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Year Number of Results
2005 3
2006 5
2007 7
2008 3
2009 6
2010 5
2011 2
2012 11
2013 4
2014 5
2015 4
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2019 2
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68 results

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Page 1
Unique 2'-O-methylation by Hen1 in eukaryotic RNA interference and bacterial RNA repair.
Huang RH. Huang RH. Biochemistry. 2012 May 22;51(20):4087-95. doi: 10.1021/bi300497x. Epub 2012 May 14. Biochemistry. 2012. PMID: 22564049 Review.
The 2'-OH group at the 3'-terminal nucleotide of certain RNAs is methylated in vivo, which is acheived by a methyltransferase named Hen1 that is mechanistically distinct from other known RNA 2'-O-methyltransferases. ...In this review, I will discuss the distribution …
The 2'-OH group at the 3'-terminal nucleotide of certain RNAs is methylated in vivo, which is acheived by a methyltransferase named …
HEN1 recognizes 21-24 nt small RNA duplexes and deposits a methyl group onto the 2' OH of the 3' terminal nucleotide.
Yang Z, Ebright YW, Yu B, Chen X. Yang Z, et al. Nucleic Acids Res. 2006 Jan 30;34(2):667-75. doi: 10.1093/nar/gkj474. Print 2006. Nucleic Acids Res. 2006. PMID: 16449203 Free PMC article.
microRNAs (miRNAs) and small interfering RNAs (siRNAs) in plants bear a methyl group on the ribose of the 3' terminal nucleotide. We showed previously that the methylation of miRNAs and siRNAs requires the protein HEN1 in vivo and that purified HEN1 pr …
microRNAs (miRNAs) and small interfering RNAs (siRNAs) in plants bear a methyl group on the ribose of the 3' terminal nucleotide. We …
Identification of substrates of the small RNA methyltransferase Hen1 in mouse spermatogonial stem cells and analysis of its methyl-transfer domain.
Peng L, Zhang F, Shang R, Wang X, Chen J, Chou JJ, Ma J, Wu L, Huang Y. Peng L, et al. J Biol Chem. 2018 Jun 29;293(26):9981-9994. doi: 10.1074/jbc.RA117.000837. Epub 2018 Apr 27. J Biol Chem. 2018. PMID: 29703750 Free PMC article.
The types and properties of sncRNAs may vary among different species, and the domain composition, structure, and function of Hen1 proteins differ accordingly. In mammals, Hen1 specifically methylates sncRNAs called P-element-induced wimpy testis-interacting R …
The types and properties of sncRNAs may vary among different species, and the domain composition, structure, and function of Hen1 pro …
Uridylation of miRNAs by hen1 suppressor1 in Arabidopsis.
Ren G, Chen X, Yu B. Ren G, et al. Curr Biol. 2012 Apr 24;22(8):695-700. doi: 10.1016/j.cub.2012.02.052. Epub 2012 Mar 29. Curr Biol. 2012. PMID: 22464191 Free PMC article.
HEN1-mediated 2'-O-methylation has been shown to be a key mechanism to protect plant microRNAs (miRNAs) and small interfering RNAs (siRNAs) as well as animal piwi-interacting RNAs (piRNAs) from degradation and 3' terminal uridylation [1-8]. However, enzymes uridylat
HEN1-mediated 2'-O-methylation has been shown to be a key mechanism to protect plant microRNAs (miRNAs) and small interfering
siRNAs compete with miRNAs for methylation by HEN1 in Arabidopsis.
Yu B, Bi L, Zhai J, Agarwal M, Li S, Wu Q, Ding SW, Meyers BC, Vaucheret H, Chen X. Yu B, et al. Nucleic Acids Res. 2010 Sep;38(17):5844-50. doi: 10.1093/nar/gkq348. Epub 2010 May 6. Nucleic Acids Res. 2010. PMID: 20448024 Free PMC article.
A mutagenesis screen for suppressors of the partial loss-of-function hen1-2 allele in Arabidopsis identified second-site mutations that restore miRNA methylation. ...A mutation in RNA-dependent RNA polymerase 2, another essential gene for the biogenesis of endogenou …
A mutagenesis screen for suppressors of the partial loss-of-function hen1-2 allele in Arabidopsis identified second-site mutations th …
Hen1 is required for oocyte development and piRNA stability in zebrafish.
Kamminga LM, Luteijn MJ, den Broeder MJ, Redl S, Kaaij LJ, Roovers EF, Ladurner P, Berezikov E, Ketting RF. Kamminga LM, et al. EMBO J. 2010 Nov 3;29(21):3688-700. doi: 10.1038/emboj.2010.233. Epub 2010 Sep 21. EMBO J. 2010. PMID: 20859253 Free PMC article.
They associate with a specific class of Argonaute proteins, named Piwi, and function through an RNA interference-like mechanism. piRNAs carry a 2'-O-methyl modification at their 3' end, which is added by the Hen1 enzyme. ...Hen1 protein localizes to nuage thr …
They associate with a specific class of Argonaute proteins, named Piwi, and function through an RNA interference-like mechanism. piRNAs carr …
Phylogenetic and Evolutionary Analysis of Plant Small RNA 2'-O-Methyltransferase (HEN1) Protein Family.
Hajieghrari B, Niazi A. Hajieghrari B, et al. J Mol Evol. 2023 Aug;91(4):424-440. doi: 10.1007/s00239-023-10109-0. Epub 2023 May 16. J Mol Evol. 2023. PMID: 37191719
HUA ENHANCER 1 (HEN1) is a pivotal mediator in protecting sRNAs from 3'-end uridylation and 3' to 5' exonuclease-mediated degradation in plants. ...By reconciling the protein and species tree, we considered the gene duplications in several given species and found 170 dupli …
HUA ENHANCER 1 (HEN1) is a pivotal mediator in protecting sRNAs from 3'-end uridylation and 3' to 5' exonuclease-mediated degradation …
Molecular phylogenetics and comparative modeling of HEN1, a methyltransferase involved in plant microRNA biogenesis.
Tkaczuk KL, Obarska A, Bujnicki JM. Tkaczuk KL, et al. BMC Evol Biol. 2006 Jan 24;6:6. doi: 10.1186/1471-2148-6-6. BMC Evol Biol. 2006. PMID: 16433904 Free PMC article.
HEN1 transfers a methyl group from S-adenosylmethionine to the 2'-OH or 3'-OH group of the last nucleotide of miRNA/miRNA* duplexes produced by the nuclease Dicer. ...RESULTS: Extensive database searches were carried out to identify orthologs and close paralogs of
HEN1 transfers a methyl group from S-adenosylmethionine to the 2'-OH or 3'-OH group of the last nucleotide of miRNA/miRNA* dup
Deep sequencing from hen1 mutants to identify small RNA 3' modifications.
Zhai J, Meyers BC. Zhai J, et al. Cold Spring Harb Symp Quant Biol. 2012;77:213-9. doi: 10.1101/sqb.2013.77.014779. Epub 2013 Feb 7. Cold Spring Harb Symp Quant Biol. 2012. PMID: 23393108 Review.
The pathway for miRNA biogenesis is well established, but less is known about miRNA turnover, largely because of difficulties in capturing miRNAs during the process of decay, in which they are both rare and ephemeral. The HEN1 protein methylates the 3' terminus of s …
The pathway for miRNA biogenesis is well established, but less is known about miRNA turnover, largely because of difficulties in capturing m …
68 results