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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1945 4
1946 18
1947 13
1948 11
1949 9
1950 6
1951 27
1952 46
1953 45
1954 46
1955 52
1956 57
1957 55
1958 60
1959 59
1960 62
1961 74
1962 47
1963 19
1964 70
1965 63
1966 71
1967 80
1968 133
1969 176
1970 177
1971 234
1972 239
1973 267
1974 300
1975 257
1976 212
1977 213
1978 236
1979 254
1980 235
1981 294
1982 321
1983 291
1984 373
1985 322
1986 298
1987 317
1988 326
1989 353
1990 346
1991 318
1992 384
1993 378
1994 355
1995 405
1996 419
1997 428
1998 404
1999 472
2000 502
2001 479
2002 559
2003 610
2004 617
2005 676
2006 833
2007 759
2008 825
2009 801
2010 955
2011 1088
2012 1075
2013 1065
2014 1081
2015 1115
2016 1150
2017 1097
2018 1151
2019 1113
2020 714
2021 44
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27,281 results
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Helminth Therapy - From the Parasite Perspective.
Sobotková K, Parker W, Levá J, Růžková J, Lukeš J, Jirků Pomajbíková K. Sobotková K, et al. Trends Parasitol. 2019 Jul;35(7):501-515. doi: 10.1016/j.pt.2019.04.009. Epub 2019 May 29. Trends Parasitol. 2019. PMID: 31153721 Review.
Studies in animal models and humans suggest that intentional exposure to helminths or helminth-derived products may hold promise for treating chronic inflammatory-associated diseases (CIADs). Although the mechanisms underlying 'helminth therapy' are be …
Studies in animal models and humans suggest that intentional exposure to helminths or helminth-derived products may hold promi …
Helminth therapy for organic diseases?
Leonardi I, Frey I, Rogler G. Leonardi I, et al. Transl Res. 2015 Dec;166(6):586-601. doi: 10.1016/j.trsl.2015.06.016. Epub 2015 Jul 3. Transl Res. 2015. PMID: 26207885 Review.
Several helminths have been proposed and tested in the search of the ideal therapeutic. In this review, the authors summarize the translational and clinical studies and review the caveats and possible solutions for the optimization of helminth therapies....
Several helminths have been proposed and tested in the search of the ideal therapeutic. In this review, the authors summarize the tra …
Soil-transmitted helminth infections: ascariasis, trichuriasis, and hookworm.
Bethony J, Brooker S, Albonico M, Geiger SM, Loukas A, Diemert D, Hotez PJ. Bethony J, et al. Lancet. 2006 May 6;367(9521):1521-32. doi: 10.1016/S0140-6736(06)68653-4. Lancet. 2006. PMID: 16679166 Review.
The three main soil-transmitted helminth infections, ascariasis, trichuriasis, and hookworm, are common clinical disorders in man. ...The use of these drugs is not limited to treatment of symptomatic soil-transmitted helminth infections, but also for large-scale pre …
The three main soil-transmitted helminth infections, ascariasis, trichuriasis, and hookworm, are common clinical disorders in man. .. …
Helminth therapy for autism under gut-brain axis- hypothesis.
Arroyo-López C. Arroyo-López C. Med Hypotheses. 2019 Apr;125:110-118. doi: 10.1016/j.mehy.2019.02.042. Epub 2019 Feb 19. Med Hypotheses. 2019. PMID: 30902137
Helminthic therapy has been previously performed in diseases such as ulcerative colitis, Crohn's disease, diabetes, multiple sclerosis, asthma, rheumatoid arthritis, and food allergies. Considering gut-brain axis, Hygiene Hypothesis, and the modulatory effect
Helminthic therapy has been previously performed in diseases such as ulcerative colitis, Crohn's disease, diabetes, mul
Human helminth therapy to treat inflammatory disorders - where do we stand?
Helmby H. Helmby H. BMC Immunol. 2015 Mar 26;16:12. doi: 10.1186/s12865-015-0074-3. BMC Immunol. 2015. PMID: 25884706 Free PMC article. Review.
Parasitic helminths have evolved together with the mammalian immune system over many millennia and as such they have become remarkably efficient modulators in order to promote their own survival. ...Thus, helminth therapy has been suggested as a possible trea …
Parasitic helminths have evolved together with the mammalian immune system over many millennia and as such they have become remarkabl …
Helminth therapy and multiple sclerosis.
Fleming JO. Fleming JO. Int J Parasitol. 2013 Mar;43(3-4):259-74. doi: 10.1016/j.ijpara.2012.10.025. Epub 2013 Jan 5. Int J Parasitol. 2013. PMID: 23298637 Review.
According to the hygiene (microbial deprivation) hypothesis, evolutionarily abnormal high levels of sanitation in the environment of the developed world may contribute to disordered immunoregulation in this and other putative autoimmune disorders. Helminths have been shown …
According to the hygiene (microbial deprivation) hypothesis, evolutionarily abnormal high levels of sanitation in the environment of the dev …
Helminth therapy (worms) for allergic rhinitis.
Croft AM, Bager P, Kumar S. Croft AM, et al. Cochrane Database Syst Rev. 2012 Apr 18;2012(4):CD009238. doi: 10.1002/14651858.CD009238.pub2. Cochrane Database Syst Rev. 2012. PMID: 22513973 Free PMC article. Review.
AUTHORS' CONCLUSIONS: There is currently insufficient evidence on the efficacy, tolerability and likely costs of helminth therapy to support its use in the routine management of allergic rhinitis. ...Future studies should collect and report comparative data on the c …
AUTHORS' CONCLUSIONS: There is currently insufficient evidence on the efficacy, tolerability and likely costs of helminth therapy
Helminth therapy or elimination: epidemiological, immunological, and clinical considerations.
Wammes LJ, Mpairwe H, Elliott AM, Yazdanbakhsh M. Wammes LJ, et al. Lancet Infect Dis. 2014 Nov;14(11):1150-1162. doi: 10.1016/S1473-3099(14)70771-6. Epub 2014 Jun 26. Lancet Infect Dis. 2014. PMID: 24981042 Review.
Deworming is rightly advocated to prevent helminth-induced morbidity. Nevertheless, in affluent countries, the deliberate infection of patients with worms is being explored as a possible treatment for inflammatory diseases. ...Further studies in endemic countries are neede …
Deworming is rightly advocated to prevent helminth-induced morbidity. Nevertheless, in affluent countries, the deliberate infection o …
Helminth therapy (worms) for induction of remission in inflammatory bowel disease.
Garg SK, Croft AM, Bager P. Garg SK, et al. Cochrane Database Syst Rev. 2014 Jan 20;(1):CD009400. doi: 10.1002/14651858.CD009400.pub2. Cochrane Database Syst Rev. 2014. PMID: 24442917 Review.
Helminths modulate immune responses of their hosts, and many observational and experimental studies support the hypothesis that helminths suppress immune-mediated chronic inflammation that occurs in asthma, allergy and IBD. ...We do not have enough evidence to deter
Helminths modulate immune responses of their hosts, and many observational and experimental studies support the hypothesis that he
Drug Combinations Against Soil-Transmitted Helminth Infections.
Moser W, Schindler C, Keiser J. Moser W, et al. Adv Parasitol. 2019;103:91-115. doi: 10.1016/bs.apar.2018.08.002. Epub 2018 Sep 7. Adv Parasitol. 2019. PMID: 30878060 Review.
The soil-transmitted helminths (STHs), Ascaris lumbricoides, hookworm and Trichuris trichiura are common in areas with warm and moist climates with little access to adequate water, sanitation, and hygiene affecting the poorest populations. ...In this review, we summarize t …
The soil-transmitted helminths (STHs), Ascaris lumbricoides, hookworm and Trichuris trichiura are common in areas with warm and moist …
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