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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1991 1
1993 1
1997 1
1998 5
1999 4
2000 6
2001 18
2002 19
2003 18
2004 39
2005 35
2006 30
2007 36
2008 35
2009 23
2010 26
2011 31
2012 36
2013 32
2014 32
2015 25
2016 27
2017 37
2018 31
2019 30
2020 26
2021 26
2022 17
2023 17
2024 34
2025 41
2026 4

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112 results

Results by year

Filters applied: Meta-Analysis, Review, Systematic Review, in the last 5 years, Humans, English. Clear all
Page 1
Role of herbal extracts in modulating drug metabolism: implications for pharmacokinetics, enzyme regulation, and therapeutic outcome.
Khan A, Abdulaziz Al-Hamoud G, Amina M, Alam P, Hawwal MF, Fantoukh OI. Khan A, et al. Drug Metab Rev. 2026 Feb;58(1):49-68. doi: 10.1080/03602532.2025.2603936. Epub 2025 Dec 27. Drug Metab Rev. 2026. PMID: 41392934 Review.
Herbal medicines are widely used worldwide, often alongside prescription drugs, creating the potential for clinically significant herb-drug interactions. These interactions are frequently mediated by effects on drug-metabolizing enzymes (DMEs), …
Herbal medicines are widely used worldwide, often alongside prescription drugs, creating the potential for clinically significant herb …
Exploring the Adverse Effects of Fenugreek in Humans: A Scoping Review.
Amiri Ardekani E, Parvizi MM, Zare R, Mosaffa Jahromi M, Rampp T, Pasalar M. Amiri Ardekani E, et al. Iran J Med Sci. 2026 Jan 1;51(1):4-18. doi: 10.30476/ijms.2025.106073.4017. eCollection 2026 Jan. Iran J Med Sci. 2026. PMID: 41625343 Free PMC article. Review.
BACKGROUND: Trigonella foenum-graecum, commonly known as fenugreek, is used both as a spice and a medicinal herb. While numerous studies investigated its therapeutic effects, this scoping review aimed to explore the reported adverse effects associated with fenugreek consum …
BACKGROUND: Trigonella foenum-graecum, commonly known as fenugreek, is used both as a spice and a medicinal herb. While numerous stud …
Ginger as a Modulator of Drug Metabolizing Enzymes and Transporters: Potential Implications for Herb-Drug Interactions.
Husain I, Idrisi M, Kotwal P, Khan IA, Khan SI. Husain I, et al. J Diet Suppl. 2026;23(2):240-256. doi: 10.1080/19390211.2025.2606752. Epub 2025 Dec 28. J Diet Suppl. 2026. PMID: 41457469 Review.
However, recent preclinical and clinical studies indicate that ginger can interact substantially with various xenobiotic receptors (e.g. PXR, CAR and AhR), drug-metabolizing cytochrome enzymes (CYP3A4, 2C9, 2D6, 1A2, and GST), and drug transporters (P-gp, BCRP, OATP …
However, recent preclinical and clinical studies indicate that ginger can interact substantially with various xenobiotic receptors (e.g. PXR …
Herb-immunosuppressive drug interactions: Implications for kidney transplant recipients.
Santana L, de Oliveira Leal V, Leal PM, de Mattos Manhães L, Mafra D, Borges NA. Santana L, et al. Fitoterapia. 2026 Jan;188:107039. doi: 10.1016/j.fitote.2025.107039. Epub 2025 Dec 16. Fitoterapia. 2026. PMID: 41412301 Review.
This modulation often occurs through the induction or inhibition of hepatic cytochrome P450 enzymes and drug transporters, leading to fluctuations in immunosuppressant blood concentrations. Such variations can predispose transplant recipients to graft rejection due to subt …
This modulation often occurs through the induction or inhibition of hepatic cytochrome P450 enzymes and drug transporters, leading to …
Network pharmacology to elucidate the role of phytotherapy in neurocognitive disorders.
Barth SW, Efferth T. Barth SW, et al. Phytomedicine. 2025 Nov 25;148:157031. doi: 10.1016/j.phymed.2025.157031. Epub 2025 Jul 14. Phytomedicine. 2025. PMID: 41166911
Here, the "phytome" which integrates herbal drug ingredients into the exposome may be a rich source with which to counteract diseased networks. ...The understanding of phytopharmaceuticals' modes of action underpin the necessity to expand the search from classic pharmacolo …
Here, the "phytome" which integrates herbal drug ingredients into the exposome may be a rich source with which to counteract diseased …
Hepatoprotective effects of silybin in liver fibrosis.
Liu XX, Hassan W, Ahmed H, Song SZ. Liu XX, et al. World J Gastroenterol. 2025 Nov 14;31(42):110449. doi: 10.3748/wjg.v31.i42.110449. World J Gastroenterol. 2025. PMID: 41278156 Free PMC article. Review.
Excessive fibrogenesis that results in the disruption of intercellular connections, interactions, and extracellular matrix composition are features of the fibrotic process mediated by various cell types and chemical mediators such as transforming growth factor-beta. ...Oth …
Excessive fibrogenesis that results in the disruption of intercellular connections, interactions, and extracellular matrix compositio …
Reimagining ethnopharmacology with generative AI: Towards inclusive, ethical, and data-driven traditional medicine.
Bhadra S, Pundir C, Mukherjee M, Kar A, Banerjee S, Charoensup R, Duangyod T, Mukherjee PK. Bhadra S, et al. Pharmacol Res. 2025 Nov;221:108002. doi: 10.1016/j.phrs.2025.108002. Epub 2025 Oct 19. Pharmacol Res. 2025. PMID: 41120019 Free article. Review.
Ethnopharmacology explores bioactive compounds rooted in traditional medical knowledge systems and holds immense promise for drug discovery, cultural preservation, and healthcare innovation. However, fragmented documentation, minimal digitization, and limited integration w …
Ethnopharmacology explores bioactive compounds rooted in traditional medical knowledge systems and holds immense promise for drug dis …
The "Cancer Bush" Sutherlandia (syn. Lessertia) frutescens. An Example of Promotional Research, or Is There Scientific Merit?
Gernandt N, van der Kooy F. Gernandt N, et al. Planta Med. 2025 Nov;91(13):730-744. doi: 10.1055/a-2654-6280. Epub 2025 Aug 5. Planta Med. 2025. PMID: 40763763 Free article. Review.
Based on available data, it must be concluded that S. frutescens does not exhibit acceptable levels of bioactivity/selectivity, and keeping in mind possible herb-drug interactions and the serious nature of cancer, which causes over 10 million deaths annually, …
Based on available data, it must be concluded that S. frutescens does not exhibit acceptable levels of bioactivity/selectivity, and keeping …
Exploring the antitumor potential of cucurbitacin B in hepatocellular carcinoma through network pharmacology, molecular docking, and molecular dynamics simulations.
Zhang H, Wu B, Ke L, Fan X, Huang L, Peng Z. Zhang H, et al. Naunyn Schmiedebergs Arch Pharmacol. 2025 Nov;398(11):14751-14769. doi: 10.1007/s00210-025-04273-x. Epub 2025 May 21. Naunyn Schmiedebergs Arch Pharmacol. 2025. PMID: 40397117 Review.
Potential CuB targets were retrieved from CTD, HERB, SwissTargetPrediction, ETCM, and PharmMapper databases. HCC-related genes were sourced from GEO datasets (GSE216613, GSE101685, GSE62232, GSE46408), GeneCard, DisGeNET, OMIM, and TTD. ...Molecular docking (Autodock Vina) …
Potential CuB targets were retrieved from CTD, HERB, SwissTargetPrediction, ETCM, and PharmMapper databases. HCC-related genes were s …
When Nature Meets Oncology: Unraveling Herb-Drug Interactions in Cancer Therapy.
Gandhi A, Master S, Bhise V. Gandhi A, et al. Int J Mol Sci. 2025 Oct 29;26(21):10494. doi: 10.3390/ijms262110494. Int J Mol Sci. 2025. PMID: 41226533 Free PMC article. Review.
This review takes on this challenge directly, moving past theoretical concerns to summarize current clinical evidence on interactions between widely used NPs and modern cancer treatments, including chemotherapy, targeted therapy, and immunotherapy. ...By examining both wel …
This review takes on this challenge directly, moving past theoretical concerns to summarize current clinical evidence on interactions …
112 results