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2008 574
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2011 625
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19,339 results

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Page 1
Structure and function of haemoglobins.
Gell DA. Gell DA. Blood Cells Mol Dis. 2018 May;70:13-42. doi: 10.1016/j.bcmd.2017.10.006. Epub 2017 Oct 31. Blood Cells Mol Dis. 2018. PMID: 29126700 Review.
Topics include structural and functional classification of Hbs; principles of O(2) binding affinity and selectivity between O(2)/NO/CO and other small ligands; hexacoordinate (containing bis-imidazole coordinated haem) Hbs; bacterial truncated Hbs; flavohaemoglobins …
Topics include structural and functional classification of Hbs; principles of O(2) binding affinity and selectivity between O(2)/NO/C …
Oxygen-binding haem proteins.
Wilson MT, Reeder BJ. Wilson MT, et al. Exp Physiol. 2008 Jan;93(1):128-32. doi: 10.1113/expphysiol.2007.039735. Epub 2007 Nov 2. Exp Physiol. 2008. PMID: 17981931 Free article. Review.
Myoglobin and haemoglobin, the respiratory pigments of mammals and some molluscs, annelids and arthropods, belong to an ancient superfamily of haem-associated globin proteins. Members of this family share common structural and spectral features. ...
Myoglobin and haemoglobin, the respiratory pigments of mammals and some molluscs, annelids and arthropods, belong to an ancient superfamily …
The C-terminal heme regulatory motifs of heme oxygenase-2 are redox-regulated heme binding sites.
Fleischhacker AS, Sharma A, Choi M, Spencer AM, Bagai I, Hoffman BM, Ragsdale SW. Fleischhacker AS, et al. Biochemistry. 2015 May 5;54(17):2709-18. doi: 10.1021/acs.biochem.5b00266. Epub 2015 Apr 22. Biochemistry. 2015. PMID: 25853617 Free PMC article.
We found that HO2tail in the disulfide-reduced state binds Fe(3+)-heme and accounts for the spectral features observed upon binding of heme to the disulfide-reduced form of HO2sol that cannot be attributed to heme binding at the catalytic …
We found that HO2tail in the disulfide-reduced state binds Fe(3+)-heme and accounts for the spectral features observed upon …
HRG-9 homologues regulate haem trafficking from haem-enriched compartments.
Sun F, Zhao Z, Willoughby MM, Shen S, Zhou Y, Shao Y, Kang J, Chen Y, Chen M, Yuan X, Hamza I, Reddi AR, Chen C. Sun F, et al. Nature. 2022 Oct;610(7933):768-774. doi: 10.1038/s41586-022-05347-z. Epub 2022 Oct 19. Nature. 2022. PMID: 36261532 Free PMC article.
Haem binding proteins are present in almost all cellular compartments, but the molecular mechanisms that regulate the transport and use of haem within the cell remain poorly understood(2,3). Here we show that haem-responsive gene 9 (HRG-9) (also known …
Haem binding proteins are present in almost all cellular compartments, but the molecular mechanisms that regulate the transpor …
The CydDC family of transporters.
Poole RK, Cozens AG, Shepherd M. Poole RK, et al. Res Microbiol. 2019 Nov-Dec;170(8):407-416. doi: 10.1016/j.resmic.2019.06.003. Epub 2019 Jul 3. Res Microbiol. 2019. PMID: 31279084 Free article. Review.
In addition, CydDC is thus far unique amongst ABC transporters in that it binds a haem cofactor that appears to modulate ATPase activity. CydDC has a diverse impact upon bacterial metabolism, growth, and virulence, and is of interest to those working on membrane tra …
In addition, CydDC is thus far unique amongst ABC transporters in that it binds a haem cofactor that appears to modulate ATPas …
The surface protein Shr of Streptococcus pyogenes binds heme and transfers it to the streptococcal heme-binding protein Shp.
Zhu H, Liu M, Lei B. Zhu H, et al. BMC Microbiol. 2008 Jan 23;8:15. doi: 10.1186/1471-2180-8-15. BMC Microbiol. 2008. PMID: 18215300 Free PMC article.
BACKGROUND: The heme acquisition machinery in Streptococcus pyogenes is believed to consist of the surface proteins, Shr and Shp, and heme-specific ATP-binding cassette transporter HtsABC. ...RESULTS: The objective of this study was to determine whether Shr …
BACKGROUND: The heme acquisition machinery in Streptococcus pyogenes is believed to consist of the surface proteins, Shr and Shp, and …
Structure of human phagocyte NADPH oxidase in the activated state.
Liu X, Shi Y, Liu R, Song K, Chen L. Liu X, et al. Nature. 2024 Mar;627(8002):189-195. doi: 10.1038/s41586-024-07056-1. Epub 2024 Feb 14. Nature. 2024. PMID: 38355798
The activation of phagocyte NADPH oxidase requires membrane translocation and the binding of several cytosolic factors(2). However, the exact mechanism by which cytosolic factors bind to and activate NOX2 is not well understood. ...The structure reveals that the p67-Rac1 c …
The activation of phagocyte NADPH oxidase requires membrane translocation and the binding of several cytosolic factors(2). However, t …
Covalent binding of carbon tetrachloride metabolites to the heme moiety of cytochrome P-450 and its degradation products.
Fernández G, Villarruel MC, de Toranzo EG, Castro JA. Fernández G, et al. Res Commun Chem Pathol Pharmacol. 1982 Feb;35(2):283-90. Res Commun Chem Pathol Pharmacol. 1982. PMID: 7071415
CCl3 by an NADPH anaerobic liver microsomal activation of CCl4, covalently binds to heme and heme degradation products from CO-binding particles. 14C from CCl4 covalently binds to heme and heme degradation products from liver CL- …
CCl3 by an NADPH anaerobic liver microsomal activation of CCl4, covalently binds to heme and heme degradation products …
Iron sensing and signalling.
Evstatiev R, Gasche C. Evstatiev R, et al. Gut. 2012 Jun;61(6):933-52. doi: 10.1136/gut.2010.214312. Epub 2011 Oct 19. Gut. 2012. PMID: 22016365 Review.
Hepcidin, the key iron-regulating peptide binds to the iron exporter ferroportin and leads to its degradation, thereby inhibiting intestinal iron absorption and cellular export. ...Such responses are mediated by a number of iron-sensitive signalling pathways, including the …
Hepcidin, the key iron-regulating peptide binds to the iron exporter ferroportin and leads to its degradation, thereby inhibiting int …
PAS domain of flagellar histidine kinase FlrB has a unique architecture and binds heme as a sensory ligand in an unconventional fashion.
Mukherjee P, Agarwal S, Mallick SB, Dasgupta J. Mukherjee P, et al. Structure. 2024 Feb 1;32(2):200-216.e5. doi: 10.1016/j.str.2023.11.014. Epub 2023 Dec 28. Structure. 2024. PMID: 38157857 Free article.
Series of biochemical/biophysical experiments on different constructs and mutants established that heme binds hydrophobically as sensory ligand in the shallow ligand-binding cleft of FlrB-PAS without axial coordination. Intriguingly, ATP binding to the …
Series of biochemical/biophysical experiments on different constructs and mutants established that heme binds hydrophobically …
19,339 results
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