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Year Number of Results
1926 1
1964 4
1965 3
1966 4
1967 6
1968 10
1969 11
1970 15
1971 31
1972 36
1973 32
1974 22
1975 82
1976 84
1977 62
1978 64
1979 78
1980 73
1981 78
1982 79
1983 103
1984 97
1985 119
1986 156
1987 160
1988 138
1989 176
1990 190
1991 184
1992 159
1993 147
1994 144
1995 119
1996 134
1997 129
1998 106
1999 96
2000 97
2001 76
2002 79
2003 78
2004 75
2005 93
2006 83
2007 81
2008 83
2009 87
2010 74
2011 75
2012 72
2013 67
2014 64
2015 77
2016 73
2017 70
2018 69
2019 58
2020 86
2021 15
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4,617 results
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Page 1
Growth hormone.
Bidlingmaier M, Strasburger CJ. Bidlingmaier M, et al. Handb Exp Pharmacol. 2010;(195):187-200. doi: 10.1007/978-3-540-79088-4_8. Handb Exp Pharmacol. 2010. PMID: 20020365 Review.
Human growth hormone (hGH) is a proteohormone secreted by the pituitary gland. It acts through binding to the hGH receptor, inducing either direct effects or initiating the production of insulin-like growth-factor I (IGF-I), the most important mediator of hGH
Human growth hormone (hGH) is a proteohormone secreted by the pituitary gland. It acts through binding to the hGH receptor, in …
Autocrine hGH stimulates oncogenicity, epithelial-mesenchymal transition and cancer stem cell-like behavior in human colorectal carcinoma.
Wang JJ, Chong QY, Sun XB, You ML, Pandey V, Chen YJ, Zhuang QS, Liu DX, Ma L, Wu ZS, Zhu T, Lobie PE. Wang JJ, et al. Oncotarget. 2017 Oct 10;8(61):103900-103918. doi: 10.18632/oncotarget.21812. eCollection 2017 Nov 28. Oncotarget. 2017. PMID: 29262609 Free PMC article.
Herein, we demonstrated a crucial oncogenic role of autocrine hGH in CRC progression. Elevated hGH expression was detected in CRC compared to normal colorectal tissue, and hGH expression in CRC was positively associated with tumor size and lymph node metastas …
Herein, we demonstrated a crucial oncogenic role of autocrine hGH in CRC progression. Elevated hGH expression was detected in …
[hGH and molecular biology].
Goossens M. Goossens M. Ann Endocrinol (Paris). 1986;47(5):363-71. Ann Endocrinol (Paris). 1986. PMID: 3548571 Review. French.
This review summarizes the progress recently made through the approaches provided by DNA recombinant technology in the knowledge of the human growth hormone (hGH) gene and of the molecular basis of hGH deficiencies. The growth hormone gene is part of a family of fiv …
This review summarizes the progress recently made through the approaches provided by DNA recombinant technology in the knowledge of the huma …
Chemical and Enzymatic Site Specific PEGylation of hGH: The Stability and in vivo Activity of PEG-N-Terminal-hGH and PEG-Gln141-hGH Conjugates.
Grigoletto A, Mero A, Zanusso I, Schiavon O, Pasut G. Grigoletto A, et al. Macromol Biosci. 2016 Jan;16(1):50-6. doi: 10.1002/mabi.201500282. Epub 2015 Sep 9. Macromol Biosci. 2016. PMID: 26350165
The biophysical characterization of two site-specific mono-PEGylated forms of human growth hormone (hGH)--chemically N-terminal PEGylated hGH (PEG-Nter-hGH) and enzymatically Gln141 PEGylated hGH (PEG-Gln141-hGH) via transglutaminase--is outline …
The biophysical characterization of two site-specific mono-PEGylated forms of human growth hormone (hGH)--chemically N-terminal PEGyl …
The 20-kilodalton (kDa) human growth hormone (hGH) differs from the 22-kDa hGH in the complex formation with cell surface hGH receptor and hGH-binding protein circulating in human plasma.
Wada M, Uchida H, Ikeda M, Tsunekawa B, Naito N, Banba S, Tanaka E, Hashimoto Y, Honjo M. Wada M, et al. Mol Endocrinol. 1998 Jan;12(1):146-56. doi: 10.1210/mend.12.1.0054. Mol Endocrinol. 1998. PMID: 9440818
In spite of recent advance in understanding of the stoichiometry of 22-kDa human GH (22K-hGH) with cell surface hGH receptor (hGHR) and hGH-binding protein (hGH-BP) circulating in human plasma, that of 20-kDa hGH (20K-hGH) is poorly under …
In spite of recent advance in understanding of the stoichiometry of 22-kDa human GH (22K-hGH) with cell surface hGH receptor ( …
Chemical and enzymatic site specific PEGylation of hGH.
da Silva Freitas D, Mero A, Pasut G. da Silva Freitas D, et al. Bioconjug Chem. 2013 Mar 20;24(3):456-63. doi: 10.1021/bc300594y. Epub 2013 Mar 4. Bioconjug Chem. 2013. PMID: 23432141
Circular dichroism studies showed that both conjugation strategies preserved the native-like secondary structures of hGH. It is vital to maintain the structural integrity of hGH if PEGylated hGH is to be used in therapeutic applications. As expected, the phar …
Circular dichroism studies showed that both conjugation strategies preserved the native-like secondary structures of hGH. It is vital …
Autocrine proliferative effects of hGH are maintained in primary cultures of human mammary carcinoma cells.
Chiesa J, Ferrer C, Arnould C, Vouyovitch CM, Diaz JJ, Gonzalez S, Mares P, Morel G, Wu ZS, Zhu T, Lobie PE, Mertani HC. Chiesa J, et al. J Clin Endocrinol Metab. 2011 Sep;96(9):E1418-26. doi: 10.1210/jc.2011-0473. Epub 2011 Jul 6. J Clin Endocrinol Metab. 2011. PMID: 21733992
RESULTS: One hundred percent of cultured primary HMCC expressed the hGH receptor, and 52% expressed hGH at the mRNA level. hGH-positive primary HMCC produced hGH protein within the cell and secreted hGH to the media. Both hGH-negative and …
RESULTS: One hundred percent of cultured primary HMCC expressed the hGH receptor, and 52% expressed hGH at the mRNA level. …
Evaluation of the bioefficacy of a stabilized form of human growth hormone (SP-hGH).
Lee SB, Park H, Koh J, Lee H, Kim J. Lee SB, et al. Horm Metab Res. 2013 Sep;45(10):722-7. doi: 10.1055/s-0033-1345126. Epub 2013 May 16. Horm Metab Res. 2013. PMID: 23681752
In this study, we evaluated the bioefficacy of hGH and SP-hGH in vivo using a mouse model. Subcutaneous injections of 30 mug of hGH or SP-hGH were administered to 8-month-old female mice, twice a week for 14 weeks. ...IGF-1 levels in the liver were inc …
In this study, we evaluated the bioefficacy of hGH and SP-hGH in vivo using a mouse model. Subcutaneous injections of 30 mug o …
Plasma concentration of hGH and anti-hGH antibodies after subcutaneous administration of hGH for 3 weeks to immunosuppressed pigs.
Agersø H, Wilken M, Drustrup J, Haahr PM, Jørgensen KD. Agersø H, et al. J Pharmacol Toxicol Methods. 1999 Feb;41(1):1-8. doi: 10.1016/s1056-8719(99)00017-9. J Pharmacol Toxicol Methods. 1999. PMID: 10507752
In the control group and group 2 the pharmacokinetic parameters of hGH were influenced by the formation of anti-hGH antibodies. In groups 3 and 4, the pharmacokinetic parameters were comparable on the first and the last day of dosing. CONCLUSION: The formation of an …
In the control group and group 2 the pharmacokinetic parameters of hGH were influenced by the formation of anti-hGH antibodies …
Application of Analyte Harvesting Nanoparticle Technology to the Measurement of Urinary HGH in Healthy Individuals.
Luchini A, Tamburro D, Magni R, Fredolini C, Espina V, Bosch J, Garaci E, Petricoin EF 3rd, Liotta LA. Luchini A, et al. J Sports Med Doping Stud. 2012;2(6):e127. doi: 10.4172/2161-0673.1000e127. J Sports Med Doping Stud. 2012. PMID: 24014257 Free PMC article.
Urine represents a valuable biofluid for noninvasive measurement of Human Growth Hormone (HGH) secretion. Unfortunately, currently available commercial HGH immunoassays do not achieve the sensitivity needed for urinary HGH measurement in the low picogram per …
Urine represents a valuable biofluid for noninvasive measurement of Human Growth Hormone (HGH) secretion. Unfortunately, currently av …
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