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1952 1
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1963 1
1964 1
1965 1
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1970 4
1971 6
1972 8
1973 12
1974 12
1975 15
1976 18
1977 8
1978 12
1979 12
1980 7
1981 15
1982 17
1983 21
1984 26
1985 19
1986 17
1987 17
1988 20
1989 16
1990 19
1991 25
1992 26
1993 37
1994 33
1995 45
1996 41
1997 77
1998 76
1999 84
2000 79
2001 88
2002 91
2003 90
2004 95
2005 142
2006 124
2007 128
2008 166
2009 147
2010 210
2011 243
2012 295
2013 318
2014 395
2015 415
2016 420
2017 404
2018 480
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2020 491
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2024 213

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Disparate kinetics in immune response of two different Haemophilus influenzae type b conjugate vaccines: Immunogenicity and safety observations from a randomized controlled phase IV study in healthy infants and toddlers using a 2+1 schedule.
Martinón-Torres F, Salamanca de la Cueva I, Horn M, Westerholt S, Bosis S, Meyer N, Cheuvart B, Virk N, Jakes RW, Duchenne M, Van den Steen P. Martinón-Torres F, et al. Hum Vaccin Immunother. 2024 Dec 31;20(1):2342630. doi: 10.1080/21645515.2024.2342630. Epub 2024 Apr 30. Hum Vaccin Immunother. 2024. PMID: 38687024 Free PMC article. Clinical Trial.
The difference in percentage of participants (Ih group - Va group) reaching GMCs 5 g/mL was -6.3% (95% CI: -14.1% to 1.5%), not reaching the predefined non-inferiority threshold. ...One month after the booster vaccination, the antibody concentration ratio between both grou …
The difference in percentage of participants (Ih group - Va group) reaching GMCs 5 g/mL was -6.3% (95% CI: -14.1% to 1.5%), not reach …
A phase 4, open-label study to evaluate the safety and immunogenicity of DTaP5-HBV-IPV-Hib in children previously vaccinated with DTaP2-HBV-IPV-Hib or DTaP5-HBV-IPV-Hib (V419-016).
Guerra A, Costantino C, Martinon-Torres F, Westerholt S, Lambeth C, Chen Z, Lumley J, Marcek T, Johnson D, Wilck M. Guerra A, et al. Hum Vaccin Immunother. 2024 Dec 31;20(1):2310900. doi: 10.1080/21645515.2024.2310900. Epub 2024 Feb 8. Hum Vaccin Immunother. 2024. PMID: 38327239 Free PMC article. Clinical Trial.
DTaP5-HBV-IPV-Hib (Vaxelis) is a hexavalent combination vaccine (HV) indicated in infants and toddlers for the prevention of diphtheria, tetanus, pertussis, hepatitis B, poliomyelitis, and invasive disease due to Haemophilus influenzae type b. ...
DTaP5-HBV-IPV-Hib (Vaxelis) is a hexavalent combination vaccine (HV) indicated in infants and toddlers for the prevention of diphtheria, tet …
Hepatic arterial infusion of autologous CD34(+) cells for hepatitis C virus-related decompensated cirrhosis: A multicenter, open-label, exploratory randomized controlled trial.
Nakamura T, Masuda A, Kako M, Enomoto H, Kaibori M, Fujita Y, Tanizawa K, Ioji T, Fujimori Y, Fukami K, Hazama T, Iwamoto H, Kako Y, Kobayashi K, Koga H, Nagafuji K, Ohtake T, Suzuki H, Takashima T, Tsukiyama T, Uojima H, Yamahara K, Yamakado K, Yamamoto H, Yoh K, Yoshihara S, Kawamoto A, Nishiguchi S, Kobayashi S, Torimura T, Kawaguchi T. Nakamura T, et al. Regen Ther. 2024 May 4;27:455-463. doi: 10.1016/j.reth.2024.04.018. eCollection 2024 Dec. Regen Ther. 2024. PMID: 38737403 Free PMC article.
INTRODUCTION: In this multicenter clinical study, we aimed to investigate the efficacy and safety of the transhepatic arterial administration of granulocyte-colony stimulating factor (G-CSF)-mobilized autologous peripheral blood (PB)-CD34(+) cells compared with standard th …
INTRODUCTION: In this multicenter clinical study, we aimed to investigate the efficacy and safety of the transhepatic arterial administratio …
Rat hepatitis E virus (Rocahepevirus ratti) exposure in cats and dogs, Hong Kong.
Shun EH, Situ J, Tsoi JY, Wu S, Cai J, Lo KH, Chew NF, Li Z, Poon RW, Teng JL, Cheng VC, Yuen KY, Sridhar S. Shun EH, et al. Emerg Microbes Infect. 2024 Dec;13(1):2337671. doi: 10.1080/22221751.2024.2337671. Epub 2024 Apr 12. Emerg Microbes Infect. 2024. PMID: 38551320 Free PMC article.
Hepatitis E virus (HEV) variants infecting humans belong to two species: Paslahepevirus balayani (bHEV) and Rocahepevirus ratti (rat hepatitis E virus; rHEV). R. ratti is a ubiquitous rodent pathogen that has recently been recognized to cause hepatitis in hum
Hepatitis E virus (HEV) variants infecting humans belong to two species: Paslahepevirus balayani (bHEV) and Rocahepevirus ratti (rat
Rat hepatitis E virus (Rocahepevirus ratti) in people living with HIV.
Casares-Jimenez M, Rivero-Juarez A, Lopez-Lopez P, Montes ML, Navarro-Soler R, Peraire J, Espinosa N, Alemán-Valls MR, Garcia-Garcia T, Caballero-Gomez J, Corona-Mata D, Perez-Valero I, Ulrich RG, Rivero A. Casares-Jimenez M, et al. Emerg Microbes Infect. 2024 Dec;13(1):2295389. doi: 10.1080/22221751.2023.2295389. Epub 2023 Dec 30. Emerg Microbes Infect. 2024. PMID: 38095070 Free PMC article.
Rat hepatitis E virus (ratHEV; species Rocahepevirus ratti) is considered a newly emerging cause of acute hepatitis of zoonotic origin. ratHEV infection of people living with HIV (PLWH) might portend a worse, as with hepatitis E virus (HEV; species Paslahepev …
Rat hepatitis E virus (ratHEV; species Rocahepevirus ratti) is considered a newly emerging cause of acute hepatitis of zoonoti …
Engineered extracellular vesicles for delivering functional Cas9/gRNA to eliminate hepatitis B virus cccDNA and integration.
Zeng W, Zheng L, Li Y, Yang J, Mao T, Zhang J, Liu Y, Ning J, Zhang T, Huang H, Chen X, Lu F. Zeng W, et al. Emerg Microbes Infect. 2024 Dec;13(1):2284286. doi: 10.1080/22221751.2023.2284286. Epub 2023 Dec 30. Emerg Microbes Infect. 2024. PMID: 37982370 Free PMC article.
Here, we developed a novel approach by combining light-induced heterodimerization and protein acylation to enhance the loading efficiency of Cas9 protein into extracellular vesicles (EVs). Moreover, vesicular stomatitis virus-glycoprotein (VSV-G) was incorporated onto the …
Here, we developed a novel approach by combining light-induced heterodimerization and protein acylation to enhance the loading efficiency of …
Anaemia is independently associated with mortality in patients with hepatocellular carcinoma.
Meischl T, Balcar L, Park YR, Bucher L, Meier P, Suhr Y, Pomej K, Mandorfer M, Reiberger T, Trauner M, Scheiner B, Pinter M. Meischl T, et al. ESMO Open. 2024 Jun 6;9(6):103593. doi: 10.1016/j.esmoop.2024.103593. Online ahead of print. ESMO Open. 2024. PMID: 38848660 Free article.
MATERIALS AND METHODS: HCC patients treated between 1992 and 2018 at the Medical University of Vienna were retrospectively analysed. Anaemia was defined as haemoglobin level <13 g/dl in men and <12 g/dl in women. RESULTS: Of 1262 assessable patients, 555 (44.0 …
MATERIALS AND METHODS: HCC patients treated between 1992 and 2018 at the Medical University of Vienna were retrospectively analysed. Anaemia …
qPCR assay for detection of Woodchuck Hepatitis Virus Post-Transcriptional Regulatory Elements from CAR-T and TCR-T cells in fresh and formalin-fixed tissue.
Pullarkat S, Black G, Bleakley M, Buenrostro D, Chapuis AG, Hirayama AV, Jaeger-Ruckstuhl CA, Kimble EL, Lee BM, Maloney DG, Radich J, Seaton BW, Specht JM, Turtle CJ, Woolston DW, Wright JH, Yeung CCS. Pullarkat S, et al. PLoS One. 2024 Jun 6;19(6):e0303057. doi: 10.1371/journal.pone.0303057. eCollection 2024. PLoS One. 2024. PMID: 38843256 Free PMC article.
Joint host-pathogen genomic analysis identifies hepatitis B virus mutations associated with human NTCP and HLA class I variation.
Xu ZM, Gnouamozi GE, Rüeger S, Shea PR, Buti M, Chan HL, Marcellin P, Lawless D, Naret O, Zeller M, Schneuing A, Scheck A, Junier T, Moradpour D, Podlaha O, Suri V, Gaggar A, Subramanian M, Correia B, Gfeller D, Urban S, Fellay J. Xu ZM, et al. Am J Hum Genet. 2024 Jun 6;111(6):1018-1034. doi: 10.1016/j.ajhg.2024.04.013. Epub 2024 May 14. Am J Hum Genet. 2024. PMID: 38749427 Free article.
Evolutionary changes in the hepatitis B virus (HBV) genome could reflect its adaptation to host-induced selective pressure. Leveraging paired human exome and ultra-deep HBV genome-sequencing data from 567 affected individuals with chronic hepatitis B, we comprehensi …
Evolutionary changes in the hepatitis B virus (HBV) genome could reflect its adaptation to host-induced selective pressure. Leveragin …
Serum IgG level in autoimmune liver diseases and its significance: Is there a need to revisit existing criteria? Experience from a tertiary care center.
Varadarajan A, Rastogi A, Maiwall R, Bihari C, Thomas S, Shasthry SM. Varadarajan A, et al. Indian J Pathol Microbiol. 2024 Jun 4. doi: 10.4103/ijpm.ijpm_865_23. Online ahead of print. Indian J Pathol Microbiol. 2024. PMID: 38847214 Free article.
BACKGROUND: Serum immunoglobulin G (IgG) level is elevated in autoimmune liver diseases (AILDs), especially autoimmune hepatitis (AIH). ...
BACKGROUND: Serum immunoglobulin G (IgG) level is elevated in autoimmune liver diseases (AILDs), especially autoimmune hepatitis
Patterns and correlates of mental healthcare utilization during the COVID-19 pandemic among individuals with pre-existing mental disorder.
Lee H, Kennedy CJ, Tu A, Restivo J, Liu CH, Naslund JA, Patel V, Choi KW, Smoller JW. Lee H, et al. PLoS One. 2024 Jun 4;19(6):e0303079. doi: 10.1371/journal.pone.0303079. eCollection 2024. PLoS One. 2024. PMID: 38833458 Free PMC article.
Using EHR data from a large healthcare system in Massachusetts, we identified three "pre-existing mental disorder" groups (PMD) based on having a documented mental disorder diagnosis within the 6 months prior to the March 2020 lockdown, related to: (1) stress-related disorders (e …
Using EHR data from a large healthcare system in Massachusetts, we identified three "pre-existing mental disorder" groups (PMD) based on hav …
Hepatitis B virus infection during pregnancy and the risk of postpartum hemorrhage: a protocol for systematic review and meta-analysis.
Zou K, Chen J, Guo J, Wei W, Liao M, Cai Q, Xiong Y. Zou K, et al. Int J Surg Protoc. 2024 Feb 12;28(2):43-46. doi: 10.1097/SP9.0000000000000020. eCollection 2024 Jun. Int J Surg Protoc. 2024. PMID: 38854710 Free PMC article.
BACKGROUND: Hepatitis B virus (HBV) infection is a significant public health issue worldwide, with a hepatitis B surface antigen (HBsAg) seroprevalence of 3.5%. ...Meta-analyses will be performed using a fixed-effects model for I (2)50% or a random-effects model oth …
BACKGROUND: Hepatitis B virus (HBV) infection is a significant public health issue worldwide, with a hepatitis B surface antig …
Predictive factors for peripheral blood stem cell mobilization in multiple myeloma in the era of novel therapies: A single-center experience.
He X, Jiang D, Zhao L, Chen S, Zhu Y, He Q, He Y. He X, et al. Cancer Med. 2024 Jun;13(11):e7356. doi: 10.1002/cam4.7356. Cancer Med. 2024. PMID: 38850125 Free PMC article.
Failure of collection occurred in 24 (11.4%) patients and was correlated with low white blood cell (WBC), 3 cycles of lenalidomide treatment before mobilization, steady-state mobilization and nouse of plerixafor are associated with mobilization failure. Daratumumab-based inductio …
Failure of collection occurred in 24 (11.4%) patients and was correlated with low white blood cell (WBC), 3 cycles of lenalidomide treatment …
Serum albumin and white matter hyperintensities.
Zahr NM, Pfefferbaum A. Zahr NM, et al. Transl Psychiatry. 2024 Jun 1;14(1):233. doi: 10.1038/s41398-024-02953-5. Transl Psychiatry. 2024. PMID: 38824150 Free PMC article.
., age, sex, body mass index (BMI), nicotine use, hypertension, diabetes), study-relevant (i.e., race, socioeconomic status, hepatitis C virus status), and disease-specific (i.e., CD4 nadir, HIV viral load, HIV duration) factors. ...Relations in both HIV and AUD groups bet …
., age, sex, body mass index (BMI), nicotine use, hypertension, diabetes), study-relevant (i.e., race, socioeconomic status, hepatitis
Clinical Characteristics of Genuine Acute Autoimmune Hepatitis.
Oliveira EMG, Amaral ACC, Oliveira PMC, Lanzoni VP, Perez RM, Narciso-Schiavon JL, Whale RC, Carvalho-Filho RJ, Silva AEB, Ferraz MLCG. Oliveira EMG, et al. GE Port J Gastroenterol. 2023 Jul 12;31(3):173-181. doi: 10.1159/000531018. eCollection 2024 Jun. GE Port J Gastroenterol. 2023. PMID: 38757065 Free PMC article.
INTRODUCTION: Autoimmune hepatitis (AIH) has a spectrum of symptoms ranging from asymptomatic disease to acute severe hepatitis, chronic hepatitis, and decompensated cirrhosis. ...Comparative analysis between patients with GAAIH and patients with acute exacer …
INTRODUCTION: Autoimmune hepatitis (AIH) has a spectrum of symptoms ranging from asymptomatic disease to acute severe hepatitis
Liver inflammation activity in patients with autoimmune hepatitis with normal alanine aminotransferase and immunoglobulin G levels.
Chen Y, Liu J, Wang J, Wu W, Wang H, Liu Y, Zhang Z, Zhang S, Pan Y, Li Y, Ding W, Zhu L, Zhu C, Li J, Qiu Y, Huang R, Wu C. Chen Y, et al. J Transl Autoimmun. 2023 Nov 28;8:100220. doi: 10.1016/j.jtauto.2023.100220. eCollection 2024 Jun. J Transl Autoimmun. 2023. PMID: 38188039 Free PMC article.
BACKGROUND AND AIMS: Normal serum transaminases and immunoglobulin G (IgG) levels are surrogate markers for hepatic histologic disease activity in autoimmune hepatitis (AIH). ...
BACKGROUND AND AIMS: Normal serum transaminases and immunoglobulin G (IgG) levels are surrogate markers for hepatic histologic diseas …
Safety and efficacy of telitacicept in refractory systemic lupus erythematosus patients who failed treatment with belimumab : A case series.
Fan Q, Yang H, Liu Y. Fan Q, et al. Z Rheumatol. 2024 Jun;83(5):387-392. doi: 10.1007/s00393-023-01461-z. Epub 2023 Dec 29. Z Rheumatol. 2024. PMID: 38157053 Free PMC article.
One case was refractory lupus hepatitis confirmed by liver pathology, and upon change to change to telitacicept treatment, liver function returned to normal. ...Telitacicept may be a promising drug for the treatment of refractory lupus hepatitis....
One case was refractory lupus hepatitis confirmed by liver pathology, and upon change to change to telitacicept treatment, liver func …
Prognostic Scores for Ursodeoxycholic Acid-Treated Patients Predict Graft Loss and Mortality in Recurrent Primary Biliary Cholangitis after Liver Transplantation.
Montano-Loza AJ, Lytvyak E, Hirschfield G, Hansen BE, Ebadi M, Berney T, Toso C, Magini G, Villamil A, Nevens F, Van den Ende N, Pares A, Ruiz P, Terrabuio D, Trivedi PJ, Abbas N, Donato MF, Yu L, Landis C, Dumortier J, Dyson JK, van der Meer AJ, de Veer R, Pedersen M, Mayo M, Manns MP, Taubert R, Theresa K, Belli LS, Mazzarelli C, Stirnimann G, Floreani A, Cazzagon N, Russo FP, Burra P, Zigmound U, Houri I, Carbone M, Mulinacci G, Fagiuoli S, Pratt DS, Bonder A, Schiano TD, Haydel B, Lohse A, Schramm C, Rüther D, Casu S, Verhelst X, Beretta-Piccoli BT, Robles M, Mason AL, Corpechot C; Global PBC Study Group. Montano-Loza AJ, et al. J Hepatol. 2024 May 29:S0168-8278(24)00345-3. doi: 10.1016/j.jhep.2024.05.010. Online ahead of print. J Hepatol. 2024. PMID: 38821360 Free article.
Previous hepatitis E virus infection is associated with increased liver stiffness in patients with autoimmune hepatitis.
Janik MK, Kempińska-Podhorodecka A, Raszeja-Wyszomirska J, Krawczyk M, Milkiewicz M, Milkiewicz P. Janik MK, et al. Pol Arch Intern Med. 2024 May 28;134(5):16733. doi: 10.20452/pamw.16733. Epub 2024 Apr 23. Pol Arch Intern Med. 2024. PMID: 38655875 Free article.
INTRODUCTION: Autoimmune hepatitis (AIH) is a chronic, progressive liver disease that, in most cases, may require lifelong immunosuppression. Hepatitis E virus (HEV) is a leading cause of acute, typically self-limited hepatitis worldwide, although immunocompr …
INTRODUCTION: Autoimmune hepatitis (AIH) is a chronic, progressive liver disease that, in most cases, may require lifelong immunosupp …
Systematic review and meta-analysis of hepatitis E seroprevalence in Southeast Asia: a comprehensive assessment of epidemiological patterns.
Mirzaev UK, Ouoba S, Ko K, Phyo Z, Chhoung C, Ataa AG, Sugiyama A, Akita T, Tanaka J. Mirzaev UK, et al. BMC Infect Dis. 2024 May 24;24(1):525. doi: 10.1186/s12879-024-09349-2. BMC Infect Dis. 2024. PMID: 38789918 Free PMC article.
The burden of hepatitis E in Southeast Asia is substantial, influenced by its distinct socio-economic and environmental factors, as well as variations in healthcare systems. The aim of this study was to assess the pooled seroprevalence of hepatitis E across countrie …
The burden of hepatitis E in Southeast Asia is substantial, influenced by its distinct socio-economic and environmental factors, as w …
The Interleukin-6 gene variants may protect against SARS-CoV-2 infection and the severity of COVID-19: a case-control study in a Moroccan population.
Noureddine R, Baba H, Aqillouch S, Abounouh K, Laazaazia O, Elmessaoudi-Idrissi M, Bahmani FZ, Tanouti IA, Ouladlahsen A, Sarih M, Dehbi H, Ezzikouri S. Noureddine R, et al. BMC Med Genomics. 2024 May 23;17(1):139. doi: 10.1186/s12920-024-01911-w. BMC Med Genomics. 2024. PMID: 38783290 Free PMC article.
The objective of this study is to investigate the association between rs1800795 (- 174 G > C) and rs1800797 (- 597 A > G) variants in the interleukin-6 (IL-6) promoter region and susceptibility to SARS-CoV-2 infection. ...However, further analysis revealed tha …
The objective of this study is to investigate the association between rs1800795 (- 174 G > C) and rs1800797 (- 597 A > G
Programmed cell death-1 is involved with peripheral blood immune cell profiles in patients with hepatitis C virus antiviral therapy.
Miura M, Nishino M, Kawaguchi K, Li S, Shimakami T, Tamai T, Nakagawa H, Terashima T, Iida N, Takatori H, Arai K, Sakai Y, Yamashita T, Honda M, Kaneko S, Mizukoshi E, Yamashita T. Miura M, et al. PLoS One. 2024 May 23;19(5):e0299424. doi: 10.1371/journal.pone.0299424. eCollection 2024. PLoS One. 2024. PMID: 38781172 Free PMC article.
Mutations in the non-structural protein regions of hepatitis C virus (HCV) are a cause of a non-sustained virological response (SVR) to treatment with direct-acting antivirals (DAAs) for chronic hepatitis; however, there are non-SVR cases without these mutations. .. …
Mutations in the non-structural protein regions of hepatitis C virus (HCV) are a cause of a non-sustained virological response (SVR) …
The state of health in the European Union (EU-27) in 2019: a systematic analysis for the Global Burden of Disease study 2019.
Santos JV, Padron-Monedero A, Bikbov B, Grad DA, Plass D, Mechili EA, Gazzelloni F, Fischer F, Sulo G, Ngwa CH, Noguer-Zambrano I, Peñalvo JL, Haagsma JA, Kissimova-Skarbek K, Monasta L, Ghith N, Sarmiento-Suarez R, Hrzic R, Haneef R, O'Caoimh R, Cuschieri S, Mondello S, Kabir Z; GBD 2019 EU State of Health Collaborators; Freitas A, Devleesschauwer B. Santos JV, et al. BMC Public Health. 2024 May 22;24(1):1374. doi: 10.1186/s12889-024-18529-3. BMC Public Health. 2024. PMID: 38778362 Free PMC article.
Respect for bioethical principles and human rights in prisons: a systematic review on the state of the art.
Esposito M, Szocik K, Capasso E, Chisari M, Sessa F, Salerno M. Esposito M, et al. BMC Med Ethics. 2024 May 22;25(1):62. doi: 10.1186/s12910-024-01049-5. BMC Med Ethics. 2024. PMID: 38773588 Free PMC article.
In most cases, the studies associated bioethics with prisoners' access to treatment for various pathologies such as vaccinations, tuberculosis, hepatitis, HIV, it was also found that bioethics in prisons was related to the mental health of prisoners, disability, ageing, th …
In most cases, the studies associated bioethics with prisoners' access to treatment for various pathologies such as vaccinations, tuberculos …
Successes and challenges of best practice alerts to identify and engage individuals living with hepatitis C virus.
Tandon S, Castaneda R, Tarasco N, Percival J, Nieto Linares R, Geiger G, Cooper CL. Tandon S, et al. Front Public Health. 2024 May 20;12:1281079. doi: 10.3389/fpubh.2024.1281079. eCollection 2024. Front Public Health. 2024. PMID: 38832223 Free PMC article.
INTRODUCTION: Many individuals living with hepatitis C virus (HCV) are unaware of their diagnosis and/or have not been linked to programs providing HCV care. ...Physicians were prompted to conduct HCV RNA testing and submit consultation requests to the TOH Viral Hepatit
INTRODUCTION: Many individuals living with hepatitis C virus (HCV) are unaware of their diagnosis and/or have not been linked to prog …
The etiology and differential diagnosis of "autoimmune hepatitis-like liver disease" in children: a single-center retrospective study.
Ma D, Liu X, Ai G, Pan W, Liu L, Huang Y, Liao Y, Lu Y, Zhang Z, Zhou H, Huang Z, Hao X, Shu S, Fang F. Ma D, et al. Front Pediatr. 2024 May 16;12:1377333. doi: 10.3389/fped.2024.1377333. eCollection 2024. Front Pediatr. 2024. PMID: 38818349 Free PMC article.
BACKGROUND: Children with autoimmune hepatitis (AIH) often present with symptoms similar to those of other liver diseases. ...The positive rates of antibodies to liver cytosol type1 (anti-LC1) and Ro52 were higher than those in the other four groups. The serum immunoglobul …
BACKGROUND: Children with autoimmune hepatitis (AIH) often present with symptoms similar to those of other liver diseases. ...The pos …
Implementing Adult Hepatitis B Immunization and Screening Using Electronic Health Records: A Practical Guide.
Kim HN, Moore KL, Sanders DL, Jackson M, Cohen C, Andrews R, Graham CS. Kim HN, et al. Vaccines (Basel). 2024 May 14;12(5):536. doi: 10.3390/vaccines12050536. Vaccines (Basel). 2024. PMID: 38793787 Free PMC article.
IMPORTANCE: Hepatitis B is a serious problem in the United States (US), with up to 2.4 million Americans living with a chronic infection. ...In 2022, the Advisory Committee on Immunization Practices of the Centers for Disease Control and Prevention (CDC) updated adult h
IMPORTANCE: Hepatitis B is a serious problem in the United States (US), with up to 2.4 million Americans living with a chronic infect …
Autoimmune hepatitis displays distinctively high multi-antennary sialylation on plasma N-glycans compared to other liver diseases.
Pongracz T, Biewenga M, Stoelinga AEC, Bladergroen MR, Nicolardi S, Trouw LA, Wuhrer M, de Haan N, van Hoek B. Pongracz T, et al. J Transl Med. 2024 May 14;22(1):456. doi: 10.1186/s12967-024-05173-z. J Transl Med. 2024. PMID: 38745252 Free PMC article.
BACKGROUND: Changes in plasma protein glycosylation are known to functionally affect proteins and to associate with liver diseases, including cirrhosis and hepatocellular carcinoma. Autoimmune hepatitis (AIH) is a liver disease characterized by liver inflammation and raise …
BACKGROUND: Changes in plasma protein glycosylation are known to functionally affect proteins and to associate with liver diseases, includin …
The impact of HBx protein on mitochondrial dynamics and associated signaling pathways strongly depends on the hepatitis B virus genotype.
Schollmeier A, Basic M, Glitscher M, Hildt E. Schollmeier A, et al. J Virol. 2024 May 14;98(5):e0042424. doi: 10.1128/jvi.00424-24. Epub 2024 Apr 17. J Virol. 2024. PMID: 38629837 Free PMC article.
Chronic hepatitis B virus (HBV) infections are strongly associated with liver cirrhosis, inflammation, and hepatocellular carcinoma. ...Key signaling pathways were profiled by kinome analysis and correlated with expression levels of mitochondrial and pathogenic markers. Co …
Chronic hepatitis B virus (HBV) infections are strongly associated with liver cirrhosis, inflammation, and hepatocellular carcinoma. …
Comparing chemical transfection, electroporation, and lentiviral vector transduction to achieve optimal transfection conditions in the Vero cell line.
Jamour P, Jamali A, Langeroudi AG, Sharafabad BE, Abdoli A. Jamour P, et al. BMC Mol Cell Biol. 2024 May 13;25(1):15. doi: 10.1186/s12860-024-00511-x. BMC Mol Cell Biol. 2024. PMID: 38741034 Free PMC article.
RESULTS: Among the tested methods, TurboFect chemical transfection exhibited the highest efficiency. Optimal transfection conditions were achieved using 1 g DNA and 4 L TurboFect in 6 10(4) Vero cells. CONCLUSION: TurboFect, a cationic polymer transfection reagent, demonst …
RESULTS: Among the tested methods, TurboFect chemical transfection exhibited the highest efficiency. Optimal transfection conditions were ac …
Enhanced external counterpulsation treatment improves multi-organ hemodynamics for postoperative liver transplantation patient. A case report.
Zeng X, Jin X, Wu Z, Hu J, Zhou W, Shen X, Du J. Zeng X, et al. J Cardiothorac Surg. 2024 May 10;19(1):284. doi: 10.1186/s13019-024-02783-y. J Cardiothorac Surg. 2024. PMID: 38730503 Free PMC article.
CASE PRESENTATION: A 51-year-old male patient, 76 kg, 172 cm, received orthotopic LT surgery for viral hepatitis B induced acute-on-chronic liver failure hepatic failure. ...A standard 35-hour EECP treatment led to significant improvement in quality of life, e.g. sl …
CASE PRESENTATION: A 51-year-old male patient, 76 kg, 172 cm, received orthotopic LT surgery for viral hepatitis B induced acute-on-c …
Sexually transmitted infections, sexual life and risk behaviours of people living with schizophrenia: systematic review and meta-analysis.
Aymerich C, Pedruzo B, Salazar de Pablo G, Madaria L, Goena J, Sanchez-Gistau V, Fusar-Poli P, McGuire P, González-Torres MÁ, Catalan A. Aymerich C, et al. BJPsych Open. 2024 May 10;10(3):e110. doi: 10.1192/bjo.2024.49. BJPsych Open. 2024. PMID: 38725352 Free PMC article. Review.
Schizophrenia samples showed a high prevalence of STIs and higher risks of HIV (odds ratio = 2.11; 95% CI 1.23-3.63), hepatitis C virus (HCV, odds ratio = 4.54; 95% CI 2.15-961) and hepatitis B virus (HBV; odds ratio = 2.42; 95% CI 1.95-3.01) infections than healthy …
Schizophrenia samples showed a high prevalence of STIs and higher risks of HIV (odds ratio = 2.11; 95% CI 1.23-3.63), hepatitis C vir …
Prevalence of Acute Hepatitis E Virus Infections in Swiss Blood Donors 2018-2020.
Niederhauser C, Gowland P, Widmer N, Amar El Dusouqui S, Mattle-Greminger M, Gottschalk J, Frey BM. Niederhauser C, et al. Viruses. 2024 May 8;16(5):744. doi: 10.3390/v16050744. Viruses. 2024. PMID: 38793625 Free PMC article.
INTRODUCTION: Hepatitis E virus (HEV) genotype 3 is the major cause of acute viral hepatitis in several European countries. ...
INTRODUCTION: Hepatitis E virus (HEV) genotype 3 is the major cause of acute viral hepatitis in several European countries. .. …
Concentration of foodborne viruses eluted from fresh and frozen produce: Applicability of ultrafiltration.
Trudel-Ferland M, Levasseur M, Goulet-Beaulieu V, Jubinville E, Hamon F, Jean J. Trudel-Ferland M, et al. Int J Food Microbiol. 2024 May 2;416:110687. doi: 10.1016/j.ijfoodmicro.2024.110687. Epub 2024 Mar 27. Int J Food Microbiol. 2024. PMID: 38554558 Free article.
Foodborne illnesses involving raw and minimally processed foods are often caused by human noroviruses (HuNoV) and hepatitis A virus (HAV). Since food is contaminated usually with small numbers of virions, these must be eluted from the food surface and then concentra …
Foodborne illnesses involving raw and minimally processed foods are often caused by human noroviruses (HuNoV) and hepatitis A
Seroprevalence of Hepatitis-E Virus-Immunoglobulin G and its association with Chronic Liver Disease.
Memon MS, Kadir B, Kamani L, Chandio AA. Memon MS, et al. Pak J Med Sci. 2024 May-Jun;40(5):1011-1016. doi: 10.12669/pjms.40.5.8448. Pak J Med Sci. 2024. PMID: 38827844 Free PMC article.
BACKGROUND & OBJECTIVE: Viral hepatitis is a major public health concern in low-middle income countries. ...Superinfection with HEV in patients with chronic liver disease (CLD) can cause severe hepatic decompensation leading to increased morbidity and mortality. To det …
BACKGROUND & OBJECTIVE: Viral hepatitis is a major public health concern in low-middle income countries. ...Superinfection with H …
Frequent Disengagement and Subsequent Mortality Among People With HIV and Hepatitis C in Canada: A Prospective Cohort Study.
Saeed S, Thomas T, Dinh DA, Moodie E, Cox J, Cooper C, Gill J, Martel-Laferriere V, Panagiotoglou D, Walmsley S, Wong A, Klein MB. Saeed S, et al. Open Forum Infect Dis. 2024 Apr 25;11(5):ofae239. doi: 10.1093/ofid/ofae239. eCollection 2024 May. Open Forum Infect Dis. 2024. PMID: 38798898 Free PMC article.
BACKGROUND: The cascade of care, commonly used to assess HIV and hepatitis C (HCV) health service delivery, has limitations in capturing the complexity of individuals' engagement patterns. ...
BACKGROUND: The cascade of care, commonly used to assess HIV and hepatitis C (HCV) health service delivery, has limitations in captur …
Enasidenib-induced hepatitis in an individual with Type II D2-hydroxyglutaric aciduria.
Gold JI, Stefanatos AK, Fraser JL, Vanderver A, Cuddapah S. Gold JI, et al. JIMD Rep. 2024 Apr 16;65(3):156-162. doi: 10.1002/jmd2.12421. eCollection 2024 May. JIMD Rep. 2024. PMID: 38736636 Free PMC article.
Our patient tolerated Enasidenib well. Urine 2-HGA decreased significantly from 244 mg/g creatinine to undetectable within 2 weeks of treatment. Inpatient admissions decreased from 8 during the 2 years preceding treatment to 1 during treatment. ...Enasidenib is a viable tr …
Our patient tolerated Enasidenib well. Urine 2-HGA decreased significantly from 244 mg/g creatinine to undetectable within 2 weeks of …
Follow-Up and Comparative Assessment of SARS-CoV-2 IgA, IgG, Neutralizing, and Total Antibody Responses After BNT162b2 or mRNA-1273 Heterologous Booster Vaccination.
Younes S, Nicolai E, Pieri M, Bernardini S, Daas HI, Al-Sadeq DW, Younes N, Shurrab FM, Nizamuddin PB, Humaira F, Al-Dewik N, Yassine HM, Abu-Raddad LJ, Ismail A, Nasrallah GK. Younes S, et al. Influenza Other Respir Viruses. 2024 May;18(5):e13290. doi: 10.1111/irv.13290. Influenza Other Respir Viruses. 2024. PMID: 38706402 Free PMC article.
Kinetics of Hepatitis E Virus Infections in Asymptomatic Persons.
Plümers R, Dreier J, Knabbe C, Steinmann E, Todt D, Vollmer T. Plümers R, et al. Emerg Infect Dis. 2024 May;30(5):934-940. doi: 10.3201/eid3005.231764. Emerg Infect Dis. 2024. PMID: 38666600 Free PMC article.
To determine the kinetics of hepatitis E virus (HEV) in asymptomatic persons and to evaluate viral load doubling time and half-life, we retrospectively tested samples retained from 32 HEV RNA-positive asymptomatic blood donors in Germany. ...Knowledge of the dynamics of HE …
To determine the kinetics of hepatitis E virus (HEV) in asymptomatic persons and to evaluate viral load doubling time and half-life, …
Seroprevalence and Shifting Endemicities of Hepatitis A Virus Infection in Two Different Geographical Areas in the Philippines.
Carlos JC, Quinones VMT, Adversario MPL, Nailes JM, Songco JC, Garcia DR, Cacayorin MG, Cero MPV, Benedicto-Delfin MPA, Blanco MCC, Natividad NS, Bernabe JD, Chacon HCT, Ascue RAC, Paggao JNK, Comendador LOP, Hernandez-Suarez G, Guzman-Holst A. Carlos JC, et al. Infect Dis Ther. 2024 May;13(5):1019-1035. doi: 10.1007/s40121-024-00955-w. Epub 2024 Apr 5. Infect Dis Ther. 2024. PMID: 38578515 Free PMC article.
INTRODUCTION: Infection with hepatitis A virus (HAV) is often asymptomatic in young children, but most adolescents and adults will have symptoms ranging from nausea and tiredness to acute liver failure and even death. ...Immunization might be an option to protect vu …
INTRODUCTION: Infection with hepatitis A virus (HAV) is often asymptomatic in young children, but most adolescents and adults …
Development and validation of a noninvasive prediction model for significant hepatic liver fibrosis in Chinese patients with autoimmune hepatitis.
Chen H, Ren W, Yang X, Hu P, Wang S, Xu C, Lv F, Zhao Y, Yin Q, Zheng W, Xu J, Pan H. Chen H, et al. Ann Hepatol. 2024 May-Jun;29(3):101287. doi: 10.1016/j.aohep.2024.101287. Epub 2024 Jan 22. Ann Hepatol. 2024. PMID: 38266674 Free article.
INTRODUCTION AND OBJECTIVES: Autoimmune hepatitis (AIH) is a prevalent noninfectious liver disease. However, there is currently a lack of noninvasive tests appropriate for evaluating liver fibrosis in AIH patients. ...RESULTS: Logistic regression analysis revealed that age …
INTRODUCTION AND OBJECTIVES: Autoimmune hepatitis (AIH) is a prevalent noninfectious liver disease. However, there is currently a lac …
Prevalence and characteristics of hepatitis delta virus infection in patients with hepatitis B in the United States: An analysis of the All-Payer Claims Database.
Gish RG, Jacobson IM, Lim JK, Waters-Banker C, Kaushik A, Kim C, Cyhaniuk A, Wong RJ. Gish RG, et al. Hepatology. 2024 May 1;79(5):1117-1128. doi: 10.1097/HEP.0000000000000687. Epub 2023 Nov 16. Hepatology. 2024. PMID: 37976395 Free PMC article.
BACKGROUND AND AIMS: HDV leads to the most severe form of viral hepatitis; however, the prevalence of HDV is not well understood. Using real-world data from the All-Payer Claims Database, this study estimates the prevalence of HBV/HDV infection among the chronic HBV popula …
BACKGROUND AND AIMS: HDV leads to the most severe form of viral hepatitis; however, the prevalence of HDV is not well understood. Usi …
Association of hepatitis delta virus with liver morbidity and mortality: A systematic literature review and meta-analysis.
Gish RG, Wong RJ, Di Tanna GL, Kaushik A, Kim C, Smith NJ, Kennedy PTF. Gish RG, et al. Hepatology. 2024 May 1;79(5):1129-1140. doi: 10.1097/HEP.0000000000000642. Epub 2023 Oct 23. Hepatology. 2024. PMID: 37870278 Free PMC article.
BACKGROUND AND AIMS: Studies have suggested that patients with chronic hepatitis B, either co- or superinfected, have more aggressive liver disease progression than those with the HDV. ...
BACKGROUND AND AIMS: Studies have suggested that patients with chronic hepatitis B, either co- or superinfected, have more aggressive …
ELIMINATE: a PCR record-based macroelimination project for systematic recall of HCV-RNA-positive persons in Austria.
Schwarz C, Bauer D, Dorn L, Jachs M, Hartl L, Chromy D, Weseslindtner L, Pfisterer N, Hennlich B, Stückler A, Strassl R, Voill-Glaninger A, Hübl W, Willheim M, Köhrer K, Jansen-Skoupy S, Tomez S, Krugluger W, Madl C, Schwarz M, Balcar L, Semmler G, Brinkmann L, Burghart L, Antonitsch L, Weidinger G, Riedl F, Laferl H, Kurteva V, Traugott M, Hind J, Wenisch C, Aburaia A, Sebesta C, Schmid D, Rothweiler S, Remetic J, Gschwantler M, Maieron A, Reiberger T. Schwarz C, et al. Wien Klin Wochenschr. 2024 May;136(9-10):278-288. doi: 10.1007/s00508-023-02275-4. Epub 2023 Sep 29. Wien Klin Wochenschr. 2024. PMID: 37773541 Free PMC article.
BACKGROUND AND AIMS: Micro-elimination projects targeted to specific hepatitis C virus (HCV) risk populations have been successful. Systematic identification of persons with HCV viremia, regardless of risk group, based on already available laboratory records may represent …
BACKGROUND AND AIMS: Micro-elimination projects targeted to specific hepatitis C virus (HCV) risk populations have been successful. S …
Clinical course of congestive hepatopathy pre/post heart transplantation.
Balcar L, Semmler G, Scheiner B, Stättermayer AF, Ćosić S, Schwabl P, Kazem N, Mandorfer M, Hülsmann M, Zuckermann A, Reiberger T. Balcar L, et al. Wien Klin Wochenschr. 2024 May;136(9-10):267-277. doi: 10.1007/s00508-023-02231-2. Epub 2023 Jun 28. Wien Klin Wochenschr. 2024. PMID: 37378679 Free PMC article.
Bile acid and nonalcoholic steatohepatitis: Molecular insights and therapeutic targets.
Cheng Z, Chen Y, Schnabl B, Chu H, Yang L. Cheng Z, et al. J Adv Res. 2024 May;59:173-187. doi: 10.1016/j.jare.2023.06.009. Epub 2023 Jun 23. J Adv Res. 2024. PMID: 37356804 Free PMC article. Review.
KEY SCIENTIFIC CONCEPTS OF REVIEW: Bile acid has a salutary effect on hepatic metabolic disorders, which can ameliorate liver fat accumulation and insulin resistance mainly through activating Takeda G-protein coupled receptor 5 and farnesoid X receptor. Moreover, bile acid …
KEY SCIENTIFIC CONCEPTS OF REVIEW: Bile acid has a salutary effect on hepatic metabolic disorders, which can ameliorate liver fat accumulati …
Opportunistic Pathogens in Drinking Water Distribution Systems-A Review.
LeChevallier MW, Prosser T, Stevens M. LeChevallier MW, et al. Microorganisms. 2024 Apr 30;12(5):916. doi: 10.3390/microorganisms12050916. Microorganisms. 2024. PMID: 38792751 Free PMC article. Review.
Historically, drinking water treatment has focused on control of frank pathogens, particularly those from human or animal sources (like Giardia lamblia, Cryptosporidium parvum, or Hepatitis A virus), but in recent years outbreaks from drinking water have increasingl …
Historically, drinking water treatment has focused on control of frank pathogens, particularly those from human or animal sources (like Giar …
Quantitative comparison and evaluation between aerial and underground parts of Gentiana straminea through simultaneous determination of five major compounds by RP-HPLC.
Hao J, Zhou J, Lin P, Wu J. Hao J, et al. Heliyon. 2024 Apr 15;10(8):e29232. doi: 10.1016/j.heliyon.2024.e29232. eCollection 2024 Apr 30. Heliyon. 2024. PMID: 38660265 Free PMC article.
Secoiridoids and flavonoids have been identified as the major active components of herbal medicines used in the treatment of hepatitis, rheumatism and many other diseases. It is the overharvesting of the roots of this plant for medicinal purposes that has led to a drastic …
Secoiridoids and flavonoids have been identified as the major active components of herbal medicines used in the treatment of hepatitis
Reduction of the Risk of Hepatocellular Carcinoma over Time Using Direct-Acting Antivirals: A Propensity Score Analysis of a Real-Life Cohort (PITER HCV).
Quaranta MG, Cavalletto L, Russo FP, Calvaruso V, Ferrigno L, Zanetto A, Mattioli B, D'Ambrosio R, Panetta V, Brancaccio G, Raimondo G, Brunetto MR, Zignego AL, Coppola C, Iannone A, Biliotti E, Rosselli Del Turco E, Massari M, Licata A, Barbaro F, Persico M, Morisco F, Pompili M, Cerini F, Puoti M, Santantonio T, Craxì A, Kondili LA, Chemello L, On Behalf Of Piter Collaborating Investigators. Quaranta MG, et al. Viruses. 2024 Apr 26;16(5):682. doi: 10.3390/v16050682. Viruses. 2024. PMID: 38793565 Free PMC article.
The treatment of hepatitis C virus (HCV) with direct-acting antivirals (DAA) leads to high sustained virological response (SVR) rates, but hepatocellular carcinoma (HCC) risk persists in people with advanced liver disease even after SVR. ...Other variables independently as …
The treatment of hepatitis C virus (HCV) with direct-acting antivirals (DAA) leads to high sustained virological response (SVR) rates …
IgG4-related autoimmune pancreatitis and sclerosing cholangitis: A case report and literature review.
Wang N, Zhu P, Xiang Y, Tao L, Huang T, Feng Z. Wang N, et al. Medicine (Baltimore). 2024 Apr 26;103(17):e37922. doi: 10.1097/MD.0000000000037922. Medicine (Baltimore). 2024. PMID: 38669380 Free PMC article. Review.
Liver and pancreatic tissue pathology showed IgG4 plasma cell infiltration, while liver biopsy indicated interface hepatitis, liver fibrosis, and pseudolobule formation, with no evidence of bile duct damage. ...
Liver and pancreatic tissue pathology showed IgG4 plasma cell infiltration, while liver biopsy indicated interface hepatitis, liver f …
Non-Invasive Diagnostic Tests for Portal Hypertension in Patients with HBV- and HCV-Related Cirrhosis: A Comprehensive Review.
Celsa C, Veneziano M, Di Giorgio FM, Cannova S, Lombardo A, Errigo E, Landro G, Simone F, Sinagra E, Calvaruso V. Celsa C, et al. Medicina (Kaunas). 2024 Apr 24;60(5):690. doi: 10.3390/medicina60050690. Medicina (Kaunas). 2024. PMID: 38792873 Free PMC article. Review.
This review comprehensively explores non-invasive diagnostic modalities for portal hypertension, focusing on NITs in the setting of hepatitis B and hepatitis C virus-related cirrhosis. Biochemical-based NITs can be represented by single serum biomarkers (e.g. …
This review comprehensively explores non-invasive diagnostic modalities for portal hypertension, focusing on NITs in the setting of hepat
Role of B Cells beyond Antibodies in HBV-Induced Oncogenesis: Fulminant Cancer in Common Variable Immunodeficiency-Clinical and Immunotransplant Implications with a Review of the Literature.
Zdziarski P, Gamian A. Zdziarski P, et al. Diseases. 2024 Apr 23;12(5):80. doi: 10.3390/diseases12050080. Diseases. 2024. PMID: 38785735 Free PMC article.
Despite lamivudine therapy and IVIG escalation (from 0.3 to 0.4 g/kg), CT showed an 11 cm intrahepatic tumor (hepatocellular carcinoma). ...Our clinical model showed an HCC pathway with important humoral host factors, contrary to epidemiological/cohort studies highlighting …
Despite lamivudine therapy and IVIG escalation (from 0.3 to 0.4 g/kg), CT showed an 11 cm intrahepatic tumor (hepatocellular carcinom …
Evaluation of respondent-driven sampling in seven studies of people who use drugs from rural populations: findings from the Rural Opioid Initiative.
Rudolph AE, Nance RM, Bobashev G, Brook D, Akhtar W, Cook R, Cooper HL, Friedmann PD, Frost SDW, Go VF, Jenkins WD, Korthuis PT, Miller WC, Pho MT, Ruderman SA, Seal DW, Stopka TJ, Westergaard RP, Young AM, Zule WA, Tsui JI, Crane HM, Whitney BM, Delaney JAC. Rudolph AE, et al. BMC Med Res Methodol. 2024 Apr 23;24(1):94. doi: 10.1186/s12874-024-02206-5. BMC Med Res Methodol. 2024. PMID: 38654219 Free PMC article.
We compared sample proportions with three RDS-adjusted estimators (two variations of RDS-I and RDS-II) for five variables of interest (past 30-day use of heroin, fentanyl, and methamphetamine; past 6-month homelessness; and being positive for hepatitis C virus (HCV) antibo …
We compared sample proportions with three RDS-adjusted estimators (two variations of RDS-I and RDS-II) for five variables of interest (past …
Association between hepatitis A seropositivity and bone mineral density in adolescents and adults: a cross-sectional study using NHANES data.
Yu Z, Hu G, Wang J, Li Z. Yu Z, et al. Sao Paulo Med J. 2024 Apr 22;142(5):e2023266. doi: 10.1590/1516-3180.2023.0266.R1.08022024. eCollection 2024. Sao Paulo Med J. 2024. PMID: 38655984 Free PMC article.
Early detection and prevention are crucial for managing osteoporosis and reducing the risk of fractures. OBJECTIVES: To investigate the relationship between Hepatitis A seropositivity and bone mineral density (BMD) in adolescents and adults and to explore the potent …
Early detection and prevention are crucial for managing osteoporosis and reducing the risk of fractures. OBJECTIVES: To investigate the rela …
Jian Gan powder ameliorates immunological liver injury in mice by modulating the gut microbiota and metabolic profiles.
Li K, Cui Y, Zheng X, Min C, Zhang J, Yan Z, Ji Y, Ge F, Ji H, Zhu F. Li K, et al. Eur J Med Res. 2024 Apr 20;29(1):240. doi: 10.1186/s40001-024-01827-2. Eur J Med Res. 2024. PMID: 38641655 Free PMC article.
Jian Gan powder (JGP) exhibits both protective and therapeutic effects on hepatitis virus-induced ILI in the clinic. However, the underlying mechanisms remain elusive. ...METHODS: The mouse model was established employing Bacillus Calmette-Guerin (BCG) plus lipopolysacchar …
Jian Gan powder (JGP) exhibits both protective and therapeutic effects on hepatitis virus-induced ILI in the clinic. However, the und …
Genetic and Epigenetic Associations with Post-Transplant Diabetes Mellitus.
Abdelrahman Z, Maxwell AP, McKnight AJ. Abdelrahman Z, et al. Genes (Basel). 2024 Apr 17;15(4):503. doi: 10.3390/genes15040503. Genes (Basel). 2024. PMID: 38674437 Free PMC article. Review.
Pre-transplant risk factors for PTDM include obesity, sedentary lifestyle, family history of diabetes, ethnicity (e.g., African-Caribbean or South Asian ancestry), and genetic risk factors. Risk factors for PTDM include immunosuppressive drugs, weight gain, hepatitis
Pre-transplant risk factors for PTDM include obesity, sedentary lifestyle, family history of diabetes, ethnicity (e.g., African-Carib …
Co-Transcriptional Regulation of HBV Replication: RNA Quality Also Matters.
Giraud G, El Achi K, Zoulim F, Testoni B. Giraud G, et al. Viruses. 2024 Apr 16;16(4):615. doi: 10.3390/v16040615. Viruses. 2024. PMID: 38675956 Free PMC article. Review.
Chronic hepatitis B (CHB) virus infection is a major public health burden and the leading cause of hepatocellular carcinoma. Despite the efficacy of current treatments, hepatitis B virus (HBV) cannot be fully eradicated due to the persistence of its minichromosome, …
Chronic hepatitis B (CHB) virus infection is a major public health burden and the leading cause of hepatocellular carcinoma. Despite …
Unveiling the Potential of Ent-Kaurane Diterpenoids: Multifaceted Natural Products for Drug Discovery.
Kibet S, Kimani NM, Mwanza SS, Mudalungu CM, Santos CBR, Tanga CM. Kibet S, et al. Pharmaceuticals (Basel). 2024 Apr 16;17(4):510. doi: 10.3390/ph17040510. Pharmaceuticals (Basel). 2024. PMID: 38675469 Free PMC article. Review.
The ranges of the physicochemical parameters were as follows: molecular weights-288.47 to 626.82 g/mol; number of heavy atoms-21 to 44; the number of hydrogen bond donors and acceptors-0 to 8 and 1 to 11, respectively; the number of rotatable bonds-0 to 11; fraction Csp3-0 …
The ranges of the physicochemical parameters were as follows: molecular weights-288.47 to 626.82 g/mol; number of heavy atoms-21 to 4 …
Detection of Hepatitis E Virus (HEV) in Pork Sold in Saint-Louis, the North of Senegal.
Tene SD, Diouara AAM, Kane A, Sané S, Coundoul S, Thiam F, Nguer CM, Diop M, Mbaye MN, Mbengue M, Lo S, Diop Ndiaye H, Toure Kane C, Ayouba A. Tene SD, et al. Life (Basel). 2024 Apr 16;14(4):512. doi: 10.3390/life14040512. Life (Basel). 2024. PMID: 38672782 Free PMC article.
The hepatitis E virus (HEV) is a zoonotic pathogen with various hosts, including pigs, which act as reservoirs. ...Then, 2 g/sample was minced to extract total nucleic acids using the Purelink Viral DNA/RNA kit. ...
The hepatitis E virus (HEV) is a zoonotic pathogen with various hosts, including pigs, which act as reservoirs. ...Then, 2 g/s …
How robust are estimates of key parameters in standard viral dynamic models?
Zitzmann C, Ke R, Ribeiro RM, Perelson AS. Zitzmann C, et al. PLoS Comput Biol. 2024 Apr 16;20(4):e1011437. doi: 10.1371/journal.pcbi.1011437. eCollection 2024 Apr. PLoS Comput Biol. 2024. PMID: 38626190 Free PMC article.
Mathematical models of viral infection have been developed, fitted to data, and provide insight into disease pathogenesis for multiple agents that cause chronic infection, including HIV, hepatitis C, and B virus. However, for agents that cause acute infections or during th …
Mathematical models of viral infection have been developed, fitted to data, and provide insight into disease pathogenesis for multiple agent …
Mechanisms of Hepatitis B Virus cccDNA and Minichromosome Formation and HBV Gene Transcription.
Gómez-Moreno A, Ploss A. Gómez-Moreno A, et al. Viruses. 2024 Apr 15;16(4):609. doi: 10.3390/v16040609. Viruses. 2024. PMID: 38675950 Free PMC article. Review.
Hepatitis B virus (HBV) is the etiologic agent of chronic hepatitis B, which puts at least 300 million patients at risk of developing fibrosis, cirrhosis, and hepatocellular carcinoma. ...
Hepatitis B virus (HBV) is the etiologic agent of chronic hepatitis B, which puts at least 300 million patients at risk of dev
Chronic exposure to ambient air pollution and the risk of non-alcoholic fatty liver disease: A cross-sectional study in Taiwan and Hong Kong.
Bo Y, Lin C, Guo C, Wong M, Huang B, Lau A, Huang Y, Lao XQ. Bo Y, et al. Ecotoxicol Environ Saf. 2024 Apr 15;275:116245. doi: 10.1016/j.ecoenv.2024.116245. Epub 2024 Mar 22. Ecotoxicol Environ Saf. 2024. PMID: 38520807 Free article.
METHODS: We recruited 329,048 adults (mean age: 41.0 years) without other liver disease (hepatitis and cirrhosis) or excessive alcohol consumption in Taiwan and Hong Kong from 2001 to 2018. ...Similarly, the prevalence of NAFLD and advanced fibrosis increased by 8% (95% CI …
METHODS: We recruited 329,048 adults (mean age: 41.0 years) without other liver disease (hepatitis and cirrhosis) or excessive alcoho …
Chronic inflammatory demyelinating polyneuropathy and HEV antibody status: A case-control study from Lazio, Italy.
Moret F, Spada E, Ceccanti M, Libonati L, D'Andrea E, Villano U, Madonna E, Chionne P, Carocci A, Pisani G, Fionda L, Antonini G, Petrucci A, Bruni R, Ciccaglione AR, Taliani G, Rivano Capparuccia M, Nobile-Orazio E, Inghilleri M, Cambieri C. Moret F, et al. J Neurol Sci. 2024 Apr 15;459:122959. doi: 10.1016/j.jns.2024.122959. Epub 2024 Mar 12. J Neurol Sci. 2024. PMID: 38490091 Free article.
INTRODUCTION: Few studies have pointed to the possible role of infectious diseases in triggering Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP). Given the association of Hepatitis E Virus (HEV) with Guillain Barre syndrome, we conducted a case-control stu …
INTRODUCTION: Few studies have pointed to the possible role of infectious diseases in triggering Chronic Inflammatory Demyelinating Polyradi …
Successful therapy with tenofovir disoproxil fumarate (TDF) in patients with chronic hepatitis B (CHB) does not guarantee amelioration of liver damage assessing by transient elastography. A retrospective - prospective multicenter study.
Kranidioti H, Zisimopoulos K, Oikonomou T, Voulgaris T, Siakavellas S, Agorastou P, Deutsch M, Triantos C, Goulis I, Papatheodoridis G, Manolakopoulos S. Kranidioti H, et al. BMC Gastroenterol. 2024 Apr 12;24(1):133. doi: 10.1186/s12876-024-03200-3. BMC Gastroenterol. 2024. PMID: 38609880 Free PMC article.
BACKGROUND: Preventing disease progression and viral suppression are the main goals of antiviral therapy in chronic hepatitis B (CHB). Liver stiffness measurement (LSM) by transient elastography is a reliable non-invasive method to assess liver fibrosis in patients with CH …
BACKGROUND: Preventing disease progression and viral suppression are the main goals of antiviral therapy in chronic hepatitis B (CHB) …
HFE-Related Hemochromatosis.
Barton JC, Parker CJ. Barton JC, et al. 2000 Apr 3 [updated 2024 Apr 11]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. 2000 Apr 3 [updated 2024 Apr 11]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. PMID: 20301613 Free Books & Documents. Review.
Treatment of arthropathy includes nonsteroidal anti-inflammatory drugs, physiotherapy, and joint replacement. Standard treatment for diabetes mellitus. Vaccination for hepatitis A and B. Treatment of hepatitis B or C with standard antiviral agents may reduce …
Treatment of arthropathy includes nonsteroidal anti-inflammatory drugs, physiotherapy, and joint replacement. Standard treatment for diabete …
Measures of Longitudinal Immune Dysfunction and Risk of AIDS and Non-AIDS Defining Malignancies in Antiretroviral-Treated People With Human Immunodeficiency Virus.
Chammartin F, Mocroft A, Egle A, Zangerle R, Smith C, Mussini C, Wit F, Vehreschild JJ, d'Arminio Monforte A, Castagna A, Bailly L, Bogner J, de Wit S, Matulionyte R, Law M, Svedhem V, Tallada J, Garges HP, Marongiu A, Borges ÁH, Jaschinski N, Neesgaard B, Ryom L, Bucher HC; RESPOND Study Group. Chammartin F, et al. Clin Infect Dis. 2024 Apr 10;78(4):995-1004. doi: 10.1093/cid/ciad671. Clin Infect Dis. 2024. PMID: 38092042 Free PMC article.
Determining Herd Immunity Thresholds for Hepatitis A Virus Transmission to Inform Vaccination Strategies Among People Who Inject Drugs in 16 US States.
Yang J, Lo NC, Dankwa EA, Donnelly CA, Gupta R, Montgomery MP, Weng MK, Martin NK. Yang J, et al. Clin Infect Dis. 2024 Apr 10;78(4):976-982. doi: 10.1093/cid/ciad552. Clin Infect Dis. 2024. PMID: 37738564 Free PMC article.
BACKGROUND: Widespread outbreaks of person-to-person transmitted hepatitis A virus (HAV), particularly among people who inject drugs (PWID), continue across the United States and globally. ...Using the prediction interval upper bound (76%) and assuming 95% vaccine e …
BACKGROUND: Widespread outbreaks of person-to-person transmitted hepatitis A virus (HAV), particularly among people who inject …
Chronic Hepatitis B Finite Treatment: Similar and Different Concerns With New Drug Classes.
Peters MG, Yuen MF, Terrault N, Fry J, Lampertico P, Gane E, Hwang C, Stamm LM, Leus M, Maini MK, Mendez P, Lonjon-Domanec I, Berg T, Wang S, Mishra P, Donaldson E, Buchholz S, Miller V, Lenz O. Peters MG, et al. Clin Infect Dis. 2024 Apr 10;78(4):983-990. doi: 10.1093/cid/ciad506. Clin Infect Dis. 2024. PMID: 37633256 Free PMC article.
Chronic hepatitis B, a major cause of liver disease and cancer, affects >250 million people worldwide. Currently there is no cure, only suppressive therapies. Efforts to develop finite curative hepatitis B virus (HBV) therapies are underway, consisting of combina …
Chronic hepatitis B, a major cause of liver disease and cancer, affects >250 million people worldwide. Currently there is no cure, …
DFT/TDDFT calculations of geometry optimization, electronic structure and spectral properties of clevudine and telbivudine for treatment of chronic hepatitis B.
Tegegn DF, Belachew HZ, Salau AO. Tegegn DF, et al. Sci Rep. 2024 Apr 8;14(1):8146. doi: 10.1038/s41598-024-58599-2. Sci Rep. 2024. PMID: 38584189 Free PMC article.
Chronic hepatitis B remains a worldwide health concern. Presently, many drugs, such as Clevudine and Telbivudine, are recommended for the treatment of chronic hepatitis B disease. ...The hybrid B3LYP functional method and the 6-311++G(d, p) basis set were use …
Chronic hepatitis B remains a worldwide health concern. Presently, many drugs, such as Clevudine and Telbivudine, are recommended for …
Immunoglobulin-like transcript 2 as an impaired anti-tumor cytotoxicity marker of natural killer cells in patients with hepatocellular carcinoma.
Sakata T, Yoshio S, Yamazoe T, Mori T, Kakazu E, Aoki Y, Aoyanagi N, Okamoto T, Ito T, Toyoda H, Kawaguchi T, Ono Y, Takahashi Y, Taketomi A, Kanto T. Sakata T, et al. Front Immunol. 2024 Apr 4;15:1389411. doi: 10.3389/fimmu.2024.1389411. eCollection 2024. Front Immunol. 2024. PMID: 38638429 Free PMC article.
High prevalence of ceftriaxone-resistant and XDR Neisseria gonorrhoeae in several cities of Cambodia, 2022-23: WHO Enhanced Gonococcal Antimicrobial Surveillance Programme (EGASP).
Ouk V, Heng LS, Virak M, Deng S, Lahra MM, Frankson R, Kreisel K, McDonald R, Escher M, Unemo M, Wi T, Maatouk I; EGASP Cambodia Working Group. Ouk V, et al. JAC Antimicrob Resist. 2024 Apr 4;6(2):dlae053. doi: 10.1093/jacamr/dlae053. eCollection 2024 Apr. JAC Antimicrob Resist. 2024. PMID: 38577702 Free PMC article.
The nationally recommended cefixime 400 mg plus azithromycin 1 g (65.4%) or ceftriaxone 1 g plus azithromycin 1 g (34.6%) was used for treatment. ...
The nationally recommended cefixime 400 mg plus azithromycin 1 g (65.4%) or ceftriaxone 1 g plus azithromycin 1 g (34.6 …
Prevalence of hyperthyroidism and hypothyroidism in liver transplant recipients and associated risk factors.
Suarez-Zdunek MA, Arentoft NS, Krohn PS, Lauridsen EHE, Afzal S, Høgh J, Thomsen MT, Knudsen AD, Nordestgaard BG, Hillingsø JG, Villadsen GE, Holland-Fischer P, Rasmussen A, Fialla AD, Feldt-Rasmussen U, Nielsen SD. Suarez-Zdunek MA, et al. Sci Rep. 2024 Apr 3;14(1):7828. doi: 10.1038/s41598-024-58544-3. Sci Rep. 2024. PMID: 38570629 Free PMC article.
Among liver transplant recipients, 14 (2.9%) had hyperthyroidism compared with 21 (1.2%) of controls (adjusted odds ratio [aOR] 2.24, 95% confidence interval [CI] 1.05-4.75, P = 0.04), while 42 (5.7%) had hypothyroidism compared with 139 (7.7%) of controls (aOR 0.68, 95% CI 0.43- …
Among liver transplant recipients, 14 (2.9%) had hyperthyroidism compared with 21 (1.2%) of controls (adjusted odds ratio [aOR] 2.24, 95% co …
Seroepidemiological assessment of SARS-CoV-2 vaccine responsiveness and associated factors in the vaccinated community of the Casablanca-Settat Region, Morocco.
Ezzikouri S, Tajudeen R, Majidi H, Redwane S, Aqillouch S, Abdulaziz M, Aragaw M, Papa Fallah M, Sembuche S, Batcho S, Kabwe P, Gonese E, Laazaazia O, Elmessaoudi-Idrissi M, Meziane N, Ainahi A, Sarih M, Ogwell Ouma AE, Maaroufi A. Ezzikouri S, et al. Sci Rep. 2024 Apr 3;14(1):7817. doi: 10.1038/s41598-024-58498-6. Sci Rep. 2024. PMID: 38570577 Free PMC article.
Complementary and alternative medicines and liver disease.
Philips CA, Theruvath AH, Ravindran R, Augustine P. Philips CA, et al. Hepatol Commun. 2024 Apr 3;8(4):e0417. doi: 10.1097/HC9.0000000000000417. eCollection 2024 Apr 1. Hepatol Commun. 2024. PMID: 38563584 Free PMC article. Review.
The clinical presentations include asymptomatic liver test abnormalities, acute hepatitis with or without jaundice, acute cholestatic liver disease (bland or with hepatitis), acute liver failure, severe hepatitis with features of portal hypertension, and acut …
The clinical presentations include asymptomatic liver test abnormalities, acute hepatitis with or without jaundice, acute cholestatic …
Noninvasive serum markers for predicting significant liver histopathology in HBeAg-negative chronic HBV-infected patients with normal alanine aminotransferase.
Gao Y, Wang M, Liu X. Gao Y, et al. Microbiol Spectr. 2024 Apr 2;12(4):e0394123. doi: 10.1128/spectrum.03941-23. Epub 2024 Mar 1. Microbiol Spectr. 2024. PMID: 38426768 Free article.
This study is to explore the proportion of significant liver histopathology in hepatitis B e antigen (HBeAg)-negative chronic hepatitis B virus (HBV)-infected patients with normal alanine aminotransferase (ALT) and investigate noninvasive indicators for predicting s …
This study is to explore the proportion of significant liver histopathology in hepatitis B e antigen (HBeAg)-negative chronic hepa
Clinical Utility of Cytokeratins for Accurate Diagnosis of Hepatocellular Carcinoma Among Hepatitis C Virus High-Risk Patients.
Al Haddad M, El-Mezayen HA, El-Kassas M, Metwally F, El-Sharkawy A. Al Haddad M, et al. Asian Pac J Cancer Prev. 2024 Apr 1;25(4):1325-1332. doi: 10.31557/APJCP.2024.25.4.1325. Asian Pac J Cancer Prev. 2024. PMID: 38679993 Free PMC article.
A novel score named CK-HCC = CK 19 (ng/ml)0.001+ CK18 (ng/ml)0.004 + AFP (U/L)5.4 - Platelets count (109)/L0.003 - Albumin (g/L)0.27-36 was developed. CK-HCC score produces AUC of 0.919 for differentiating patients with HCC from those with liver cirrhosis with sensitivity …
A novel score named CK-HCC = CK 19 (ng/ml)0.001+ CK18 (ng/ml)0.004 + AFP (U/L)5.4 - Platelets count (109)/L0.003 - Albumin (g/L)0.27- …
Detection of significant liver fibrosis in Chinese psoriasis patients receiving methotrexate: a comparison between transient elastography and liver histology.
Wong CSM, Mak LLY, Lee VKH, Lo RCL, Chung MMH, Chu F, Yeung CK, Yuen MF, Chan HHL. Wong CSM, et al. Hong Kong Med J. 2024 Apr;30(2):110-119. doi: 10.12809/hkmj2210364. Hong Kong Med J. 2024. PMID: 38651202 Free article.
Exclusion criteria were known liver cirrhosis, positive viral hepatitis carrier status, or conditions influencing TE performance. Liver biopsy was performed when liver stiffness was 7.1 kilopascals (kPa) or when the total cumulative dose (TCD) of MTX was 3.5 g. RESU …
Exclusion criteria were known liver cirrhosis, positive viral hepatitis carrier status, or conditions influencing TE performance. Liv …
Hepatitis C Virus Antiviral Drug Resistance and Salvage Therapy Outcomes Across Australia.
Wang DS, Phu A, McKee K, Strasser SI, Sheils S, Weltman M, Sellar S, Davis JS, Young M, Braund A, Farrell GC, Blunn A, Harding D, Ralton L, Muller K, Davison SA, Shaw D, Wood M, Hajkowicz K, Skolen R, Davies J, Tate-Baker J, Doyle A, Tuma R, Hazeldine S, Lam W, Edmiston N, Zohrab K, Pratt W, Watson B, Zekry A, Stephens C, Clark PJ, Day M, Park G, Kim H, Wilson M, McGarity B, Menzies N, Russell D, Lam T, Boyd P, Kok J, George J, Douglas MW. Wang DS, et al. Open Forum Infect Dis. 2024 Mar 18;11(4):ofae155. doi: 10.1093/ofid/ofae155. eCollection 2024 Apr. Open Forum Infect Dis. 2024. PMID: 38651137 Free PMC article.
BACKGROUND: Hepatitis C virus (HCV) infection can now be cured with well-tolerated direct-acting antiviral (DAA) therapy. ...
BACKGROUND: Hepatitis C virus (HCV) infection can now be cured with well-tolerated direct-acting antiviral (DAA) therapy. ...
Determination of the reference interval for urine kidney injury molecule-1 in 50 healthy cats.
Brown T, Defarges A, Monteith G, Appleby R, Bienzle D. Brown T, et al. J Feline Med Surg. 2024 Apr;26(4):1098612X241238923. doi: 10.1177/1098612X241238923. J Feline Med Surg. 2024. PMID: 38647460 Free article.
There were 35 male cats and 15 female cats, with a median age of 4.3 years (range 1.0-12.3), median weight of 5.11 kg (range 2.52-8.45) and median BCS of 6/9 (range 3-8). The median serum concentrations were SDMA 11.0 g/dl (range 2-14), SCr 88.5 mol/l (range 47-136), phosp …
There were 35 male cats and 15 female cats, with a median age of 4.3 years (range 1.0-12.3), median weight of 5.11 kg (range 2.52-8.45) and …
Traditional Chinese medicine Pien-Tze-Huang ameliorates LPS-induced sepsis through bile acid-mediated activation of TGR5-STAT3-A20 signalling.
Li B, Zhang Y, Liu X, Zhang Z, Zhuang S, Zhong X, Chen W, Hong Y, Mo P, Lin S, Wang S, Yu C. Li B, et al. J Pharm Anal. 2024 Apr;14(4):100915. doi: 10.1016/j.jpha.2023.12.005. Epub 2023 Dec 10. J Pharm Anal. 2024. PMID: 38634065 Free PMC article.
Pien Tze Huang (PZH), a class I nationally protected traditional Chinese medicine (TCM), has been used to treat liver diseases such as hepatitis; however, the effect of PZH on the progression of sepsis is unknown. ...Mechanistically, PZH stimulated signal transducer and ac …
Pien Tze Huang (PZH), a class I nationally protected traditional Chinese medicine (TCM), has been used to treat liver diseases such as he
Gender differences in hepatitis A seropositivity rates according to the Republic of Korea's vaccination policy.
Son H, Ahn S, Park W, Chun G, Go U, Lee SG, Lee EH. Son H, et al. Osong Public Health Res Perspect. 2024 Apr;15(2):168-173. doi: 10.24171/j.phrp.2023.0263. Epub 2024 Apr 16. Osong Public Health Res Perspect. 2024. PMID: 38621763 Free PMC article.
BACKGROUND: This study aimed to investigate differences in the anti-hepatitis A virus (HAV) antibody seropositivity rate by age and gender. METHODS: We collected information on anti-HAV immunoglobulin G and immunoglobulin M status from samples submitted for H …
BACKGROUND: This study aimed to investigate differences in the anti-hepatitis A virus (HAV) antibody seropositivity rate by ag …
Vaccine Safety and Immunogenicity in Patients With Multiple Sclerosis Treated With Natalizumab.
Carvajal R, Zabalza A, Carbonell-Mirabent P, Martínez-Gómez X, Esperalba J, Pappolla A, Rando A, Cobo-Calvo A, Tur C, Rodriguez M, Río J, Comabella M, Castilló J, Rodrigo-Pendás JÁ, Braga N, Mongay-Ochoa N, Guío-Sánchez C, Vidal-Jordana Á, Arrambide G, Rodríguez-Acevedo B, Midaglia L, Borras-Bermejo B, Galán I, Sastre-Garriga J, Montalban X, Otero-Romero S, Tintoré M. Carvajal R, et al. JAMA Netw Open. 2024 Apr 1;7(4):e246345. doi: 10.1001/jamanetworkopen.2024.6345. JAMA Netw Open. 2024. PMID: 38607624 Free PMC article.
Eligible participants included adults with MS who completed immunization for hepatitis B virus (HBV), hepatitis A virus (HAV), and COVID-19 during natalizumab therapy. ...MAIN OUTCOMES AND MEASURES: Demographic, clinical, and radiological characteristics were …
Eligible participants included adults with MS who completed immunization for hepatitis B virus (HBV), hepatitis A virus …
Hepatotoxicity in patients with non-small cell lung cancer treated with sotorasib after prior immunotherapy: a comprehensive clinical and pharmacokinetic analysis.
Ernst SM, Hofman MM, van der Horst TE, Paats MS, Heijboer FWJ, Aerts JGJV, Dumoulin DW, Cornelissen R, von der Thüsen JH, de Bruijn P, Hoop EO, Mathijssen RHJ, Koolen SLW, Dingemans AC. Ernst SM, et al. EBioMedicine. 2024 Apr;102:105074. doi: 10.1016/j.ebiom.2024.105074. Epub 2024 Mar 19. EBioMedicine. 2024. PMID: 38507877 Free PMC article.
INTERPRETATION: In this preliminary prospective study, sotorasib after PD-(L)1 blockade was associated with severe hepatotoxicity, especially in patients with a short interval between treatments, prior immune-related hepatitis and higher anti-PD-1 plasma concentrations. Ou …
INTERPRETATION: In this preliminary prospective study, sotorasib after PD-(L)1 blockade was associated with severe hepatotoxicity, especiall …
Racial and ethnic disparities in alcohol-associated liver disease in the United States: A systematic review and meta-analysis.
Anouti A, Seif El Dahan K, Rich NE, Louissaint J, Lee WM, Lieber SR, Arab JP, Zhang BY, Patel MJ, Thimphittaya C, Díaz LA, Gregory DL, Kozlitina J, VanWagner LB, King AC, Mitchell MC, Singal AG, Cotter TG. Anouti A, et al. Hepatol Commun. 2024 Mar 18;8(4):e0409. doi: 10.1097/HC9.0000000000000409. eCollection 2024 Apr 1. Hepatol Commun. 2024. PMID: 38497931 Free PMC article.
BACKGROUND: Alcohol-associated liver disease (ALD), encompassing alcohol-associated hepatitis and alcohol-associated cirrhosis, is rising in the United States. ...We calculated pooled prevalence and incidence by race and ethnicity, including risk ratios and ORs for ALD poo …
BACKGROUND: Alcohol-associated liver disease (ALD), encompassing alcohol-associated hepatitis and alcohol-associated cirrhosis, is ri …
Plant stanol consumption increases anti-COVID-19 antibody responses, independent of changes in serum cholesterol concentrations: a randomized controlled trial.
van Brakel L, Mensink RP, Lütjohann D, Plat J. van Brakel L, et al. Am J Clin Nutr. 2024 Apr;119(4):969-980. doi: 10.1016/j.ajcnut.2024.01.017. Epub 2024 Jan 24. Am J Clin Nutr. 2024. PMID: 38278364 Free article. Clinical Trial.
Plant stanol ester previously increased the combined IgM/IgG antibody titers toward a hepatitis A vaccination in patients with allergic asthma, but the underlying mechanism is unknown. ...Thirty-two subjects with overweight/obesity consumed products with added plant …
Plant stanol ester previously increased the combined IgM/IgG antibody titers toward a hepatitis A vaccination in patients with …
In Vitro Hepatotoxicity of Routinely Used Opioids and Sedative Drugs.
Haller K, Doß S, Sauer M. Haller K, et al. Curr Issues Mol Biol. 2024 Mar 30;46(4):3022-3038. doi: 10.3390/cimb46040189. Curr Issues Mol Biol. 2024. PMID: 38666919 Free PMC article.
These drugs should be given with caution to patients vulnerable to hepatotoxic drugs, e.g., patients with pre-existing liver disease or liver impairment as part of their underlying disease (e.g., hypoxic hepatitis or cholestatic liver dysfunction in sepsis). …
These drugs should be given with caution to patients vulnerable to hepatotoxic drugs, e.g., patients with pre-existing liver disease …
Predictive three-biomarker panel in peripheral blood mononuclear cells for detecting hepatocellular carcinoma.
Fayazzadeh S, Ghorbaninejad M, Rabbani A, Zahiri J, Meyfour A. Fayazzadeh S, et al. Sci Rep. 2024 Mar 29;14(1):7527. doi: 10.1038/s41598-024-58158-9. Sci Rep. 2024. PMID: 38553531 Free PMC article.
In this study, we analyzed the gene expression profiles of 20 HCC patients, 12 individuals with chronic hepatitis, and 15 healthy controls. Enrichment analysis revealed that platelet aggregation, secretory granule lumen, and G-protein-coupled purinergic nucleotide r …
In this study, we analyzed the gene expression profiles of 20 HCC patients, 12 individuals with chronic hepatitis, and 15 healthy con …
Hepatitis E Virus Infection in Voluntary Blood Donors in the Russian Federation.
Potemkin IA, Kyuregyan KK, Karlsen AA, Isaeva OV, Kichatova VS, Lopatukhina MA, Asadi Mobarkhan FA, Zlobina AG, Zheltobriukh AV, Bocharova KA, Belyakova VV, Rassolova SV, Ivanova NV, Solonin SA, Bazhenov AI, Godkov MA, Mikhailov MI. Potemkin IA, et al. Viruses. 2024 Mar 28;16(4):526. doi: 10.3390/v16040526. Viruses. 2024. PMID: 38675869 Free PMC article.
Transfusion-transmitted hepatitis E virus (HEV) infection is an increasing concern in many countries. ...
Transfusion-transmitted hepatitis E virus (HEV) infection is an increasing concern in many countries. ...
Conserved Functions of Orthohepadnavirus X Proteins to Inhibit Type-I Interferon Signaling.
Choonnasard A, Shofa M, Okabayashi T, Saito A. Choonnasard A, et al. Int J Mol Sci. 2024 Mar 28;25(7):3753. doi: 10.3390/ijms25073753. Int J Mol Sci. 2024. PMID: 38612565 Free PMC article.
Orthohepadnavirus causes chronic hepatitis in a broad range of mammals, including primates, cats, woodchucks, and bats. Hepatitis B virus (HBV) X protein inhibits type-I interferon (IFN) signaling, thereby promoting HBV escape from the human innate immune system and …
Orthohepadnavirus causes chronic hepatitis in a broad range of mammals, including primates, cats, woodchucks, and bats. Hepatitis
The Three-Dimensional Reference Interaction Site Model Approach as a Promising Tool for Studying Hydrated Viruses and Their Complexes with Ligands.
Fedotova MV, Chuev GN. Fedotova MV, et al. Int J Mol Sci. 2024 Mar 26;25(7):3697. doi: 10.3390/ijms25073697. Int J Mol Sci. 2024. PMID: 38612508 Free PMC article. Review.
We discuss various biophysical aspects of the 3D-RISM results and demonstrate capabilities, limitations, achievements, and prospects of the method using examples of viruses such as influenza, hepatitis, and SARS-CoV-2 viruses....
We discuss various biophysical aspects of the 3D-RISM results and demonstrate capabilities, limitations, achievements, and prospects of the …
Staff-Facilitated Telemedicine Care Delivery for Treatment of Hepatitis C Infection among People Who Inject Drugs.
Kim RG, McDonell C, McKinney J, Catalli L, Price JC, Morris MD. Kim RG, et al. Healthcare (Basel). 2024 Mar 25;12(7):715. doi: 10.3390/healthcare12070715. Healthcare (Basel). 2024. PMID: 38610138 Free PMC article.
METHODS: The No One Waits (NOW) Study is a single-arm clinical trial measuring the acceptability, feasibility, and safety of an urban point-of-diagnosis hepatitis C (HCV) treatment initiation model delivered in a non-clinical community setting. ...
METHODS: The No One Waits (NOW) Study is a single-arm clinical trial measuring the acceptability, feasibility, and safety of an urban point- …
PIM1 inhibitor SMI-4a attenuated concanavalin A-induced acute hepatitis through suppressing inflammatory responses.
Wu X, Chen Y, Jiang M, Guo L. Wu X, et al. Transl Gastroenterol Hepatol. 2024 Mar 22;9:14. doi: 10.21037/tgh-23-93. eCollection 2024. Transl Gastroenterol Hepatol. 2024. PMID: 38716217 Free PMC article.
This study aims to investigate the effects of PIM1 kinase inhibitor and its protective mechanism in ConA-induced acute hepatitis. METHODS: C57/BL six mice were injected with ConA (20, 15, and 12 mg/kg) to induce acute hepatitis, and PIM1 kinase inhibitor SMI-4a (60 …
This study aims to investigate the effects of PIM1 kinase inhibitor and its protective mechanism in ConA-induced acute hepatitis. MET …
G-quadruplexes control hepatitis B virus replication by promoting cccDNA transcription and phase separation in hepatocytes.
Giraud G, Rodà M, Huchon P, Michelet M, Maadadi S, Jutzi D, Montserret R, Ruepp MD, Parent R, Combet C, Zoulim F, Testoni B. Giraud G, et al. Nucleic Acids Res. 2024 Mar 21;52(5):2290-2305. doi: 10.1093/nar/gkad1200. Nucleic Acids Res. 2024. PMID: 38113270 Free PMC article.
Hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) is an episomal minichromosome whose persistence is at the basis of chronic infection. Identifying the mechanisms controlling its transcriptional activity is indispensable to develop new therapeutic strategies
Hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) is an episomal minichromosome whose persistence is at the basis of ch
Haemophilia and Cancer: A Literature Review.
Zanon E, Porreca A, Simioni P. Zanon E, et al. J Clin Med. 2024 Mar 19;13(6):1770. doi: 10.3390/jcm13061770. J Clin Med. 2024. PMID: 38541994 Free PMC article. Review.
In the past decade, the literature mainly focused on the epidemiology and outcome of blood-borne cancers in the haemophilia patient group, as the incidence of hepatitis B virus (HBV), hepatitis C (HCV), and HIV infection were high among them. ...
In the past decade, the literature mainly focused on the epidemiology and outcome of blood-borne cancers in the haemophilia patient group, a …
Immune Thrombocytopenic Purpura Associated With Systemic Lupus Erythematosus, Helicobacter pylori, and Hepatitis B.
Johnson BO, Nimawat A, Doar NW, Nguyen T, Thwin M. Johnson BO, et al. Cureus. 2024 Mar 18;16(3):e56411. doi: 10.7759/cureus.56411. eCollection 2024 Mar. Cureus. 2024. PMID: 38638794 Free PMC article.
It can be either idiopathic (primary), with no discernible etiologic cause, or secondary to various conditions such as autoimmune diseases (e.g., systemic lupus erythematosus), viral infections (e.g., human immunodeficiency virus (HIV), hepatitis C virus (HCV …
It can be either idiopathic (primary), with no discernible etiologic cause, or secondary to various conditions such as autoimmune diseases ( …
Multifaceted Characterization for the Hepatic Clearance of Graphene Oxide and Size-Related Hepatic Toxicity.
Su Z, Chen W, Liang S, Fang H, Zhang M, Wang M, Zheng L, Wang B, Bi Y, Feng W. Su Z, et al. Molecules. 2024 Mar 17;29(6):1335. doi: 10.3390/molecules29061335. Molecules. 2024. PMID: 38542971 Free PMC article.
In combination with ICP-MS, LA-ICP-MS, and synchrotron radiation FTIR techniques, we found that more s-GO sheets in the liver were prone to be cleared via hepatobiliary excretion than l-GO sheets. A Raman imaging analysis of I(D)/I(G) ratios further indicated that both s-G …
In combination with ICP-MS, LA-ICP-MS, and synchrotron radiation FTIR techniques, we found that more s-GO sheets in the liver were prone to …
Kidney Histopathology of Patients with Hepatitis C Infection and Diabetes Mellitus before and after Availability of Direct-Acting Antiviral Therapy.
Kung VL, Giannini G, Nast CC. Kung VL, et al. Glomerular Dis. 2024 Mar 15;4(1):74-83. doi: 10.1159/000537977. eCollection 2024 Jan-Dec. Glomerular Dis. 2024. PMID: 38623264 Free PMC article.
INTRODUCTION: Type 2 diabetes mellitus (DM) and diabetic kidney disease are increasing. Hepatitis C infection (HCV) occurs in 1% of the world population and can induce several kidney diseases. ...METHODS: Case review identifying patients with kidney biopsy and clinical his …
INTRODUCTION: Type 2 diabetes mellitus (DM) and diabetic kidney disease are increasing. Hepatitis C infection (HCV) occurs in 1% of t …
Sexually transmitted coinfections among at-risk HIV-positive MSM: implications for optimal preemptive treatment.
Wu TY, Lin KY, Su LH, Sun HY, Huang YS, Liu WD, Liu WC, Chang LH, Chang SY, Hung CC. Wu TY, et al. Front Med (Lausanne). 2024 Mar 15;11:1328589. doi: 10.3389/fmed.2024.1328589. eCollection 2024. Front Med (Lausanne). 2024. PMID: 38560383 Free PMC article.
METHODS: From September 2021 to September 2023, HIV-positive MSM underwent STI testing when they had symptoms suggestive of STIs or recently acquired hepatitis C virus (HCV) infection or early syphilis. The oral rinse, rectal swab, and urethral swab specimens were tested f …
METHODS: From September 2021 to September 2023, HIV-positive MSM underwent STI testing when they had symptoms suggestive of STIs or recently …
The molecular epidemiology of hepatitis E virus genotype 3 in Canada.
Borlang J, Murphy D, Harlow J, Osiowy C, Nasheri N. Borlang J, et al. Epidemiol Infect. 2024 Mar 15;152:e55. doi: 10.1017/S0950268824000475. Epidemiol Infect. 2024. PMID: 38487841 Free PMC article.
Autochthonous hepatitis E virus (HEV) infection is increasingly reported in industrialized countries and is mostly associated with zoonotic HEV genotype 3 (HEV-3). ...
Autochthonous hepatitis E virus (HEV) infection is increasingly reported in industrialized countries and is mostly associated with zo …
Germline HAVCR2/TIM-3 Checkpoint Inhibitor Receptor Deficiency in Recurrent Autoinflammatory Myocarditis.
Pernaa N, Vakkuri A, Arvonen M, Kuismin O, Santaniemi W, Glumoff V, Lappi-Blanco E, Lantto U, Okkonen M, Kaikkonen K, Junttila J, Kerkelä R, Åström P, Hautala T. Pernaa N, et al. J Clin Immunol. 2024 Mar 15;44(3):81. doi: 10.1007/s10875-024-01685-x. J Clin Immunol. 2024. PMID: 38485795 Free PMC article.
Electrocardiography, troponin I/T, echocardiography, myocardial magnetic resonance imaging and histological findings were consistent with recurrent myocarditis episodes. Homozygous c.245 A > G p.Tyr82Cys pathogenic variant in Hepatitis A Virus Cellular Rec …
Electrocardiography, troponin I/T, echocardiography, myocardial magnetic resonance imaging and histological findings were consistent with re …
Transcriptomic signatures of progressive and regressive liver fibrosis and portal hypertension.
Petrenko O, Königshofer P, Brusilovskaya K, Hofer BS, Bareiner K, Simbrunner B, Jühling F, Baumert TF, Lupberger J, Trauner M, Kauschke SG, Pfisterer L, Simon E, Rendeiro AF, de Rooij LPMH, Schwabl P, Reiberger T. Petrenko O, et al. iScience. 2024 Feb 20;27(3):109301. doi: 10.1016/j.isci.2024.109301. eCollection 2024 Mar 15. iScience. 2024. PMID: 38469563 Free PMC article.
We linked the dynamics of key disease readouts, such as portal pressure, collagen area, and transaminase levels, to differentially expressed genes, enabling the identification of transcriptomic signatures of progressive vs. regressive liver fibrosis and portal hypertension. These …
We linked the dynamics of key disease readouts, such as portal pressure, collagen area, and transaminase levels, to differentially expressed …
Cytosine base editing inhibits hepatitis B virus replication and reduces HBsAg expression in vitro and in vivo.
Smekalova EM, Martinez MG, Combe E, Kumar A, Dejene S, Leboeuf D, Chen CY, Dorkin JR, Shuang LS, Kieft S, Young L, Barrera LA, Packer MS, Ciaramella G, Testoni B, Gregoire F, Zoulim F. Smekalova EM, et al. Mol Ther Nucleic Acids. 2023 Dec 27;35(1):102112. doi: 10.1016/j.omtn.2023.102112. eCollection 2024 Mar 12. Mol Ther Nucleic Acids. 2023. PMID: 38292874 Free PMC article.
Chronic hepatitis B virus (HBV) infection remains a global health problem due to the lack of treatments that prevent viral rebound from HBV covalently closed circular (ccc)DNA. In addition, HBV DNA integrates in the human genome, serving as a source of hepatitis B s …
Chronic hepatitis B virus (HBV) infection remains a global health problem due to the lack of treatments that prevent viral rebound fr …
Validation of Baveno VII criteria and other non-invasive diagnostic algorithms for clinically significant portal hypertension in hepatitis delta.
Jachs M, Sandmann L, Hartl L, Tergast T, Schwarz M, Bauer DJM, Balcar L, Ehrenbauer A, Hofer BS, Cornberg M, Lenzen H, Deterding K, Trauner M, Mandorfer M, Wedemeyer H, Reiberger T, Maasoumy B. Jachs M, et al. J Hepatol. 2024 Mar 11:S0168-8278(24)00156-9. doi: 10.1016/j.jhep.2024.03.005. Online ahead of print. J Hepatol. 2024. PMID: 38479612 Free article.
BACKGROUND & AIMS: Non-invasive tests (NITs) for clinically significant portal hypertension (CSPH) require validation in patients with hepatitis D virus (HDV)-related compensated advanced chronic liver disease (cACLD). ...Patients with CSPH had significantly higher LSM …
BACKGROUND & AIMS: Non-invasive tests (NITs) for clinically significant portal hypertension (CSPH) require validation in patients with …
Impact of ITPA gene polymorphism for predicting anemia and treatment outcome in HCV infected patients taking Sofosbuvir Ribavirin therapy.
Amjed S, Saleem HGM, Ullah S, Latif S, Shabana, Jafar J, Waqar AB. Amjed S, et al. BMC Infect Dis. 2024 Mar 11;24(1):301. doi: 10.1186/s12879-024-09188-1. BMC Infect Dis. 2024. PMID: 38468199 Free PMC article.
ITPA rs1127354-CA genotype was significantly (P 0.05) protective against 2 g/dl Hb reduction from baseline to 1st, 2nd and 6th months of therapy. During treatment, Hb reduction 10 g/dl was frequently observed in rs1127354-CC genotype and rs7270101-AA genotype patien …
ITPA rs1127354-CA genotype was significantly (P 0.05) protective against 2 g/dl Hb reduction from baseline to 1st, 2nd and 6th months …
Efficient Estimates of Surface Diffusion Parameters for Spatio-Temporally Resolved Virus Replication Dynamics.
Knodel MM, Wittum G, Vollmer J. Knodel MM, et al. Int J Mol Sci. 2024 Mar 5;25(5):2993. doi: 10.3390/ijms25052993. Int J Mol Sci. 2024. PMID: 38474240 Free PMC article.
For instance, an essential component of the replication of the hepatitis C virus (HCV) proceeds under the influence of nonstructural HCV proteins (NSPs) that are anchored to the endoplasmatic reticulum (ER), such as the NS5A protein. ...
For instance, an essential component of the replication of the hepatitis C virus (HCV) proceeds under the influence of nonstructural …
GRAND PLAN: Safety and Efficacy of Glecaprevir/Pibrentasvir for the Treatment of Hepatitis C Virus Infection Among People Initially Disengaged From Health Care Who Use Drugs-A Systematic Multidisciplinary Approach.
Conway B, Yi S, Yung R, Sharma S. Conway B, et al. Open Forum Infect Dis. 2024 Mar 5;11(3):ofad638. doi: 10.1093/ofid/ofad638. eCollection 2024 Mar. Open Forum Infect Dis. 2024. PMID: 38444819 Free PMC article.
Based at a single center and with a single arm, GRAND PLAN evaluated the safety and efficacy of an 8-week course of glecaprevir/pibrentasvir (G/P) among active drug users with hepatitis C virus (HCV) infection in a population enriched for factors that may reduce tre …
Based at a single center and with a single arm, GRAND PLAN evaluated the safety and efficacy of an 8-week course of glecaprevir/pibrentasvir …
Thrombospondin 1 enhances systemic inflammation and disease severity in acute-on-chronic liver failure.
Hassan HM, Liang X, Xin J, Lu Y, Cai Q, Shi D, Ren K, Li J, Chen Q, Li J, Li P, Guo B, Yang H, Luo J, Yao H, Zhou X, Hu W, Jiang J, Li J. Hassan HM, et al. BMC Med. 2024 Mar 5;22(1):95. doi: 10.1186/s12916-024-03318-x. BMC Med. 2024. PMID: 38439091 Free PMC article.
METHODS: Biobanked peripheral blood mononuclear cells (PBMCs) from 330 subjects with hepatitis B virus (HBV)-related etiologies, including HBV-ACLF, liver cirrhosis (LC), and chronic hepatitis B (CHB), and normal controls (NC) randomly selected from the Chinese Grou …
METHODS: Biobanked peripheral blood mononuclear cells (PBMCs) from 330 subjects with hepatitis B virus (HBV)-related etiologies, incl …
Toward a SARS-CoV-2 VLP Vaccine: HBc/G as a Carrier for SARS-CoV-2 Spike RBM and Nucleocapsid Protein-Derived Peptides.
Petrovskis I, Skrastina D, Jansons J, Dislers A, Bogans J, Spunde K, Neprjakhina A, Zakova J, Zajakina A, Sominskaya I. Petrovskis I, et al. Vaccines (Basel). 2024 Mar 4;12(3):267. doi: 10.3390/vaccines12030267. Vaccines (Basel). 2024. PMID: 38543900 Free PMC article.
Here, we used HBc of the HBV genotype G (HBc/G) as a technologically promising VLP carrier for the presentation of spike RBM and nucleocapsid protein-derived peptides of the SARS-CoV-2 Delta variant for subsequent immunological evaluations of obtained fusion protein …
Here, we used HBc of the HBV genotype G (HBc/G) as a technologically promising VLP carrier for the presentation of spike RBM a …
Comparable safety and non-inferior immunogenicity of the SARS-CoV-2 mRNA vaccine candidate PTX-COVID19-B and BNT162b2 in a phase 2 randomized, observer-blinded study.
Reiter L, Greffrath J, Zidel B, Ostrowski M, Gommerman J, Madhi SA, Tran R, Martin-Orozco N, Panicker RKG, Cooper C, Pastrak A. Reiter L, et al. Sci Rep. 2024 Mar 4;14(1):5365. doi: 10.1038/s41598-024-55320-1. Sci Rep. 2024. PMID: 38438427 Free PMC article. Clinical Trial.
This observer-blind, double-dummy, randomized immunobridging phase 2 study (NCT05175742) aimed to compare the immunogenicity induced by two doses of 40 mug PTX-COVID19-B vaccine candidate administered 28 days apart, with the response induced by two doses of 30 g Pfizer-Bio …
This observer-blind, double-dummy, randomized immunobridging phase 2 study (NCT05175742) aimed to compare the immunogenicity induced by two …
Exploring strategies to optimise outcomes in hepatitis-associated aplastic anaemia patients following haematopoietic stem cell transplantation.
Li J, Liu Y, Wang J, Wang Y, Pang A, Yang D, Chen X, Zhang R, Wei J, Ma Q, Zhai W, He Y, Jiang E, Han M, Feng S. Li J, et al. Sci Rep. 2024 Mar 2;14(1):5178. doi: 10.1038/s41598-024-55843-7. Sci Rep. 2024. PMID: 38431738 Free PMC article.
This study aimed to assess haematopoietic stem cell transplantation (HSCT) safety and efficacy while exploring strategies for optimising outcomes in patients with hepatitis-associated aplastic anaemia (HAAA). We retrospectively reviewed 35 HAAA patients who underwent HSCT …
This study aimed to assess haematopoietic stem cell transplantation (HSCT) safety and efficacy while exploring strategies for optimising out …
Heat stability of foodborne viruses - Findings, methodological challenges and current developments.
Johne R, Scholz J, Falkenhagen A. Johne R, et al. Int J Food Microbiol. 2024 Mar 2;413:110582. doi: 10.1016/j.ijfoodmicro.2024.110582. Epub 2024 Jan 25. Int J Food Microbiol. 2024. PMID: 38290272 Free article. Review.
Here, the published literature on heat stability and inactivation of human norovirus (NoV), hepatitis A virus (HAV) and hepatitis E virus (HEV) was reviewed. Data for surrogate viruses were not included. ...In addition, the applied method largely influenced t …
Here, the published literature on heat stability and inactivation of human norovirus (NoV), hepatitis A virus (HAV) and hep
Diagnostic Performance of Epithelial Cell Adhesion Molecule for Early Detection of Hepatocellular Carcinoma Among HCV High-Risk Patients.
Nasser R, Al Haddad M, El-Kassas MM, Metwally FM, El-Mezayen HA, El-Sharkawy A. Nasser R, et al. Asian Pac J Cancer Prev. 2024 Mar 1;25(3):1045-1052. doi: 10.31557/APJCP.2024.25.3.1045. Asian Pac J Cancer Prev. 2024. PMID: 38546087 Free PMC article.
RESULTS: A novel score named EpCAM-HCC = AFP (U/L) 0.11 - Albumin (g/dl) 1.5 + EpCAM % 2.9 - Platelets count (10(9))/L 0.75 - 93. ...
RESULTS: A novel score named EpCAM-HCC = AFP (U/L) 0.11 - Albumin (g/dl) 1.5 + EpCAM % 2.9 - Platelets count (10(9))/L 0.75 - 93. ...
The Development of a Novel Fiber-2 Subunit Vaccine against Fowl Adenovirus Serotype 4 Formulated with Oil Adjuvants.
Liu W, Liu M, Wang S, Tang Z, Liu J, Song S, Yan L. Liu W, et al. Vaccines (Basel). 2024 Mar 1;12(3):263. doi: 10.3390/vaccines12030263. Vaccines (Basel). 2024. PMID: 38543897 Free PMC article.
Hepatitis-hydropericardium syndrome (HHS), caused by fowl adenovirus serotype 4 (FAdV-4), has been widely spread across China, resulting in great financial losses in the poultry industry. ...Then, the efficacy of the two recombinant proteins formulated with cheap and widel
Hepatitis-hydropericardium syndrome (HHS), caused by fowl adenovirus serotype 4 (FAdV-4), has been widely spread across China, result
Clinical and Epidemiological Characteristics of the 2022 Mpox Outbreak in Spain (CEME-22 Study).
Ramírez-Olivencia G, Velasco Arribas M, Vera García MM, Casabona J, Martínez MJ, Membrillo De Novales FJ; CEME-22 Study Group. Ramírez-Olivencia G, et al. Open Forum Infect Dis. 2024 Feb 26;11(3):ofae105. doi: 10.1093/ofid/ofae105. eCollection 2024 Mar. Open Forum Infect Dis. 2024. PMID: 38524223 Free PMC article.
Simultaneously diagnosed sexually transmitted infections included syphilis (n = 129), gonococcal infection (n = 91), HIV (n = 67), chlamydia (n = 56), hepatitis B (n = 14), and hepatitis C (n = 11). No therapy was used in 479 patients (33%). ...
Simultaneously diagnosed sexually transmitted infections included syphilis (n = 129), gonococcal infection (n = 91), HIV (n = 67), chlamydia …
Reasons for disengagement from antiretroviral care in the era of "Treat All" in low- or middle-income countries: a systematic review.
Burke RM, Rickman HM, Pinto C, Ehrenkranz P, Choko A, Ford N. Burke RM, et al. J Int AIDS Soc. 2024 Mar;27(3):e26230. doi: 10.1002/jia2.26230. J Int AIDS Soc. 2024. PMID: 38494657 Free PMC article.
Conceptually, studies described underlying vulnerability factors (individual, interpersonal, structural and healthcare) but that often unexpected proximal events (e.g. unanticipated mobility) acted as the trigger for disengagement to occur. ...
Conceptually, studies described underlying vulnerability factors (individual, interpersonal, structural and healthcare) but that often unexp …
Safety and Immune Responses Following Anti-PD-1 Monoclonal Antibody Infusions in Healthy Persons With Human Immunodeficiency Virus on Antiretroviral Therapy.
Gay CL, Bosch RJ, McKhann A, Cha R, Morse GD, Wimbish CL, Campbell DM, Moseley KF, Hendrickx S, Messer M, Benson CA, Overton ET, Paccaly A, Jankovic V, Miller E, Tressler R, Li JZ, Kuritzkes DR, Macatangay BJC, Eron JJ, Hardy WD; A5370 Team. Gay CL, et al. Open Forum Infect Dis. 2024 Jan 11;11(3):ofad694. doi: 10.1093/ofid/ofad694. eCollection 2024 Mar. Open Forum Infect Dis. 2024. PMID: 38449916 Free PMC article. Clinical Trial.
One participant had a probable irAE (thyroiditis, grade 2); another had a possible irAE (hepatitis, grade 3), both after a single low-dose (0.3 mg/kg) infusion. ...
One participant had a probable irAE (thyroiditis, grade 2); another had a possible irAE (hepatitis, grade 3), both after a single low …
Genotypic analysis of hepatitis E virus (HEV) from sporadic symptomatic cases in Pakistan.
Ejaz M, Zohaib A, Usman M, Anwar MM, Khan HS, Ammar M, Saqib M, Khan SG, Athar MA, Mansoor MK, Ullah A, Naseem M, Hussain MH, Javed A. Ejaz M, et al. Infect Genet Evol. 2024 Mar;118:105567. doi: 10.1016/j.meegid.2024.105567. Epub 2024 Feb 9. Infect Genet Evol. 2024. PMID: 38342162 Free article.
These drastic population shifts make it vulnerable to the efficient spread of the Hepatitis E virus (HEV). The current study analyzed the genotypic characteristics and variants of the Hepatitis E virus circulating in the population of Pakistan. ...Sequencing and phy …
These drastic population shifts make it vulnerable to the efficient spread of the Hepatitis E virus (HEV). The current study analyzed …
Patient and healthcare provider perceptions of acceptability of fingerstick point-of-care hepatitis C testing at Aboriginal Community Controlled Health Services in Australia.
Lafferty L, Beadman M, Ward J, Flynn E, Hosseini-Hooshyar S, Martinello M, Treloar C. Lafferty L, et al. Int J Drug Policy. 2024 Mar;125:104335. doi: 10.1016/j.drugpo.2024.104335. Epub 2024 Feb 10. Int J Drug Policy. 2024. PMID: 38342050 Free article.
BACKGROUND: Hepatitis C (HCV) is highly prevalent in First Nations communities globally. ...HCV test-and-treat models of care delivered by ACCHS simplify the HCV care pathway and ensure all HCV care is provided in a culturally safe setting (e.g., patients did not ne …
BACKGROUND: Hepatitis C (HCV) is highly prevalent in First Nations communities globally. ...HCV test-and-treat models of care deliver …
Prevalence of transfusion-transmitted infections in hospitalized patients before transfusion and volunteer blood donors in Zhejiang Province, China.
Mengjiao L, Yushan X, Yan L, Dawei C, Xiaojun Z, Yongjun W, Cuifen S, Jue X. Mengjiao L, et al. Infect Dis Now. 2024 Mar;54(2):104861. doi: 10.1016/j.idnow.2024.104861. Epub 2024 Feb 3. Infect Dis Now. 2024. PMID: 38316362 Free article.
METHODS: We collected 2760 serum samples from three regions of Hangzhou, Ningbo and Huzhou from April 2021 to March 2022, and they tested by enzyme-linked immunosorbent assay (ELISA) for Hepatitis B surface antigen (HBsAg), Hepatitis C (HCV), Treponema pallidum (TP) …
METHODS: We collected 2760 serum samples from three regions of Hangzhou, Ningbo and Huzhou from April 2021 to March 2022, and they tested by …
Whole-transcriptome sequencing revealed the role of noncoding RNAs in susceptibility and resistance of Pekin ducks to DHAV-3.
Ding D, Zhao H, Liu Y, Li S, Wei J, Yang Y, Wang S, Xing G, Hou S, Wang X, Zhang Y. Ding D, et al. Poult Sci. 2024 Mar;103(3):103416. doi: 10.1016/j.psj.2023.103416. Epub 2023 Dec 30. Poult Sci. 2024. PMID: 38301494 Free PMC article.
As the most prevalent pathogen of duck viral hepatitis (DVH), duck hepatitis A virus genotype 3 (DHAV-3) has caused huge economic losses to the duck industry in China. ...With the construction of lncRNA-miRNA-mRNA axis, we further identified a few aberrantly …
As the most prevalent pathogen of duck viral hepatitis (DVH), duck hepatitis A virus genotype 3 (DHAV-3) has caused hug …
Genome-wide loss-of-function genetic screen identifies INSIG2 as the vulnerability of hepatitis B virus-integrated hepatoma cells.
Fukuoka M, Kodama T, Murai K, Hikita H, Sometani E, Sung J, Shimoda A, Shigeno S, Motooka D, Nishio A, Furuta K, Tatsumi T, Yusa K, Takehara T. Fukuoka M, et al. Cancer Sci. 2024 Mar;115(3):859-870. doi: 10.1111/cas.16070. Epub 2024 Jan 29. Cancer Sci. 2024. PMID: 38287498 Free PMC article.
There are approximately 250 million people chronically infected with hepatitis B virus (HBV) worldwide. Although HBV is often integrated into the host genome and promotes hepatocarcinogenesis, vulnerability of HBV integration in liver cancer cells has not been clarified. . …
There are approximately 250 million people chronically infected with hepatitis B virus (HBV) worldwide. Although HBV is often integra …
Efficacy and safety of antiviral plus anti-spike monoclonal antibody combination therapy vs. monotherapy for high-risk immunocompromised patients with mild-to-moderate SARS-CoV2 infection during the Omicron era: A prospective cohort study.
Calderón-Parra J, Gutiérrez-Villanueva A, Ronda-Roca G, Jimenez MLM, de la Torre H, Ródenas-Baquero M, Paniura-Pinedo M, Lozano-Llano C, Pintos-Pascual I, Fernández-Cruz A, Ramos-Martínez A, Muñez-Rubio E. Calderón-Parra J, et al. Int J Antimicrob Agents. 2024 Mar;63(3):107095. doi: 10.1016/j.ijantimicag.2024.107095. Epub 2024 Jan 18. Int J Antimicrob Agents. 2024. PMID: 38244814 Free article.
Primary outcome occurred more frequently after monotherapy (4.6% vs. 0%, P=0.154). Among patients with anti-spike immunoglobulin G (anti-S IgG) titre <750 BAU/mL, COVID-19 progression was more common after monotherapy (23.9% vs. 0%, P=0.001), including more frequent COV …
Primary outcome occurred more frequently after monotherapy (4.6% vs. 0%, P=0.154). Among patients with anti-spike immunoglobulin G (a …
The dynamic variation position and predominant quasispecies of hepatitis B virus: Novel predictors of early hepatocarcinoma.
Zhang C, An S, Lv R, Li K, Liu H, Li J, Tang Y, Cai Z, Huang T, Long L, Deng W. Zhang C, et al. Virus Res. 2024 Mar;341:199317. doi: 10.1016/j.virusres.2024.199317. Epub 2024 Jan 19. Virus Res. 2024. PMID: 38242020 Free PMC article.
The HBV predominant quasispecies and their consensus sequences were identified by genetic evolution analysis, in which the high HBS and HBC quasispecies heterogeneity were found associated with the forming of multifarious quasispecies clones, and the HBX gene had the highest prop …
The HBV predominant quasispecies and their consensus sequences were identified by genetic evolution analysis, in which the high HBS and HBC …
Dynamic Elevation of Aromatic Amino Acids in Hepatitis C Virus-Induced Cirrhosis After a Standard Meal.
Hill KL, Haddad JA, Ali RO, Zhang GY, Quinn GM, Townsend E, Everson GT, Helmke SM, Bagheri M, Schoenfeld M, Yang S, Koh C, Levy EB, Kleiner DE, Sacks DB, Etzion O, Heller T. Hill KL, et al. Clin Transl Gastroenterol. 2024 Mar 1;15(3):e00666. doi: 10.14309/ctg.0000000000000666. Clin Transl Gastroenterol. 2024. PMID: 38088382 Free PMC article.
The aim of this study was to evaluate the dynamic, postprandial relationship between hepatitis C virus-induced liver disease and amino acid concentrations in patients with compensated liver disease. METHODS: Patients infected with hepatitis C virus underwent a basel …
The aim of this study was to evaluate the dynamic, postprandial relationship between hepatitis C virus-induced liver disease and amin …
Impact of customized electronic duplicate order alerts on microbiology test ordering: Financial and environmental cost savings.
Graham M, Gugasyan R, Dharmaraj D, Yap G, Webb B, Dhulia A, Kumar B. Graham M, et al. Infect Control Hosp Epidemiol. 2024 Mar;45(3):343-350. doi: 10.1017/ice.2023.198. Epub 2023 Oct 27. Infect Control Hosp Epidemiol. 2024. PMID: 37887261 Free PMC article.
For fecal polymerase chain reaction (PCR), our second most common test, there was a 54% reduction in test ordering. For our most commonly ordered expensive test, hepatitis C PCR, there was a 42% reduction in test ordering: 25 tests were cancelled.Cancelled tests resulted i …
For fecal polymerase chain reaction (PCR), our second most common test, there was a 54% reduction in test ordering. For our most commonly or …
Hepatitis C Virus Elimination Programs in Louisiana and Washington: Importance of Screening and Surveillance Systems.
Talal AH, Dharia A, Kapadia SN, Tyson GL, Birch S, Zerzan-Thul J, Sullivan D, Britton E, Wethington E, Gonzalez CJ, Fliss M, Mizroch B, McCall F, Lloyd AR, Shapiro MF, Franco R. Talal AH, et al. J Public Health Manag Pract. 2024 Mar-Apr 01;30(2):208-212. doi: 10.1097/PHH.0000000000001808. Epub 2023 Aug 18. J Public Health Manag Pract. 2024. PMID: 37594263 Free PMC article.
The US government has established a national goal of hepatitis C virus (HCV) elimination by 2030. To date, most HCV elimination planning and activity have been at the state level. ...
The US government has established a national goal of hepatitis C virus (HCV) elimination by 2030. To date, most HCV elimination plann …
Long-Term Treatment With Tenofovir Alafenamide for Chronic Hepatitis B Results in High Rates of Viral Suppression and Favorable Renal and Bone Safety.
Chan HLY, Buti M, Lim YS, Agarwal K, Marcellin P, Brunetto M, Chuang WL, Janssen HLA, Fung S, Izumi N, Abdurakhmanov D, Jabłkowski M, Celen MK, Ma X, Caruntu F, Flaherty JF, Abramov F, Wang H, Camus G, Osinusi A, Pan CQ, Shalimar, Seto WK, Gane E; GS-US-320-0110 and GS-US-320-0108 investigators. Chan HLY, et al. Am J Gastroenterol. 2024 Mar 1;119(3):486-496. doi: 10.14309/ajg.0000000000002468. Epub 2023 Aug 9. Am J Gastroenterol. 2024. PMID: 37561058 Free PMC article. Clinical Trial.
INTRODUCTION: The results from 2 phase 3 studies, through 2 years, in chronic hepatitis B infection showed tenofovir alafenamide (TAF) had similar efficacy to tenofovir disoproxil fumarate (TDF) with superior renal and bone safety. ...METHODS: Patients with HBeAg-negative …
INTRODUCTION: The results from 2 phase 3 studies, through 2 years, in chronic hepatitis B infection showed tenofovir alafenamide (TAF …
Hepatitis C prevalence and cascade of care among patients in the decentralised opioid agonist therapy programme of the canton of St Gallen, Switzerland: a cross-sectional study.
Wissel K, Vernazza P, Kuster S, Hensel-Koch K, Bregenzer A. Wissel K, et al. Swiss Med Wkly. 2024 Feb 29;154:3352. doi: 10.57187/s.3352. Swiss Med Wkly. 2024. PMID: 38579293 Free article.
BACKGROUND: To eliminate chronic hepatitis C virus (HCV) infection by 2030, 90% of those infected must be diagnosed and 80% treated. ...HCV screening in the decentralised setting needs improvement, e.g. by increasing awareness and simplifying testing. High HCV treat …
BACKGROUND: To eliminate chronic hepatitis C virus (HCV) infection by 2030, 90% of those infected must be diagnosed and 80% treated. …
Interim Estimates of 2023-24 Seasonal Influenza Vaccine Effectiveness - United States.
Frutos AM, Price AM, Harker E, Reeves EL, Ahmad HM, Murugan V, Martin ET, House S, Saade EA, Zimmerman RK, Gaglani M, Wernli KJ, Walter EB, Michaels MG, Staat MA, Weinberg GA, Selvarangan R, Boom JA, Klein EJ, Halasa NB, Ginde AA, Gibbs KW, Zhu Y, Self WH, Tartof SY, Klein NP, Dascomb K, DeSilva MB, Weber ZA, Yang DH, Ball SW, Surie D, DeCuir J, Dawood FS, Moline HL, Toepfer AP, Clopper BR, Link-Gelles R, Payne AB, Chung JR, Flannery B, Lewis NM, Olson SM, Adams K, Tenforde MW, Garg S, Grohskopf LA, Reed C, Ellington S; CDC Influenza Vaccine Effectiveness Collaborators. Frutos AM, et al. MMWR Morb Mortal Wkly Rep. 2024 Feb 29;73(8):168-174. doi: 10.15585/mmwr.mm7308a3. MMWR Morb Mortal Wkly Rep. 2024. PMID: 38421935 Free PMC article.
Exploring the Antimicrobial, Antioxidant, and Antiviral Potential of Eco-Friendly Synthesized Silver Nanoparticles Using Leaf Aqueous Extract of Portulaca oleracea L.
Abdel-Rahman MA, Alshallash KS, Eid AM, Hassan SE, Salih M, Hamza MF, Fouda A. Abdel-Rahman MA, et al. Pharmaceuticals (Basel). 2024 Feb 28;17(3):317. doi: 10.3390/ph17030317. Pharmaceuticals (Basel). 2024. PMID: 38543103 Free PMC article.
The synthesized Ag-NPs exhibited promising antimicrobial efficacy toward various prokaryotic and eukaryotic pathogenic microorganisms with low MIC values of 12.5 g mL(-1) and 6.25 g mL(-1), respectively. Additionally, the P. oleracea-formed Ag-NPs showed optimistic …
The synthesized Ag-NPs exhibited promising antimicrobial efficacy toward various prokaryotic and eukaryotic pathogenic microorganisms with l …
Isoniazid Toxicity.
Badrinath M, Chen P, John S. Badrinath M, et al. 2024 Feb 28. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. 2024 Feb 28. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 30285383 Free Books & Documents.
Acute toxicity manifests as neurological symptoms, specifically seizures. Consumption of as little as 2 g of INH can predispose a patient to acute toxicity. Patients with certain risk factors and prolonged use can develop chronic toxicity, presenting as hepatotoxicity and …
Acute toxicity manifests as neurological symptoms, specifically seizures. Consumption of as little as 2 g of INH can predispose a pat …
Interleukins in liver disease treatment.
Yang M, Zhang CY. Yang M, et al. World J Hepatol. 2024 Feb 27;16(2):140-145. doi: 10.4254/wjh.v16.i2.140. World J Hepatol. 2024. PMID: 38495285 Free PMC article.
Here, we review the functions of ILs in the pathogenesis and resolution of liver diseases, such as liver inflammation (e.g., IL-35), alcohol-related liver disease (e.g., IL-11), non-alcoholic steatohepatitis (e.g., IL-22), liver fibrosis (e.g., Il-17a) …
Here, we review the functions of ILs in the pathogenesis and resolution of liver diseases, such as liver inflammation (e.g., IL-35), …
Liver imaging and pregnancy: what to expect when your patient is expecting.
Porrello G, Cannella R, Bernuau J, Agman A, Brancatelli G, Dioguardi Burgio M, Vilgrain V. Porrello G, et al. Insights Imaging. 2024 Feb 27;15(1):66. doi: 10.1186/s13244-024-01622-x. Insights Imaging. 2024. PMID: 38411871 Free PMC article. Review.
Three groups of liver diseases may be observed during pregnancy: (1) diseases related to pregnancy: intrahepatic cholestasis of pregnancy, pre-eclampsia, eclampsia, hemolysis, elevated liver enzymes and low platelets (HELLP) syndrome, and acute fatty liver of pregnancy; (2) liver …
Three groups of liver diseases may be observed during pregnancy: (1) diseases related to pregnancy: intrahepatic cholestasis of pregnancy, p …
Hepatitis C virus antibody seropositivity is associated with albuminuria but not peripheral artery disease in patients with type 2 diabetes.
Cheng YC, Lee TY, Li YH, Lu CL, Liu HC, Sheu ML, Lee IT. Cheng YC, et al. Sci Rep. 2024 Feb 26;14(1):4607. doi: 10.1038/s41598-024-55352-7. Sci Rep. 2024. PMID: 38409227 Free PMC article.
Hepatitis C virus (HCV) infection is prevalent in patients with type 2 diabetes mellitus (DM). ...Multivariable regression analyses revealed that albuminuria showed a dose-dependent association with HCV Ab seropositivity (UACR [30-299 mg/g]: odds ratio [OR] = 1.463,
Hepatitis C virus (HCV) infection is prevalent in patients with type 2 diabetes mellitus (DM). ...Multivariable regression analyses r
mRNA Therapeutic Vaccine for Hepatitis B Demonstrates Immunogenicity and Efficacy in the AAV-HBV Mouse Model.
De Pooter D, Pierson W, Pourshahian S, Dockx K, De Clerck B, Najera I, Davis H, Van Gulck E, Boden D. De Pooter D, et al. Vaccines (Basel). 2024 Feb 25;12(3):237. doi: 10.3390/vaccines12030237. Vaccines (Basel). 2024. PMID: 38543871 Free PMC article.
Chronic infection with hepatitis B virus (HBV) develops in millions of patients per year, despite the availability of effective prophylactic vaccines. Patients who resolve acute HBV infection develop HBV-specific polyfunctional T cells accompanied by neutralizing antibodie …
Chronic infection with hepatitis B virus (HBV) develops in millions of patients per year, despite the availability of effective proph …
Construction of viral-based expression vectors for high-level production of human interferon alpha 2b in plants.
Sindarovska Y, Kuchuk M. Sindarovska Y, et al. Appl Microbiol Biotechnol. 2024 Feb 23;108(1):229. doi: 10.1007/s00253-024-13069-7. Appl Microbiol Biotechnol. 2024. PMID: 38393430 Free PMC article.
The average yield of hINF alpha 2b produced in N. benthamiana plants was 0.56 mg/g of fresh leaf weight (FW) or 6% of the total soluble cell proteins (TSP). The maximal level reached up to 1.2 mg/g FW or 9% TSP. We estimated that about 0.67 mg of hINF can be obtaine …
The average yield of hINF alpha 2b produced in N. benthamiana plants was 0.56 mg/g of fresh leaf weight (FW) or 6% of the total solub …
A phase III randomized-controlled study of safety and immunogenicity of DTwP-HepB-IPV-Hib vaccine (HEXASIIL®) in infants.
Sharma H, Parekh S, Pujari P, Shewale S, Desai S, Kawade A, Lalwani S, Ravi MD, Kamath V, Mahopatra J, Kulkarni G, Tayade D, Ramanan PV, Uttam KG, Rawal L, Gawande A, Kumar NR, Tiple N, Vagha J, Thakkar P, Khandgave P, Deshmukh BJ, Agarwal A, Dogar V, Gautam M, Jaganathan KS, Kumar R, Sharma I, Gairola S. Sharma H, et al. NPJ Vaccines. 2024 Feb 22;9(1):41. doi: 10.1038/s41541-024-00828-w. NPJ Vaccines. 2024. PMID: 38383584 Free PMC article.
A fully liquid hexavalent containing Diphtheria (D), Tetanus (T) toxoids, whole cell Pertussis (wP), Hepatitis B (Hep B), type 1, 2, 3 of inactivated poliovirus (IPV) and Haemophilus influenzae type b (Hib) conjugate vaccine (DTwP-HepB-IPV-Hib vaccine, HEXASIIL()) was test …
A fully liquid hexavalent containing Diphtheria (D), Tetanus (T) toxoids, whole cell Pertussis (wP), Hepatitis B (Hep B), type 1, 2, …
Stabilization of G-Quadruplex Structures of the SARS-CoV-2 Genome by TMPyP4, BRACO19, and PhenDC3.
Cervenak M, Molnár OR, Horváth P, Smeller L. Cervenak M, et al. Int J Mol Sci. 2024 Feb 20;25(5):2482. doi: 10.3390/ijms25052482. Int J Mol Sci. 2024. PMID: 38473730 Free PMC article.
The G-quadruplex is one of the non-canonical structures formed by nucleic acids, which can be formed by guanine-rich sequences. ...The addition of the ligands caused an increase in the unfolding temperature, but this effect was smaller compared to that found earlier in the …
The G-quadruplex is one of the non-canonical structures formed by nucleic acids, which can be formed by guanine-rich sequences. ...Th …
Noninvasive Models to Assess Liver Inflammation and Fibrosis in Chronic HBV Infected Patients with Normal or Mildly Elevated Alanine Transaminase Levels: Which One Is Most Suitable?
Ma S, Zhou L, Lin S, Li M, Luo J, Chen L. Ma S, et al. Diagnostics (Basel). 2024 Feb 20;14(5):456. doi: 10.3390/diagnostics14050456. Diagnostics (Basel). 2024. PMID: 38472929 Free PMC article.
The prevalence of substantial inflammation or fibrosis in treatment-naive patients with chronic hepatitis B (CHB) and normal alanine transaminase (ALT) levels is high. ...The other top two models, GAPI and XIE, also outperformed models based on other chronic hepatitis
The prevalence of substantial inflammation or fibrosis in treatment-naive patients with chronic hepatitis B (CHB) and normal alanine …
Identification of HDV-like theta ribozymes involved in tRNA-based recoding of gut bacteriophages.
Kienbeck K, Malfertheiner L, Zelger-Paulus S, Johannsen S, von Mering C, Sigel RKO. Kienbeck K, et al. Nat Commun. 2024 Feb 20;15(1):1559. doi: 10.1038/s41467-024-45653-w. Nat Commun. 2024. PMID: 38378708 Free PMC article.
Bacteriophages, the dominant virome constituents, can utilize suppressor tRNAs to switch to alternative genetic codes (e.g., the UAG stop-codon is reassigned to glutamine) while infecting hosts with the standard bacterial code. However, what triggers this switch and how th …
Bacteriophages, the dominant virome constituents, can utilize suppressor tRNAs to switch to alternative genetic codes (e.g., the UAG …
Self-DNA driven inflammation in COVID-19 and after mRNA-based vaccination: lessons for non-COVID-19 pathologies.
Heil M. Heil M. Front Immunol. 2024 Feb 19;14:1259879. doi: 10.3389/fimmu.2023.1259879. eCollection 2023. Front Immunol. 2024. PMID: 38439942 Free PMC article.
Pathologies reported 'de novo' for patients infected with Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV)-2 to be outcomes of self-DNA-driven inflammation in fact had been linked earlier to self-DNA in different contexts, e.g., the infection with Human Immunodefic …
Pathologies reported 'de novo' for patients infected with Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV)-2 to be outcomes of self- …
Hepatitis E outbreak in the health district of Bocaranga-Koui, Central African Republic, 2018-2019.
de Marguerite Nombot-Yazenguet MP, Doté JW, Koyaweda GW, Zemingui-Bembete PA, Selekon B, Vickos U, Manirakiza A, Nakoune E, Gouandjika-Vasilache I, Komas NPJ. de Marguerite Nombot-Yazenguet MP, et al. BMC Infect Dis. 2024 Feb 19;24(1):215. doi: 10.1186/s12879-024-09116-3. BMC Infect Dis. 2024. PMID: 38374096 Free PMC article.
BACKGROUND: Hepatitis E virus (HEV) is a major public health disease causing large outbreaks and sporadic cases of acute hepatitis. ...
BACKGROUND: Hepatitis E virus (HEV) is a major public health disease causing large outbreaks and sporadic cases of acute hepatitis
The Role of Cannabidiol in Liver Disease: A Systemic Review.
Chen S, Kim JK. Chen S, et al. Int J Mol Sci. 2024 Feb 17;25(4):2370. doi: 10.3390/ijms25042370. Int J Mol Sci. 2024. PMID: 38397045 Free PMC article. Review.
Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as non-alcoholic fatty liver disease (NAFLD), alcoholic liver disease, and viral hepatitis stand as prominent causes of morbidity and mortality in chronic liver diseases globally. ...Important …
Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as non-alcoholic fatty liver disease (NAFLD), alcoholic liv …
Ratio of hemoglobin to red cell distribution width: an inflammatory predictor of survival in AIDS-related DLBCL.
Chen J, Wu Y, Zhao H, Ruan G, Qin S. Chen J, et al. Front Immunol. 2024 Feb 15;15:1354325. doi: 10.3389/fimmu.2024.1354325. eCollection 2024. Front Immunol. 2024. PMID: 38426083 Free PMC article.
Among the potential inflammatory markers examined, only the ratio of hemoglobin (g/dL) to red cell distribution width (%) (Hb/RDW) emerged as an independent prognostic parameter for OS in the training (hazard ratios [HR] = 2.645, 95% CI = 1.267-5.522, P = 0.010) and valida …
Among the potential inflammatory markers examined, only the ratio of hemoglobin (g/dL) to red cell distribution width (%) (Hb/RDW) em …
Understanding the impact of mobility on Plasmodium spp. carriage in an Amazon cross-border area with low transmission rate.
Tréhard H, Musset L, Lazrek Y, Djossou F, Epelboin L, Roux E, Landier J, Gaudart J, Mosnier E. Tréhard H, et al. PLOS Glob Public Health. 2024 Feb 13;4(2):e0002706. doi: 10.1371/journal.pgph.0002706. eCollection 2024. PLOS Glob Public Health. 2024. PMID: 38349936 Free PMC article.
Specific surveillance systems and interventions which take into account different types of mobility are needed in cross-border areas to achieve and maintain malaria elimination (e.g., reactive case detection and treatment in the places visited)....
Specific surveillance systems and interventions which take into account different types of mobility are needed in cross-border areas to achi …
Hepatitis E virus infections among patients with acute febrile jaundice in two regions of Cameroon: First molecular characterization of hepatitis E virus genotype 4.
Modiyinji AF, Tankeu LTA, Monamele CG, Yifomnjou Moumbeket MH, Tagnouokam Ngoupo PA, Tchetgna Simo H, Njei Ngu A, Mirdad K, Njouom R. Modiyinji AF, et al. PLoS One. 2024 Feb 12;19(2):e0298723. doi: 10.1371/journal.pone.0298723. eCollection 2024. PLoS One. 2024. PMID: 38346054 Free PMC article.
BACKGROUND: Febrile jaundice is a common indicator of certain infectious diseases, including hepatitis E. In Cameroon, the yellow fever virus is the only pathogen that is monitored in patients who present with this symptom. However, more than 90% of the samples received as …
BACKGROUND: Febrile jaundice is a common indicator of certain infectious diseases, including hepatitis E. In Cameroon, the yellow fev …
A systemic lupus erythematosus patient with persistent elevated conjugated bilirubin as the initial symptom: A case report.
Liu J, Shen T, Li L, Li X, Zhao F, Liu X, Zhang S, Wu P, Li N, Zeng J. Liu J, et al. Medicine (Baltimore). 2024 Feb 9;103(6):e36999. doi: 10.1097/MD.0000000000036999. Medicine (Baltimore). 2024. PMID: 38335395 Free PMC article.
DIAGNOSES: Persistent non-conjugated bilirubin elevation due to lupus hepatitis. INTERVENTIONS: The use of methylprednisolone sodium succinate (40 mg/Qd) and mycophenolate mofetil (0.75 g/d) suppressed immunity, polyolefin choline (20 mL/d) and glutathione (0.6 g
DIAGNOSES: Persistent non-conjugated bilirubin elevation due to lupus hepatitis. INTERVENTIONS: The use of methylprednisolone sodium …
Splenic marginal zone lymphoma with monoclonal IgG: A case report.
Zhang X, Ren S, Zhang N, Wang X, Qiu L, Sun H, Yi H, Fan F. Zhang X, et al. Medicine (Baltimore). 2024 Feb 9;103(6):e37158. doi: 10.1097/MD.0000000000037158. Medicine (Baltimore). 2024. PMID: 38335376 Free PMC article.
PATIENT CONCERNS: We report a case of SMZL (49-year-old, male) with monoclonal IgG, MYD88L265P mutation and hepatitis B virus infection. DIAGNOSES: The patient was presented to our hospital with aggravating complaints of dizziness, fatigue, postprandial abdominal distensio …
PATIENT CONCERNS: We report a case of SMZL (49-year-old, male) with monoclonal IgG, MYD88L265P mutation and hepatitis B virus infecti …
Hydroxypropyl-Beta Cyclodextrin Barrier Prevents Respiratory Viral Infections: A Preclinical Study.
Lu A, Ebright B, Naik A, Tan HL, Cohen NA, Bouteiller JC, Lazzi G, Louie SG, Humayun MS, Asante I. Lu A, et al. Int J Mol Sci. 2024 Feb 8;25(4):2061. doi: 10.3390/ijms25042061. Int J Mol Sci. 2024. PMID: 38396738 Free PMC article.
In vitro efficacy studies were further conducted using lentiviruses, murine hepatitis virus (MHV), and influenza A virus subtype H1N1. These findings suggest HPBCD may be used as an agnostic barrier against transmissible pathogens, including but not limited to SARS-CoV-2.. …
In vitro efficacy studies were further conducted using lentiviruses, murine hepatitis virus (MHV), and influenza A virus subtype H1N1 …
Beta-Thalassemia.
Langer AL. Langer AL. 2000 Sep 28 [updated 2024 Feb 8]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. 2000 Sep 28 [updated 2024 Feb 8]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. PMID: 20301599 Free Books & Documents. Review.
Supportive care: For beta-thalassemia major, regular red blood cell transfusions with iron chelation therapy (e.g., deferoxamine B, deferiprone, deferasirox). Transfusion requirements may be reduced with the use of luspatercept. ...In adults: bone densitometry to assess fo …
Supportive care: For beta-thalassemia major, regular red blood cell transfusions with iron chelation therapy (e.g., deferoxamine B, d …
VSpipe-GUI, an Interactive Graphical User Interface for Virtual Screening and Hit Selection.
Hussain R, Hackett AS, Álvarez-Carretero S, Tabernero L. Hussain R, et al. Int J Mol Sci. 2024 Feb 7;25(4):2002. doi: 10.3390/ijms25042002. Int J Mol Sci. 2024. PMID: 38396680 Free PMC article.
We have now improved and expanded the initial command-line version into an interactive graphical user interface: VSpipe-GUI, a cross-platform open-source Python toolkit functional in various operating systems (e.g., Linux distributions, Windows, and Mac OS X). The new impl …
We have now improved and expanded the initial command-line version into an interactive graphical user interface: VSpipe-GUI, a cross-platfor …
Primaquine in glucose-6-phosphate dehydrogenase deficiency: an adaptive pharmacometric assessment of ascending dose regimens in healthy volunteers.
Pukrittayakamee S, Jittamala P, Watson JA, Hanboonkunupakarn B, Leungsinsiri P, Poovorawan K, Chotivanich K, Bancone G, Chu CS, Imwong M, Day NPJ, Taylor WRJ, White NJ. Pukrittayakamee S, et al. Elife. 2024 Feb 6;12:RP87318. doi: 10.7554/eLife.87318. Elife. 2024. PMID: 38319064 Free PMC article. Clinical Trial.
In Part 1, the median haemoglobin concentration decline was 3.7 g/dL (range: 2.1-5.9; relative decline of 26% [range: 15-40%]). ...In Part 2, the median haemoglobin concentration decline was 1.7 g/dL (range 0.9-4.1; relative fall of 12% [range: 7-30% decrease]). ...
In Part 1, the median haemoglobin concentration decline was 3.7 g/dL (range: 2.1-5.9; relative decline of 26% [range: 15-40%]). ...In …
Gut-Lung Microbiota Characterization in Patients with Non-Small Cell Lung Carcinoma and COVID-19 Coinfection.
Vakili B, Shoaei P, Shahzamani K, Siadat SD, Shojaei H, Esfandiari Z, Nasri E, Shabani S, Zamani Moghadam A, Ataei B. Vakili B, et al. Arch Iran Med. 2024 Feb 1;27(2):62-71. doi: 10.34172/aim.2024.11. Arch Iran Med. 2024. PMID: 38619029 Free PMC article.
., in NSCLC patients with COVID-19 were significantly higher than those of healthy individuals (8.490.70 log CFU/g wet feces vs 8.490.70 log CFU/g wet feces). Prevotella spp. were enriched in the gut and respiratory tracts of COVID-19 patient groups. ...
., in NSCLC patients with COVID-19 were significantly higher than those of healthy individuals (8.490.70 log CFU/g wet feces vs 8.490 …
Scale-up of Direct-Acting Antiviral Treatment in Prisons Is Both Cost-effective and Key to Hepatitis C Virus Elimination.
Shih STF, Stone J, Martin NK, Hajarizadeh B, Cunningham EB, Kwon JA, McGrath C, Grant L, Grebely J, Dore GJ, Lloyd AR, Vickerman P, Chambers GM. Shih STF, et al. Open Forum Infect Dis. 2023 Dec 18;11(2):ofad637. doi: 10.1093/ofid/ofad637. eCollection 2024 Feb. Open Forum Infect Dis. 2023. PMID: 38344130 Free PMC article.
BACKGROUND: The Surveillance and Treatment of Prisoners With Hepatitis C (SToP-C) study demonstrated that scaling up of direct-acting antiviral (DAA) treatment reduced hepatitis C virus (HCV) transmission. ...
BACKGROUND: The Surveillance and Treatment of Prisoners With Hepatitis C (SToP-C) study demonstrated that scaling up of direct-acting …
Cholangiocarcinoma Insights: Established Foundations and Cutting-Edge Innovations from Dr. James Cleary's Pioneering Research.
Cortiana V, Chorya H, Joshi M, Kannan S, Mahendru D, Vallabhaneni H, Coloma HS, Leyfman Y, Park CH. Cortiana V, et al. Cancers (Basel). 2024 Feb 1;16(3):632. doi: 10.3390/cancers16030632. Cancers (Basel). 2024. PMID: 38339383 Free PMC article.
Stratifying these factors into two groups, those unrelated to fluke infestations (e.g., viral hepatitis and fatty liver conditions) and those associated with fluke infestations (e.g., chronic liver inflammation), facilitates predictive modeling. ...
Stratifying these factors into two groups, those unrelated to fluke infestations (e.g., viral hepatitis and fatty liver condit …
Survey of selected viral agents (herpesvirus, adenovirus and hepatitis E virus) in liver and lung samples of cetaceans, Brazil.
Sacristán C, Ewbank AC, Duarte-Benvenuto A, Sacristán I, Zamana-Ramblas R, Costa-Silva S, Lanes Ribeiro V, Bertozzi CP, Del Rio do Valle R, Castilho PV, Colosio AC, Marcondes MCC, Lailson-Brito J, de Freitas Azevedo A, Carvalho VL, Pessi CF, Cremer M, Esperón F, Catão-Dias JL. Sacristán C, et al. Sci Rep. 2024 Feb 1;14(1):2689. doi: 10.1038/s41598-023-45315-9. Sci Rep. 2024. PMID: 38302481 Free PMC article.
Hepatic and pulmonary lesions are common in cetaceans, despite their poorly understood viral etiology. Herpesviruses (HV), adenoviruses (AdV) and hepatitis E virus (HEV) are emerging agents in cetaceans, associated with liver and/or pulmonary damage in mammals. ...
Hepatic and pulmonary lesions are common in cetaceans, despite their poorly understood viral etiology. Herpesviruses (HV), adenoviruses (AdV …
Liver iron overload and fat content analyzed by magnetic resonance contribute to evaluatingthe progression of chronic hepatitis B.
Luo J, Liu Z, Wang Q, Tan S. Luo J, et al. Biomed Rep. 2023 Dec 19;20(2):23. doi: 10.3892/br.2023.1711. eCollection 2024 Feb. Biomed Rep. 2023. PMID: 38169881 Free PMC article.
Chronic hepatitis B (CHB) and its complications still have a major role in liver-related mortality. ...A total of 340 patients were included in the current study. For LIC, the median value was 1.68 mg/g and elevated LIC was seen in 122 patients (35.9%). For liver fa …
Chronic hepatitis B (CHB) and its complications still have a major role in liver-related mortality. ...A total of 340 patients were i …
Real-World Safety and Effectiveness of an 8-Week Regimen of Glecaprevir/Pibrentasvir in Patients with Hepatitis C and Cirrhosis.
Lu M, Rupp LB, Melkonian C, Trudeau S, Daida YG, Schmidt MA, Gordon SC. Lu M, et al. Adv Ther. 2024 Feb;41(2):744-758. doi: 10.1007/s12325-023-02748-y. Epub 2024 Jan 2. Adv Ther. 2024. PMID: 38169058 Free PMC article.
INTRODUCTION: In 2019, an 8-week regimen of glecaprevir/ pibrentasvir (GLE/PIB) was FDA-approved for treatment of chronic hepatitis C (HCV) in patients with cirrhosis. We used data from the Chronic Hepatitis Cohort Study (CHeCS) to evaluate treatment response and ad …
INTRODUCTION: In 2019, an 8-week regimen of glecaprevir/ pibrentasvir (GLE/PIB) was FDA-approved for treatment of chronic hepatitis C …
Building a Simple Model to Assess the Impact of Case Investigation and Contact Tracing for Sexually Transmitted Diseases: Lessons From COVID-19.
Castonguay FM, Chesson HW, Jeon S, Rainisch G, Fischer LS, Adhikari BB, Kahn EB, Greening B Jr, Gift TL, Meltzer MI. Castonguay FM, et al. AJPM Focus. 2023 Sep 25;3(1):100147. doi: 10.1016/j.focus.2023.100147. eCollection 2024 Feb. AJPM Focus. 2023. PMID: 38149077 Free PMC article.
METHODS: The key epidemiologic differences between sexually transmitted diseases and respiratory diseases (e.g., mixing patterns, incubation period, duration of infection, and the availability of treatment) were identified, and their implications for modeling case investig …
METHODS: The key epidemiologic differences between sexually transmitted diseases and respiratory diseases (e.g., mixing patterns, inc …
Serum Exosome-Derived microRNA-193a-5p and miR-381-3p Regulate Adenosine 5'-Monophosphate-Activated Protein Kinase/Transforming Growth Factor Beta/Smad2/3 Signaling Pathway and Promote Fibrogenesis.
Wang S, Chen Y, Lei G, Ma X, An L, Wang H, Song Z, Lin L, He Q, Xu R, Zhan X, Bai Z, Yang Y. Wang S, et al. Clin Transl Gastroenterol. 2024 Feb 1;15(2):e00662. doi: 10.14309/ctg.0000000000000662. Clin Transl Gastroenterol. 2024. PMID: 38099588 Free PMC article.
Compared with healthy control group, the high expression of serum exosome-derived miR-193a-5p and miR-381-3 in chronic hepatitis B (n = 42) was closely associated with advanced liver fibrosis and cirrhosis. ...
Compared with healthy control group, the high expression of serum exosome-derived miR-193a-5p and miR-381-3 in chronic hepatitis B (n …
Cohort Profile: International Collaboration on Hepatitis C Elimination in HIV Cohorts (InCHEHC).
van Santen DK, Stewart A, Doyle JS, Stoové MA, Asselin J, Klein MB, Young J, Berenguer J, Jarrin I, Lacombe K, Wittkop L, Leleux O, Salmon D, Bonnet F, Rauch A, Mugglin C, Matthews G, Prins M, Smit C, Boyd A, van der Valk M, Sacks-Davis R, Hellard ME; InCHEHC Study Group. van Santen DK, et al. Int J Epidemiol. 2024 Feb 1;53(1):dyad154. doi: 10.1093/ije/dyad154. Int J Epidemiol. 2024. PMID: 38066671 Free PMC article. No abstract available.
Retention and Viral Suppression Among Adolescents Newly Initiating Antiretroviral Therapy in Adult HIV Care in Lima, Peru: A Retrospective Cohort Study.
Niwa M, Matos E, Rodriguez C, Wong M, Errea RA, Ramos A, Senador L, Contreras C, Galea JT, Lindeborg A, Benites C, Shin SS, Lecca L, Franke MF. Niwa M, et al. J Adolesc Health. 2024 Feb;74(2):260-267. doi: 10.1016/j.jadohealth.2023.08.041. Epub 2023 Oct 7. J Adolesc Health. 2024. PMID: 37804297 Free article.
We conducted regression analyses to assess factors associated with successful transition to adult HIV care, including gender, age, occupation, nationality, pregnancy, same-sex sexual behavior, presence of treatment supporter, number of living parents, and social risk factors that …
We conducted regression analyses to assess factors associated with successful transition to adult HIV care, including gender, age, occupatio …
No evidence of hepatitis E virus (HEV) infection among pet cats and dogs, and low seroprevalence of hepatitis E virus among pet rabbits in Poland.
Turlewicz-Podbielska H, Ruszkowski JJ, Wojciechowski J, Pomorska-Mól M. Turlewicz-Podbielska H, et al. Vet Res Commun. 2024 Feb;48(1):597-602. doi: 10.1007/s11259-023-10223-w. Epub 2023 Sep 23. Vet Res Commun. 2024. PMID: 37740104 Free PMC article.
The seroprevalence of Paslahepevirus balayani genotype 3 (hepatitis E virus genotype 3 - HEV-3; Hepeviridae family, genus Paslahepevirus) in pet cats, dogs and rabbits was evaluated. ...
The seroprevalence of Paslahepevirus balayani genotype 3 (hepatitis E virus genotype 3 - HEV-3; Hepeviridae family, genus Paslahepevi …
How does alcohol use impact morbidity and mortality of liver cirrhosis? A systematic review and dose-response meta-analysis.
Llamosas-Falcón L, Probst C, Buckley C, Jiang H, Lasserre AM, Puka K, Tran A, Zhu Y, Rehm J. Llamosas-Falcón L, et al. Hepatol Int. 2024 Feb;18(1):216-224. doi: 10.1007/s12072-023-10584-z. Epub 2023 Sep 8. Hepatol Int. 2024. PMID: 37684424 Free article.
Non-linear dose-response relationships were identified, attenuated for higher levels of consumption. For morbidity, drinking 25 g/day was associated with a RR of 1.81 (95% CI 1.68-1.94) compared to lifetime abstention; 50 g/day and 100 g/day corresponded to 3 …
Non-linear dose-response relationships were identified, attenuated for higher levels of consumption. For morbidity, drinking 25 g/day …
Single-cell atlas of the liver myeloid compartment before and after cure of chronic viral hepatitis.
Cui A, Li B, Wallace MS, Gonye ALK, Oetheimer C, Patel H, Tonnerre P, Holmes JA, Lieb D, Yao BS, Ma A, Roberts K, Damasio M, Chen JH, Piou D, Carlton-Smith C, Brown J, Mylvaganam R, Hon Fung JM, Sade-Feldman M, Aneja J, Gustafson J, Epstein ET, Salloum S, Brisac C, Thabet A, Kim AY, Lauer GM, Hacohen N, Chung RT, Alatrakchi N. Cui A, et al. J Hepatol. 2024 Feb;80(2):251-267. doi: 10.1016/j.jhep.2023.02.040. Epub 2023 Mar 25. J Hepatol. 2024. PMID: 36972796 Free article.
BACKGROUND & AIMS: Chronic viral infections present serious public health challenges; however, direct-acting antivirals (DAAs) are now able to cure nearly all patients infected with hepatitis C virus (HCV), representing the only cure of a human chronic viral infection …
BACKGROUND & AIMS: Chronic viral infections present serious public health challenges; however, direct-acting antivirals (DAAs) are now a …
The temporal association of CapZ with early endosomes regulates endosomal trafficking and viral entry into host cells.
Zhu H, Wang D, Ye Z, Huang L, Wei W, Chan KM, Zhang R, Zhang L, Yue J. Zhu H, et al. BMC Biol. 2024 Jan 25;22(1):12. doi: 10.1186/s12915-024-01819-y. BMC Biol. 2024. PMID: 38273307 Free PMC article.
Remarkably, CapZ knockout or artificially tethering CapZ to EEs via rapamycin significantly inhibited flaviviruses, e.g., Zika virus (ZIKV) and dengue virus (DENV), or beta-coronavirus, e.g., murine hepatitis virus (MHV), infection by preventing the escape of …
Remarkably, CapZ knockout or artificially tethering CapZ to EEs via rapamycin significantly inhibited flaviviruses, e.g., Zika virus …
Sargramostim for Prophylactic Management of Gastrointestinal Immune-Related Adverse Events of Immune Checkpoint Inhibitor Therapy for Cancer.
Dougan M, Nguyen LH, Buchbinder EI, Lazarus HM. Dougan M, et al. Cancers (Basel). 2024 Jan 24;16(3):501. doi: 10.3390/cancers16030501. Cancers (Basel). 2024. PMID: 38339253 Free PMC article. Review.
The treatment for these potentially severe and even fatal GI irAEs which include enterocolitis, severe diarrhea, and hepatitis may interfere with the anti-cancer approach. Sargramostim (glycosylated, yeast-derived, recombinant human GM-CSF) is an agent that has been used i …
The treatment for these potentially severe and even fatal GI irAEs which include enterocolitis, severe diarrhea, and hepatitis may in …
Dysregulation of the Skin-Liver Axis in Prurigo Nodularis: An Integrated Genomic, Transcriptomic, and Population-Based Analysis.
Marani M, Madan V, Le TK, Deng J, Lee KK, Ma EZ, Kwatra SG. Marani M, et al. Genes (Basel). 2024 Jan 23;15(2):146. doi: 10.3390/genes15020146. Genes (Basel). 2024. PMID: 38397136 Free PMC article.

This analysis revealed that PN patients had a higher risk (p < 0.001) of developing liver cirrhosis, acute and subacute hepatic failure, inflammatory liver disease, chronic hepatitis, nonalcoholic steatohepatitis, portal hypertension, fatty liver, chronic passive conges

This analysis revealed that PN patients had a higher risk (p < 0.001) of developing liver cirrhosis, acute and subacute hepatic failure,

Abundance of G-Quadruplex Forming Sequences in the Hepatitis Delta Virus Genomes.
Brázda V, Valková N, Dobrovolná M, Mergny JL. Brázda V, et al. ACS Omega. 2024 Jan 9;9(3):4096-4101. doi: 10.1021/acsomega.3c09288. eCollection 2024 Jan 23. ACS Omega. 2024. PMID: 38284014 Free PMC article.
Hepatitis delta virus (HDV) is a highly unusual RNA satellite virus that depends on the presence of hepatitis B virus (HBV) to be infectious. ...The significance of noncanonical secondary structures such as G-quadruplexes (G4s) is increasingly recognized at t
Hepatitis delta virus (HDV) is a highly unusual RNA satellite virus that depends on the presence of hepatitis B virus (HBV) to
EGFR core fucosylation, induced by hepatitis C virus, promotes TRIM40-mediated-RIG-I ubiquitination and suppresses interferon-I antiviral defenses.
Pan Q, Xie Y, Zhang Y, Guo X, Wang J, Liu M, Zhang XL. Pan Q, et al. Nat Commun. 2024 Jan 22;15(1):652. doi: 10.1038/s41467-024-44960-6. Nat Commun. 2024. PMID: 38253527 Free PMC article.
Here we find that multiple viral envelope proteins, including Hepatitis C Virus (HCV)-E2, Vesicular stomatitis virus (VSV)-G, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-Spike and human immunodeficiency virus (HIV)-gp120, enhance FUT8 expression and …
Here we find that multiple viral envelope proteins, including Hepatitis C Virus (HCV)-E2, Vesicular stomatitis virus (VSV)-G, …
First report of Botrytis cinerea causing gray mold on Alternanthera philoxeroides in China.
Zhao Y, Li J, Zhou L, Hao N, Zhao B, Liu Y. Zhao Y, et al. Plant Dis. 2024 Jan 19. doi: 10.1094/PDIS-08-23-1668-PDN. Online ahead of print. Plant Dis. 2024. PMID: 38243183 Free article.
One of notable active components is flavonoids, which have been found to exhibit anti-Hepatitis B Virus activity (Li et al. 2016). In 2021, a leaf spot on A. philoxeroides was observed in the science and education experimental park of Hebei Agricultural University (3849'38 …
One of notable active components is flavonoids, which have been found to exhibit anti-Hepatitis B Virus activity (Li et al. 2016). In …
Add-on immunosuppressive therapy may benefit selected patients with primary biliary cholangitis and autoimmune phenomena.
Li M, Chen S, Li S, Lv T, Li B, Shan S, Li M, Zeng N, Wang Q, Kong Y, Ma H, Zhao X, Ou X, You H, Duan W, Jia J. Li M, et al. Therap Adv Gastroenterol. 2024 Jan 18;17:17562848231224840. doi: 10.1177/17562848231224840. eCollection 2024. Therap Adv Gastroenterol. 2024. PMID: 38250015 Free PMC article.
BACKGROUND: Mildly elevated levels of transaminase and/or immunoglobulin G (IgG) are common in patients with primary biliary cholangitis (PBC). It is still unclear whether adding immunosuppressive therapy to ursodeoxycholic acid (UDCA) benefits those patients who are not f …
BACKGROUND: Mildly elevated levels of transaminase and/or immunoglobulin G (IgG) are common in patients with primary biliary cholangi …
Linoleate-pazopanib conjugation as active pharmacological ingredient to abolish hepatocellular carcinoma growth.
Wang K, Liao PY, Chang WC, Yang CR, Su YT, Wu PC, Wu YC, Hung YC, Akhtar N, Lai HC, Ma WL. Wang K, et al. Front Pharmacol. 2024 Jan 16;14:1281067. doi: 10.3389/fphar.2023.1281067. eCollection 2023. Front Pharmacol. 2024. PMID: 38293667 Free PMC article.
In an efficacy trial comparing placebo, oral pazopanib, and LAPC treatments in the hepatitis B virus transgene-related spontaneous HCC mouse model (HBVtg-HCC), the LAPC treatment demonstrated superior tumor ablating capacity in comparison to both placebo and pazopanib trea …
In an efficacy trial comparing placebo, oral pazopanib, and LAPC treatments in the hepatitis B virus transgene-related spontaneous HC …
Molecular genetic association of rs8099917 and rs1800795 polymorphisms in the progression of hepatitis Delta virus liver disease.
Passos-Silva AM, Silva ECE, Borzacov LMP, Araújo A, Porto AS, Salcedo JMV, Vieira D. Passos-Silva AM, et al. J Venom Anim Toxins Incl Trop Dis. 2024 Jan 12;30:e20230025. doi: 10.1590/1678-9199-JVATITD-2023-0025. eCollection 2024. J Venom Anim Toxins Incl Trop Dis. 2024. PMID: 38221914 Free PMC article.
RESULTS: The rs8099917 T allele, from the IFNL3 gene, showed a higher frequency in both groups; however, it was not possible to establish an association with HDV infection [OR = 1.42 (0.42 - 4.75; p = 0.556 (95% CI). For IL-6, the rs1800795 G allele was superior to rs18007 …
RESULTS: The rs8099917 T allele, from the IFNL3 gene, showed a higher frequency in both groups; however, it was not possible to establish an …
Report of an Iranian child with chronic abdominal pain and constipation diagnosed as glycogen storage disease type IX: a case report.
Zamanfar D, Hashemi-Soteh SM, Ghazaiean M, Keyhanian E. Zamanfar D, et al. J Med Case Rep. 2024 Jan 12;18(1):14. doi: 10.1186/s13256-023-04295-0. J Med Case Rep. 2024. PMID: 38212860 Free PMC article.
With the help of the pediatric gastroenterologists, cholestasis, Wilson disease, and autoimmune hepatitis were ruled out. Given that glycogen storage diseases type I and type III are the most common, we initially managed the patient with frequent feedings and a diet that i …
With the help of the pediatric gastroenterologists, cholestasis, Wilson disease, and autoimmune hepatitis were ruled out. Given that …
Serum albumin and white matter hyperintensities.
Zahr N, Pfefferbaum A. Zahr N, et al. Res Sq [Preprint]. 2024 Jan 11:rs.3.rs-3822513. doi: 10.21203/rs.3.rs-3822513/v1. Res Sq. 2024. Update in: Transl Psychiatry. 2024 Jun 1;14(1):233. doi: 10.1038/s41398-024-02953-5. PMID: 38260299 Free PMC article. Updated. Preprint.
In a sample of 160 individuals with alcohol use disorder (AUD), 142 infected with HIV, and 102 healthy controls, the hypothesis was tested that lower serum albumin levels would predict larger WMH volumes and worse cognitive performance irrespective of diagnosis. After considering …
In a sample of 160 individuals with alcohol use disorder (AUD), 142 infected with HIV, and 102 healthy controls, the hypothesis was tested t …
Multisystem Immune-Related Adverse Events from Dual-Agent Immunotherapy Use.
Li Y, Pond G, McWhirter E. Li Y, et al. Curr Oncol. 2024 Jan 11;31(1):425-435. doi: 10.3390/curroncol31010028. Curr Oncol. 2024. PMID: 38248113 Free PMC article.
The most common irAE type was dermatitis (22%), followed by colitis (19%) and hepatitis (17%). CONCLUSIONS: Our study demonstrated that multisystem irAEs are prevalent amongst patients receiving ipilimumab and nivolumab. ...
The most common irAE type was dermatitis (22%), followed by colitis (19%) and hepatitis (17%). CONCLUSIONS: Our study demonstrated th …
Use of Hepatitis C Virus Antibody-Positive Donors in Kidney Transplantation.
Ventura S, Figueiredo C, Sousa C, Almeida M, Martins S. Ventura S, et al. Cureus. 2024 Jan 8;16(1):e51849. doi: 10.7759/cureus.51849. eCollection 2024 Jan. Cureus. 2024. PMID: 38327969 Free PMC article.
Background The use of kidney donors with hepatitis C virus (HCV) has been arising as a possibility to increase the donor pool. ...At the end of follow-up, mean creatinine and proteinuria were 1.45 1.12 mg/dL and 0.099 0.045 g/g, respectively. We did not obser …
Background The use of kidney donors with hepatitis C virus (HCV) has been arising as a possibility to increase the donor pool. ...At …
Associations between genetic variants in sphingolipid metabolism pathway genes and hepatitis B virus-related hepatocellular carcinoma survival.
Jiang B, Qiu M, Qin L, Tang J, Zhan S, Lin Q, Wei J, Liu Y, Zhou Z, Liang X, Cao J, Lian J, Mai Y, Jiang Y, Yu H. Jiang B, et al. Front Oncol. 2024 Jan 8;13:1252158. doi: 10.3389/fonc.2023.1252158. eCollection 2023. Front Oncol. 2024. PMID: 38260847 Free PMC article.
We also used the online database TIMER2.0 (http://timer.comp-genomics.org/) to analyze the relationship between the corresponding mRNA expression levels and immune cell infiltration. RESULTS: Our study found that GBA2 rs1570247 G>A was significantly associated with elev …
We also used the online database TIMER2.0 (http://timer.comp-genomics.org/) to analyze the relationship between the corresponding mRNA expre …
G-Quadruplexes in the Regulation of Viral Gene Expressions and Their Impacts on Controlling Infection.
Zareie AR, Dabral P, Verma SC. Zareie AR, et al. Pathogens. 2024 Jan 8;13(1):60. doi: 10.3390/pathogens13010060. Pathogens. 2024. PMID: 38251367 Free PMC article. Review.
G-quadruplexes (G4s) are noncanonical nucleic acid structures that play significant roles in regulating various biological processes, including replication, transcription, translation, and recombination. Recent studies have identified G4s in the genomes of several viruses,
G-quadruplexes (G4s) are noncanonical nucleic acid structures that play significant roles in regulating various biological processes,
Assessment of Variables Related to the Risk of Severe Adverse Events in Cutaneous Melanoma Patients Treated with Immune Checkpoint Inhibitors.
Trichkova KP, Görtler F, Bjørge L, Schuster C. Trichkova KP, et al. Cancers (Basel). 2024 Jan 5;16(2):250. doi: 10.3390/cancers16020250. Cancers (Basel). 2024. PMID: 38254742 Free PMC article. Review.
Out of 1694 articles, 13 were included in the final analysis. We analyzed BCs and the occurrence of severe colitis, hepatitis, and pneumonitis in 22 treatment arms and 3 treatment groups: anti-CTLA-4 (n = 2904), anti-PD-1 (n = 1301), or combination therapy (n = 822). ...De …
Out of 1694 articles, 13 were included in the final analysis. We analyzed BCs and the occurrence of severe colitis, hepatitis, and pn …