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2,971 results

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Page 1
The plant heterotrimeric G-protein complex.
Temple BR, Jones AM. Temple BR, et al. Annu Rev Plant Biol. 2007;58:249-66. doi: 10.1146/annurev.arplant.58.032806.103827. Annu Rev Plant Biol. 2007. PMID: 17201690 Review.
Heterotrimeric G-protein complexes couple extracellular signals via cell surface receptors to downstream enzymes called effectors. Heterotrimeric G-protein complexes, together with their cognate receptors and effectors, oper …
Heterotrimeric G-protein complexes couple extracellular signals via cell surface receptors to downstream enzymes …
G Protein-Coupled receptors and heterotrimeric G proteins as cancer drivers.
Arang N, Gutkind JS. Arang N, et al. FEBS Lett. 2020 Dec;594(24):4201-4232. doi: 10.1002/1873-3468.14017. FEBS Lett. 2020. PMID: 33270228 Free PMC article. Review.
G protein-coupled receptors (GPCRs) and heterotrimeric G proteins play central roles in a diverse array of cellular processes. As such, dysregulation of GPCRs and their coupled heterotrimeric G proteins can dramatically alter the signalling landscape a …
G protein-coupled receptors (GPCRs) and heterotrimeric G proteins play central roles in a diverse array of cellular processes. …
Heterotrimeric G Protein alpha-Subunits - Structures, Peptide-Derived Inhibitors, and Mechanisms.
Voss JH, Müller CE. Voss JH, et al. Curr Med Chem. 2022;29(42):6359-6378. doi: 10.2174/0929867329666220308112424. Curr Med Chem. 2022. PMID: 35260051 Review.
The guanine nucleotide-binding Galpha proteins represent the main relays by which GPCRs induce intracellular effects. More than 800 different GPCRs interact with 16 Galpha proteins belonging to 4 families, Galpha(i), Galpha(s), Galpha(q), and Galpha(12/13). The dire …
The guanine nucleotide-binding Galpha proteins represent the main relays by which GPCRs induce intracellular effects. More than 800 d …
Emerging insights into heterotrimeric G protein signaling in plants.
Xu Q, Zhao M, Wu K, Fu X, Liu Q. Xu Q, et al. J Genet Genomics. 2016 Aug 20;43(8):495-502. doi: 10.1016/j.jgg.2016.06.004. Epub 2016 Jul 6. J Genet Genomics. 2016. PMID: 27520410 Review.
In plants, the repertoire of the heterotrimeric G protein complex, which is composed of the Galpha, Gbeta, and Ggamma subunits, is much simpler than that in metazoans, and the identity of typical G protein-coupled receptors (GPCRs) together with their …
In plants, the repertoire of the heterotrimeric G protein complex, which is composed of the Galpha, Gbeta, and G …
Signal transduction by plant heterotrimeric G-protein.
Ofoe R. Ofoe R. Plant Biol (Stuttg). 2021 Jan;23(1):3-10. doi: 10.1111/plb.13172. Epub 2020 Oct 5. Plant Biol (Stuttg). 2021. PMID: 32803877 Review.
Heterotrimeric G-proteins are complexes that regulate important signalling pathways essential for growth and development in both plants and animals. Although plant cells are composed of the core components (Galpha, Gbeta and Ggamma subunits) found in animal G …
Heterotrimeric G-proteins are complexes that regulate important signalling pathways essential for growth and developmen …
Promiscuous G-protein activation by the calcium-sensing receptor.
Zuo H, Park J, Frangaj A, Ye J, Lu G, Manning JJ, Asher WB, Lu Z, Hu GB, Wang L, Mendez J, Eng E, Zhang Z, Lin X, Grassucci R, Hendrickson WA, Clarke OB, Javitch JA, Conigrave AD, Fan QR. Zuo H, et al. Nature. 2024 May;629(8011):481-488. doi: 10.1038/s41586-024-07331-1. Epub 2024 Apr 17. Nature. 2024. PMID: 38632411 Free PMC article.
The functional pleiotropy of CaSR arises in part from its ability to signal through several G-protein subtypes(6). We determined structures of CaSR in complex with G proteins from three different subfamilies: G(q), G(i) and G(s). We found that the homodimeric CaSR o …
The functional pleiotropy of CaSR arises in part from its ability to signal through several G-protein subtypes(6). We determined structures …
Mapping the conformational landscape of the stimulatory heterotrimeric G protein.
Huang SK, Picard LP, Rahmatullah RSM, Pandey A, Van Eps N, Sunahara RK, Ernst OP, Sljoka A, Prosser RS. Huang SK, et al. Nat Struct Mol Biol. 2023 Apr;30(4):502-511. doi: 10.1038/s41594-023-00957-1. Epub 2023 Mar 30. Nat Struct Mol Biol. 2023. PMID: 36997760
Heterotrimeric G proteins serve as membrane-associated signaling hubs, in concert with their cognate G-protein-coupled receptors. Fluorine nuclear magnetic resonance spectroscopy was employed to monitor the conformational equilibria of the human stimulatory G-protei …
Heterotrimeric G proteins serve as membrane-associated signaling hubs, in concert with their cognate G-protein-coupled recepto …
Heterotrimeric G-Protein-Dependent Proteome and Phosphoproteome in Unstimulated Arabidopsis Roots.
Song G, Brachova L, Nikolau BJ, Jones AM, Walley JW. Song G, et al. Proteomics. 2018 Dec;18(24):e1800323. doi: 10.1002/pmic.201800323. Proteomics. 2018. PMID: 30407730 Free PMC article.
De-repression appears to involve specific phosphorylation of key elements of the G-protein complex and possibly target proteins that are positioned downstream of this complex. To address this possibility, protein abundance and phosphorylation state are quanti …
De-repression appears to involve specific phosphorylation of key elements of the G-protein complex and possibly target proteins …
Heterotrimeric G protein activation by G-protein-coupled receptors.
Oldham WM, Hamm HE. Oldham WM, et al. Nat Rev Mol Cell Biol. 2008 Jan;9(1):60-71. doi: 10.1038/nrm2299. Nat Rev Mol Cell Biol. 2008. PMID: 18043707 Review.
Heterotrimeric G proteins have a crucial role as molecular switches in signal transduction pathways mediated by G-protein-coupled receptors. Extracellular stimuli activate these receptors, which then catalyse GTP-GDP exchange on the G protein alpha-subunit. The c …
Heterotrimeric G proteins have a crucial role as molecular switches in signal transduction pathways mediated by G-protein-coup …
Plant Morphology of Heterotrimeric G Protein Mutants.
Urano D, Miura K, Wu Q, Iwasaki Y, Jackson D, Jones AM. Urano D, et al. Plant Cell Physiol. 2016 Mar;57(3):437-45. doi: 10.1093/pcp/pcw002. Epub 2016 Jan 10. Plant Cell Physiol. 2016. PMID: 26755691 Free PMC article. Review.
The heterotrimeric G protein complex, comprising Galpha, Ggamma and Ggamma subunits, is an evolutionarily conserved signaling molecular machine that transmits signals from transmembrane receptors to downstream target proteins. ...Genetic evidenc …
The heterotrimeric G protein complex, comprising Galpha, Ggamma and Ggamma subunits, is an evolutionarily conser …
2,971 results