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Page 1
Intestinal iron absorption.
Fuqua BK, Vulpe CD, Anderson GJ. Fuqua BK, et al. J Trace Elem Med Biol. 2012 Jun;26(2-3):115-9. doi: 10.1016/j.jtemb.2012.03.015. Epub 2012 May 8. J Trace Elem Med Biol. 2012. PMID: 22575541 Review.
Enterocyte iron is exported to the blood via ferroportin 1 on the basolateral membrane. This transporter acts in partnership with the ferroxidase hephaestin that oxidizes exported ferrous iron to facilitate its binding to plasma transferrin. ...The levels of iron an …
Enterocyte iron is exported to the blood via ferroportin 1 on the basolateral membrane. This transporter acts in partnership with the …
Hephaestin--a ferroxidase of cellular iron export.
Petrak J, Vyoral D. Petrak J, et al. Int J Biochem Cell Biol. 2005 Jun;37(6):1173-8. doi: 10.1016/j.biocel.2004.12.007. Epub 2005 Jan 26. Int J Biochem Cell Biol. 2005. PMID: 15778082 Review.
Hephaestin is a transmembrane copper-dependent ferroxidase necessary for effective iron transport from intestinal enterocytes into the circulation. ...So far, hephaestin has not been linked to a human disease....
Hephaestin is a transmembrane copper-dependent ferroxidase necessary for effective iron transport from intestinal enterocytes …
The ceruloplasmin homolog hephaestin and the control of intestinal iron absorption.
Anderson GJ, Frazer DM, McKie AT, Vulpe CD. Anderson GJ, et al. Blood Cells Mol Dis. 2002 Nov-Dec;29(3):367-75. doi: 10.1006/bcmd.2002.0576. Blood Cells Mol Dis. 2002. PMID: 12547227 Review.
Hephaestin is the gene affected in the sex-linked anemic (sla) mouse. These animals have a defect in the export of iron from intestinal enterocytes into the circulation and this implicates hephaestin in the basolateral transfer step of iron absorption. Hep …
Hephaestin is the gene affected in the sex-linked anemic (sla) mouse. These animals have a defect in the export of iron from intestin …
The multicopper ferroxidase hephaestin enhances intestinal iron absorption in mice.
Fuqua BK, Lu Y, Darshan D, Frazer DM, Wilkins SJ, Wolkow N, Bell AG, Hsu J, Yu CC, Chen H, Dunaief JL, Anderson GJ, Vulpe CD. Fuqua BK, et al. PLoS One. 2014 Jun 4;9(6):e98792. doi: 10.1371/journal.pone.0098792. eCollection 2014. PLoS One. 2014. PMID: 24896847 Free PMC article.
Hephaestin is mutated in the sex-linked anemia mouse, resulting in iron deficiency. However, sex-linked anemia mice still retain some hephaestin ferroxidase activity. ...In addition, the similarities of the phenotypes of the whole body and intestine-specific heph …
Hephaestin is mutated in the sex-linked anemia mouse, resulting in iron deficiency. However, sex-linked anemia mice still retain some …
Decreased hephaestin activity in the intestine of copper-deficient mice causes systemic iron deficiency.
Chen H, Huang G, Su T, Gao H, Attieh ZK, McKie AT, Anderson GJ, Vulpe CD. Chen H, et al. J Nutr. 2006 May;136(5):1236-41. doi: 10.1093/jn/136.5.1236. J Nutr. 2006. PMID: 16614410 Free article.
Interestingly, hephaestin protein levels were significantly decreased to approximately 40% of control, suggesting that decreased enterocyte copper content leads to decreased hephaestin synthesis and/or stability. We also examined the effect of copper deficien …
Interestingly, hephaestin protein levels were significantly decreased to approximately 40% of control, suggesting that decreased e …
Molecular mediators governing iron-copper interactions.
Gulec S, Collins JF. Gulec S, et al. Annu Rev Nutr. 2014;34:95-116. doi: 10.1146/annurev-nutr-071812-161215. Epub 2014 Jun 2. Annu Rev Nutr. 2014. PMID: 24995690 Free PMC article. Review.
Copper accumulation and/or redistribution within enterocytes may influence iron transport, and high hepatic copper may enhance biosynthesis of a circulating ferroxidase, which potentiates iron release from stores. ...
Copper accumulation and/or redistribution within enterocytes may influence iron transport, and high hepatic copper may enhance biosyn …
Mislocalisation of hephaestin, a multicopper ferroxidase involved in basolateral intestinal iron transport, in the sex linked anaemia mouse.
Kuo YM, Su T, Chen H, Attieh Z, Syed BA, McKie AT, Anderson GJ, Gitschier J, Vulpe CD. Kuo YM, et al. Gut. 2004 Feb;53(2):201-6. doi: 10.1136/gut.2003.019026. Gut. 2004. PMID: 14724150 Free PMC article.
BACKGROUND: Hephaestin is a multicopper ferroxidase required for basolateral transport of iron from enterocytes. ...In normal intestinal enterocytes, hephaestin was also present on the basolateral surface. In sla mice, hephaestin was present onl …
BACKGROUND: Hephaestin is a multicopper ferroxidase required for basolateral transport of iron from enterocytes. ...In normal …
Large scale expression and purification of secreted mouse hephaestin.
Deshpande CN, Xin V, Lu Y, Savage T, Anderson GJ, Jormakka M. Deshpande CN, et al. PLoS One. 2017 Sep 7;12(9):e0184366. doi: 10.1371/journal.pone.0184366. eCollection 2017. PLoS One. 2017. PMID: 28880952 Free PMC article.
Hephaestin is a large membrane-anchored multicopper ferroxidase involved in mammalian iron metabolism. Newly absorbed dietary iron is exported across the enterocyte basolateral membrane by the ferrous iron transporter ferroportin, but hephaestin increases the …
Hephaestin is a large membrane-anchored multicopper ferroxidase involved in mammalian iron metabolism. Newly absorbed dietary iron is …
Decreased hephaestin expression and activity leads to decreased iron efflux from differentiated Caco2 cells.
Chen H, Attieh ZK, Dang T, Huang G, van der Hee RM, Vulpe C. Chen H, et al. J Cell Biochem. 2009 Jul 1;107(4):803-8. doi: 10.1002/jcb.22178. J Cell Biochem. 2009. PMID: 19452451
Iron is transported across intestinal brush border cells into the circulation in at least two distinct steps. Iron can enter the enterocyte via the apical surface through several paths. However, iron egress from the basolateral side of enterocytes converges on a sin …
Iron is transported across intestinal brush border cells into the circulation in at least two distinct steps. Iron can enter the enterocy …
Iron repletion relocalizes hephaestin to a proximal basolateral compartment in polarized MDCK and Caco2 cells.
Lee SM, Attieh ZK, Son HS, Chen H, Bacouri-Haidar M, Vulpe CD. Lee SM, et al. Biochem Biophys Res Commun. 2012 May 11;421(3):449-55. doi: 10.1016/j.bbrc.2012.04.008. Epub 2012 Apr 7. Biochem Biophys Res Commun. 2012. PMID: 22503983 Free PMC article.
Enterocytes contact the gut lumen via the apical surface of the cell, and through the basolateral surface, to the body. ...These results support the hypothesis that hephaestin is involved in iron mobilization of iron from the intestine to circulation....
Enterocytes contact the gut lumen via the apical surface of the cell, and through the basolateral surface, to the body. ...These resu …
65 results