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1953 1
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1965 4
1966 9
1967 12
1968 16
1969 24
1970 27
1971 49
1972 81
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1974 117
1975 136
1976 142
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1978 166
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1980 129
1981 107
1982 119
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1988 165
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1998 617
1999 645
2000 809
2001 1054
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2003 1267
2004 1370
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2006 1438
2007 1584
2008 1629
2009 1803
2010 1897
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2012 2285
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2014 2366
2015 2315
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50,345 results

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Page 1
Non-histone binding functions of PHD fingers.
Gaurav N, Kutateladze TG. Gaurav N, et al. Trends Biochem Sci. 2023 Jul;48(7):610-617. doi: 10.1016/j.tibs.2023.03.005. Epub 2023 Apr 14. Trends Biochem Sci. 2023. PMID: 37061424 Free PMC article. Review.
Plant homeodomain (PHD) fingers comprise a large and well-established family of epigenetic readers that recognize histone H3. A typical PHD finger binds to the unmodified or methylated amino-terminal tail of H3. ...However, a set of PHD fingers has recently been sho …
Plant homeodomain (PHD) fingers comprise a large and well-established family of epigenetic readers that recognize histone H3. A typic …
KAT2A coupled with the alpha-KGDH complex acts as a histone H3 succinyltransferase.
Wang Y, Guo YR, Liu K, Yin Z, Liu R, Xia Y, Tan L, Yang P, Lee JH, Li XJ, Hawke D, Zheng Y, Qian X, Lyu J, He J, Xing D, Tao YJ, Lu Z. Wang Y, et al. Nature. 2017 Dec 14;552(7684):273-277. doi: 10.1038/nature25003. Epub 2017 Dec 6. Nature. 2017. PMID: 29211711 Free PMC article.
However, the mechanism and functional consequences of histone succinylation are unknown. Here we show that the alpha-ketoglutarate dehydrogenase (alpha-KGDH) complex is localized in the nucleus in human cell lines and binds to lysine acetyltransferase 2A (KAT2A, als …
However, the mechanism and functional consequences of histone succinylation are unknown. Here we show that the alpha-ketoglutarate de …
Competitive binding studies of the nucleosomal histone targeting drug, [Ru(eta(6)-p-cymene)Cl(2)(pta)] (RAPTA-C), with oligonucleotide-peptide mixtures.
Mansouri F, Ortiz D, Dyson PJ. Mansouri F, et al. J Inorg Biochem. 2023 Jan;238:112043. doi: 10.1016/j.jinorgbio.2022.112043. Epub 2022 Nov 1. J Inorg Biochem. 2023. PMID: 36370502 Free article.
Protein crystallography and biochemical assays reveal that the organometallic drug, [Ru(eta(6)-p-cymene)Cl(2)(pta)] (RAPTA-C), preferentially binds to nucleosomal histone proteins in chromatin. To better understand the binding mechanism we report here a mass …
Protein crystallography and biochemical assays reveal that the organometallic drug, [Ru(eta(6)-p-cymene)Cl(2)(pta)] (RAPTA-C), preferentiall …
Binding of heterochromatin protein Rhino to a subset of piRNA clusters depends on a combination of two histone marks.
Akkouche A, Kneuss E, Bornelöv S, Renaud Y, Eastwood EL, van Lopik J, Gueguen N, Jiang M, Creixell P, Maupetit-Mehouas S, Sobieszek A, Gui Y, Czech Nicholson B, Brasset E, Hannon GJ. Akkouche A, et al. Nat Struct Mol Biol. 2025 Aug;32(8):1517-1527. doi: 10.1038/s41594-025-01584-8. Epub 2025 Jun 17. Nat Struct Mol Biol. 2025. PMID: 40527990 Free PMC article.
Here we identify a Kipferl-independent mode of Rhino recruitment that, in addition to the previously established role of H3K9me3, also depends on the histone H3 lysine 27 methyltransferase Enhancer of Zeste. At Kipferl-independent sites, we find that Rhino specifically …
Here we identify a Kipferl-independent mode of Rhino recruitment that, in addition to the previously established role of H3K9me3, also depen …
Histone H1 binding to nucleosome arrays depends on linker DNA length and trajectory.
Dombrowski M, Engeholm M, Dienemann C, Dodonova S, Cramer P. Dombrowski M, et al. Nat Struct Mol Biol. 2022 May;29(5):493-501. doi: 10.1038/s41594-022-00768-w. Epub 2022 May 17. Nat Struct Mol Biol. 2022. PMID: 35581345 Free PMC article.
The structures show a zig-zag arrangement of nucleosomes, with nucleosomes 1 and 3 forming a stack. H1 binding to stacked nucleosomes depends on the NRL, whereas H1 always binds to the non-stacked nucleosomes 2 and 4. Short NRLs lead to altered trajectories of linke …
The structures show a zig-zag arrangement of nucleosomes, with nucleosomes 1 and 3 forming a stack. H1 binding to stacked nucleosomes …
The fork protection complex promotes parental histone recycling and epigenetic memory.
Charlton SJ, Flury V, Kanoh Y, Genzor AV, Kollenstart L, Ao W, Brøgger P, Weisser MB, Adamus M, Alcaraz N, Delvaux de Fenffe CM, Mattiroli F, Montoya G, Masai H, Groth A, Thon G. Charlton SJ, et al. Cell. 2024 Sep 5;187(18):5029-5047.e21. doi: 10.1016/j.cell.2024.07.017. Epub 2024 Aug 1. Cell. 2024. PMID: 39094569 Free PMC article.
Mrc1 mutants in a key connector domain disrupted segregation of parental histones to the lagging strand comparable to Mcm2 histone-binding mutants. Both mutants showed clonal and asymmetric loss of H3K9me-mediated gene silencing. AlphaFold predicted co-chaper …
Mrc1 mutants in a key connector domain disrupted segregation of parental histones to the lagging strand comparable to Mcm2 histone …
Linker Histone in Diseases.
Ye X, Feng C, Gao T, Mu G, Zhu W, Yang Y. Ye X, et al. Int J Biol Sci. 2017 Jul 18;13(8):1008-1018. doi: 10.7150/ijbs.19891. eCollection 2017. Int J Biol Sci. 2017. PMID: 28924382 Free PMC article. Review.
The linker histone is a protein that binds with the nucleosome, which is generally considered to achieve chromatin condensation in the nucleus. Accumulating evidences suggest that the linker histone is essential in the pathogenesis of several diseases. In thi …
The linker histone is a protein that binds with the nucleosome, which is generally considered to achieve chromatin condensatio …
Structural insights into an atypical histone binding mechanism by a PHD finger.
Grégoire S, Grégoire J, Yang Y, Capitani S, Joshi M, Sarvan S, Zaker A, Ning Z, Figeys D, Ulrich K, Brunzelle JS, Mer A, Couture JF. Grégoire S, et al. Structure. 2024 Sep 5;32(9):1498-1506.e4. doi: 10.1016/j.str.2024.06.017. Epub 2024 Jul 18. Structure. 2024. PMID: 39029460 Free article.
This configuration minimizes Cfp1(PHD) reliance on canonical residues important for histone binding functions of other PHD domains. Cancer-related mutations in Cfp1(PHD) impair H3K4me3 binding, implying a potential impact on epigenetic signaling. Our work hig …
This configuration minimizes Cfp1(PHD) reliance on canonical residues important for histone binding functions of other PHD dom …
Histone H1.
Wolffe AP. Wolffe AP. Int J Biochem Cell Biol. 1997 Dec;29(12):1463-6. doi: 10.1016/s1357-2725(97)00026-5. Int J Biochem Cell Biol. 1997. PMID: 9570139 Review.
Linker histones of which histone H1 is a representative are a diverse family of architectural proteins within the eukaryotic nucleus. These proteins have a variety of structures, but invariably contain a region enriched in lysine, serine, alanine and proline. All me …
Linker histones of which histone H1 is a representative are a diverse family of architectural proteins within the eukaryotic n …
Structural analysis of ING3 protein and histone H3 binding.
Ferreras-Gutiérrez M, Chaves-Arquero B, González-Magaña A, Merino N, Amusategui-Mateu I, Huecas S, Medrano FJ, Blanco FJ. Ferreras-Gutiérrez M, et al. Int J Biol Macromol. 2023 Jul 1;242(Pt 1):124724. doi: 10.1016/j.ijbiomac.2023.124724. Epub 2023 May 4. Int J Biol Macromol. 2023. PMID: 37148949 Free article.
ING3 facilitates acetylation of histones H2A and H4 by the NuA4-Tip60 MYST histone acetyl transferase complex, and it has been proposed to be an oncoprotein. ...These structures explain the possible deleterious effects of ING3 mutations detected in tumors. The PHD …
ING3 facilitates acetylation of histones H2A and H4 by the NuA4-Tip60 MYST histone acetyl transferase complex, and it has been …
50,345 results
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