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Protective Effect of Ergothioneine Against Stroke in Rodent Models.
Ong WY, Kao MH, Cheung WM, Leow DM, Cheah IK, Lin TN. Ong WY, et al. Neuromolecular Med. 2023 Jun;25(2):205-216. doi: 10.1007/s12017-022-08727-w. Epub 2022 Oct 19. Neuromolecular Med. 2023. PMID: 36261765
Recent studies have shown a beneficial effect of ET on neurological functions, including cognition and animal models of depression. The aim of this study is to elucidate a possible effect of ET in rodent models of stroke. ...Together, results of this study indicate …
Recent studies have shown a beneficial effect of ET on neurological functions, including cognition and animal models of depres …
The Potential of Carnosine in Brain-Related Disorders: A Comprehensive Review of Current Evidence.
Schön M, Mousa A, Berk M, Chia WL, Ukropec J, Majid A, Ukropcová B, de Courten B. Schön M, et al. Nutrients. 2019 May 28;11(6):1196. doi: 10.3390/nu11061196. Nutrients. 2019. PMID: 31141890 Free PMC article. Review.
Neurological, neurodegenerative, and psychiatric disorders represent a serious burden because of their increasing prevalence, risk of disability, and the lack of effective causal/disease-modifying treatments. ...Although most studies to date have focused on the role of car …
Neurological, neurodegenerative, and psychiatric disorders represent a serious burden because of their increasing prevalence, risk of …
Histidine provides long-term neuroprotection after cerebral ischemia through promoting astrocyte migration.
Liao RJ, Jiang L, Wang RR, Zhao HW, Chen Y, Li Y, Wang L, Jie LY, Zhou YD, Zhang XN, Chen Z, Hu WW. Liao RJ, et al. Sci Rep. 2015 Oct 20;5:15356. doi: 10.1038/srep15356. Sci Rep. 2015. PMID: 26481857 Free PMC article.
With various administration regimens constructed for histidine, a precursor of histamine, we found that histidine treatment at a high dose at early stage and a low dose at late stage demonstrated the most remarkable long-term neuroprotection with decreased infarct v …
With various administration regimens constructed for histidine, a precursor of histamine, we found that histidine treatment at …
Identification of altered brain metabolites associated with TNAP activity in a mouse model of hypophosphatasia using untargeted NMR-based metabolomics analysis.
Cruz T, Gleizes M, Balayssac S, Mornet E, Marsal G, Millán JL, Malet-Martino M, Nowak LG, Gilard V, Fonta C. Cruz T, et al. J Neurochem. 2017 Mar;140(6):919-940. doi: 10.1111/jnc.13950. J Neurochem. 2017. PMID: 28072448 Free PMC article.
Tissue non-specific alkaline phosphatase (TNAP) is a key player of bone mineralization and TNAP gene (ALPL) mutations in human are responsible for hypophosphatasia (HPP), a rare heritable disease affecting the mineralization of bones and teeth. Moreover, TNAP is also expressed by …
Tissue non-specific alkaline phosphatase (TNAP) is a key player of bone mineralization and TNAP gene (ALPL) mutations in human are responsib …
Metabolic Remodeling of the Parkinson's Disease Frontal Cortex Revealed by LC-MS/MS Metabolomics.
Daramola O, Nwaiwu J, Oluokun O, Fowowe M, Lux A, Lopez I, Bennett AI, Mechref Y. Daramola O, et al. Biomolecules. 2026 Jun 12;16(6):866. doi: 10.3390/biom16060866. Biomolecules. 2026. PMID: 42352332 Free PMC article.
While metabolomics studies in PD have largely focused on peripheral biofluids or subcortical brain regions, metabolic remodeling within cortical regions critical for cognition remains poorly characterized. Here, we applied LC-MS/MS-based untargeted metabolomics to p …
While metabolomics studies in PD have largely focused on peripheral biofluids or subcortical brain regions, metabolic remodeling with …
Synthesis of CNS active thyrotropin-releasing hormone (TRH)-like peptides: Biological evaluation and effect on cognitive impairment induced by cerebral ischemia in mice.
Meena CL, Thakur A, Nandekar PP, Sangamwar AT, Sharma SS, Jain R. Meena CL, et al. Bioorg Med Chem. 2015 Sep 1;23(17):5641-53. doi: 10.1016/j.bmc.2015.07.022. Epub 2015 Jul 17. Bioorg Med Chem. 2015. PMID: 26216015
Thyrotropin-releasing hormone (TRH)-like peptides were synthesized by replacing critical histidine and pGlu residues in the native peptide. The peptides were evaluated in vitro for receptor binding activity assay and in the cell functional assay; the peptides exhibit selec …
Thyrotropin-releasing hormone (TRH)-like peptides were synthesized by replacing critical histidine and pGlu residues in the native pe …