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Lion's Mane Mushroom (Hericium erinaceus): A Neuroprotective Fungus with Antioxidant, Anti-Inflammatory, and Antimicrobial Potential-A Narrative Review.
Contato AG, Conte-Junior CA. Contato AG, et al. Nutrients. 2025 Apr 9;17(8):1307. doi: 10.3390/nu17081307. Nutrients. 2025. PMID: 40284172 Free PMC article. Review.
Hericium erinaceus, commonly known as lion's mane mushroom, has gained increasing scientific interest due to its rich composition of bioactive compounds and diverse health-promoting properties. ...The mushroom's capacity to stimulate nerve growth factor (NGF) synthesis has …
Hericium erinaceus, commonly known as lion's mane mushroom, has gained increasing scientific interest due to its rich composition of …
Therapeutic Potential of Hericium erinaceus for Depressive Disorder.
Chong PS, Fung ML, Wong KH, Lim LW. Chong PS, et al. Int J Mol Sci. 2019 Dec 25;21(1):163. doi: 10.3390/ijms21010163. Int J Mol Sci. 2019. PMID: 31881712 Free PMC article. Review.
Depression is a common and severe neuropsychiatric disorder that is one of the leading causes of global disease burden. Although various anti-depressants are currently available, their efficacies are barely adequate and many have side effects. ...It has been used to treat …
Depression is a common and severe neuropsychiatric disorder that is one of the leading causes of global disease burden. Although vari …
Hericium erinaceus: A possible future therapeutic treatment for the prevention and delayed progression of Alzheimer's disease? - A narrative review.
Cornford N, Charnley M. Cornford N, et al. Nutr Res Rev. 2025 Feb 24:1-15. doi: 10.1017/S0954422425000058. Online ahead of print. Nutr Res Rev. 2025. PMID: 39988819 Review.
At present, the treatment of Alzheimer's disease involves only symptomatic medications which have continually demonstrated little efficacy, primarily due to the presence of biological barriers. ...This review systematically investigates evidence pertaining to …
At present, the treatment of Alzheimer's disease involves only symptomatic medications which have continually demonstra …
Hericium coralloides Ameliorates Alzheimer's Disease Pathologies and Cognitive Disorders by Activating Nrf2 Signaling and Regulating Gut Microbiota.
Guan Y, Shi D, Wang S, Sun Y, Song W, Liu S, Wang C. Guan Y, et al. Nutrients. 2023 Aug 30;15(17):3799. doi: 10.3390/nu15173799. Nutrients. 2023. PMID: 37686830 Free PMC article.
Alzheimer's disease (AD) is prone to onset and progression under oxidative stress conditions. Hericium coralloides (HC) is an edible medicinal fungus that contains various nutrients and possesses antioxidant properties. ...
Alzheimer's disease (AD) is prone to onset and progression under oxidative stress conditions. Hericium coralloid …
Hericium erinaceus in Neurodegenerative Diseases: From Bench to Bedside and Beyond, How Far from the Shoreline?
Brandalise F, Roda E, Ratto D, Goppa L, Gargano ML, Cirlincione F, Priori EC, Venuti MT, Pastorelli E, Savino E, Rossi P. Brandalise F, et al. J Fungi (Basel). 2023 May 10;9(5):551. doi: 10.3390/jof9050551. J Fungi (Basel). 2023. PMID: 37233262 Free PMC article. Review.
Among the group of the so-called medicinal mushrooms (MMs), Hericium erinaceus has become one of the most promising candidates. In fact, some of the bioactive compounds extracted from H. erinaceus have been shown to recover, or at least ameliorate, a wide range of patholog …
Among the group of the so-called medicinal mushrooms (MMs), Hericium erinaceus has become one of the most promising candidates. In fa …
Prevention of Early Alzheimer's Disease by Erinacine A-Enriched Hericium erinaceus Mycelia Pilot Double-Blind Placebo-Controlled Study.
Li IC, Chang HH, Lin CH, Chen WP, Lu TH, Lee LY, Chen YW, Chen YP, Chen CC, Lin DP. Li IC, et al. Front Aging Neurosci. 2020 Jun 3;12:155. doi: 10.3389/fnagi.2020.00155. eCollection 2020. Front Aging Neurosci. 2020. PMID: 32581767 Free PMC article.
OBJECTIVE: To investigate the efficacy and safety of three H. erinaceus mycelia (EAHE) capsules (350 mg/capsule; containing 5 mg/g erinacine A active ingredient) per day for the treatment of patients with mild Alzheimer's Disease (AD). METHODS: This study com …
OBJECTIVE: To investigate the efficacy and safety of three H. erinaceus mycelia (EAHE) capsules (350 mg/capsule; containing 5 mg/g erinacine …
Erinacine A-enriched Hericium erinaceus mycelium ameliorates Alzheimer's disease-related pathologies in APPswe/PS1dE9 transgenic mice.
Tsai-Teng T, Chin-Chu C, Li-Ya L, Wan-Ping C, Chung-Kuang L, Chien-Chang S, Chi-Ying HF, Chien-Chih C, Shiao YJ. Tsai-Teng T, et al. J Biomed Sci. 2016 Jun 27;23(1):49. doi: 10.1186/s12929-016-0266-z. J Biomed Sci. 2016. PMID: 27350344 Free PMC article.
BACKGROUND: The fruiting body of Hericium erinaceus has been demonstrated to possess anti-dementia activity in mouse model of Alzheimer's disease and people with mild cognitive impairment. However, the therapeutic potential of Hericium erinaceus …
BACKGROUND: The fruiting body of Hericium erinaceus has been demonstrated to possess anti-dementia activity in mouse model of Alzh …
Structural characterization of Hericium coralloides polysaccharide and its neuroprotective function in Alzheimer's disease.
Guan Y, Wang C, Li L, Dai X, Liu Y, Hsiang T, Liu S, Wang D. Guan Y, et al. Int J Biol Macromol. 2024 Oct;277(Pt 1):133865. doi: 10.1016/j.ijbiomac.2024.133865. Epub 2024 Jul 15. Int J Biol Macromol. 2024. PMID: 39019356
Alzheimer's disease (AD) is a common neurodegenerative disorder. Polysaccharides have been scientifically demonstrated to possess neuroprotective properties. ...The neuroprotective effects of HCP were investigated in an APP/PS1 mouse model of Alzheimer …
Alzheimer's disease (AD) is a common neurodegenerative disorder. Polysaccharides have been scientifically demonstrated …
Neuroprotective Effects of Dehydroepiandrosterone and Hericium erinaceus in Scopolamine-induced Alzheimer's Diseases-like Symptoms in Male Rats.
Shirvani M, Nouri F, Sarihi A, Habibi P, Mohammadi M. Shirvani M, et al. Cell Biochem Biophys. 2024 Sep;82(3):2853-2864. doi: 10.1007/s12013-024-01400-y. Epub 2024 Jul 11. Cell Biochem Biophys. 2024. PMID: 38990419
BACKGROUND: The neuroprotective effects of Dehydroepiandrosterone (DHEA) and Hericium erinaceus (H. erinaceus) mushroom extract against scopolamine-induced Alzheimer's disease-like symptoms in male Wistar rats were investigated. ...CONCLUSION: Interest …
BACKGROUND: The neuroprotective effects of Dehydroepiandrosterone (DHEA) and Hericium erinaceus (H. erinaceus) mushroom extract again …
Key Mechanisms and Potential Implications of Hericium erinaceus in NLRP3 Inflammasome Activation by Reactive Oxygen Species during Alzheimer's Disease.
Cordaro M, Salinaro AT, Siracusa R, D'Amico R, Impellizzeri D, Scuto M, Ontario ML, Cuzzocrea S, Di Paola R, Fusco R, Calabrese V. Cordaro M, et al. Antioxidants (Basel). 2021 Oct 22;10(11):1664. doi: 10.3390/antiox10111664. Antioxidants (Basel). 2021. PMID: 34829535 Free PMC article.
Alzheimer's disease (AD) is the principal cause of dementia, and its incidence increases with age. ...In this study, we evaluated the effects of Hericium erinaceus, a nutritional mushroom with important antioxidant effects, in a rat model of AD. ...
Alzheimer's disease (AD) is the principal cause of dementia, and its incidence increases with age. ...In this study, we …
40 results