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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1993 1
2000 1
2001 5
2002 10
2003 11
2004 26
2005 40
2006 61
2007 64
2008 76
2009 86
2010 140
2011 168
2012 189
2013 251
2014 257
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2017 326
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2022 453
2023 399
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4,789 results

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Page 1
The Liver as an Endocrine Organ-Linking NAFLD and Insulin Resistance.
Watt MJ, Miotto PM, De Nardo W, Montgomery MK. Watt MJ, et al. Endocr Rev. 2019 Oct 1;40(5):1367-1393. doi: 10.1210/er.2019-00034. Endocr Rev. 2019. PMID: 31098621 Free article. Review.
Dysfunctional hepatic lipid metabolism is a cause of nonalcoholic fatty liver disease (NAFLD), the most common chronic liver disorder worldwide, and is closely associated with insulin resistance and type 2 diabetes. ...In th …
Dysfunctional hepatic lipid metabolism is a cause of nonalcoholic fatty liver disease (NAFLD), the most c …
Role of Insulin Resistance in MAFLD.
Sakurai Y, Kubota N, Yamauchi T, Kadowaki T. Sakurai Y, et al. Int J Mol Sci. 2021 Apr 16;22(8):4156. doi: 10.3390/ijms22084156. Int J Mol Sci. 2021. PMID: 33923817 Free PMC article. Review.
Many studies have reported that metabolic dysfunction is closely involved in the complex mechanism underlying the development of non-alcoholic fatty liver disease (NAFLD), which has prompted a movement to consider renaming NAFLD as …
Many studies have reported that metabolic dysfunction is closely involved in the complex mechanism underlying the development of non- …
VEGFB ameliorates insulin resistance in NAFLD via the PI3K/AKT signal pathway.
Li Y, Li W, Zhu X, Xu N, Meng Q, Jiang W, Zhang L, Yang M, Xu F, Li Y. Li Y, et al. J Transl Med. 2024 Oct 28;22(1):976. doi: 10.1186/s12967-024-05621-w. J Transl Med. 2024. PMID: 39468621 Free PMC article.
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is one of the most universal liver diseases with complicated pathogenesis throughout the world. Insulin resistance is a leading risk factor that contributes to the …
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is one of the most universal liver di …
Pediatric MASLD: current understanding and practical approach.
Stroes AR, Vos M, Benninga MA, Koot BGP. Stroes AR, et al. Eur J Pediatr. 2024 Nov 19;184(1):29. doi: 10.1007/s00431-024-05848-1. Eur J Pediatr. 2024. PMID: 39560782 Review.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is now the most prevalent chronic liver disease in children in industrialized countries mainly due to the rise in obesity and overweight. Besides risk of progressive liver damage, …
Metabolic dysfunction-associated steatotic liver disease (MASLD) is now the most prevalent chronic liver disease …
Non-alcoholic fatty liver disease: pathophysiological concepts and treatment options.
Grander C, Grabherr F, Tilg H. Grander C, et al. Cardiovasc Res. 2023 Aug 7;119(9):1787-1798. doi: 10.1093/cvr/cvad095. Cardiovasc Res. 2023. PMID: 37364164 Free PMC article. Review.
The prevalence of non-alcoholic fatty liver disease (NAFLD) is continually increasing due to the global obesity epidemic. NAFLD comprises a systemic metabolic disease accompanied frequently by insulin resistance …
The prevalence of non-alcoholic fatty liver disease (NAFLD) is continually increasing due to the g …
Endoplasmic reticulum stress signalling and the pathogenesis of non-alcoholic fatty liver disease.
Lebeaupin C, Vallée D, Hazari Y, Hetz C, Chevet E, Bailly-Maitre B. Lebeaupin C, et al. J Hepatol. 2018 Oct;69(4):927-947. doi: 10.1016/j.jhep.2018.06.008. Epub 2018 Jun 27. J Hepatol. 2018. PMID: 29940269 Free article. Review.
The global epidemic of obesity has been accompanied by a rising burden of non-alcoholic fatty liver disease (NAFLD), with manifestations ranging from simple steatosis to non-alcoholic steatohepatitis, potentially developing …
The global epidemic of obesity has been accompanied by a rising burden of non-alcoholic fatty liver disease …
Epigenetics of Hepatic Insulin Resistance.
Maude H, Sanchez-Cabanillas C, Cebola I. Maude H, et al. Front Endocrinol (Lausanne). 2021 May 11;12:681356. doi: 10.3389/fendo.2021.681356. eCollection 2021. Front Endocrinol (Lausanne). 2021. PMID: 34046015 Free PMC article. Review.
Insulin resistance (IR) is largely recognized as a unifying feature that underlies metabolic dysfunction. ...We discuss the broad epigenetic changes observed in the insulin resistant liver and its associated pathophysiological states and leverage on th …
Insulin resistance (IR) is largely recognized as a unifying feature that underlies metabolic dysfunction. ...We discuss the br …
Hepatic ChREBP reciprocally modulates systemic insulin sensitivity in NAFLD.
Sen A, Thakur S, Rawat P, Jaswal K, Dehury B, Mondal P. Sen A, et al. J Biol Chem. 2025 Jun;301(6):108556. doi: 10.1016/j.jbc.2025.108556. Epub 2025 Apr 29. J Biol Chem. 2025. PMID: 40311678 Free PMC article.
These findings identify hepatic ChREBP as a critical modulator of systemic insulin signaling and suggest that ChREBP downregulation may lead to protection against insulin resistance. ...We report that Quercetin treatment can sequester ChREBP in the cyt …
These findings identify hepatic ChREBP as a critical modulator of systemic insulin signaling and suggest that ChREBP downregul …
NAFLD and cardiovascular diseases: a clinical review.
Kasper P, Martin A, Lang S, Kütting F, Goeser T, Demir M, Steffen HM. Kasper P, et al. Clin Res Cardiol. 2021 Jul;110(7):921-937. doi: 10.1007/s00392-020-01709-7. Epub 2020 Jul 21. Clin Res Cardiol. 2021. PMID: 32696080 Free PMC article. Review.
Non-alcoholic fatty liver DISEASE (NAFLD) is the most common chronic liver disease in Western countries and affects approximately 25% of the adult population. ...The natural history of NAFLD is variable and the vast m …
Non-alcoholic fatty liver DISEASE (NAFLD) is the most common chronic liver disease i …
Geniposide Mitigates Insulin Resistance and Hepatic Fibrosis via Insulin Signaling Pathway.
Oh SH, Lee MS, Lee BC. Oh SH, et al. Int J Mol Sci. 2025 Aug 21;26(16):8079. doi: 10.3390/ijms26168079. Int J Mol Sci. 2025. PMID: 40869401 Free PMC article.
Insulin resistance is a key driver of metabolic disorders, including type 2 diabetes and non-alcoholic fatty liver disease (NAFLD), progressing to non-alcoholic steatohepatitis (NASH). ...In conclusion, GP impr …
Insulin resistance is a key driver of metabolic disorders, including type 2 diabetes and non-alcoholic fatty …
4,789 results