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62,960 results

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Page 1
Histidine-lysine peptides as carriers of nucleic acids.
Leng Q, Goldgeier L, Zhu J, Cambell P, Ambulos N, Mixson AJ. Leng Q, et al. Drug News Perspect. 2007 Mar;20(2):77-86. doi: 10.1358/dnp.2007.20.2.1083026. Drug News Perspect. 2007. PMID: 17440630 Free article. Review.
This review will focus on the sequence and branching patterns of peptide carriers composed primarily of histidines and lysines. While lysines within peptides are important for binding to the negatively charged phosphates, histidines are critical for endosomal lysis …
This review will focus on the sequence and branching patterns of peptide carriers composed primarily of histidines and lysines. While …
Histidine Protonation and Conformational Switching in Diphtheria Toxin Translocation Domain.
Rodnin MV, Vasques-Montes V, Kyrychenko A, Oliveira NFB, Kashipathy MM, Battaile KP, Douglas J, Lovell S, Machuqueiro M, Ladokhin AS. Rodnin MV, et al. Toxins (Basel). 2023 Jun 25;15(7):410. doi: 10.3390/toxins15070410. Toxins (Basel). 2023. PMID: 37505680 Free PMC article.
Here, for the first time, we report the pK(a) values of the histidine residues of the T-domain, measured by NMR-monitored pH titrations. Most peaks in the histidine side chain spectral region are titrated with pK(a)s ranging from 6.2 to 6.8. ...Taken together, our e …
Here, for the first time, we report the pK(a) values of the histidine residues of the T-domain, measured by NMR-monitored pH titratio …
Reversible phosphorylation of histidine residues in proteins from vertebrates.
Klumpp S, Krieglstein J. Klumpp S, et al. Sci Signal. 2009 Mar 10;2(61):pe13. doi: 10.1126/scisignal.261pe13. Sci Signal. 2009. PMID: 19278958 Review.
We are just beginning to appreciate that such signaling mechanisms are extended and enriched by the reversible phosphorylation of histidine residues. The most exciting developments in this field to date come from studies on the beta subunit of heterotrimeric guanosine trip …
We are just beginning to appreciate that such signaling mechanisms are extended and enriched by the reversible phosphorylation of histidi …
Histidine, the less interactive cousin of arginine.
Muller L, Jackson SN, Woods AS. Muller L, et al. Eur J Mass Spectrom (Chichester). 2019 Apr;25(2):212-218. doi: 10.1177/1469066718791793. Eur J Mass Spectrom (Chichester). 2019. PMID: 31018697 Free PMC article.
We show that adjacent histidines can also form stable noncovalent bonds and that those bonds are probably formed by a salt bridge between the phosphate or the acid residues and the histidines. However, noncovalent complexes with the arginine epitopes form more readi …
We show that adjacent histidines can also form stable noncovalent bonds and that those bonds are probably formed by a salt bridge bet …
[N-IM-2, 4-DINITROPHENYL-L-HISTIDINE].
SIEPMANN E, ZAHN H. SIEPMANN E, et al. Biochim Biophys Acta. 1964 Feb 10;82:412-5. Biochim Biophys Acta. 1964. PMID: 14123579 German. No abstract available.
Proton Transfer Kinetics in Histidine Side Chains Determined by pH-Dependent Multi-Nuclear NMR Relaxation.
Raum HN, Modig K, Akke M, Weininger U. Raum HN, et al. J Am Chem Soc. 2024 Aug 14;146(32):22284-22294. doi: 10.1021/jacs.4c04647. Epub 2024 Aug 5. J Am Chem Soc. 2024. PMID: 39103163 Free PMC article.
Commonly, two or all three states coexist and interchange rapidly, enabling histidine to act as both donor and acceptor of hydrogen bonds, coordinate metal ions, and engage in acid/base catalysis. ...Our approach should enable critical insights into enzymatic acid/base cat …
Commonly, two or all three states coexist and interchange rapidly, enabling histidine to act as both donor and acceptor of hydrogen b …
Interaction of a Histidine-Rich Antimicrobial Saliva Peptide with Model Cell Membranes: The Role of Histidines.
Skog AE, Corucci G, Tully MD, Fragneto G, Gerelli Y, Skepö M. Skog AE, et al. Langmuir. 2023 Jun 6;39(22):7694-7706. doi: 10.1021/acs.langmuir.3c00498. Epub 2023 May 25. Langmuir. 2023. PMID: 37227075 Free PMC article.
Histatin 5 is a histidine-rich, intrinsically disordered, multifunctional saliva protein known to act as a first line of defense against oral candidiasis caused by Candida albicans. ...However, it was shown to affect the penetration depth of the peptide into the bilayer, w …
Histatin 5 is a histidine-rich, intrinsically disordered, multifunctional saliva protein known to act as a first line of defense agai …
HrgS (Avin_34990), a novel histidine-kinase related to GacS, regulates alginate synthesis in Azotobacter vinelandii.
López-Pliego L, González-Acocal V, García-González DL, Reyes-Nicolau JI, Sánchez-Cuapio Z, Meneses-Carbajal AS, Fuentes-Ramírez LE, Castañeda M. López-Pliego L, et al. FEMS Microbiol Lett. 2022 Feb 24;369(1):fnac024. doi: 10.1093/femsle/fnac024. FEMS Microbiol Lett. 2022. PMID: 35266527 Free article.
In Pseudomonas aeruginosa, GacS/GacA is influenced by other histidine-kinases constituting a multicomponent signal transduction system. In this study, we explore the presence of GacS-related histidine-kinases in A. vinelandii and discover a novel histidine-ki …
In Pseudomonas aeruginosa, GacS/GacA is influenced by other histidine-kinases constituting a multicomponent signal transduction syste …
Improved Structure-Based Histidine pK(a) Prediction for pH-Responsive Protein Design.
Hogues H, Wei W, Sulea T. Hogues H, et al. J Chem Inf Model. 2025 Feb 10;65(3):1560-1569. doi: 10.1021/acs.jcim.4c01957. Epub 2025 Jan 18. J Chem Inf Model. 2025. PMID: 39826152 Free PMC article.
The near neutral pK(a) of histidine is commonly exploited to engineer pH-sensitive biomolecules. For example, histidine mutations introduced in the complementarity-determining region (CDR) of therapeutic antibodies can enhance selectivity for antigens in the acidic …
The near neutral pK(a) of histidine is commonly exploited to engineer pH-sensitive biomolecules. For example, histidine mutati …
Iodide enhances degradation of histidine sidechain and imidazoles and forms new iodinated aromatic disinfection byproducts during chlorination.
Choi SY, Ji H, Park J, Choe JK. Choi SY, et al. J Hazard Mater. 2024 Aug 5;474:134748. doi: 10.1016/j.jhazmat.2024.134748. Epub 2024 May 27. J Hazard Mater. 2024. PMID: 38815391
Previous studies suggested that histidine has low reactivity with chlorine only; this study indicates that iodide substantially enhances histidine reactivity with the disinfectant at a time scale from days to hours. Mono- and di-iodinated histidines were iden …
Previous studies suggested that histidine has low reactivity with chlorine only; this study indicates that iodide substantially enhan …
62,960 results
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