heart regeneration.
Aix E, Gallinat A, Flores I. Aix E, et al. Differentiation. 2018 Mar-Apr;100:26-30. doi: 10.1016/j.diff.2018.01.003. Epub 2018 Feb 3. Differentiation. 2018. PMID: 29453108 Review.
Although recent advances have overturned the old view of the human heart as an inert postmitotic organ, it is clear that the adult hearts capacity to regenerate after an ischemic episode is very limited. Unlike humans, zebrafish and other lower vertebrates vi …
Although recent advances have overturned the old view of the human heart as an inert postmitotic organ, it is clear that the adult …
Transient regenerative potential of the neonatal mouse heart.
Porrello ER, Mahmoud AI, Simpson E, Hill JA, Richardson JA, Olson EN, Sadek HA. Porrello ER, et al. Science. 2011 Feb 25;331(6020):1078-80. doi: 10.1126/science.1200708. Science. 2011. PMID: 21350179 Free PMC article.
We found that the hearts of 1-day-old neonatal mice can regenerate after partial surgical resection, but this capacity is lost by 7 days of age. ...Thus, for a brief period after birth, the mammalian heart appears to have the capacity to regenerate....
We found that the hearts of 1-day-old neonatal mice can regenerate after partial surgical resection, but this capacity is lost …
Toward drug-induced heart regeneration.
Yuan X, Braun T. Yuan X, et al. Nat Cardiovasc Res. 2024 Mar;3(3):260-261. doi: 10.1038/s44161-024-00446-8. Nat Cardiovasc Res. 2024. PMID: 39196122 No abstract available.
Resetting the epigenome for heart regeneration.
Quaife-Ryan GA, Sim CB, Porrello ER, Hudson JE. Quaife-Ryan GA, et al. Semin Cell Dev Biol. 2016 Oct;58:2-13. doi: 10.1016/j.semcdb.2015.12.021. Epub 2016 Jan 7. Semin Cell Dev Biol. 2016. PMID: 26773213 Review.
In contrast to adults, recent evidence suggests that neonatal mice are able to regenerate following cardiac injury. This regenerative capacity is reliant on robust induction of cardiomyocyte proliferation, which is required for faithful regeneration of the heart …
In contrast to adults, recent evidence suggests that neonatal mice are able to regenerate following cardiac injury. This regenerative …
Reactive oxygen species during heart regeneration in zebrafish: Lessons for future clinical therapies.
Helston O, Amaya E. Helston O, et al. Wound Repair Regen. 2021 Mar;29(2):211-224. doi: 10.1111/wrr.12892. Epub 2021 Jan 20. Wound Repair Regen. 2021. PMID: 33471940 Free PMC article. Review.
An alternative approach would be to identify the critical downstream targets of ROS in the promotion of heart regeneration, and then target these clinically using drugs. One such family of potential downstream targets of ROS during heart regeneration a …
An alternative approach would be to identify the critical downstream targets of ROS in the promotion of heart regeneration, an …
The Application of scRNA-Seq in Heart Development and Regeneration.
Gao J, Yu L, Qi H, Qi J, Zheng Z. Gao J, et al. Genesis. 2025 Apr;63(2):e70013. doi: 10.1002/dvg.70013. Genesis. 2025. PMID: 40300044 Review.
Tens of millions of patients worldwide suffer from heart injuries and other types of heart disease. Neonatal mammalian hearts and certain adult vertebrate species, such as zebrafish, can fully regenerate after myocardial injury. However, the adult mamm …
Tens of millions of patients worldwide suffer from heart injuries and other types of heart disease. Neonatal mammalian hear …
Keeping the Heart Healthy: The Role of Exercise in Cardiac Repair and Regeneration.
Jiang J, Ni L, Zhang X, Chatterjee E, Lehmann HI, Li G, Xiao J. Jiang J, et al. Antioxid Redox Signal. 2023 Dec;39(16-18):1088-1107. doi: 10.1089/ars.2023.0301. Epub 2023 Jun 21. Antioxid Redox Signal. 2023. PMID: 37132606 Review.
Significance: Heart failure is often accompanied by a decrease in the number of cardiomyocytes. Although the adult mammalian hearts have limited regenerative capacity, the rate of regeneration is extremely low and decreases with age. ...Moderate exercise can …
Significance: Heart failure is often accompanied by a decrease in the number of cardiomyocytes. Although the adult mammalian heart …
A Systematic Exposition of Methods used for Quantification of Heart Regeneration after Apex Resection in Zebrafish.
Juul Belling H, Hofmeister W, Andersen DC. Juul Belling H, et al. Cells. 2020 Feb 26;9(3):548. doi: 10.3390/cells9030548. Cells. 2020. PMID: 32111059 Free PMC article.
This is mainly caused by the adult human heart lacking the ability to regenerate upon injury, whereas zebrafish have the capacity through cardiomyocyte proliferation to fully regenerate the heart following injury such as apex resection (AR). But a syst …
This is mainly caused by the adult human heart lacking the ability to regenerate upon injury, whereas zebrafish have the capac …
Malat1 deficiency prevents neonatal heart regeneration by inducing cardiomyocyte binucleation.
Aslan GS, Jaé N, Manavski Y, Fouani Y, Shumliakivska M, Kettenhausen L, Kirchhof L, Günther S, Fischer A, Luxán G, Dimmeler S. Aslan GS, et al. JCI Insight. 2023 Mar 8;8(5):e162124. doi: 10.1172/jci.insight.162124. JCI Insight. 2023. PMID: 36883566 Free PMC article.
The adult mammalian heart has limited regenerative capacity, while the neonatal heart fully regenerates during the first week of life. ...Here, using in vivo and in vitro approaches, we identified the lncRNA Malat1 as a key player in postnatal cardiac rege …
The adult mammalian heart has limited regenerative capacity, while the neonatal heart fully regenerates during the firs …
Heart repair and regeneration: recent insights from zebrafish studies.
Lien CL, Harrison MR, Tuan TL, Starnes VA. Lien CL, et al. Wound Repair Regen. 2012 Sep-Oct;20(5):638-46. doi: 10.1111/j.1524-475X.2012.00814.x. Epub 2012 Jul 20. Wound Repair Regen. 2012. PMID: 22818295 Free PMC article. Review.
In contrast to humans and other mammals, zebrafish hearts regenerate after substantial injury or tissue damage. Here, we review recent progress in studying zebrafish heart regeneration, addressing the molecular and cellular responses in the three tissu …
In contrast to humans and other mammals, zebrafish hearts regenerate after substantial injury or tissue damage. Here, we revie …
Heart regeneration: The endothelial cell comes first.
Mathison M, Rosengart TK. Mathison M, et al. J Thorac Cardiovasc Surg. 2018 Mar;155(3):1128-1129. doi: 10.1016/j.jtcvs.2017.09.106. Epub 2017 Oct 3. J Thorac Cardiovasc Surg. 2018. PMID: 29452462 Free PMC article. No abstract available.
Nitrite Improves Heart Regeneration in Zebrafish.
Rochon ER, Missinato MA, Xue J, Tejero J, Tsang M, Gladwin MT, Corti P. Rochon ER, et al. Antioxid Redox Signal. 2020 Feb 20;32(6):363-377. doi: 10.1089/ars.2018.7687. Epub 2019 Dec 12. Antioxid Redox Signal. 2020. PMID: 31724431 Free PMC article.
Unlike mammals, the adult zebrafish maintain the innate ability to regenerate their hearts after injury, providing an important model to study cardiac regeneration. ...Innovation: This is the first study to evaluate effects of physiological levels of nitrite …
Unlike mammals, the adult zebrafish maintain the innate ability to regenerate their hearts after injury, providing an importan …
Heart Regeneration in the Mexican Cavefish.
Stockdale WT, Lemieux ME, Killen AC, Zhao J, Hu Z, Riepsaame J, Hamilton N, Kudoh T, Riley PR, van Aerle R, Yamamoto Y, Mommersteeg MTM. Stockdale WT, et al. Cell Rep. 2018 Nov 20;25(8):1997-2007.e7. doi: 10.1016/j.celrep.2018.10.072. Cell Rep. 2018. PMID: 30462998 Free PMC article.
Although Astyanax mexicanus surface fish regenerate their hearts after injury, their Pachon cave-dwelling counterparts cannot and, instead, form a permanent fibrotic scar, similar to the human heart. ...Similar to cavefish, knockout of lrrc10 in zebrafish imp …
Although Astyanax mexicanus surface fish regenerate their hearts after injury, their Pachon cave-dwelling counterparts cannot …
Evidence for hormonal control of heart regenerative capacity during endothermy acquisition.
Hirose K, Payumo AY, Cutie S, Hoang A, Zhang H, Guyot R, Lunn D, Bigley RB, Yu H, Wang J, Smith M, Gillett E, Muroy SE, Schmid T, Wilson E, Field KA, Reeder DM, Maden M, Yartsev MM, Wolfgang MJ, Grützner F, Scanlan TS, Szweda LI, Buffenstein R, Hu G, Flamant F, Olgin JE, Huang GN. Hirose K, et al. Science. 2019 Apr 12;364(6436):184-188. doi: 10.1126/science.aar2038. Epub 2019 Mar 7. Science. 2019. PMID: 30846611 Free PMC article.
Conversely, exogenous thyroid hormones inhibit zebrafish heart regeneration. Thus, our findings suggest that loss of heart regenerative capacity in adult mammals is triggered by increasing thyroid hormones and may be a trade-off for the acquisition of endothe …
Conversely, exogenous thyroid hormones inhibit zebrafish heart regeneration. Thus, our findings suggest that loss of heart …
Cardiac regeneration: repopulating the heart.
Rubart M, Field LJ. Rubart M, et al. Annu Rev Physiol. 2006;68:29-49. doi: 10.1146/annurev.physiol.68.040104.124530. Annu Rev Physiol. 2006. PMID: 16460265 Review.
Many forms of pediatric and adult heart disease result from a deficiency in cardiomyocyte number. Through repopulation of the heart with new cardiomyocytes (that is, induction of regenerative cardiac growth), cardiac disease potentially can be reversed, provided tha …
Many forms of pediatric and adult heart disease result from a deficiency in cardiomyocyte number. Through repopulation of the hear …
Medicinal Chemistry Approaches to Heart Regeneration.
Schade D, Plowright AT. Schade D, et al. J Med Chem. 2015 Dec 24;58(24):9451-79. doi: 10.1021/acs.jmedchem.5b00446. Epub 2015 Sep 3. J Med Chem. 2015. PMID: 26288266 Review.
Because of the minimal and clearly insufficient ability of the adult heart to regenerate after ischemic injury, there is a great opportunity to identify biological mechanisms, substances, and factors that enhance this process. Hence, innovative therapeutic managemen …
Because of the minimal and clearly insufficient ability of the adult heart to regenerate after ischemic injury, there is a gre …
Advances in understanding the mechanism of zebrafish heart regeneration.
Kikuchi K. Kikuchi K. Stem Cell Res. 2014 Nov;13(3 Pt B):542-55. doi: 10.1016/j.scr.2014.07.003. Epub 2014 Jul 19. Stem Cell Res. 2014. PMID: 25127427 Free article. Review.
The adult mammalian heart was once believed to be a post-mitotic organ without any capacity for regeneration, but recent findings have challenged this dogma. ...By understanding how these animals regenerate a damaged heart, one might obtain valuable in …
The adult mammalian heart was once believed to be a post-mitotic organ without any capacity for regeneration, but recent findi …
Transition from fetal to postnatal state in the heart: Crosstalk between metabolism and regeneration.
Sada T, Kimura W. Sada T, et al. Dev Growth Differ. 2024 Dec;66(9):438-451. doi: 10.1111/dgd.12947. Epub 2024 Oct 27. Dev Growth Differ. 2024. PMID: 39463005 Free PMC article. Review.
Some of these methods have been successfully applied to enhance metabolic reprogramming and myocardial regeneration. This review discusses recently acquired insights into the interplay between metabolism and myocardial proliferation, emphasizing postnatal metabolic transit …
Some of these methods have been successfully applied to enhance metabolic reprogramming and myocardial regeneration. This review disc …
The heart of the neural crest: cardiac neural crest cells in development and regeneration.
George RM, Maldonado-Velez G, Firulli AB. George RM, et al. Development. 2020 Oct 15;147(20):dev188706. doi: 10.1242/dev.188706. Development. 2020. PMID: 33060096 Free PMC article. Review.
These cNCC-derived cardiomyocytes appear to be required for the successful repair and regeneration of injured zebrafish hearts. In addition, recent work examining the response to cardiac injury in the mammalian heart has suggested that cNCC-derived cardiomyoc …
These cNCC-derived cardiomyocytes appear to be required for the successful repair and regeneration of injured zebrafish hearts …
Current Applications of Polycaprolactone as a Scaffold Material for Heart Regeneration.
Schmitt PR, Dwyer KD, Coulombe KLK. Schmitt PR, et al. ACS Appl Bio Mater. 2022 Jun 20;5(6):2461-2480. doi: 10.1021/acsabm.2c00174. Epub 2022 May 27. ACS Appl Bio Mater. 2022. PMID: 35623101 Review.
The recent growth in the field of cardiac tissue engineering has the potential to not only reduce the downstream effects of injured tissues on heart function and longevity but also re-engineer cardiac function through regeneration of contractile tissue. ...Polycapro …
The recent growth in the field of cardiac tissue engineering has the potential to not only reduce the downstream effects of injured tissues …
Heart regeneration using reprogramming technology.
Ieda M. Ieda M. Proc Jpn Acad Ser B Phys Biol Sci. 2013;89(3):118-28. doi: 10.2183/pjab.89.118. Proc Jpn Acad Ser B Phys Biol Sci. 2013. PMID: 23474887 Free PMC article. Review.
Loss of terminally differentiated cardiomyocytes due to heart disease is irreversible and current therapeutic regimes are limited. Cell therapy using stem cell-derived cardiomyocytes is an attractive option to repair injured hearts. ...We found that functional cardi …
Loss of terminally differentiated cardiomyocytes due to heart disease is irreversible and current therapeutic regimes are limited. Ce …
Dynamic Transcriptional Responses to Injury of Regenerative and Non-regenerative Cardiomyocytes Revealed by Single-Nucleus RNA Sequencing.
Cui M, Wang Z, Chen K, Shah AM, Tan W, Duan L, Sanchez-Ortiz E, Li H, Xu L, Liu N, Bassel-Duby R, Olson EN. Cui M, et al. Dev Cell. 2020 Apr 6;53(1):102-116.e8. doi: 10.1016/j.devcel.2020.02.019. Epub 2020 Mar 26. Dev Cell. 2020. PMID: 32220304 Free PMC article.
The adult mammalian heart is incapable of regeneration following injury. In contrast, the neonatal mouse heart can efficiently regenerate during the first week of life. ...Here, by single-nucleus RNA sequencing, we map the dynamic transcriptional lands …
The adult mammalian heart is incapable of regeneration following injury. In contrast, the neonatal mouse heart can effi …
A Watershed Finding for Heart Regeneration.
Bardot ES, Dubois NC. Bardot ES, et al. Cell. 2019 Feb 21;176(5):947-949. doi: 10.1016/j.cell.2019.01.053. Cell. 2019. PMID: 30794778 Free PMC article.
The adult mammalian heart is minimally regenerative after injury, whereas neonatal hearts fully recover even after major damage. New work from the Red-Horse and Woo labs (Das et al., 2019) shows that collateral artery formation is a key mechanism contributing to suc …
The adult mammalian heart is minimally regenerative after injury, whereas neonatal hearts fully recover even after major damag …
The ontogeny, activation and function of the epicardium during heart development and regeneration.
Simões FC, Riley PR. Simões FC, et al. Development. 2018 Mar 28;145(7):dev155994. doi: 10.1242/dev.155994. Development. 2018. PMID: 29592950 Review.
However, therapeutically manipulating the epicardium and epicardium-derived cells (EPDCs) requires insights into their developmental origin and the mechanisms driving their activation, recruitment and contribution to both the embryonic and adult injured heart. In recent ye …
However, therapeutically manipulating the epicardium and epicardium-derived cells (EPDCs) requires insights into their developmental origin …
Reprogramming toward heart regeneration: stem cells and beyond.
Aguirre A, Sancho-Martinez I, Izpisua Belmonte JC. Aguirre A, et al. Cell Stem Cell. 2013 Mar 7;12(3):275-84. doi: 10.1016/j.stem.2013.02.008. Cell Stem Cell. 2013. PMID: 23472869 Free article. Review.
Recent investigations have started to unveil the mechanisms of mammalian heart regeneration. The study of the regenerative mechanisms in lower vertebrate and mammalian animal models has provided clues for the experimental activation of proregenerative responses in t …
Recent investigations have started to unveil the mechanisms of mammalian heart regeneration. The study of the regenerative mec …
The HeArt of regeneration.
Curado S, Stainier DY. Curado S, et al. Cell. 2006 Nov 3;127(3):462-4. doi: 10.1016/j.cell.2006.10.025. Cell. 2006. PMID: 17081969 Free article.
Fish and amphibian hearts are known to regenerate after partial resection, but the molecular mechanisms underlying this process remain unclear. In this issue of Cell, Lipilina et al. analyze regeneration in the zebrafish heart. Their work indicates tha …
Fish and amphibian hearts are known to regenerate after partial resection, but the molecular mechanisms underlying this proces …
Introduction to the special issue on heart regeneration and rejuvenation.
Harvey RP, Graham RM, Pu WT. Harvey RP, et al. Stem Cell Res. 2014 Nov;13(3 Pt B):521-2. doi: 10.1016/j.scr.2014.10.003. Epub 2014 Oct 12. Stem Cell Res. 2014. PMID: 25459518 Free PMC article.
Despite therapeutic advances that slow its progression, heart disease remains the world's leading cause of death. Until recently, the "Holy Grail" of cardiac biology, to regenerate the damaged heart, appeared to be a fantastical and quixotic quest. However, r …
Despite therapeutic advances that slow its progression, heart disease remains the world's leading cause of death. Until recently, the …
Interplay between calcium and sarcomeres directs cardiomyocyte maturation during regeneration.
Nguyen PD, Gooijers I, Campostrini G, Verkerk AO, Honkoop H, Bouwman M, de Bakker DEM, Koopmans T, Vink A, Lamers GEM, Shakked A, Mars J, Mulder AA, Chocron S, Bartscherer K, Tzahor E, Mummery CL, de Boer TP, Bellin M, Bakkers J. Nguyen PD, et al. Science. 2023 May 19;380(6646):758-764. doi: 10.1126/science.abo6718. Epub 2023 May 18. Science. 2023. PMID: 37200435
Zebrafish hearts can regenerate by replacing damaged tissue with new cardiomyocytes. Although the steps leading up to the proliferation of surviving cardiomyocytes have been extensively studied, little is known about the mechanisms that control proliferation and red …
Zebrafish hearts can regenerate by replacing damaged tissue with new cardiomyocytes. Although the steps leading up to the prol …
Signaling and transcriptional networks in heart development and regeneration.
Bruneau BG. Bruneau BG. Cold Spring Harb Perspect Biol. 2013 Mar 1;5(3):a008292. doi: 10.1101/cshperspect.a008292. Cold Spring Harb Perspect Biol. 2013. PMID: 23457256 Free PMC article. Review.
Defects in heart formation lead to congenital heart defects, underscoring the finesse with which the heart is assembled. ...Knowledge of the developing heart is important for effective strategies of cardiac regeneration, providing new hope for f …
Defects in heart formation lead to congenital heart defects, underscoring the finesse with which the heart is assembled …
Stem-cell angiogenesis and regeneration of the heart: review of a saga of 2 decades.
Liebson PR. Liebson PR. Clin Cardiol. 2015 May;38(5):309-16. doi: 10.1002/clc.22381. Epub 2015 May 8. Clin Cardiol. 2015. PMID: 25955103 Free PMC article. Review.
Advances in the novel approach to control ischemic heart disease and heart failure using stem cells or progenitor cells from bone marrow, mesenchyme, or myocardial tissue itself have demonstrated efficacy for increasing left ventricular function, decreasing infarct …
Advances in the novel approach to control ischemic heart disease and heart failure using stem cells or progenitor cells from b …
The zebrafish as a model of heart regeneration.
Raya A, Consiglio A, Kawakami Y, Rodriguez-Esteban C, Izpisúa-Belmonte JC. Raya A, et al. Cloning Stem Cells. 2004;6(4):345-51. doi: 10.1089/clo.2004.6.345. Cloning Stem Cells. 2004. PMID: 15671662 Review.
Recently, it has been shown that adult zebrafish can also regenerate their hearts, thus offering new possibilities for experimentally approaching this fascinating biological phenomenon. The first insights into heart regeneration gained by studying this …
Recently, it has been shown that adult zebrafish can also regenerate their hearts, thus offering new possibilities for experim …
Autophagy Activation in Zebrafish Heart Regeneration.
Chávez MN, Morales RA, López-Crisosto C, Roa JC, Allende ML, Lavandero S. Chávez MN, et al. Sci Rep. 2020 Feb 10;10(1):2191. doi: 10.1038/s41598-020-59106-z. Sci Rep. 2020. PMID: 32042056 Free PMC article.
In this regard, the zebrafish is considered a hallmark model for vertebrate regeneration, since contrary to adult mammals, it is able to faithfully regenerate cardiac tissue. Interestingly, the role that autophagy may play in zebrafish heart regeneration …
In this regard, the zebrafish is considered a hallmark model for vertebrate regeneration, since contrary to adult mammals, it is able …
Strategies and Challenges to Improve Cellular Programming-Based Approaches for Heart Regeneration Therapy.
Jiang L, Liang J, Huang W, Wu Z, Paul C, Wang Y. Jiang L, et al. Int J Mol Sci. 2020 Oct 16;21(20):7662. doi: 10.3390/ijms21207662. Int J Mol Sci. 2020. PMID: 33081233 Free PMC article. Review.
Limited adult cardiac cell proliferation after cardiovascular disease, such as heart failure, hampers regeneration, resulting in a major loss of cardiomyocytes (CMs) at the site of injury. Recent studies in cellular reprogramming approaches have provided the opportu …
Limited adult cardiac cell proliferation after cardiovascular disease, such as heart failure, hampers regeneration, resulting …
A complete heart regeneration model with inflammation as a key component.
Liu C, Wang L, Wang X, Hou X. Liu C, et al. Exp Anim. 2021 Nov 10;70(4):479-487. doi: 10.1538/expanim.20-0191. Epub 2021 Jun 15. Exp Anim. 2021. PMID: 34135270 Free PMC article.
Inhibition of inflammation by Dex impaired heart regeneration. These demonstrated that cardiomyocytes death and heart regeneration occurred in this model and inflammation might play a crucial role in it. Modulating inflammation may provide a promising …
Inhibition of inflammation by Dex impaired heart regeneration. These demonstrated that cardiomyocytes death and heart …
Regeneration and reprogramming.
Knapp D, Tanaka EM. Knapp D, et al. Curr Opin Genet Dev. 2012 Oct;22(5):485-93. doi: 10.1016/j.gde.2012.09.006. Epub 2012 Oct 19. Curr Opin Genet Dev. 2012. PMID: 23084810 Review.
Such cellular traits are observed under natural conditions in animals that regenerate complex organs. A number of invertebrates display the amazing trait of whole body regeneration. Underlying this trait is the maintenance of pluripotent cells in somatic tissue, and …
Such cellular traits are observed under natural conditions in animals that regenerate complex organs. A number of invertebrates displ …
Cardiac enhancers: Gateway to the regulatory mechanisms of heart regeneration.
Begeman IJ, Guyer ME, Kang J. Begeman IJ, et al. Semin Cell Dev Biol. 2025 Jun;170:103610. doi: 10.1016/j.semcdb.2025.103610. Epub 2025 Apr 10. Semin Cell Dev Biol. 2025. PMID: 40215762 Review.
In contrast, neonatal mice and zebrafish possess the ability to repair injured hearts. Cardiac regeneration is driven by profound transcriptional changes, which are controlled by gene regulatory elements, such as tissue regeneration enhancer elements (TREEs). …
In contrast, neonatal mice and zebrafish possess the ability to repair injured hearts. Cardiac regeneration is driven by profo …
Hypoxia-induced myocardial regeneration.
Kimura W, Nakada Y, Sadek HA. Kimura W, et al. J Appl Physiol (1985). 2017 Dec 1;123(6):1676-1681. doi: 10.1152/japplphysiol.00328.2017. Epub 2017 Aug 17. J Appl Physiol (1985). 2017. PMID: 28819000 Free PMC article. Review.
The underlying cause of systolic heart failure is the inability of the adult mammalian heart to regenerate damaged myocardium. ...Moreover, reducing oxygen metabolism in the adult mammalian heart can induce cardiomyocyte cell cycle reentry through blun …
The underlying cause of systolic heart failure is the inability of the adult mammalian heart to regenerate damaged myoc …
Regulation of heart regeneration by LSD1 through suppressing CEND1.
Liu H, Dong J, Liu S, Luo Y, Fang Y, Su H, Xue W, Zhou R, Huang W, Lai B, Xiong Y, Wang S, Liang L, Wang Z, Zhang D, Wu L, Zhang Y, Zhou B, Shyy JY, Yuan Z, Wang Y. Liu H, et al. Theranostics. 2025 May 25;15(13):6313-6328. doi: 10.7150/thno.110297. eCollection 2025. Theranostics. 2025. PMID: 40521201 Free PMC article.
Rationale: Improving heart regeneration through reactivating cardiomyocyte proliferation holds a great potential for repairing diseased hearts. ...Results: Cardiomyocyte-specific deletion impeded neonatal heart regeneration, while overexpression …
Rationale: Improving heart regeneration through reactivating cardiomyocyte proliferation holds a great potential for repairing …
Epicardium in Heart Development.
Cao Y, Duca S, Cao J. Cao Y, et al. Cold Spring Harb Perspect Biol. 2020 Feb 3;12(2):a037192. doi: 10.1101/cshperspect.a037192. Cold Spring Harb Perspect Biol. 2020. PMID: 31451510 Free PMC article. Review.
The epicardium, the outermost tissue layer that envelops all vertebrate hearts, plays a crucial role in cardiac development and regeneration and has been implicated in potential strategies for cardiac repair. ...Characterized by its high cellular plasticity, the epi …
The epicardium, the outermost tissue layer that envelops all vertebrate hearts, plays a crucial role in cardiac development and re …
Mechanistic basis of neonatal heart regeneration revealed by transcriptome and histone modification profiling.
Wang Z, Cui M, Shah AM, Ye W, Tan W, Min YL, Botten GA, Shelton JM, Liu N, Bassel-Duby R, Olson EN. Wang Z, et al. Proc Natl Acad Sci U S A. 2019 Sep 10;116(37):18455-18465. doi: 10.1073/pnas.1905824116. Epub 2019 Aug 26. Proc Natl Acad Sci U S A. 2019. PMID: 31451669 Free PMC article.
The adult mammalian heart has limited capacity for regeneration following injury, whereas the neonatal heart can readily regenerate within a short period after birth. ...Our data provide insights into the molecular basis of neonatal heart reg …
The adult mammalian heart has limited capacity for regeneration following injury, whereas the neonatal heart can readil …
Ex Vivo Techniques to Study Heart Regeneration in Zebrafish.
Duca S, Cao J. Duca S, et al. Methods Mol Biol. 2021;2158:211-222. doi: 10.1007/978-1-0716-0668-1_16. Methods Mol Biol. 2021. PMID: 32857376
Due to its pronounced regenerative capacity, the zebrafish heart represents an advantageous model system for exploring the cellular and molecular mechanisms of cardiac regeneration. Upon injury, the epicardium, the outermost mesothelial tissue layer of vertebrate …
Due to its pronounced regenerative capacity, the zebrafish heart represents an advantageous model system for exploring the cellular a …
Formation and Growth of Cardiac Lymphatics during Embryonic Development, Heart Regeneration, and Disease.
Gancz D, Perlmoter G, Yaniv K. Gancz D, et al. Cold Spring Harb Perspect Biol. 2020 Jun 1;12(6):a037176. doi: 10.1101/cshperspect.a037176. Cold Spring Harb Perspect Biol. 2020. PMID: 31818858 Free PMC article. Review.
Yet, the unique molecular properties and functions of the heart's lymphatic system have only recently begun to be addressed. In this review, we discuss the mechanisms underlying the formation and growth of cardiac lymphatics during embryonic development and describe …
Yet, the unique molecular properties and functions of the heart's lymphatic system have only recently begun to be addressed. I …
The epicardium signals the way towards heart regeneration.
Masters M, Riley PR. Masters M, et al. Stem Cell Res. 2014 Nov;13(3 Pt B):683-92. doi: 10.1016/j.scr.2014.04.007. Epub 2014 Apr 29. Stem Cell Res. 2014. PMID: 24933704 Free PMC article. Review.
From historical studies of developing chick hearts to recent advances in regenerative injury models, the epicardium has arisen as a key player in heart genesis and repair. ...Furthermore, injury-induced epicardial signalling is essential for heart regenera …
From historical studies of developing chick hearts to recent advances in regenerative injury models, the epicardium has arisen as a k …
RNA-Binding Protein LIN28a Regulates New Myocyte Formation in the Heart Through Long Noncoding RNA-H19.
Rigaud VOC, Hoy RC, Kurian J, Zarka C, Behanan M, Brosious I, Pennise J, Patel T, Wang T, Johnson J, Kraus LM, Mohsin S, Houser SR, Khan M. Rigaud VOC, et al. Circulation. 2023 Jan 24;147(4):324-337. doi: 10.1161/CIRCULATIONAHA.122.059346. Epub 2022 Oct 31. Circulation. 2023. PMID: 36314132 Free PMC article.
Cardiomyocyte metabolism undergoes a profound shift that coincides with cessation of regeneration in the postnatal heart. However, whether reprogramming metabolism promotes persistence of regenerative mononuclear diploid cardiomyocytes enhancing cardiac function and …
Cardiomyocyte metabolism undergoes a profound shift that coincides with cessation of regeneration in the postnatal heart. Howe …
Metabolic Changes Associated With Cardiomyocyte Dedifferentiation Enable Adult Mammalian Cardiac Regeneration.
Cheng YY, Gregorich Z, Prajnamitra RP, Lundy DJ, Ma TY, Huang YH, Lee YC, Ruan SC, Lin JH, Lin PJ, Kuo CW, Chen P, Yan YT, Tian R, Kamp TJ, Hsieh PCH. Cheng YY, et al. Circulation. 2022 Dec 20;146(25):1950-1967. doi: 10.1161/CIRCULATIONAHA.122.061960. Epub 2022 Nov 24. Circulation. 2022. PMID: 36420731 Free PMC article.
BACKGROUND: Cardiac regeneration after injury is limited by the low proliferative capacity of adult mammalian cardiomyocytes (CMs). However, certain animals readily regenerate lost myocardium through a process involving dedifferentiation, which unlocks their prolife …
BACKGROUND: Cardiac regeneration after injury is limited by the low proliferative capacity of adult mammalian cardiomyocytes (CMs). H …
Comparative single-cell profiling reveals distinct cardiac resident macrophages essential for zebrafish heart regeneration.
Wei KH, Lin IT, Chowdhury K, Lim KL, Liu KT, Ko TM, Chang YM, Yang KC, Lai SB. Wei KH, et al. Elife. 2023 Jul 27;12:e84679. doi: 10.7554/eLife.84679. Elife. 2023. PMID: 37498060 Free PMC article.
Zebrafish exhibit a robust ability to regenerate their hearts following injury, and the immune system plays a key role in this process. ...Here, we further investigate the mechanistic insights of heart regeneration by comparing the non-regenerative mac …
Zebrafish exhibit a robust ability to regenerate their hearts following injury, and the immune system plays a key role in this …
RNA-Binding Proteins as Critical Post-Transcriptional Regulators of Cardiac Regeneration.
Shi DL. Shi DL. Int J Mol Sci. 2023 Jul 26;24(15):12004. doi: 10.3390/ijms241512004. Int J Mol Sci. 2023. PMID: 37569379 Free PMC article. Review.
Myocardial injury causes death to cardiomyocytes and leads to heart failure. The adult mammalian heart has very limited regenerative capacity. However, the heart from early postnatal mammals and from adult lower vertebrates can fully regenerate after a …
Myocardial injury causes death to cardiomyocytes and leads to heart failure. The adult mammalian heart has very limited regene …
Cardiac Regeneration: Lessons From Development.
Galdos FX, Guo Y, Paige SL, VanDusen NJ, Wu SM, Pu WT. Galdos FX, et al. Circ Res. 2017 Mar 17;120(6):941-959. doi: 10.1161/CIRCRESAHA.116.309040. Circ Res. 2017. PMID: 28302741 Free PMC article. Review.
However, these procedures often place pressure and volume loads on the heart, and over time, these chronic loads can cause heart failure. Current therapeutic options for initial surgery and chronic heart failure that results from failed palliation are limited …
However, these procedures often place pressure and volume loads on the heart, and over time, these chronic loads can cause heart …
Cardiac regeneration by resident stem and progenitor cells in the adult heart.
Lyngbaek S, Schneider M, Hansen JL, Sheikh SP. Lyngbaek S, et al. Basic Res Cardiol. 2007 Mar;102(2):101-14. doi: 10.1007/s00395-007-0638-3. Epub 2007 Jan 5. Basic Res Cardiol. 2007. PMID: 17216393 Review.
Two main pieces of data have created a new field in cardiac research. First, the traditional view on the heart as a postmitotic organ has been challenged by the finding of small dividing cells in the heart expressing cardiac contractile proteins with stem cell prope …
Two main pieces of data have created a new field in cardiac research. First, the traditional view on the heart as a postmitotic organ …
Mechanisms of Cardiac Regeneration.
Uygur A, Lee RT. Uygur A, et al. Dev Cell. 2016 Feb 22;36(4):362-74. doi: 10.1016/j.devcel.2016.01.018. Dev Cell. 2016. PMID: 26906733 Free PMC article. Review.
Adult humans fail to regenerate their hearts following injury, and this failure to regenerate myocardium is a leading cause of heart failure and death worldwide. ...The mechanisms of heart regeneration among model organisms, including neo …
Adult humans fail to regenerate their hearts following injury, and this failure to regenerate myocardium is a leading c …
Regenerating the heart by metabolically reprogramming the cardiomyocyte epigenome.
Tang X. Tang X. Cell Metab. 2023 Nov 7;35(11):1849-1851. doi: 10.1016/j.cmet.2023.10.007. Cell Metab. 2023. PMID: 37939655 Free article.
In mammal adolescence, cardiomyocytes rapidly exit the cell cycle, and heart regeneration in adults is limited after cardiac injury. Recent work by Li et al. in Nature revealed that inhibition of fatty acid oxidation can rewire cell metabolism and lead to epigenetic …
In mammal adolescence, cardiomyocytes rapidly exit the cell cycle, and heart regeneration in adults is limited after cardiac i …
Thymosin beta4: multiple functions in protection, repair and regeneration of the mammalian heart.
Bollini S, Riley PR, Smart N. Bollini S, et al. Expert Opin Biol Ther. 2015;15 Suppl 1:S163-74. doi: 10.1517/14712598.2015.1022526. Epub 2015 Jun 22. Expert Opin Biol Ther. 2015. PMID: 26094634 Review.
This has sustained the development of several regenerative strategies based on the use of stem cells and tissue engineering approaches in order to achieve cardiac repair and regeneration by enhancing coronary neovascularization, modulating acute inflammation and supporting …
This has sustained the development of several regenerative strategies based on the use of stem cells and tissue engineering approaches in or …
Hydrogen peroxide primes heart regeneration with a derepression mechanism.
Han P, Zhou XH, Chang N, Xiao CL, Yan S, Ren H, Yang XZ, Zhang ML, Wu Q, Tang B, Diao JP, Zhu X, Zhang C, Li CY, Cheng H, Xiong JW. Han P, et al. Cell Res. 2014 Sep;24(9):1091-107. doi: 10.1038/cr.2014.108. Epub 2014 Aug 15. Cell Res. 2014. PMID: 25124925 Free PMC article.
While the adult human heart has very limited regenerative potential, the adult zebrafish heart can fully regenerate after 20% ventricular resection. Although previous reports suggest that developmental signaling pathways such as FGF and PDGF are reused in adu …
While the adult human heart has very limited regenerative potential, the adult zebrafish heart can fully regenerate aft …
Peptidomics Analysis of Transient Regeneration in the Neonatal Mouse Heart.
Fan Y, Zhang Q, Li H, Cheng Z, Li X, Chen Y, Shen Y, Wang L, Song G, Qian L. Fan Y, et al. J Cell Biochem. 2017 Sep;118(9):2828-2840. doi: 10.1002/jcb.25933. Epub 2017 May 18. J Cell Biochem. 2017. PMID: 28198139
Neonatal mouse hearts have completely regenerative capability after birth, but the ability to regenerate rapidly lost after 7 days, the mechanism has not been clarified. ...So far, there is no research of peptidomics related to heart regeneration. In o …
Neonatal mouse hearts have completely regenerative capability after birth, but the ability to regenerate rapidly lost after 7 …
A Role for Ploidy in Heart Regeneration.
Kadow ZA, Martin JF. Kadow ZA, et al. Dev Cell. 2018 Feb 26;44(4):403-404. doi: 10.1016/j.devcel.2018.02.004. Dev Cell. 2018. PMID: 29486188 Free article.
Proteomics Analysis of Extracellular Matrix Remodeling During Zebrafish Heart Regeneration.
Garcia-Puig A, Mosquera JL, Jiménez-Delgado S, García-Pastor C, Jorba I, Navajas D, Canals F, Raya A. Garcia-Puig A, et al. Mol Cell Proteomics. 2019 Sep;18(9):1745-1755. doi: 10.1074/mcp.RA118.001193. Epub 2019 Jun 20. Mol Cell Proteomics. 2019. PMID: 31221719 Free PMC article.
However, the role of the extracellular matrix (ECM) during zebrafish heart regeneration has been comparatively rarely explored. Here, we set out to characterize the ECM protein composition in adult zebrafish hearts, and whether it changed during the regenerat …
However, the role of the extracellular matrix (ECM) during zebrafish heart regeneration has been comparatively rarely explored …
Expression analysis of Baf60c during heart regeneration in axolotls and neonatal mice.
Nakamura R, Koshiba-Takeuchi K, Tsuchiya M, Kojima M, Miyazawa A, Ito K, Ogawa H, Takeuchi JK. Nakamura R, et al. Dev Growth Differ. 2016 May;58(4):367-82. doi: 10.1111/dgd.12281. Epub 2016 Apr 29. Dev Growth Differ. 2016. PMID: 27125315
Some organisms, such as zebrafish, urodele amphibians, and newborn mice, have a capacity for heart regeneration following injury. However, adult mammals fail to regenerate their hearts. ...These data suggested that Baf60c plays an important role in car …
Some organisms, such as zebrafish, urodele amphibians, and newborn mice, have a capacity for heart regeneration following inju …
Cardiac regeneration as an environmental adaptation.
Sakaguchi A, Nishiyama C, Kimura W. Sakaguchi A, et al. Biochim Biophys Acta Mol Cell Res. 2020 Apr;1867(4):118623. doi: 10.1016/j.bbamcr.2019.118623. Epub 2019 Dec 12. Biochim Biophys Acta Mol Cell Res. 2020. PMID: 31837984 Free article. Review.
Heart failure is a devastating disease that affects more than 26 million individuals worldwide and has a 5-year survival rate of less than 50%, with its development in part reflecting the inability of the adult mammalian heart to regenerate damaged myocardium …
Heart failure is a devastating disease that affects more than 26 million individuals worldwide and has a 5-year survival rate of less …
Telomerase Is Essential for Zebrafish Heart Regeneration.
Bednarek D, González-Rosa JM, Guzmán-Martínez G, Gutiérrez-Gutiérrez Ó, Aguado T, Sánchez-Ferrer C, Marques IJ, Galardi-Castilla M, de Diego I, Gómez MJ, Cortés A, Zapata A, Jiménez-Borreguero LJ, Mercader N, Flores I. Bednarek D, et al. Cell Rep. 2015 Sep 8;12(10):1691-703. doi: 10.1016/j.celrep.2015.07.064. Epub 2015 Aug 28. Cell Rep. 2015. PMID: 26321646 Free PMC article.
After myocardial infarction in humans, lost cardiomyocytes are replaced by an irreversible fibrotic scar. In contrast, zebrafish hearts efficiently regenerate after injury. Complete regeneration of the zebrafish heart is driven by the strong proliferat …
After myocardial infarction in humans, lost cardiomyocytes are replaced by an irreversible fibrotic scar. In contrast, zebrafish hearts …
The heart's content-renewable resources.
Faucherre A, Jopling C. Faucherre A, et al. Int J Cardiol. 2013 Aug 20;167(4):1141-6. doi: 10.1016/j.ijcard.2012.09.051. Epub 2012 Oct 6. Int J Cardiol. 2013. PMID: 23044434 Review.
Heart regeneration is a huge, complex area involving numerous lines of research ranging from the stem cell therapy to xenografts and bioengineering. ...In this review, we will discuss the current understanding of how heart regeneration could be achieve …
Heart regeneration is a huge, complex area involving numerous lines of research ranging from the stem cell therapy to xenograf …
Limited Regeneration Potential with Minimal Epicardial Progenitor Conversions in the Neonatal Mouse Heart after Injury.
Cai W, Tan J, Yan J, Zhang L, Cai X, Wang H, Liu F, Ye M, Cai CL. Cai W, et al. Cell Rep. 2019 Jul 2;28(1):190-201.e3. doi: 10.1016/j.celrep.2019.06.003. Cell Rep. 2019. PMID: 31269439 Free PMC article.
The regeneration capacity of neonatal mouse heart is controversial. In addition, whether epicardial cells provide a progenitor pool for de novo heart regeneration is incompletely defined. ...These observations suggest that early embryonic heart …
The regeneration capacity of neonatal mouse heart is controversial. In addition, whether epicardial cells provide a progenitor …
Oxidant stress-sensitive circRNA Mdc1 controls cardiomyocyte chromosome stability and cell cycle re-entry during heart regeneration.
Ma W, Wang X, Sun H, Xu B, Song R, Tian Y, Zhao L, Xu Y, Zhao Y, Yang F, Chen H, Gong R, Yu Y, Li X, Li S, Zhang W, Zhang T, Ne J, Cai B. Ma W, et al. Pharmacol Res. 2022 Oct;184:106422. doi: 10.1016/j.phrs.2022.106422. Epub 2022 Sep 1. Pharmacol Res. 2022. PMID: 36058431
In vivo, the cardiac-specific adeno-associated virus-mediated knockdown of circMdc1 promoted cardiac regeneration and heart repair accompanied by improved heart function. Conversely, circMdc1 overexpression blunted the regenerative capacity of neonatal hea …
In vivo, the cardiac-specific adeno-associated virus-mediated knockdown of circMdc1 promoted cardiac regeneration and heart re …
Apex Resection in Zebrafish (Danio rerio) as a Model of Heart Regeneration: A Video-Assisted Guide.
Ellman DG, Slaiman IM, Mathiesen SB, Andersen KS, Hofmeister W, Ober EA, Andersen DC. Ellman DG, et al. Int J Mol Sci. 2021 May 30;22(11):5865. doi: 10.3390/ijms22115865. Int J Mol Sci. 2021. PMID: 34070781 Free PMC article.
In contrast, zebrafish retain a regenerative capacity of the heart throughout their lifetimes. Apex resection (AR) is a popular zebrafish model for studying heart regeneration, and entails resecting 10-20% of the heart in the apex region, whereafter th …
In contrast, zebrafish retain a regenerative capacity of the heart throughout their lifetimes. Apex resection (AR) is a popular zebra …
Mammalian Heart Regeneration: The Race to the Finish Line.
Doppler SA, Deutsch MA, Serpooshan V, Li G, Dzilic E, Lange R, Krane M, Wu SM. Doppler SA, et al. Circ Res. 2017 Feb 17;120(4):630-632. doi: 10.1161/CIRCRESAHA.116.310051. Circ Res. 2017. PMID: 28209796 Free PMC article.
A long-standing goal of cardiovascular scientists is to repair damaged hearts following myocardial infarction by overcoming the limited regenerative capacity of the adult mammalian heart. ...The race is on for the first demonstration of durable therapeutic heart …
A long-standing goal of cardiovascular scientists is to repair damaged hearts following myocardial infarction by overcoming the limit …
Harnessing the regenerative potential of interleukin11 to enhance heart repair.
Shin K, Rodriguez-Parks A, Kim C, Silaban IM, Xia Y, Sun J, Dong C, Keles S, Wang J, Cao J, Kang J. Shin K, et al. Nat Commun. 2024 Nov 8;15(1):9666. doi: 10.1038/s41467-024-54060-0. Nat Commun. 2024. PMID: 39516197 Free PMC article.
The role of Interleukin 11 (IL11) in heart regeneration remains controversial, as both regenerative and fibrotic functions have been reported. ...While deciphering the regenerative and fibrotic effects of il11a, we found that il11-dependent fibrosis, but not rege …
The role of Interleukin 11 (IL11) in heart regeneration remains controversial, as both regenerative and fibrotic functions hav …
Tp53 Suppression Promotes Cardiomyocyte Proliferation during Zebrafish Heart Regeneration.
Shoffner A, Cigliola V, Lee N, Ou J, Poss KD. Shoffner A, et al. Cell Rep. 2020 Sep 1;32(9):108089. doi: 10.1016/j.celrep.2020.108089. Cell Rep. 2020. PMID: 32877671 Free PMC article.
Zebrafish regenerate heart muscle through division of pre-existing cardiomyocytes. To discover underlying regulation, we assess transcriptome datasets for dynamic gene networks during heart regeneration and identify suppression of genes associated with …
Zebrafish regenerate heart muscle through division of pre-existing cardiomyocytes. To discover underlying regulation, we asses …
Hippo signaling impedes adult heart regeneration.
Heallen T, Morikawa Y, Leach J, Tao G, Willerson JT, Johnson RL, Martin JF. Heallen T, et al. Development. 2013 Dec;140(23):4683-90. doi: 10.1242/dev.102798. Development. 2013. PMID: 24255096 Free PMC article.
Heart failure due to cardiomyocyte loss after ischemic heart disease is the leading cause of death in the United States in large part because heart muscle regenerates poorly. ...In damaged hearts, Hippo mutant cardiomyocytes also have elevated p …
Heart failure due to cardiomyocyte loss after ischemic heart disease is the leading cause of death in the United States in lar …
Nerves Regulate Cardiomyocyte Proliferation and Heart Regeneration.
Mahmoud AI, O'Meara CC, Gemberling M, Zhao L, Bryant DM, Zheng R, Gannon JB, Cai L, Choi WY, Egnaczyk GF, Burns CE, Burns CG, MacRae CA, Poss KD, Lee RT. Mahmoud AI, et al. Dev Cell. 2015 Aug 24;34(4):387-99. doi: 10.1016/j.devcel.2015.06.017. Epub 2015 Aug 6. Dev Cell. 2015. PMID: 26256209 Free PMC article.
Some organisms, such as adult zebrafish and newborn mice, have the capacity to regenerate heart tissue following injury. Unraveling the mechanisms of heart regeneration is fundamental to understanding why regeneration fails in adult humans. ...T …
Some organisms, such as adult zebrafish and newborn mice, have the capacity to regenerate heart tissue following injury. Unrav …
Myocardial Polyploidization Creates a Barrier to Heart Regeneration in Zebrafish.
González-Rosa JM, Sharpe M, Field D, Soonpaa MH, Field LJ, Burns CE, Burns CG. González-Rosa JM, et al. Dev Cell. 2018 Feb 26;44(4):433-446.e7. doi: 10.1016/j.devcel.2018.01.021. Dev Cell. 2018. PMID: 29486195 Free PMC article.
Correlative evidence suggests that polyploidization of heart muscle, which occurs naturally in post-natal mammals, creates a barrier to heart regeneration. ...Diploid cardiomyocytes outcompeted their polyploid neighbors in producing regenerated hear …
Correlative evidence suggests that polyploidization of heart muscle, which occurs naturally in post-natal mammals, creates a barrier …
Cardiac tissue engineering: regeneration of the wounded heart.
Zammaretti P, Jaconi M. Zammaretti P, et al. Curr Opin Biotechnol. 2004 Oct;15(5):430-4. doi: 10.1016/j.copbio.2004.08.007. Curr Opin Biotechnol. 2004. PMID: 15464373 Review.
New solutions are needed to regenerate hearts damaged by myocardial infarction, to overcome bad prognosis of patients with heart failure, and to address the shortage of heart donors. ...In this short review, we present an overview on the most promising …
New solutions are needed to regenerate hearts damaged by myocardial infarction, to overcome bad prognosis of patients with …
Microenvironment stiffness requires decellularized cardiac extracellular matrix to promote heart regeneration in the neonatal mouse heart.
Wang X, Senapati S, Akinbote A, Gnanasambandam B, Park PS, Senyo SE. Wang X, et al. Acta Biomater. 2020 Sep 1;113:380-392. doi: 10.1016/j.actbio.2020.06.032. Epub 2020 Jun 23. Acta Biomater. 2020. PMID: 32590172 Free PMC article.
The transient period of regeneration potential in the postnatal heart suggests molecular changes with maturation influence the cardiac response to damage. We have previously demonstrated that injury and exercise can stimulate cardiomyocyte proliferation in the adult …
The transient period of regeneration potential in the postnatal heart suggests molecular changes with maturation influence the …
Immune-mediated cardiac development and regeneration.
Byatt TC, Razaghi E, Tüzüner S, Simões FC. Byatt TC, et al. Semin Cell Dev Biol. 2025 Jul;171:103613. doi: 10.1016/j.semcdb.2025.103613. Epub 2025 May 1. Semin Cell Dev Biol. 2025. PMID: 40315634 Free article. Review.
From the earliest stages of cardiogenesis, where primitive macrophages guide heart tube formation, to the complex choreography of inflammation and its resolution during regeneration, immune cells emerge as central orchestrators of cardiac fate. ...In this Review, we …
From the earliest stages of cardiogenesis, where primitive macrophages guide heart tube formation, to the complex choreography of inf …
Regenerating the heart.
Laflamme MA, Murry CE. Laflamme MA, et al. Nat Biotechnol. 2005 Jul;23(7):845-56. doi: 10.1038/nbt1117. Nat Biotechnol. 2005. PMID: 16003373 Review.
Cell-based cardiac repair offers the promise of rebuilding the injured heart from its component parts. Work began with committed cells such as skeletal myoblasts, but recently the field has expanded to explore an array of cell types, including bone marrow cells, endothelia …
Cell-based cardiac repair offers the promise of rebuilding the injured heart from its component parts. Work began with committed cell …
3D-culture system for heart regeneration and cardiac medicine.
Kawaguchi N, Hatta K, Nakanishi T. Kawaguchi N, et al. Biomed Res Int. 2013;2013:895967. doi: 10.1155/2013/895967. Epub 2013 Sep 8. Biomed Res Int. 2013. PMID: 24083247 Free PMC article. Review.
By combining informatics-based studies, including proteomic analyses and microarrays, we sought to generate methods that modeled cardiac regeneration which can ultimately be used to build artificial hearts. Here, we describe the use of biodegradable beads or 3D cult …
By combining informatics-based studies, including proteomic analyses and microarrays, we sought to generate methods that modeled cardiac …
Heart regeneration: a tale of cell reprogramming.
Aguirre A, Sancho-Martinez I, Izpisua Belmonte JC. Aguirre A, et al. Circ Res. 2013 Oct 25;113(10):1109-11. doi: 10.1161/CIRCRESAHA.113.302519. Circ Res. 2013. PMID: 24158574 No abstract available.
Endogenous Mechanisms of Cardiac Regeneration.
Xiang MS, Kikuchi K. Xiang MS, et al. Int Rev Cell Mol Biol. 2016;326:67-131. doi: 10.1016/bs.ircmb.2016.04.002. Epub 2016 Jul 14. Int Rev Cell Mol Biol. 2016. PMID: 27572127 Review.
Zebrafish possess a remarkable capacity for cardiac regeneration throughout their lifetime, providing a model for investigating endogenous cellular and molecular mechanisms regulating myocardial regeneration. By contrast, adult mammals have an extremely limited capa …
Zebrafish possess a remarkable capacity for cardiac regeneration throughout their lifetime, providing a model for investigating endog …
Cardiac regeneration: epicardial mediated repair.
Kennedy-Lydon T, Rosenthal N. Kennedy-Lydon T, et al. Proc Biol Sci. 2015 Dec 22;282(1821):20152147. doi: 10.1098/rspb.2015.2147. Proc Biol Sci. 2015. PMID: 26702046 Free PMC article. Review.
The hearts of lower vertebrates such as fish and salamanders display scarless regeneration following injury, although this feature is lost in adult mammals. The remarkable capacity of the neonatal mammalian heart to regenerate suggests that the underly …
The hearts of lower vertebrates such as fish and salamanders display scarless regeneration following injury, although this fea …
Regulatory T-cells regulate neonatal heart regeneration by potentiating cardiomyocyte proliferation in a paracrine manner.
Li J, Yang KY, Tam RCY, Chan VW, Lan HY, Hori S, Zhou B, Lui KO. Li J, et al. Theranostics. 2019 Jun 9;9(15):4324-4341. doi: 10.7150/thno.32734. eCollection 2019. Theranostics. 2019. PMID: 31285764 Free PMC article.
The neonatal mouse heart is capable of transiently regenerating after injury from postnatal day (P) 0-7 and macrophages are found important in this process. ...Treg directly promote proliferation of both mouse and human cardiomyocytes in a paracrine manner; and thei …
The neonatal mouse heart is capable of transiently regenerating after injury from postnatal day (P) 0-7 and macrophages are fo …
Monitoring of Adult Zebrafish Heart Regeneration Using High-Frequency Ultrasound Spectral Doppler and Nakagami Imaging.
Yeo S, Yoon C, Lien CL, Song TK, Shung KK. Yeo S, et al. Sensors (Basel). 2019 Sep 22;19(19):4094. doi: 10.3390/s19194094. Sensors (Basel). 2019. PMID: 31546705 Free PMC article.
This paper reports the feasibility of Nakagami imaging in monitoring the regeneration process of zebrafish hearts in a noninvasive manner. In addition, spectral Doppler waveforms that are typically used to access the diastolic function were measured to validate the …
This paper reports the feasibility of Nakagami imaging in monitoring the regeneration process of zebrafish hearts in a noninva …
Trends in tissue repair and regeneration.
Galliot B, Crescenzi M, Jacinto A, Tajbakhsh S. Galliot B, et al. Development. 2017 Feb 1;144(3):357-364. doi: 10.1242/dev.144279. Development. 2017. PMID: 28143842 Free article. Review.
The 6th EMBO conference on the Molecular and Cellular Basis of Regeneration and Tissue Repair took place in Paestum (Italy) on the 17th-21st September, 2016. The 160 scientists who attended discussed the importance of cellular and tissue plasticity, biophysical aspects of …
The 6th EMBO conference on the Molecular and Cellular Basis of Regeneration and Tissue Repair took place in Paestum (Italy) on the 17 …
Cardiac neural crest contributes to cardiomyocytes in amniotes and heart regeneration in zebrafish.
Tang W, Martik ML, Li Y, Bronner ME. Tang W, et al. Elife. 2019 Aug 8;8:e47929. doi: 10.7554/eLife.47929. Elife. 2019. PMID: 31393264 Free PMC article.
To test the intriguing possibility that neural crest cells contribute to heart repair, we examined Danio rerio adult heart regeneration in the neural crest transgenic line, Tg(-4.9sox10:eGFP). Whereas the adult heart has few sox10+ cells in the apex, s …
To test the intriguing possibility that neural crest cells contribute to heart repair, we examined Danio rerio adult heart …
Is zebrafish heart regeneration "complete"? Lineage-restricted cardiomyocytes proliferate to pre-injury numbers but some fail to differentiate in fibrotic hearts.
Bertozzi A, Wu CC, Nguyen PD, Vasudevarao MD, Mulaw MA, Koopman CD, de Boer TP, Bakkers J, Weidinger G. Bertozzi A, et al. Dev Biol. 2021 Mar;471:106-118. doi: 10.1016/j.ydbio.2020.12.004. Epub 2020 Dec 10. Dev Biol. 2021. PMID: 33309949 Free article.
Thus, a subset of regenerated cardiomyocytes failed to fully mature. While lineage-tracing experiments have shown that regenerating cardiomyocytes are derived from differentiated cardiomyocytes, technical limitations have previously made it impossible to test whethe …
Thus, a subset of regenerated cardiomyocytes failed to fully mature. While lineage-tracing experiments have shown that regeneratin …
Non-coding RNAs in Cardiac Regeneration.
van der Ven CFT, Hogewoning BCR, van Mil A, Sluijter JPG. van der Ven CFT, et al. Adv Exp Med Biol. 2020;1229:163-180. doi: 10.1007/978-981-15-1671-9_9. Adv Exp Med Biol. 2020. PMID: 32285411 Review.
Cardiovascular disease is a leading cause of death worldwide, and with the dramatically increasing numbers of heart failure patients in the next 10 years, mortality will only increase [1]. For patients with end-stage heart failure, heart transplantation is th …
Cardiovascular disease is a leading cause of death worldwide, and with the dramatically increasing numbers of heart failure patients …
Cardiac regeneration in children.
Rupp S, Schranz D. Rupp S, et al. Pediatr Cardiol. 2015 Apr;36(4):713-8. doi: 10.1007/s00246-015-1120-x. Epub 2015 Jan 30. Pediatr Cardiol. 2015. PMID: 25633820 Review.
Very young mammals have an impressive cardiac regeneration capacity. In contrast, cardiac regeneration is very limited in adult humans. The hearts of young children have a higher regenerative capacity compared with adults, as, for example, seen after surgical …
Very young mammals have an impressive cardiac regeneration capacity. In contrast, cardiac regeneration is very limited in adul …
Building and re-building the heart by cardiomyocyte proliferation.
Foglia MJ, Poss KD. Foglia MJ, et al. Development. 2016 Mar 1;143(5):729-40. doi: 10.1242/dev.132910. Development. 2016. PMID: 26932668 Free PMC article. Review.
The adult human heart does not regenerate significant amounts of lost tissue after injury. Rather than making new, functional muscle, human hearts are prone to scarring and hypertrophy, which can often lead to fatal arrhythmias and heart failure. ...He …
The adult human heart does not regenerate significant amounts of lost tissue after injury. Rather than making new, functional …
Manipulating the Hippo-Yap signal cascade in stem cells for heart regeneration.
Cai WF, Wang L, Liu GS, Zhu P, Paul C, Wang Y. Cai WF, et al. Ann Palliat Med. 2016 Apr;5(2):125-34. doi: 10.21037/apm.2016.03.03. Ann Palliat Med. 2016. PMID: 27121740 Free article. Review.
The Hippo-Yap pathway was originally recognized as a crucial signal cascade controlling organ size, and more recently identified as an important component involved in the regulation of cardiomyocyte survival, proliferation, and regeneration. Negative stress responses can a …
The Hippo-Yap pathway was originally recognized as a crucial signal cascade controlling organ size, and more recently identified as an impor …
A sustained-release drug-delivery system of synthetic prostacyclin agonist, ONO-1301SR: a new reagent to enhance cardiac tissue salvage and/or regeneration in the damaged heart.
Fukushima S, Miyagawa S, Sakai Y, Sawa Y. Fukushima S, et al. Heart Fail Rev. 2015 Jul;20(4):401-13. doi: 10.1007/s10741-015-9477-8. Heart Fail Rev. 2015. PMID: 25708182 Free PMC article. Review.
Cardiac failure is a major cause of mortality and morbidity worldwide, since the standard treatment for cardiac failure in the clinical practice is chiefly to focus on removal of insults against the heart or minimisation of additional factors to exacerbate cardiac failure, …
Cardiac failure is a major cause of mortality and morbidity worldwide, since the standard treatment for cardiac failure in the clinical prac …
A neonatal leporine model of age-dependent natural heart regeneration after myocardial infarction.
Wang H, Hironaka CE, Mullis DM, Lucian HJ, Shin HS, Tran NA, Thakore AD, Anilkumar S, Wu MA, Paulsen MJ, Zhu Y, Baker SW, Woo YJ. Wang H, et al. J Thorac Cardiovasc Surg. 2022 Dec;164(6):e389-e405. doi: 10.1016/j.jtcvs.2021.08.013. Epub 2021 Aug 17. J Thorac Cardiovasc Surg. 2022. PMID: 34649718 Free article.
OBJECTIVES: Neonatal rodents and piglets naturally regenerate the injured heart after myocardial infarction. We hypothesized that neonatal rabbits also exhibit natural heart regeneration after myocardial infarction. ...CONCLUSIONS: A neonatal leporine …
OBJECTIVES: Neonatal rodents and piglets naturally regenerate the injured heart after myocardial infarction. We hypothesized t …
Fate predetermination of cardiac myocytes during zebrafish heart regeneration.
Tekeli I, Garcia-Puig A, Notari M, García-Pastor C, Aujard I, Jullien L, Raya A. Tekeli I, et al. Open Biol. 2017 Jun;7(6):170116. doi: 10.1098/rsob.170116. Open Biol. 2017. PMID: 28659386 Free PMC article.
Finally, our results show an extensive predetermination of CM fate during adult heart regeneration, with cells from each myocardial layer giving rise to cells that retain their layer identity in the regenerated myocardium. Overall, our results indicate that a …
Finally, our results show an extensive predetermination of CM fate during adult heart regeneration, with cells from each myoca …
Cardiac regeneration: All work and no repair?
Kennedy-Lydon T, Rosenthal N. Kennedy-Lydon T, et al. Sci Transl Med. 2017 Mar 29;9(383):eaad9019. doi: 10.1126/scitranslmed.aad9019. Sci Transl Med. 2017. PMID: 28356512 Review.
Structural changes in the developing heart may influence the limited regenerative capacity of the adult heart. We examine how the workload exerted on the adult mammalian heart may limit regenerative capability and discuss recent therapies that demonstrate ben …
Structural changes in the developing heart may influence the limited regenerative capacity of the adult heart. We examine how …
High-resolution tissue Doppler imaging of the zebrafish heart during its regeneration.
Huang CC, Su TH, Shih CC. Huang CC, et al. Zebrafish. 2015 Feb;12(1):48-57. doi: 10.1089/zeb.2014.1026. Epub 2014 Dec 17. Zebrafish. 2015. PMID: 25517185 Free PMC article.
The human heart cannot regenerate after injury, whereas the adult zebrafish can fully regenerate its heart even after 20% of the ventricle is amputated. ...However, the dynamic functions of the zebrafish heart during regeneration are not …
The human heart cannot regenerate after injury, whereas the adult zebrafish can fully regenerate its heart even …
Myocardial NF-kappaB activation is essential for zebrafish heart regeneration.
Karra R, Knecht AK, Kikuchi K, Poss KD. Karra R, et al. Proc Natl Acad Sci U S A. 2015 Oct 27;112(43):13255-60. doi: 10.1073/pnas.1511209112. Epub 2015 Oct 15. Proc Natl Acad Sci U S A. 2015. PMID: 26472034 Free PMC article.
Heart regeneration offers a novel therapeutic strategy for heart failure. Unlike mammals, lower vertebrates such as zebrafish mount a strong regenerative response following cardiac injury. Heart regeneration in zebrafish occurs by cardiomyocyte …
Heart regeneration offers a novel therapeutic strategy for heart failure. Unlike mammals, lower vertebrates such as zeb …
Gene expression analysis of zebrafish heart regeneration.
Lien CL, Schebesta M, Makino S, Weber GJ, Keating MT. Lien CL, et al. PLoS Biol. 2006 Aug;4(8):e260. doi: 10.1371/journal.pbio.0040260. PLoS Biol. 2006. PMID: 16869712 Free PMC article.
Mammalian hearts cannot regenerate. In contrast, zebrafish hearts regenerate even when up to 20% of the ventricle is amputated. ...The expression patterns of several secreted molecules around the wound suggest that they play important roles in heart …
Mammalian hearts cannot regenerate. In contrast, zebrafish hearts regenerate even when up to 20% of the ventricl …
The impact of aging on cardiac repair and regeneration.
Anwar I, Wang X, Pratt RE, Dzau VJ, Hodgkinson CP. Anwar I, et al. J Biol Chem. 2024 Sep;300(9):107682. doi: 10.1016/j.jbc.2024.107682. Epub 2024 Aug 17. J Biol Chem. 2024. PMID: 39159819 Free PMC article. Review.
In contrast to neonates and lower organisms, the adult mammalian heart lacks any capacity to regenerate following injury. The vast majority of our understanding of cardiac regeneration is based on research in young animals. ...This is unfortunate as aging ind …
In contrast to neonates and lower organisms, the adult mammalian heart lacks any capacity to regenerate following injury. The …
Strategies for cardiac regeneration and repair.
Lin Z, Pu WT. Lin Z, et al. Sci Transl Med. 2014 Jun 4;6(239):239rv1. doi: 10.1126/scitranslmed.3006681. Sci Transl Med. 2014. PMID: 24898748 Free PMC article. Review.
Heart failure is a growing epidemic caused by cardiomyocyte depletion. Current therapies prolong survival by protecting remaining cardiomyocytes but are unable to overcome the fundamental problem of regenerating lost cardiomyocytes. Several strategies for promoting …
Heart failure is a growing epidemic caused by cardiomyocyte depletion. Current therapies prolong survival by protecting remaining car …
In vivo proximity labeling identifies cardiomyocyte protein networks during zebrafish heart regeneration.
Pronobis MI, Zheng S, Singh SP, Goldman JA, Poss KD. Pronobis MI, et al. Elife. 2021 Mar 25;10:e66079. doi: 10.7554/eLife.66079. Elife. 2021. PMID: 33764296 Free PMC article.
Here, we apply BioID2 proximity labeling to capture protein networks acting within cardiomyocytes during a key model of innate heart regeneration in zebrafish. Transgenic zebrafish expressing a promiscuous BirA2 localized to the entire myocardial cell or membrane co …
Here, we apply BioID2 proximity labeling to capture protein networks acting within cardiomyocytes during a key model of innate heart …
Heart of newt: a recipe for regeneration.
Singh BN, Koyano-Nakagawa N, Garry JP, Weaver CV. Singh BN, et al. J Cardiovasc Transl Res. 2010 Aug;3(4):397-409. doi: 10.1007/s12265-010-9191-9. Epub 2010 Jun 16. J Cardiovasc Transl Res. 2010. PMID: 20559775
The field of regenerative medicine holds tremendous promise for the treatment of chronic diseases. While the adult mammalian heart has limited regenerative capacity, previous studies have focused on cellular therapeutic strategies in an attempt to modulate cardiac regen …
The field of regenerative medicine holds tremendous promise for the treatment of chronic diseases. While the adult mammalian heart ha …
Novel Therapies Targeting Cardioprotection and Regeneration.
Garrido V, Mendoza-Torres E, Riquelme JA, Díaz A, Pizarro M, Bustamante M, Chavez MN, Ocaranza MP, Mellado R, Corbalan R, Allende ML, Lavandero S. Garrido V, et al. Curr Pharm Des. 2017;23(18):2592-2615. doi: 10.2174/1381612823666170112122637. Curr Pharm Des. 2017. PMID: 28079007 Review.
Cardiovascular disease is the leading cause of death worldwide. The heart is susceptible to pathologies that impact the myocardium directly, such as myocardial infarction and consequent heart failure, as well as conditions with indirect cardiac effects, such as canc …
Cardiovascular disease is the leading cause of death worldwide. The heart is susceptible to pathologies that impact the myocardium di …
Primary contribution to zebrafish heart regeneration by gata4(+) cardiomyocytes.
Kikuchi K, Holdway JE, Werdich AA, Anderson RM, Fang Y, Egnaczyk GF, Evans T, Macrae CA, Stainier DY, Poss KD. Kikuchi K, et al. Nature. 2010 Mar 25;464(7288):601-5. doi: 10.1038/nature08804. Nature. 2010. PMID: 20336144 Free PMC article.
Yet, there is little or no significant cardiac muscle regeneration after an injury such as acute myocardial infarction. By contrast, zebrafish efficiently regenerate lost cardiac muscle, providing a model for understanding how natural heart regeneration …
Yet, there is little or no significant cardiac muscle regeneration after an injury such as acute myocardial infarction. By contrast, …
Myocardial regeneration in heart failure: integrated development of biological therapeutic approaches.
Herreros J, Bustamante J. Herreros J, et al. Expert Rev Cardiovasc Ther. 2011 Aug;9(8):1027-39. doi: 10.1586/erc.11.114. Expert Rev Cardiovasc Ther. 2011. PMID: 21878047 Review.
Heart failure currently constitutes one of the greatest health problems in the Western world. ...Of these, and leaving aside surgical treatments, myocardial regeneration by means of cellular therapy, new concepts in tissue engineering and their results, and the appl …
Heart failure currently constitutes one of the greatest health problems in the Western world. ...Of these, and leaving aside surgical …
The transmembrane glycoprotein Gpnmb is required for the immune and fibrotic responses during zebrafish heart regeneration.
Gupta S, Bajwa GK, El-Sammak H, Mattonet K, Günther S, Looso M, Stainier DYR, Marín-Juez R. Gupta S, et al. Dev Biol. 2025 May;521:153-162. doi: 10.1016/j.ydbio.2025.02.011. Epub 2025 Feb 19. Dev Biol. 2025. PMID: 39983908 Free article.
Myocardial infarction occurs when the coronary supply of oxygen and nutrients to part of the heart is interrupted. In contrast to adult mammals, adult zebrafish have a remarkable ability to regenerate their heart after cardiac injury. ...Furthermore, gpnmb(-/ …
Myocardial infarction occurs when the coronary supply of oxygen and nutrients to part of the heart is interrupted. In contrast to adu …
Mononuclear diploid cardiomyocytes support neonatal mouse heart regeneration in response to paracrine IGF2 signaling.
Shen H, Gan P, Wang K, Darehzereshki A, Wang K, Kumar SR, Lien CL, Patterson M, Tao G, Sucov HM. Shen H, et al. Elife. 2020 Mar 13;9:e53071. doi: 10.7554/eLife.53071. Elife. 2020. PMID: 32167474 Free PMC article.
Injury to the newborn mouse heart is efficiently regenerated, but this capacity is lost by one week after birth. We found that IGF2, an important mitogen in heart development, is required for neonatal heart regeneration. ...Thus, IGF2 is a parac …
Injury to the newborn mouse heart is efficiently regenerated, but this capacity is lost by one week after birth. We found that …
Non-coding RNAs in cardiac regeneration.
Tao L, Bei Y, Zhou Y, Xiao J, Li X. Tao L, et al. Oncotarget. 2015 Dec 15;6(40):42613-22. doi: 10.18632/oncotarget.6073. Oncotarget. 2015. PMID: 26462179 Free PMC article. Review.
Though promising, methods to promote cardiac regeneration have had limited success due to the weak regenerative capacity of the adult mammalian heart. ...Exploring non-coding RNA-based methods to enhance cardiac regeneration would be instrumental for devising …
Though promising, methods to promote cardiac regeneration have had limited success due to the weak regenerative capacity of the adult …
An organ-wide spatiotemporal transcriptomic and cellular atlas of the regenerating zebrafish heart.
Li L, Lu M, Guo L, Zhang X, Liu Q, Zhang M, Gao J, Xu M, Lu Y, Zhang F, Li Y, Zhang R, Liu X, Pan S, Zhang X, Li Z, Chen Y, Su X, Zhang N, Guo W, Yang T, Chen J, Qin Y, Zhang Z, Cui W, Yu L, Gu Y, Yang H, Xu X, Wang J, Burns CE, Burns CG, Han K, Zhao L, Fan G, Su Y. Li L, et al. Nat Commun. 2025 Apr 19;16(1):3716. doi: 10.1038/s41467-025-59070-0. Nat Commun. 2025. PMID: 40253397 Free PMC article.
Adult zebrafish robustly regenerate injured hearts through a complex orchestration of molecular and cellular activities. ...Moreover, we uncover the activation of ifrd1 and atp6ap2 genes as a unique feature of regenerative hearts. Lastly, we reconstruct a 4D …
Adult zebrafish robustly regenerate injured hearts through a complex orchestration of molecular and cellular activities. ...Mo …
Multiple cryoinjuries modulate the efficiency of zebrafish heart regeneration.
Bise T, Sallin P, Pfefferli C, Jaźwińska A. Bise T, et al. Sci Rep. 2020 Jul 14;10(1):11551. doi: 10.1038/s41598-020-68200-1. Sci Rep. 2020. PMID: 32665622 Free PMC article.
Zebrafish can regenerate their damaged hearts throughout their lifespan. It is, however, unknown, whether regeneration remains effective when challenged with successive cycles of cardiac damage in the same animals. ...Using transgenic cell-lineage tracing ana …
Zebrafish can regenerate their damaged hearts throughout their lifespan. It is, however, unknown, whether regeneration …
Histone deacetylase 1 controls cardiomyocyte proliferation during embryonic heart development and cardiac regeneration in zebrafish.
Bühler A, Gahr BM, Park DD, Bertozzi A, Boos A, Dalvoy M, Pott A, Oswald F, Kovall RA, Kühn B, Weidinger G, Rottbauer W, Just S. Bühler A, et al. PLoS Genet. 2021 Nov 1;17(11):e1009890. doi: 10.1371/journal.pgen.1009890. eCollection 2021 Nov. PLoS Genet. 2021. PMID: 34723970 Free PMC article.
However, neither the molecular mechanisms that orchestrate the proliferation of cardiomyocytes during developmental heart growth nor in the context of regeneration in the adult are sufficiently defined yet. ...Hdac1 inhibition significantly reduces cardiomyocyte pro …
However, neither the molecular mechanisms that orchestrate the proliferation of cardiomyocytes during developmental heart growth nor …
Allogeneic transplantation of iPS cell-derived cardiomyocytes regenerates primate hearts.
Shiba Y, Gomibuchi T, Seto T, Wada Y, Ichimura H, Tanaka Y, Ogasawara T, Okada K, Shiba N, Sakamoto K, Ido D, Shiina T, Ohkura M, Nakai J, Uno N, Kazuki Y, Oshimura M, Minami I, Ikeda U. Shiba Y, et al. Nature. 2016 Oct 20;538(7625):388-391. doi: 10.1038/nature19815. Epub 2016 Oct 10. Nature. 2016. PMID: 27723741
Collectively, our data demonstrate that allogeneic iPSC-CM transplantation is sufficient to regenerate the infarcted non-human primate heart; however, further research to control post-transplant arrhythmias is necessary....
Collectively, our data demonstrate that allogeneic iPSC-CM transplantation is sufficient to regenerate the infarcted non-human primat …
Extracellular Vesicles in Cardiac Regeneration: Potential Applications for Tissues-on-a-Chip.
Wagner KT, Nash TR, Liu B, Vunjak-Novakovic G, Radisic M. Wagner KT, et al. Trends Biotechnol. 2021 Aug;39(8):755-773. doi: 10.1016/j.tibtech.2020.08.005. Epub 2020 Sep 19. Trends Biotechnol. 2021. PMID: 32958383 Free PMC article. Review.
Strategies to regenerate cardiac tissue postinjury are limited and heart transplantation remains the only 'cure' for a failing heart. Extracellular vesicles (EVs), membrane-bound cell secretions important in intercellular signaling, have been shown to play a …
Strategies to regenerate cardiac tissue postinjury are limited and heart transplantation remains the only 'cure' for a failing …
Electrocardiogram signals to assess zebrafish heart regeneration: implication of long QT intervals.
Yu F, Li R, Parks E, Takabe W, Hsiai TK. Yu F, et al. Ann Biomed Eng. 2010 Jul;38(7):2346-57. doi: 10.1007/s10439-010-9993-6. Epub 2010 Mar 11. Ann Biomed Eng. 2010. PMID: 20221900 Free PMC article.
Zebrafish is an emerging model system for cardiac conduction and regeneration. Zebrafish heart regenerates after 20% ventricular resection within 60 days. ...Thus, we observed delayed electric repolarization in either the regenerated hearts or s …
Zebrafish is an emerging model system for cardiac conduction and regeneration. Zebrafish heart regenerates after 20% ve …
Cardiac repair using regenerating neonatal heart tissue-derived extracellular vesicles.
Li H, Liu Y, Lin Y, Li S, Liu C, Cai A, Li W, Zhang W, Gao X, Ren Z, Ji H, Yu Y, Wang X, Ma W, Wang N, Zhao D, Li T, Liu Y, Cai B. Li H, et al. Nat Commun. 2025 Feb 3;16(1):1292. doi: 10.1038/s41467-025-56384-x. Nat Commun. 2025. PMID: 39900896 Free PMC article.
Neonatal mammalian hearts are capable of regenerating by inducing cardiomyocyte proliferation after injury. However, this regenerative capability in adult mammalian hearts almost disappears. Extracellular vesicles (EVs) have been shown to play vital cardiopro …
Neonatal mammalian hearts are capable of regenerating by inducing cardiomyocyte proliferation after injury. However, this rege …
Hydrogen Sulfide Promotes Cardiomyocyte Proliferation and Heart Regeneration via ROS Scavenging.
Pei J, Wang F, Pei S, Bai R, Cong X, Nie Y, Chen X. Pei J, et al. Oxid Med Cell Longev. 2020 May 21;2020:1412696. doi: 10.1155/2020/1412696. eCollection 2020. Oxid Med Cell Longev. 2020. PMID: 32566074 Free PMC article.
Neonatal mouse hearts can regenerate completely in 21 days after cardiac injury, providing an ideal model to exploring heart regenerative therapeutic targets. ...Our results demonstrated for the first time that H(2)S promotes heart regeneration …
Neonatal mouse hearts can regenerate completely in 21 days after cardiac injury, providing an ideal model to exploring hear …
A change of heart: understanding the mechanisms regulating cardiac proliferation and metabolism before and after birth.
Dimasi CG, Darby JRT, Morrison JL. Dimasi CG, et al. J Physiol. 2023 Apr;601(8):1319-1341. doi: 10.1113/JP284137. Epub 2023 Mar 13. J Physiol. 2023. PMID: 36872609 Free PMC article. Review.
Immature cardiomyocytes contribute to cardiac growth via proliferation and thus the heart has the capacity to regenerate. To prepare for postnatal life, structural and metabolic changes associated with increased cardiac output and function must occur. ...However, th …
Immature cardiomyocytes contribute to cardiac growth via proliferation and thus the heart has the capacity to regenerate. To p …
Extensive scar formation and regression during heart regeneration after cryoinjury in zebrafish.
González-Rosa JM, Martín V, Peralta M, Torres M, Mercader N. González-Rosa JM, et al. Development. 2011 May;138(9):1663-74. doi: 10.1242/dev.060897. Epub 2011 Mar 23. Development. 2011. PMID: 21429987
The zebrafish heart has the capacity to regenerate after ventricular resection. Although this regeneration model has proved useful for the elucidation of certain regeneration mechanisms, it is based on the removal of heart tissue rather than its …
The zebrafish heart has the capacity to regenerate after ventricular resection. Although this regeneration model has pr …
Metabolic Control of Cardiomyocyte Cell Cycle.
Menendez-Montes I, Garry DJ, Zhang JJ, Sadek HA. Menendez-Montes I, et al. Methodist Debakey Cardiovasc J. 2023 Nov 16;19(5):26-36. doi: 10.14797/mdcvj.1309. eCollection 2023. Methodist Debakey Cardiovasc J. 2023. PMID: 38028975 Free PMC article. Review.
Current therapies for heart failure aim to prevent the deleterious remodeling that occurs after MI injury, but currently no therapies are available to replace lost cardiomyocytes. Several organisms now being studied are capable of regenerating their myocardium by th …
Current therapies for heart failure aim to prevent the deleterious remodeling that occurs after MI injury, but currently no therapies …
Mechanisms of myocardial regeneration.
Hosoda T, Kajstura J, Leri A, Anversa P. Hosoda T, et al. Circ J. 2010 Jan;74(1):13-7. doi: 10.1253/circj.cj-09-0665. Epub 2009 Nov 17. Circ J. 2010. PMID: 19920358 Free article. Review.
The plasticity of bone marrow-derived progenitor cells (BMPCs) and their ability to acquire the myocyte lineage and regenerate dead myocardium after infarction has been challenged. Similarly, although several laboratories have identified cardiac progenitor cells (CPCs), th …
The plasticity of bone marrow-derived progenitor cells (BMPCs) and their ability to acquire the myocyte lineage and regenerate dead m …
Development, Proliferation, and Growth of the Mammalian Heart.
Günthel M, Barnett P, Christoffels VM. Günthel M, et al. Mol Ther. 2018 Jul 5;26(7):1599-1609. doi: 10.1016/j.ymthe.2018.05.022. Epub 2018 Jun 19. Mol Ther. 2018. PMID: 29929790 Free PMC article. Review.
This proliferative capacity is lost soon after birth, with heart growth continuing by an increase in cardiomyocyte volume. The failure of the injured adult heart to regenerate often leads to the development of heart failure, a major cause of death. Wit …
This proliferative capacity is lost soon after birth, with heart growth continuing by an increase in cardiomyocyte volume. The failur …
The Molecular Mechanisms Associated with Aerobic Exercise-Induced Cardiac Regeneration.
Bo B, Zhou Y, Zheng Q, Wang G, Zhou K, Wei J. Bo B, et al. Biomolecules. 2020 Dec 27;11(1):19. doi: 10.3390/biom11010019. Biomolecules. 2020. PMID: 33375497 Free PMC article. Review.
The leading cause of heart failure is cardiomyopathy and damage to the cardiomyocytes. Adult mammalian cardiomyocytes have the ability to regenerate, but this cannot wholly compensate for myocardial cell loss after myocardial injury. ...The topics discussed herein p …
The leading cause of heart failure is cardiomyopathy and damage to the cardiomyocytes. Adult mammalian cardiomyocytes have the abilit …
Cardiac muscle regeneration: lessons from development.
Mercola M, Ruiz-Lozano P, Schneider MD. Mercola M, et al. Genes Dev. 2011 Feb 15;25(4):299-309. doi: 10.1101/gad.2018411. Genes Dev. 2011. PMID: 21325131 Free PMC article. Review.
The adult human heart is an ideal target for regenerative intervention since it does not functionally restore itself after injury yet has a modest regenerative capacity that could be enhanced by innovative therapies. Adult cardiac cells with regenerative potential share ge …
The adult human heart is an ideal target for regenerative intervention since it does not functionally restore itself after injury yet …
Cardiac regeneration: Unraveling the complex network of intercellular crosstalk.
Wu B, Constanty F, Beisaw A. Wu B, et al. Semin Cell Dev Biol. 2025 Jul;171:103619. doi: 10.1016/j.semcdb.2025.103619. Epub 2025 May 13. Semin Cell Dev Biol. 2025. PMID: 40367899 Free article. Review.
In response to cardiac injury or disease, cell-cell interactions and intercellular crosstalk contribute to remodeling to compensate reduced heart function. In some vertebrates, the heart can regenerate following cardiac injury. ...Lastly, we explore recent st …
In response to cardiac injury or disease, cell-cell interactions and intercellular crosstalk contribute to remodeling to compensate reduced …
Developing insights into cardiac regeneration.
Christoffels VM, Pu WT. Christoffels VM, et al. Development. 2013 Oct;140(19):3933-7. doi: 10.1242/dev.096867. Development. 2013. PMID: 24046314 Review.
Owing to its intrinsic beauty and biomedical importance, the heart has been the focus of intensive research. The recent EMBO/EMBL-sponsored symposium 'Cardiac Biology: From Development to Regeneration' gathered cardiovascular scientists from across the globe to disc …
Owing to its intrinsic beauty and biomedical importance, the heart has been the focus of intensive research. The recent EMBO/EMBL-spo …
Myocardial regeneration: role of epicardium and implicated genes.
Saifi O, Ghandour B, Jaalouk D, Refaat M, Mahfouz R. Saifi O, et al. Mol Biol Rep. 2019 Dec;46(6):6661-6674. doi: 10.1007/s11033-019-05075-0. Epub 2019 Sep 23. Mol Biol Rep. 2019. PMID: 31549371 Review.
Lower invertebrates' hearts such as those of zebrafish have the capacity for scarless myocardial regeneration which is lost by mammalian hearts as they form a fibrotic scar tissue instead of regenerating the injured area. However, neonatal mammalian …
Lower invertebrates' hearts such as those of zebrafish have the capacity for scarless myocardial regeneration which is lost by …
Coronary Revascularization During Heart Regeneration Is Regulated by Epicardial and Endocardial Cues and Forms a Scaffold for Cardiomyocyte Repopulation.
Marín-Juez R, El-Sammak H, Helker CSM, Kamezaki A, Mullapuli ST, Bibli SI, Foglia MJ, Fleming I, Poss KD, Stainier DYR. Marín-Juez R, et al. Dev Cell. 2019 Nov 18;51(4):503-515.e4. doi: 10.1016/j.devcel.2019.10.019. Dev Cell. 2019. PMID: 31743664 Free PMC article.
Efficient revascularization after infarction is essential to support tissue repair and function. Zebrafish hearts exhibit a remarkable ability to regenerate, and coronary revascularization initiates within hours of injury, but how this process is regulated remains u …
Efficient revascularization after infarction is essential to support tissue repair and function. Zebrafish hearts exhibit a remarkabl …
Immune modulation of stem cells and regeneration.
Aurora AB, Olson EN. Aurora AB, et al. Cell Stem Cell. 2014 Jul 3;15(1):14-25. doi: 10.1016/j.stem.2014.06.009. Cell Stem Cell. 2014. PMID: 24996166 Free PMC article. Review.
In recent years, there has been a growing appreciation that cellular and humoral components of the immune system also contribute to regeneration of damaged tissues, including limbs, skeletal muscle, heart, and the nervous system. ...We highlight clinical conditions …
In recent years, there has been a growing appreciation that cellular and humoral components of the immune system also contribute to regen …
Endocrine Influence on Cardiac Metabolism in Development and Regeneration.
Graham N, Huang GN. Graham N, et al. Endocrinology. 2021 Sep 1;162(9):bqab081. doi: 10.1210/endocr/bqab081. Endocrinology. 2021. PMID: 33880553 Free PMC article. Review.
Mammalian cardiomyocytes mostly utilize oxidation of fatty acids to generate ATP. The fetal heart, in stark contrast, mostly uses anaerobic glycolysis. During perinatal development, thyroid hormone drives extensive metabolic remodeling in the heart for adaptation to …
Mammalian cardiomyocytes mostly utilize oxidation of fatty acids to generate ATP. The fetal heart, in stark contrast, mostly uses ana …
H3K27me3-mediated silencing of structural genes is required for zebrafish heart regeneration.
Ben-Yair R, Butty VL, Busby M, Qiu Y, Levine SS, Goren A, Boyer LA, Burns CG, Burns CE. Ben-Yair R, et al. Development. 2019 Oct 9;146(19):dev178632. doi: 10.1242/dev.178632. Development. 2019. PMID: 31427288 Free PMC article.
To move beyond an association, we generated an inducible transgenic strain expressing a mutant version of histone 3, H3.3(K27M), that inhibits H3K27me3 catalysis in cardiomyocytes during the regenerative window. Hearts comprising H3.3(K27M)-expressing cardiomyocytes fail t …
To move beyond an association, we generated an inducible transgenic strain expressing a mutant version of histone 3, H3.3(K27M), that inhibi …
Neonatal injury models: integral tools to decipher the molecular basis of cardiac regeneration.
Costa A, Cushman S, Haubner BJ, Derda AA, Thum T, Bär C. Costa A, et al. Basic Res Cardiol. 2022 May 3;117(1):26. doi: 10.1007/s00395-022-00931-w. Basic Res Cardiol. 2022. PMID: 35503383 Free PMC article. Review.
Myocardial injury often leads to heart failure due to the loss and insufficient regeneration of resident cardiomyocytes. ...We summarize pioneering studies that demonstrate the potential of using neonatal cardiac injury models to identify factors that may stimulate …
Myocardial injury often leads to heart failure due to the loss and insufficient regeneration of resident cardiomyocytes. ...We …
Recent Insights into Endogenous Mammalian Cardiac Regeneration Post-Myocardial Infarction.
Fiorino E, Rossin D, Vanni R, Aubry M, Giachino C, Rastaldo R. Fiorino E, et al. Int J Mol Sci. 2024 Nov 1;25(21):11747. doi: 10.3390/ijms252111747. Int J Mol Sci. 2024. PMID: 39519298 Free PMC article. Review.
Myocardial infarction (MI) is a critical global health issue and a leading cause of heart failure. Indeed, while neonatal mammals can regenerate cardiac tissue mainly through cardiomyocyte proliferation, this ability is lost shortly after birth, resulting in the adu …
Myocardial infarction (MI) is a critical global health issue and a leading cause of heart failure. Indeed, while neonatal mammals can …
Adult T-cells impair neonatal cardiac regeneration.
Dolejsi T, Delgobo M, Schuetz T, Tortola L, Heinze KG, Hofmann U, Frantz S, Bauer A, Ruschitzka F, Penninger JM, Campos Ramos G, Haubner BJ. Dolejsi T, et al. Eur Heart J. 2022 Jul 21;43(28):2698-2709. doi: 10.1093/eurheartj/ehac153. Eur Heart J. 2022. PMID: 35417553 Free PMC article.
Patients who survive a myocardial infarction (MI) often develop chronic heart failure due to the heart's poor regeneration capacity. We hypothesized that the cardiac 'regenerative-to-scarring' transition might be driven by the perinatal shifts observed …
Patients who survive a myocardial infarction (MI) often develop chronic heart failure due to the heart's poor regene …
Programming and reprogramming a human heart cell.
Sahara M, Santoro F, Chien KR. Sahara M, et al. EMBO J. 2015 Mar 12;34(6):710-38. doi: 10.15252/embj.201490563. Epub 2015 Feb 20. EMBO J. 2015. PMID: 25712211 Free PMC article. Review.
The latest discoveries and advanced knowledge in the fields of stem cell biology and developmental cardiology hold great promise for cardiac regenerative medicine, enabling researchers to design novel therapeutic tools and approaches to regenerate cardiac muscle for diseas …
The latest discoveries and advanced knowledge in the fields of stem cell biology and developmental cardiology hold great promise for cardiac …
Functional and structural regeneration in the axolotl heart (Ambystoma mexicanum) after partial ventricular amputation.
Cano-Martínez A, Vargas-González A, Guarner-Lans V, Prado-Zayago E, León-Oleda M, Nieto-Lima B. Cano-Martínez A, et al. Arch Cardiol Mex. 2010 Apr-Jun;80(2):79-86. Arch Cardiol Mex. 2010. PMID: 21147570
One day after PVA, ventricular-tension (VT) (16 3%), atrium-tension (AT) (46 4%) and heart rate (HR) (58+10%) resulted lower in comparison to control hearts. On days five, 30 and 90 after damage, values achieved a 61 5, 93 3, and 98 5% (VT), 60 4, 96 3 and 99 5% (AT …
One day after PVA, ventricular-tension (VT) (16 3%), atrium-tension (AT) (46 4%) and heart rate (HR) (58+10%) resulted lower in compa …
Mechanisms of myocardial regeneration.
Leri A, Kajstura J, Anversa P. Leri A, et al. Trends Cardiovasc Med. 2011 Feb;21(2):52-8. doi: 10.1016/j.tcm.2012.02.006. Trends Cardiovasc Med. 2011. PMID: 22578241 Free PMC article. Review.
However, the discovery that cardiac stem cells live in the heart and differentiate into the various cardiac cell lineages has dramatically changed our understanding of myocardial biology. ...These multiple mechanisms of cell growth may act in concert to regenerate c …
However, the discovery that cardiac stem cells live in the heart and differentiate into the various cardiac cell lineages has dramati …
Zebrafish heart regenerates after chemoptogenetic cardiomyocyte depletion.
Missinato MA, Zuppo DA, Watkins SC, Bruchez MP, Tsang M. Missinato MA, et al. Dev Dyn. 2021 Jul;250(7):986-1000. doi: 10.1002/dvdy.305. Epub 2021 Feb 8. Dev Dyn. 2021. PMID: 33501711 Free PMC article.
BACKGROUND: Zebrafish can regenerate adult cardiac tissue following injuries from ventricular apex amputation, cryoinjury, and cardiomyocyte genetic ablation. ...This approach represents a useful model to study specifically cardiomyocyte injury, proliferation and regene …
BACKGROUND: Zebrafish can regenerate adult cardiac tissue following injuries from ventricular apex amputation, cryoinjury, and cardio …
Apical Resection Mouse Model to Study Early Mammalian Heart Regeneration.
Xiong J, Hou J. Xiong J, et al. J Vis Exp. 2016 Jan 23;(107):e53488. doi: 10.3791/53488. J Vis Exp. 2016. PMID: 26862937 Free PMC article.
Cardiovascular disease plagues the whole world due to intensive lifestyle changes. Heart regeneration holds great promise for repairing and restoring cardiomyocytes lost due to injury and disease. In contrast to the robust cardiac regeneration of certain lowe …
Cardiovascular disease plagues the whole world due to intensive lifestyle changes. Heart regeneration holds great promise for …
Cardiomyocyte heterogeneity during zebrafish development and regeneration.
Tsedeke AT, Allanki S, Gentile A, Jimenez-Amilburu V, Rasouli SJ, Guenther S, Lai SL, Stainier DYR, Marín-Juez R. Tsedeke AT, et al. Dev Biol. 2021 Aug;476:259-271. doi: 10.1016/j.ydbio.2021.03.014. Epub 2021 Apr 12. Dev Biol. 2021. PMID: 33857482 Free article.
Using newly developed reporter lines for these genes, we investigated their expression dynamics during heart development and regeneration. tnnc2 reporter lines label most CMs at embryonic stages, and this labeling declines rapidly during larval stages; in adult h …
Using newly developed reporter lines for these genes, we investigated their expression dynamics during heart development and regen …
The winding road to regenerating the human heart.
Gerbin KA, Murry CE. Gerbin KA, et al. Cardiovasc Pathol. 2015 May-Jun;24(3):133-40. doi: 10.1016/j.carpath.2015.02.004. Epub 2015 Feb 19. Cardiovasc Pathol. 2015. PMID: 25795463 Free PMC article. Review.
Regenerating the human heart is a challenge that has engaged researchers and clinicians around the globe for nearly a century. ...However, chronic heart failure remains a leading pathological burden worldwide. Why has regenerating the human heart …
Regenerating the human heart is a challenge that has engaged researchers and clinicians around the globe for nearly a century. …
Myocardial regeneration: the role of progenitor cells derived from bone marrow and heart.
Wang X, From AH, Zhang J. Wang X, et al. Prog Mol Biol Transl Sci. 2012;111:195-215. doi: 10.1016/B978-0-12-398459-3.00009-5. Prog Mol Biol Transl Sci. 2012. PMID: 22917232 Review.
The possibility that preexisting cardiomyocytes can be induced to reenter the cell cycle and regenerate replacement cardiomyocytes is also discussed....
The possibility that preexisting cardiomyocytes can be induced to reenter the cell cycle and regenerate replacement cardiomyocytes is …
Notch signaling regulates cardiomyocyte proliferation during zebrafish heart regeneration.
Zhao L, Borikova AL, Ben-Yair R, Guner-Ataman B, MacRae CA, Lee RT, Burns CG, Burns CE. Zhao L, et al. Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):1403-8. doi: 10.1073/pnas.1311705111. Epub 2014 Jan 13. Proc Natl Acad Sci U S A. 2014. PMID: 24474765 Free PMC article.
The human heart's failure to replace ischemia-damaged myocardium with regenerated muscle contributes significantly to the worldwide morbidity and mortality associated with coronary artery disease. ...Unexpectedly, hyperactivation of Notch signaling also suppr …
The human heart's failure to replace ischemia-damaged myocardium with regenerated muscle contributes significantly to t …
Achieving stable myocardial regeneration after apical resection in neonatal mice.
Li Y, Feng J, Li Y, Hu S, Nie Y. Li Y, et al. J Cell Mol Med. 2020 Jun;24(11):6500-6504. doi: 10.1111/jcmm.15223. Epub 2020 Apr 28. J Cell Mol Med. 2020. PMID: 32343038 Free PMC article.
The neonatal heart completely regenerates after apical resection (AR), providing a desirable research model to study the mechanism of cardiac regeneration and cardiomyocyte proliferation. ...The combination of the optimized AR operation and the whole-heart …
The neonatal heart completely regenerates after apical resection (AR), providing a desirable research model to study the mecha …
Large Animal Models of Cell-Free Cardiac Regeneration.
Spannbauer A, Mester-Tonczar J, Traxler D, Kastner N, Zlabinger K, Hašimbegović E, Riesenhuber M, Pavo N, Goliasch G, Gyöngyösi M. Spannbauer A, et al. Biomolecules. 2020 Sep 29;10(10):1392. doi: 10.3390/biom10101392. Biomolecules. 2020. PMID: 33003617 Free PMC article. Review.
The adult mammalian heart lacks the ability to sufficiently regenerate itself, leading to the progressive deterioration of function and heart failure after ischemic injuries such as myocardial infarction. ...In this review, we give an overview of the state-of …
The adult mammalian heart lacks the ability to sufficiently regenerate itself, leading to the progressive deterioration of fun …
Regenerating the human heart: direct reprogramming strategies and their current limitations.
Ghiroldi A, Piccoli M, Ciconte G, Pappone C, Anastasia L. Ghiroldi A, et al. Basic Res Cardiol. 2017 Oct 27;112(6):68. doi: 10.1007/s00395-017-0655-9. Basic Res Cardiol. 2017. PMID: 29079873 Free article. Review.
Unfortunately, current therapies are often only palliative, consequently essentially making heart transplantation necessary for many patients. However, several novel therapeutic approaches in the past two decades have yielded quite encouraging results. The generation of in …
Unfortunately, current therapies are often only palliative, consequently essentially making heart transplantation necessary for many …
[Generation of new cardiomyocytes in the adult heart: Prospects of myocardial regeneration as an alternative to cardiac transplantation].
Nadal-Ginard B. Nadal-Ginard B. Rev Esp Cardiol. 2001 May;54(5):543-50. doi: 10.1016/s0300-8932(01)76354-3. Rev Esp Cardiol. 2001. PMID: 11412743 Free article. Spanish.
By themselves, these high rates of normal cell death provide a very compelling argument in favor of cardiomyocyte regeneration. Without cell renewal, these rates of cell death would be incompatible with survival because the heart would disappear before early adultho …
By themselves, these high rates of normal cell death provide a very compelling argument in favor of cardiomyocyte regeneration. Witho …
Cell-Based Therapies for Cardiac Regeneration: A Comprehensive Review of Past and Ongoing Strategies.
Ghiroldi A, Piccoli M, Cirillo F, Monasky MM, Ciconte G, Pappone C, Anastasia L. Ghiroldi A, et al. Int J Mol Sci. 2018 Oct 16;19(10):3194. doi: 10.3390/ijms19103194. Int J Mol Sci. 2018. PMID: 30332812 Free PMC article. Review.
Despite considerable improvements in the treatment of cardiovascular diseases, heart failure (HF) still represents one of the leading causes of death worldwide. Poor prognosis is mostly due to the limited regenerative capacity of the adult human heart, which ultimat …
Despite considerable improvements in the treatment of cardiovascular diseases, heart failure (HF) still represents one of the leading …
A dual epimorphic and compensatory mode of heart regeneration in zebrafish.
Sallin P, de Preux Charles AS, Duruz V, Pfefferli C, Jaźwińska A. Sallin P, et al. Dev Biol. 2015 Mar 1;399(1):27-40. doi: 10.1016/j.ydbio.2014.12.002. Epub 2014 Dec 31. Dev Biol. 2015. PMID: 25557620 Free article.
Zebrafish heart regeneration relies on the capacity of cardiomyocytes to proliferate upon injury. ...During the advanced regenerative phase, the population of undifferentiated cardiomyocytes disperses within the regenerating myocardium and it is not detected …
Zebrafish heart regeneration relies on the capacity of cardiomyocytes to proliferate upon injury. ...During the advanced regen …
Non-coding RNAs in endothelial cell signalling and hypoxia during cardiac regeneration.
Peters MMC, Sampaio-Pinto V, da Costa Martins PA. Peters MMC, et al. Biochim Biophys Acta Mol Cell Res. 2020 Mar;1867(3):118515. doi: 10.1016/j.bbamcr.2019.07.010. Epub 2019 Jul 27. Biochim Biophys Acta Mol Cell Res. 2020. PMID: 31362011 Free article. Review.
In contrast to the adult mammalian heart, which has low regenerative capacity, newborn mammalian and zebrafish hearts can completely regenerate after injury. ...In this review, we highlight the molecular interactions between endothelial cells (ECs) and CMs in …
In contrast to the adult mammalian heart, which has low regenerative capacity, newborn mammalian and zebrafish hearts can comp …
Dating the Heart: Exploring Cardiomyocyte Renewal in Humans.
Graham E, Bergmann O. Graham E, et al. Physiology (Bethesda). 2017 Jan;32(1):33-41. doi: 10.1152/physiol.00015.2016. Physiology (Bethesda). 2017. PMID: 27927803 Free article. Review.
Regenerative mechanisms reported in the hearts of lower vertebrates have been recapitulated in the mammalian milieu, and recent studies have provided strong evidence for cardiomyocyte turnover in humans. These findings speak to an emerging consensus that adult mammalian ca …
Regenerative mechanisms reported in the hearts of lower vertebrates have been recapitulated in the mammalian milieu, and recent studi …
Triiodothyronine induces a proinflammatory monocyte/macrophage profile and impedes cardiac regeneration.
Chen Z, Cai D, Xie Y, Zhong J, Wu M, Yang H, Feng J, Lian H, Dou K, Nie Y. Chen Z, et al. J Mol Cell Cardiol. 2024 Jun;191:7-11. doi: 10.1016/j.yjmcc.2024.04.007. Epub 2024 Apr 10. J Mol Cell Cardiol. 2024. PMID: 38608929 Free article.
Neonatal mouse hearts can regenerate post-injury, unlike adult hearts that form fibrotic scars. The mechanism of thyroid hormone signaling in cardiac regeneration warrants further study. ...Our study unveils a novel role of triiodothyronine in mediatin …
Neonatal mouse hearts can regenerate post-injury, unlike adult hearts that form fibrotic scars. The mechanism of thyroi …
[Stem cells to regenerate cardiac tissue in heart failure].
Prósper Cardoso F, Herreros González J, Alegría Ezquerra E. Prósper Cardoso F, et al. Rev Esp Cardiol. 2003 Oct;56(10):935-9. doi: 10.1016/s0300-8932(03)76987-5. Rev Esp Cardiol. 2003. PMID: 14563284 Free article. Review. Spanish.
Myocardial regeneration is one of the most promising therapeutic strategies for heart failure patients. Many experimental studies have demonstrated that different types of stem cell can differentiate into myocardial cells and tissues necessary for regeneration …
Myocardial regeneration is one of the most promising therapeutic strategies for heart failure patients. Many experimental stud …
Genetic and epigenetic regulation of cardiomyocytes in development, regeneration and disease.
Cui M, Wang Z, Bassel-Duby R, Olson EN. Cui M, et al. Development. 2018 Dec 20;145(24):dev171983. doi: 10.1242/dev.171983. Development. 2018. PMID: 30573475 Free PMC article. Review.
These cells, termed cardiomyocytes, display many fascinating behaviors, including complex morphogenic movements, interactions with other cell types of the heart, persistent contractility and quiescence after birth. Each of these behaviors depends on complex interactions be …
These cells, termed cardiomyocytes, display many fascinating behaviors, including complex morphogenic movements, interactions with other cel …
Networks that Govern Cardiomyocyte Proliferation to Facilitate Repair of the Injured Mammalian Heart.
Garry DJ, Zhang JJ, Larson TA, Sadek HA, Garry MG. Garry DJ, et al. Methodist Debakey Cardiovasc J. 2023 Nov 16;19(5):16-25. doi: 10.14797/mdcvj.1300. eCollection 2023. Methodist Debakey Cardiovasc J. 2023. PMID: 38028968 Free PMC article. Review.
Cardiovascular diseases frequently progress to end-stage heart failure, and curative therapies are extremely limited. Intense interest has focused on deciphering the cascades and networks that govern cardiomyocyte proliferation and regeneration of the injured hea …
Cardiovascular diseases frequently progress to end-stage heart failure, and curative therapies are extremely limited. Intense interes …
Recovery of the Xenopus laevis heart from ROS-induced stress utilizes conserved pathways of cardiac regeneration.
Jewhurst K, McLaughlin KA. Jewhurst K, et al. Dev Growth Differ. 2019 Apr;61(3):212-227. doi: 10.1111/dgd.12602. Epub 2019 Mar 28. Dev Growth Differ. 2019. PMID: 30924142
Using an optogenetic stress induction model that utilizes the protein KillerRed, we have investigated the extent to which mechanisms of cardiac regeneration are conserved during the restoration of normal heart morphology post oxidative stress in X. laevis tadpoles. …
Using an optogenetic stress induction model that utilizes the protein KillerRed, we have investigated the extent to which mechanisms of card …
Myocardial regeneration: expanding the repertoire of thymosin beta4 in the ischemic heart.
Smart N, Bollini S, Dubé KN, Vieira JM, Zhou B, Riegler J, Price AN, Lythgoe MF, Davidson S, Yellon D, Pu WT, Riley PR. Smart N, et al. Ann N Y Acad Sci. 2012 Oct;1269:92-101. doi: 10.1111/j.1749-6632.2012.06708.x. Ann N Y Acad Sci. 2012. PMID: 23045976 Free PMC article.
However, insight into how to stimulate repair of the human heart is currently limited. Using the embryonic paradigm of regeneration, we demonstrated that the actin-binding peptide thymosin beta4 (Tbeta4), required for epicardium-derived coronary vasculogenesis, can …
However, insight into how to stimulate repair of the human heart is currently limited. Using the embryonic paradigm of regeneratio …
The scarless heart.
Leferovich JM, Heber-Katz E. Leferovich JM, et al. Semin Cell Dev Biol. 2002 Oct;13(5):327-33. doi: 10.1016/s1084952102000885. Semin Cell Dev Biol. 2002. PMID: 12324214 Review.
However, the fact remains that after injury to the heart, the overriding response is scar formation with little myocardial replacement. One exception to this response is the MRL mouse, which heals with little scarring and shows nearly full myocardial replacement after inju …
However, the fact remains that after injury to the heart, the overriding response is scar formation with little myocardial replacemen …
Thyroid hormone and cardiac repair/regeneration: from Prometheus myth to reality?
Pantos C, Mourouzis I, Cokkinos DV. Pantos C, et al. Can J Physiol Pharmacol. 2012 Aug;90(8):977-87. doi: 10.1139/y2012-031. Epub 2012 Jul 4. Can J Physiol Pharmacol. 2012. PMID: 22762197 Review.
Nature's models of repair and (or) regeneration provide substantial evidence that a natural healing process may exist in the heart. ...Analogies exist between the damaged and developing heart, indicating that a regulatory network that drives embryonic hear …
Nature's models of repair and (or) regeneration provide substantial evidence that a natural healing process may exist in the heart …
Cellular and Molecular Mechanism of Cardiac Regeneration: A Comparison of Newts, Zebrafish, and Mammals.
de Wit L, Fang J, Neef K, Xiao J, A Doevendans P, Schiffelers RM, Lei Z, Sluijter JPG. de Wit L, et al. Biomolecules. 2020 Aug 19;10(9):1204. doi: 10.3390/biom10091204. Biomolecules. 2020. PMID: 32825069 Free PMC article. Review.
Current palliative treatments can slow the progression of heart failure, but ultimately, the only curative treatment for end-stage heart failure is heart transplantation, which is only available for a minority of patients due to lack of donors' hearts. …
Current palliative treatments can slow the progression of heart failure, but ultimately, the only curative treatment for end-stage …
Regeneration of cryoinjury induced necrotic heart lesions in zebrafish is associated with epicardial activation and cardiomyocyte proliferation.
Schnabel K, Wu CC, Kurth T, Weidinger G. Schnabel K, et al. PLoS One. 2011 Apr 12;6(4):e18503. doi: 10.1371/journal.pone.0018503. PLoS One. 2011. PMID: 21533269 Free PMC article.
In contrast, zebrafish have a high capacity to regenerate the heart after surgical resection of myocardial tissue. However, whether zebrafish can also regenerate lesions caused by cell death has not been tested. ...Our injury model will be a useful tool to st …
In contrast, zebrafish have a high capacity to regenerate the heart after surgical resection of myocardial tissue. However, wh …
Single epicardial cell transcriptome sequencing identifies Caveolin 1 as an essential factor in zebrafish heart regeneration.
Cao J, Navis A, Cox BD, Dickson AL, Gemberling M, Karra R, Bagnat M, Poss KD. Cao J, et al. Development. 2016 Jan 15;143(2):232-43. doi: 10.1242/dev.130534. Epub 2015 Dec 10. Development. 2016. PMID: 26657776 Free PMC article.
Moreover, cav1 mutant zebrafish generated by genome editing showed grossly normal heart development and adult cardiac anatomy, but displayed profound defects in injury-induced cardiomyocyte proliferation and heart regeneration. Our study defines a new platfor …
Moreover, cav1 mutant zebrafish generated by genome editing showed grossly normal heart development and adult cardiac anatomy, but di …
Visualization of regenerating and repairing hearts.
Powers N, Huang GN. Powers N, et al. Clin Sci (Lond). 2022 May 27;136(10):787-798. doi: 10.1042/CS20211116. Clin Sci (Lond). 2022. PMID: 35621122 Free PMC article.
With heart failure continuing to become more prevalent, investigating the mechanisms of heart injury and repair holds much incentive. ...However, this task remains challenging for the heart due to its rhythmic contraction and anatomical location. Here, we sum …
With heart failure continuing to become more prevalent, investigating the mechanisms of heart injury and repair holds much inc …
Extending the time window of mammalian heart regeneration by thymosin beta 4.
Rui L, Yu N, Hong L, Feng H, Chunyong H, Jian M, Zhe Z, Shengshou H. Rui L, et al. J Cell Mol Med. 2014 Dec;18(12):2417-24. doi: 10.1111/jcmm.12421. Epub 2014 Oct 6. J Cell Mol Med. 2014. PMID: 25284727 Free PMC article.
Recent studies demonstrated that the heart of 1-day-old neonatal mice could regenerate, with Wt1(+) EPDCs migrating into myocardial regions after partial surgical resection, but this capacity was lost by 7 days of age. ...These characteristics of Wt1(+) EPDCs were a …
Recent studies demonstrated that the heart of 1-day-old neonatal mice could regenerate, with Wt1(+) EPDCs migrating into myoca …
Regeneration Tensed Up: Polyploidy Takes the Lead.
Spiró Z, Heisenberg CP. Spiró Z, et al. Dev Cell. 2017 Sep 25;42(6):559-560. doi: 10.1016/j.devcel.2017.09.008. Dev Cell. 2017. PMID: 28950096 Free article.
The cellular mechanisms allowing tissues to efficiently regenerate are not fully understood. In this issue of Developmental Cell, Cao et al. (2017) discover that during zebrafish heart regeneration, epicardial cells at the leading edge of regenerating …
The cellular mechanisms allowing tissues to efficiently regenerate are not fully understood. In this issue of Developmental Cell, Cao …
STEMIN and YAP5SA, the future of heart repair?
Bejar N, Xiao S, Iyer D, Muili A, Adeleye A, McConnell BK, Schwartz RJ. Bejar N, et al. Exp Biol Med (Maywood). 2024 Oct 31;249:10246. doi: 10.3389/ebm.2024.10246. eCollection 2024. Exp Biol Med (Maywood). 2024. PMID: 39544432 Free PMC article. Review.
This review outlines some of the many approaches taken over a decade or more to repair damaged hearts. We showcase the recent breakthroughs in organ regeneration elicited by reprogramming factors OCT3/4, SOX2, KLF4, and C-MYC (OKSM). ...Injected STEMIN and YAP5SA sy …
This review outlines some of the many approaches taken over a decade or more to repair damaged hearts. We showcase the recent breakth …
Regulation of cardiomyocyte fate plasticity: a key strategy for cardiac regeneration.
Gong R, Jiang Z, Zagidullin N, Liu T, Cai B. Gong R, et al. Signal Transduct Target Ther. 2021 Jan 27;6(1):31. doi: 10.1038/s41392-020-00413-2. Signal Transduct Target Ther. 2021. PMID: 33500391 Free PMC article. Review.
With the high morbidity and mortality rates, cardiovascular diseases have become one of the most concerning diseases worldwide. The heart of adult mammals can hardly regenerate naturally after injury because adult cardiomyocytes have already exited the cell cycle, w …
With the high morbidity and mortality rates, cardiovascular diseases have become one of the most concerning diseases worldwide. The heart …
Induced Cardiomyocyte Proliferation: A Promising Approach to Cure Heart Failure.
Salama ABM, Gebreil A, Mohamed TMA, Abouleisa RRE. Salama ABM, et al. Int J Mol Sci. 2021 Jul 19;22(14):7720. doi: 10.3390/ijms22147720. Int J Mol Sci. 2021. PMID: 34299340 Free PMC article. Review.
Unlike some lower vertebrates which can completely regenerate their heart, the human heart is a terminally differentiated organ. Cardiomyocytes lost during cardiac injury and heart failure cannot be replaced due to their limited proliferative capacity. …
Unlike some lower vertebrates which can completely regenerate their heart, the human heart is a terminally differentiat …
An emerging consensus on cardiac regeneration.
van Berlo JH, Molkentin JD. van Berlo JH, et al. Nat Med. 2014 Dec;20(12):1386-93. doi: 10.1038/nm.3764. Nat Med. 2014. PMID: 25473919 Free PMC article.
Cardiac regeneration is a rapidly evolving and controversial field of research. The identification some 12 years ago of progenitor cells that reside within the heart spurred enthusiasm for cell-based regenerative therapies. ...Here, we discuss recent developments th …
Cardiac regeneration is a rapidly evolving and controversial field of research. The identification some 12 years ago of progenitor ce …
Role of Mononuclear Cardiomyocytes in Cardiac Turnover and Regeneration.
Becker C, Hesse M. Becker C, et al. Curr Cardiol Rep. 2020 May 19;22(6):39. doi: 10.1007/s11886-020-01289-y. Curr Cardiol Rep. 2020. PMID: 32430578 Free PMC article. Review.
PURPOSE OF REVIEW: The typical remodeling process after cardiac injury is scarring and compensatory hypertrophy. The limited regeneration potential of the adult heart is thought to be due to the post-mitotic status of postnatal cardiomyocytes, which are mostly binuc …
PURPOSE OF REVIEW: The typical remodeling process after cardiac injury is scarring and compensatory hypertrophy. The limited regeneration …
Toward the latest advancements in cardiac regeneration using induced pluripotent stem cells (iPSCs) technology: approaches and challenges.
Farboud SP, Fathi E, Valipour B, Farahzadi R. Farboud SP, et al. J Transl Med. 2024 Aug 22;22(1):783. doi: 10.1186/s12967-024-05499-8. J Transl Med. 2024. PMID: 39175068 Free PMC article. Review.
A novel approach to treating heart failures was developed with the introduction of iPSC technology. Knowledge in regenerative medicine, developmental biology, and the identification of illnesses at the cellular level has exploded since the discovery of iPSCs. One of the mo …
A novel approach to treating heart failures was developed with the introduction of iPSC technology. Knowledge in regenerative medicin …
Myocardial Regeneration for Humans - Modifying Biology and Manipulating Evolution.
Broughton KM, Sussman MA. Broughton KM, et al. Circ J. 2017 Jan 25;81(2):142-148. doi: 10.1253/circj.CJ-16-1228. Epub 2016 Dec 27. Circ J. 2017. PMID: 28025465 Free article. Review.
Adult stem cells were successful in entering numerous clinical trials over the past 15 years in attempts to regenerate the heart. First-generation adult stem cell therapies for myocardial regeneration were highly promising in small animal models but realized …
Adult stem cells were successful in entering numerous clinical trials over the past 15 years in attempts to regenerate the heart …
Systemic inhibition of mitochondrial fatty acid beta-oxidation impedes zebrafish ventricle regeneration.
Zhao Y, Lv H, Yu C, Liang J, Yu H, Du Z, Zhang R. Zhao Y, et al. Biochim Biophys Acta Mol Basis Dis. 2024 Oct;1870(7):167442. doi: 10.1016/j.bbadis.2024.167442. Epub 2024 Jul 24. Biochim Biophys Acta Mol Basis Dis. 2024. PMID: 39059593
Unlike humans and other mammals, zebrafish demonstrate a remarkable capacity to regenerate their injured hearts throughout life. Mitochondrial fatty acid beta-oxidation (FAO) contributes to major energy demands of the adult hearts under physiological conditio …
Unlike humans and other mammals, zebrafish demonstrate a remarkable capacity to regenerate their injured hearts throughout lif …
The long non-coding road to endogenous cardiac regeneration.
Afify ARY. Afify ARY. Heart Fail Rev. 2019 Jul;24(4):587-600. doi: 10.1007/s10741-019-09782-5. Heart Fail Rev. 2019. PMID: 30900115 Review.
The human heart has a markedly low regenerative capacity, leaving patients who suffered from cardiac insults vulnerable to heart failure. ...Although adult mammals seem to lack the ability to regenerate, some lower vertebrates have a cardio-regenerative poten …
The human heart has a markedly low regenerative capacity, leaving patients who suffered from cardiac insults vulnerable to heart …
17,243 results
You have reached the last available page of results. Please see the User Guide for more information.