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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1907 1
1911 1
1913 1
1914 5
1915 1
1927 3
1946 2
1948 1
1950 4
1951 3
1952 2
1953 6
1956 2
1957 4
1958 5
1959 4
1960 6
1961 4
1962 4
1963 6
1964 9
1965 6
1966 8
1967 14
1968 8
1969 14
1970 10
1971 5
1972 8
1973 10
1974 8
1975 13
1976 13
1977 8
1978 10
1979 15
1980 21
1981 13
1982 18
1983 22
1984 17
1985 27
1986 45
1987 33
1988 64
1989 64
1990 90
1991 185
1992 127
1993 135
1994 145
1995 194
1996 197
1997 161
1998 170
1999 179
2000 179
2001 165
2002 166
2003 160
2004 171
2005 148
2006 156
2007 151
2008 155
2009 146
2010 157
2011 150
2012 149
2013 144
2014 135
2015 147
2016 118
2017 126
2018 95
2019 98
2020 104
2021 96
2022 83
2023 84
2024 94
2025 73
2026 22

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5,259 results

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Page 1
Hirudin variants production by genetic engineered microbial factory.
Zhang J, Lan N. Zhang J, et al. Biotechnol Genet Eng Rev. 2018 Oct;34(2):261-280. doi: 10.1080/02648725.2018.1506898. Epub 2018 Aug 10. Biotechnol Genet Eng Rev. 2018. PMID: 30095033 Review.
Hirudin was discovered as an active anticoagulant in leech extracts almost 60 years ago. ...Some hirudin variants have been approved for clinical use and released into the marketplace. ...
Hirudin was discovered as an active anticoagulant in leech extracts almost 60 years ago. ...Some hirudin variants have been ap …
Hirudin in heparin-induced thrombocytopenia.
Lubenow N, Greinacher A. Lubenow N, et al. Semin Thromb Hemost. 2002 Oct;28(5):431-8. doi: 10.1055/s-2002-35283. Semin Thromb Hemost. 2002. PMID: 12420238 Review.
Heparin-induced thrombocytopenia (HIT), a serious side effect of heparin treatment, requires alternative anticoagulation in most affected patients. The recombinant hirudin (r-hirudin) lepirudin has been approved for this purpose after two prospective trials in labor …
Heparin-induced thrombocytopenia (HIT), a serious side effect of heparin treatment, requires alternative anticoagulation in most affected pa …
Hirudin ameliorates diabetic nephropathy by inhibiting Gsdmd-mediated pyroptosis.
Han J, Zuo Z, Shi X, Zhang Y, Peng Z, Xing Y, Pang X. Han J, et al. Cell Biol Toxicol. 2023 Jun;39(3):573-589. doi: 10.1007/s10565-021-09622-z. Epub 2021 Jul 2. Cell Biol Toxicol. 2023. PMID: 34212273
Hirudin ameliorated Gsdmd-mediated pyroptosis by inhibiting irf2, leading to the improvement of kidney injury. Therefore, hirudin might serve as a potential therapeutic strategy to treat DN....
Hirudin ameliorated Gsdmd-mediated pyroptosis by inhibiting irf2, leading to the improvement of kidney injury. Therefore, hirudin …
Hirudin as alternative anticoagulant--a historical review.
Markwardt F. Markwardt F. Semin Thromb Hemost. 2002 Oct;28(5):405-14. doi: 10.1055/s-2002-35292. Semin Thromb Hemost. 2002. PMID: 12420235 Review.
The search for the development of hirudin from leech extract to genetically engineered products as an alternative anticoagulant has been resumed. ...The progress in molecular biology has stimulated the interest in the structure and function of hirudin. This developm …
The search for the development of hirudin from leech extract to genetically engineered products as an alternative anticoagulant has b …
Hirudin: the famous anticoagulant agent.
Markwardt F. Markwardt F. Adv Exp Med Biol. 1993;340:191-211. doi: 10.1007/978-1-4899-2418-6_18. Adv Exp Med Biol. 1993. PMID: 8154337 Review. No abstract available.
Hirudin in renal insufficiency.
Fischer KG. Fischer KG. Semin Thromb Hemost. 2002 Oct;28(5):467-82. doi: 10.1055/s-2002-35288. Semin Thromb Hemost. 2002. PMID: 12420243 Review.
R-hirudins are almost exclusively eliminated by the kidneys, and a close correlation between r-hirudin clearance and endogenous creatinine clearance has been observed. ...High-volume hemofiltration with r-hirudin-permeable hemodialyzers constitutes a valuable …
R-hirudins are almost exclusively eliminated by the kidneys, and a close correlation between r-hirudin clearance and endogenou …
Hirudin for diagnostic purposes.
Stocker K. Stocker K. Haemostasis. 1991;21 Suppl 1:161-7. doi: 10.1159/000216279. Haemostasis. 1991. PMID: 1894191 Review.
Hirudin serves as a versatile tool for the control of thrombin activity in hemostaseology. ...Unlike heparin-antithrombin III complex which exclusively inhibits alpha-and gamma-thrombin, hirudin also inhibits meizothrombin, a precursor of alpha-thrombin. Thus, hi …
Hirudin serves as a versatile tool for the control of thrombin activity in hemostaseology. ...Unlike heparin-antithrombin III complex …
Hirudin enhances perforator flap survival: Clinical application report and mechanistic exploration.
Wei D, Lyu J, Wang B, He Y, Bi L. Wei D, et al. J Stomatol Oral Maxillofac Surg. 2024 Jun;125(3S):101868. doi: 10.1016/j.jormas.2024.101868. Epub 2024 Apr 6. J Stomatol Oral Maxillofac Surg. 2024. PMID: 38588856 Free article.
BACKGROUND AND PURPOSE: Hirudin, a potent anticoagulant, is used in traditional Chinese medicine (TCM) to treat thrombotic conditions and prevent postoperative thrombosis. Coagulation-related vascular complications are a common cause of perforator flaps failure. This study …
BACKGROUND AND PURPOSE: Hirudin, a potent anticoagulant, is used in traditional Chinese medicine (TCM) to treat thrombotic conditions …
The direct thrombin inhibitor hirudin.
Greinacher A, Warkentin TE. Greinacher A, et al. Thromb Haemost. 2008 May;99(5):819-29. doi: 10.1160/TH07-11-0693. Thromb Haemost. 2008. PMID: 18449411 Review.
This review discusses the pharmacology and clinical applications of hirudin, a bivalent direct thrombin inhibitor (DTI). Besides the current major indication for hirudin--anticoagulation of patients with heparin-induced thrombocytopenia (HIT)--the experience with …
This review discusses the pharmacology and clinical applications of hirudin, a bivalent direct thrombin inhibitor (DTI). Besides the …
Recombinant hirudin: genetic engineering and structure analysis.
Märki WE, Grossenbacher H, Grütter MG, Liersch MH, Meyhack B, Heim J. Märki WE, et al. Semin Thromb Hemost. 1991 Apr;17(2):88-93. doi: 10.1055/s-2007-1002594. Semin Thromb Hemost. 1991. PMID: 1771417 Review. No abstract available.
5,259 results