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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1966 1
1967 1
1969 3
1971 1
1972 3
1973 3
1974 4
1975 2
1976 4
1977 4
1978 8
1979 2
1980 5
1981 7
1982 13
1983 12
1984 3
1985 8
1986 4
1987 4
1988 4
1989 7
1990 4
1991 7
1992 4
1993 2
1994 2
1995 1
1996 7
1997 8
1998 4
1999 2
2000 8
2001 7
2002 6
2003 1
2004 9
2005 3
2006 10
2007 11
2008 5
2009 4
2010 4
2011 16
2012 11
2013 12
2014 13
2015 8
2016 7
2017 7
2018 7
2019 11
2020 7
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293 results
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Page 1
Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis.
Cohen JA, Barkhof F, Comi G, Hartung HP, Khatri BO, Montalban X, Pelletier J, Capra R, Gallo P, Izquierdo G, Tiel-Wilck K, de Vera A, Jin J, Stites T, Wu S, Aradhye S, Kappos L; TRANSFORMS Study Group. Cohen JA, et al. N Engl J Med. 2010 Feb 4;362(5):402-15. doi: 10.1056/NEJMoa0907839. Epub 2010 Jan 20. N Engl J Med. 2010. PMID: 20089954 Free article. Clinical Trial.
METHODS: In this 12-month, double-blind, double-dummy study, we randomly assigned 1292 patients with relapsing-remitting multiple sclerosis who had a recent history of at least one relapse to receive either oral fingolimod at a daily dose of either 1.25 or 0.5 mg or …
METHODS: In this 12-month, double-blind, double-dummy study, we randomly assigned 1292 patients with relapsing-remitting multiple
Multiple sclerosis treatment with fingolimod: profile of non-cardiologic adverse events.
Fragoso YD. Fragoso YD. Acta Neurol Belg. 2017 Dec;117(4):821-827. doi: 10.1007/s13760-017-0794-7. Epub 2017 May 20. Acta Neurol Belg. 2017. PMID: 28528469 Review.
Fingolimod was the first oral medication approved for management of multiple sclerosis and is currently used by tens of thousands patients worldwide. ...Among these there are infections (herpes simplex, herpes zoster, Cryptococcus, Epstein-Barr …
Fingolimod was the first oral medication approved for management of multiple sclerosis and is currently used by tens of thousa …
Herpes Simplex Virus 1 Induces Brain Inflammation and Multifocal Demyelination in the Cotton Rat Sigmodon hispidus.
Boukhvalova MS, Mortensen E, Mbaye A, Lopez D, Kastrukoff L, Blanco JCG. Boukhvalova MS, et al. J Virol. 2019 Dec 12;94(1):e01161-19. doi: 10.1128/JVI.01161-19. Print 2019 Dec 12. J Virol. 2019. PMID: 31597775 Free PMC article.
Demyelinating central nervous system (CNS) disorders like multiple sclerosis (MS) and acute disseminated encephalomyelitis (ADEM) have been difficult to study and treat due to the lack of understanding of their etiology. Numerous cases point to the link between h
Demyelinating central nervous system (CNS) disorders like multiple sclerosis (MS) and acute disseminated encephalomyelitis (AD …
Herpes simplex virus encephalitis temporally associated with dimethyl fumarate-induced lymphopenia in a multiple sclerosis patient.
Perini P, Rinaldi F, Puthenparampil M, Marcon M, Perini F, Gallo P. Perini P, et al. Mult Scler Relat Disord. 2018 Nov;26:68-70. doi: 10.1016/j.msard.2018.09.009. Epub 2018 Sep 11. Mult Scler Relat Disord. 2018. PMID: 30227312
BACKGROUND: Dimethyl fumarate (DMF) is approved as first line therapy for relapsing-remitting multiple sclerosis (RRMS). In some (3%) patients, DMF induces a marked lymphopenia. Herpes simplex encephalitis (HSE) may occur in lymphopenic subjects under …
BACKGROUND: Dimethyl fumarate (DMF) is approved as first line therapy for relapsing-remitting multiple sclerosis (RRMS). In so …
Trials of antivirals in the treatment of multiple sclerosis.
Lycke J. Lycke J. Acta Neurol Scand. 2017 Nov;136 Suppl 201:45-48. doi: 10.1111/ane.12839. Acta Neurol Scand. 2017. PMID: 29068492 Review.
There is increasing evidence that human herpes viruses and human endogenous retroviruses (HERV) are involved in the aetiology and pathogenesis of multiple sclerosis (MS). ...
There is increasing evidence that human herpes viruses and human endogenous retroviruses (HERV) are involved in the aetiology and pat …
Subacute herpes simplex virus type 1 encephalitis as an initial presentation of chronic lymphocytic leukemia and multiple sclerosis: a case report.
Singhal RL, Corman LC. Singhal RL, et al. J Med Case Rep. 2011 Feb 11;5:59. doi: 10.1186/1752-1947-5-59. J Med Case Rep. 2011. PMID: 21314934 Free PMC article.
INTRODUCTION: Herpes simplex virus type 1 encephalitis presents acutely in patients who are immunocompetent. We report what we believe to be the first published case of a subacute course of herpes simplex virus type 1 encephalitis in a patient with asy …
INTRODUCTION: Herpes simplex virus type 1 encephalitis presents acutely in patients who are immunocompetent. We report what we …
Herpes Virus Reactivation in Astronauts During Spaceflight and Its Application on Earth.
Rooney BV, Crucian BE, Pierson DL, Laudenslager ML, Mehta SK. Rooney BV, et al. Front Microbiol. 2019 Feb 7;10:16. doi: 10.3389/fmicb.2019.00016. eCollection 2019. Front Microbiol. 2019. PMID: 30792698 Free PMC article. Review.
Astronauts shed Epstein-Barr virus (EBV), varicella-zoster virus (VZV), and herpes-simplex-1 (HSV-1) in saliva and cytomegalovirus (CMV) in urine. ...Our spaceflight-developed technologies for saliva collection/rapid viral detection have been extended to include cli …
Astronauts shed Epstein-Barr virus (EBV), varicella-zoster virus (VZV), and herpes-simplex-1 (HSV-1) in saliva and cytomegalov …
Contributions of neurotropic human herpesviruses herpes simplex virus 1 and human herpesvirus 6 to neurodegenerative disease pathology.
Hogestyn JM, Mock DJ, Mayer-Proschel M. Hogestyn JM, et al. Neural Regen Res. 2018 Feb;13(2):211-221. doi: 10.4103/1673-5374.226380. Neural Regen Res. 2018. PMID: 29557362 Free PMC article. Review.
In this review, we discuss the potential mechanisms by which neurotropic HVs contribute to neurodegenerative disease (NDD) pathology by highlighting two prominent members of the HV family, herpes simplex virus 1 (HSV-1) and human herpesvirus 6 (HHV-6). We (i) introd …
In this review, we discuss the potential mechanisms by which neurotropic HVs contribute to neurodegenerative disease (NDD) pathology by high …
Herpes simplex virus types 1 and 2 and multiple sclerosis.
Martin JR. Martin JR. Lancet. 1981 Oct 10;2(8250):777-81. doi: 10.1016/s0140-6736(81)90188-4. Lancet. 1981. PMID: 6116906
A hypothesis is proposed which states that multiple sclerosis (MS) is caused by herpes simplex virus type 2 (HSV-2) in persons lacking herpes simplex virus type 1(HSV-1) immunity. ...
A hypothesis is proposed which states that multiple sclerosis (MS) is caused by herpes simplex virus type 2 (HSV …
Does natalizumab treatment increase the risk of herpes simplex encephalitis in multiple sclerosis? Case and discussion.
Sharma K, Ballham SA, Inglis KE, Renowden S, Cottrell DA. Sharma K, et al. Mult Scler Relat Disord. 2013 Oct;2(4):385-7. doi: 10.1016/j.msard.2013.02.006. Epub 2013 Mar 16. Mult Scler Relat Disord. 2013. PMID: 25877850
This report presents the 4th documented case worldwide of herpes simplex encephalitis in multiple sclerosis (MS) patients treated with natalizumab and the first case in the UK. Natalizumab is licensed for relapsing remitting multiple sclerosi
This report presents the 4th documented case worldwide of herpes simplex encephalitis in multiple sclerosis (MS) …
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