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Year Number of Results
2002 3
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31 results

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Page 1
WDR5 associates with histone H3 methylated at K4 and is essential for H3 K4 methylation and vertebrate development.
Wysocka J, Swigut T, Milne TA, Dou Y, Zhang X, Burlingame AL, Roeder RG, Brivanlou AH, Allis CD. Wysocka J, et al. Cell. 2005 Jun 17;121(6):859-72. doi: 10.1016/j.cell.2005.03.036. Cell. 2005. PMID: 15960974 Free article.
Here we show that a common component of MLL1, MLL2, and hSet1 H3 K4 methyltransferase complexes, the WD40-repeat protein WDR5, directly associates with histone H3 di- and trimethylated at K4 and with H3-K4-dimethylated nucleosomes. WDR5 i …
Here we show that a common component of MLL1, MLL2, and hSet1 H3 K4 methyltransferase complexes, the WD40-repeat protei …
Allosteric regulation of histone lysine methyltransferases: from context-specific regulation to selective drugs.
Davidovich C, Zhang Q. Davidovich C, et al. Biochem Soc Trans. 2021 Apr 30;49(2):591-607. doi: 10.1042/BST20200238. Biochem Soc Trans. 2021. PMID: 33769454 Free PMC article. Review.
Histone lysine methyltransferases (HKMTs) are key regulators of many cellular processes. ...We review the molecular mechanisms of allosteric regulation of HKMTs using well-studied histone H3 (K4, K9, K27 and K36) methyltransferases as exa …
Histone lysine methyltransferases (HKMTs) are key regulators of many cellular processes. ...We review the molecular mechanisms …
SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins.
Schultz DC, Ayyanathan K, Negorev D, Maul GG, Rauscher FJ 3rd. Schultz DC, et al. Genes Dev. 2002 Apr 15;16(8):919-32. doi: 10.1101/gad.973302. Genes Dev. 2002. PMID: 11959841 Free PMC article.
However, the mechanisms that target and coordinate these activities to specific genes is poorly understood. Here we report that the KAP-1 corepressor for the KRAB-ZFP superfamily of transcriptional silencers binds to SETDB1, a novel SET domain protein with histon …
However, the mechanisms that target and coordinate these activities to specific genes is poorly understood. Here we report tha …
Set9, a novel histone H3 methyltransferase that facilitates transcription by precluding histone tail modifications required for heterochromatin formation.
Nishioka K, Chuikov S, Sarma K, Erdjument-Bromage H, Allis CD, Tempst P, Reinberg D. Nishioka K, et al. Genes Dev. 2002 Feb 15;16(4):479-89. doi: 10.1101/gad.967202. Genes Dev. 2002. PMID: 11850410 Free PMC article.
Set9 methylates specifically lysine 4 (K4) of histone H3 (H3-K4) and potentiates transcription activation. ...Moreover, methylation of H3-K4 impairs Suv39h1-mediated methylation at K9 of H3 (H3-K9). The interplay between the Set9 a …
Set9 methylates specifically lysine 4 (K4) of histone H3 (H3-K4) and potentiates transcription activation …
Histone H3 K4 demethylation during activation and attenuation of GAL1 transcription in Saccharomyces cerevisiae.
Ingvarsdottir K, Edwards C, Lee MG, Lee JS, Schultz DC, Shilatifard A, Shiekhattar R, Berger SL. Ingvarsdottir K, et al. Mol Cell Biol. 2007 Nov;27(22):7856-64. doi: 10.1128/MCB.00801-07. Epub 2007 Sep 17. Mol Cell Biol. 2007. PMID: 17875926 Free PMC article.
In mammalian cells, histone lysine demethylation is carried out by two classes of enzymes, the LSD1/BHC110 class and the jumonji class. The enzymes of the jumonji class in the yeast Saccharomyces cerevisiae have recently also been shown to have lysine demethylation acti …
In mammalian cells, histone lysine demethylation is carried out by two classes of enzymes, the LSD1/BHC110 class and the jumonji clas …
Barrier-to-Autointegration Factor influences specific histone modifications.
Montes de Oca R, Andreassen PR, Wilson KL. Montes de Oca R, et al. Nucleus. 2011 Nov-Dec;2(6):580-90. doi: 10.4161/nucl.2.6.17960. Epub 2011 Nov 1. Nucleus. 2011. PMID: 22127260 Free PMC article.
BAF overexpression significantly reduced global histone H3 acetylation by 18%. In cells that stably overexpressed BAF 3-fold, silencing mark H3-K27-Me1/3 and active marks H4-K16-Ac and H4-Ac5 decreased significantly. Significant increases were also seen for silencin …
BAF overexpression significantly reduced global histone H3 acetylation by 18%. In cells that stably overexpressed BAF 3-fold, silenci …
Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF.
Dou Y, Milne TA, Tackett AJ, Smith ER, Fukuda A, Wysocka J, Allis CD, Chait BT, Hess JL, Roeder RG. Dou Y, et al. Cell. 2005 Jun 17;121(6):873-85. doi: 10.1016/j.cell.2005.04.031. Cell. 2005. PMID: 15960975 Free article.
The purified complex has a robust MLL1-mediated histone methyltransferase activity that can effect mono-, di-, and trimethylation of H3 K4 and a MOF-mediated histone acetyltransferase activity that is specific for H4 K16. .. …
The purified complex has a robust MLL1-mediated histone methyltransferase activity that can effect mono-, di-, and trim …
PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex.
Cho YW, Hong T, Hong S, Guo H, Yu H, Kim D, Guszczynski T, Dressler GR, Copeland TD, Kalkum M, Ge K. Cho YW, et al. J Biol Chem. 2007 Jul 13;282(28):20395-406. doi: 10.1074/jbc.M701574200. Epub 2007 May 11. J Biol Chem. 2007. PMID: 17500065 Free PMC article.
PTIP complex carries robust HMT activity and specifically methylates lysine 4 (K4) on histone H3. Furthermore, PA1 binds PTIP directly and requires PTIP for interaction with the rest of the complex. ...As histone H3 K4 methylation associa …
PTIP complex carries robust HMT activity and specifically methylates lysine 4 (K4) on histone H3. Furthermore, PA1 bind …
[The roles of histone lysine methylation in epigenetic regulation].
Du TT, Huang QH. Du TT, et al. Yi Chuan. 2007 Apr;29(4):387-92. doi: 10.1360/yc-007-0387. Yi Chuan. 2007. PMID: 17548299 Review. Chinese.
Histone lysine methylation plays a key role in epigenetic regulation.There are five lysines within histone H3(K4, K9, K27, K36, K79). Besides, one lysine within histone H4(K20) has been shown to be methylated by specific histone ly …
Histone lysine methylation plays a key role in epigenetic regulation.There are five lysines within histone H3(K4 …
T-bet's ability to regulate individual target genes requires the conserved T-box domain to recruit histone methyltransferase activity and a separate family member-specific transactivation domain.
Lewis MD, Miller SA, Miazgowicz MM, Beima KM, Weinmann AS. Lewis MD, et al. Mol Cell Biol. 2007 Dec;27(24):8510-21. doi: 10.1128/MCB.01615-07. Epub 2007 Oct 8. Mol Cell Biol. 2007. PMID: 17923685 Free PMC article.
T-bet is both necessary and sufficient to induce permissive histone H3-K4 dimethyl modifications at the CXCR3 and IFN-gamma promoters. A T-bet structure-function analysis revealed that the conserved T-box domain, with a small C-terminal portion, is required f …
T-bet is both necessary and sufficient to induce permissive histone H3-K4 dimethyl modifications at the CXCR3 and IFN-g …
31 results