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2017 5
2018 3
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Pathophysiological Role of HERV-W in Schizophrenia.
Aftab A, Shah AA, Hashmi AM. Aftab A, et al. J Neuropsychiatry Clin Neurosci. 2016 Winter;28(1):17-25. doi: 10.1176/appi.neuropsych.15030059. Epub 2015 Sep 25. J Neuropsychiatry Clin Neurosci. 2016. PMID: 26404170 Review.
Studies have identified retroviral nucleotide sequences, envelope and capsid proteins, and elevated transcription of HERV-W elements in CSF, blood, and brain samples from individuals with schizophrenia. ...This review presents a concise synthesis of available …
Studies have identified retroviral nucleotide sequences, envelope and capsid proteins, and elevated transcription of HERV-W el …
Human endogenous retrovirus type W (HERV-W) in schizophrenia: a new avenue of research at the gene-environment interface.
Leboyer M, Tamouza R, Charron D, Faucard R, Perron H. Leboyer M, et al. World J Biol Psychiatry. 2013 Mar;14(2):80-90. doi: 10.3109/15622975.2010.601760. Epub 2011 Sep 22. World J Biol Psychiatry. 2013. PMID: 21936762 Review.
OBJECTIVES: Provide a synthetic review of recent studies evidencing an association between human endogenous retrovirus-W (HERV-W) and schizophrenia. ...A specific type of HERVs, called HERV-W, has through several recent studies been assoc …
OBJECTIVES: Provide a synthetic review of recent studies evidencing an association between human endogenous retrovirus-W (HERV
HERV-W env regulates calcium influx via activating TRPC3 channel together with depressing DISC1 in human neuroblastoma cells.
Chen Y, Yan Q, Zhou P, Li S, Zhu F. Chen Y, et al. J Neurovirol. 2019 Feb;25(1):101-113. doi: 10.1007/s13365-018-0692-7. Epub 2018 Nov 5. J Neurovirol. 2019. PMID: 30397826
The activation and involvement of human endogenous retroviruses W family envelope gene (HERV-W env, also called ERVWE1) have been reported in several neuropsychiatric disorders, including schizophrenia, as well as in multiple sclerosis (MS). ...These f …
The activation and involvement of human endogenous retroviruses W family envelope gene (HERV-W env, also called ERVWE1) …
Activation of elements in HERV-W family by caffeine and aspirin.
Liu C, Chen Y, Li S, Yu H, Zeng J, Wang X, Zhu F. Liu C, et al. Virus Genes. 2013 Oct;47(2):219-27. doi: 10.1007/s11262-013-0939-6. Epub 2013 Jun 28. Virus Genes. 2013. PMID: 23813246
Caffeine and aspirin have been suggested to be involved in neurologic diseases, such as schizophrenia, and previous data have revealed that abnormal expression of HERV-W elements may be an important factor in the etiopathogenesis of those diseases. ...Western …
Caffeine and aspirin have been suggested to be involved in neurologic diseases, such as schizophrenia, and previous data have reveale …
Transcription of human endogenous retroviruses in human brain by RNA-seq analysis.
Li F, Sabunciyan S, Yolken RH, Lee D, Kim S, Karlsson H. Li F, et al. PLoS One. 2019 Jan 3;14(1):e0207353. doi: 10.1371/journal.pone.0207353. eCollection 2019. PLoS One. 2019. PMID: 30605476 Free PMC article.
Increased levels of transcripts from the W and H families of HERV have been observed in association with human diseases, such as multiple sclerosis and schizophrenia. ...Notably, we demonstrated a trend of increased expression of overall HERV, as well …
Increased levels of transcripts from the W and H families of HERV have been observed in association with human diseases, such …
GABBR1 has a HERV-W LTR in its regulatory region--a possible implication for schizophrenia.
Hegyi H. Hegyi H. Biol Direct. 2013 Feb 7;8:5. doi: 10.1186/1745-6150-8-5. Biol Direct. 2013. PMID: 23391219 Free PMC article.
Schizophrenia is a complex disease with uncertain aetiology. We suggest GABBR1, GABA receptor B1 implicated in schizophrenia based on a HERV-W LTR in the regulatory region of GABBR1. Our hypothesis is supported by: (i) GABBR1 is in the 6p22 genomic reg
Schizophrenia is a complex disease with uncertain aetiology. We suggest GABBR1, GABA receptor B1 implicated in schizophrenia b
Human leukemia antigen-A*0201-restricted epitopes of human endogenous retrovirus W family envelope (HERV-W env) induce strong cytotoxic T lymphocyte responses.
Tu X, Li S, Zhao L, Xiao R, Wang X, Zhu F. Tu X, et al. Virol Sin. 2017 Aug;32(4):280-289. doi: 10.1007/s12250-017-3984-9. Epub 2017 Aug 22. Virol Sin. 2017. PMID: 28840564 Free PMC article.
These data demonstrate that human T cells can be sensitized toward HERV-W env peptides (W, Q and T) and, moreover, pose a high killing potential toward HERV-W env-expressing U251 cells. ...Our data strengthen the view that HERV-W e …
These data demonstrate that human T cells can be sensitized toward HERV-W env peptides (W, Q and T) and, moreover, pose …
Molecular characteristics of Human Endogenous Retrovirus type-W in schizophrenia and bipolar disorder.
Perron H, Hamdani N, Faucard R, Lajnef M, Jamain S, Daban-Huard C, Sarrazin S, LeGuen E, Houenou J, Delavest M, Moins-Teisserenc H, Bengoufa D, Yolken R, Madeira A, Garcia-Montojo M, Gehin N, Burgelin I, Ollagnier G, Bernard C, Dumaine A, Henrion A, Gombert A, Le Dudal K, Charron D, Krishnamoorthy R, Tamouza R, Leboyer M. Perron H, et al. Transl Psychiatry. 2012 Dec 4;2(12):e201. doi: 10.1038/tp.2012.125. Transl Psychiatry. 2012. PMID: 23212585 Free PMC article.
The involvement of genetic elements such as Human Endogenous Retroviruses type 'W' family (HERV-W) has consistently been associated with SZ. ...Thus, particular infections would act as activators of HERV-W elements in earliest life, resulting in …
The involvement of genetic elements such as Human Endogenous Retroviruses type 'W' family (HERV-W) has consistently bee …
Elevation of Ser9 phosphorylation of GSK3β is required for HERV-W env-mediated BDNF signaling in human U251 cells.
Qin C, Li S, Yan Q, Wang X, Chen Y, Zhou P, Lu M, Zhu F. Qin C, et al. Neurosci Lett. 2016 Aug 3;627:84-91. doi: 10.1016/j.neulet.2016.05.036. Epub 2016 May 25. Neurosci Lett. 2016. PMID: 27235578
Human endogenous retrovirus W family (HERV-W) envelope (env) is known to be associated with neurological and psychiatric disorders, such as multiple sclerosis and schizophrenia. ...Both BDNF and GSK3β are schizophrenia-related genes. In this pap …
Human endogenous retrovirus W family (HERV-W) envelope (env) is known to be associated with neurological and psychiatri …
Neural Cell Responses Upon Exposure to Human Endogenous Retroviruses.
Gruchot J, Kremer D, Küry P. Gruchot J, et al. Front Genet. 2019 Jul 11;10:655. doi: 10.3389/fgene.2019.00655. eCollection 2019. Front Genet. 2019. PMID: 31354794 Free PMC article. Review.
Subsequent retrotransposition events amplified these sequences, resulting in approximately 8% of the human genome being composed of HERV sequences today. ...Therefore, the main scope of this review is a description of the current knowledge on the involvement of HERV
Subsequent retrotransposition events amplified these sequences, resulting in approximately 8% of the human genome being composed of HERV
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