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144 results

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Page 1
Taurine, homotaurine, GABA and hydrophobic amino acids content influences "in vitro" antioxidant and SIRT1 modulation activities of enzymatic protein hydrolysates from algae.
Terriente-Palacios C, Rubiño S, Hortós M, Peteiro C, Castellari M. Terriente-Palacios C, et al. Sci Rep. 2022 Dec 2;12(1):20832. doi: 10.1038/s41598-022-25130-4. Sci Rep. 2022. PMID: 36460715 Free PMC article.
Pearson's correlation test and Principal Component Analysis revealed significant correlations between (1) total peptide and hydrophobic amino acid content in EPHs and their antioxidant activities, and (2) concentrations of taurine, homotaurine, and amino acid
Pearson's correlation test and Principal Component Analysis revealed significant correlations between (1) total peptide and hydrophobic amin …
GABA(A) receptors as plausible molecular targets and mediators for taurine and homotaurine actions.
Meera P, Uusi-Oukari M, Lipshutz GS, Wallner M. Meera P, et al. Front Pharmacol. 2023 Dec 14;14:1271203. doi: 10.3389/fphar.2023.1271203. eCollection 2023. Front Pharmacol. 2023. PMID: 38155909 Free PMC article.
HT also has beneficial effects in a mouse model of multiple sclerosis likely through an anti-inflammatory mechanism mediated by GABA(A) receptor (GABA(A)R) agonism in immune cells. While both taurine and HT are structural GABA analogs and thought to be GAB
HT also has beneficial effects in a mouse model of multiple sclerosis likely through an anti-inflammatory mechanism mediated by GABA( …
Homotaurine, a safe blood-brain barrier permeable GABA(A)-R-specific agonist, ameliorates disease in mouse models of multiple sclerosis.
Tian J, Dang H, Wallner M, Olsen R, Kaufman DL. Tian J, et al. Sci Rep. 2018 Nov 8;8(1):16555. doi: 10.1038/s41598-018-32733-3. Sci Rep. 2018. PMID: 30410049 Free PMC article.
Homotaurine is a BBB-permeable amino acid that antagonizes amyloid fibril formation and was found to be safe but ineffective in long-term Alzheimer's disease clinical trials. Homotaurine also acts as GABA(A)-R agonist with better pharmacokinetics than
Homotaurine is a BBB-permeable amino acid that antagonizes amyloid fibril formation and was found to be safe but ineffective i
Effects of taurine, homotaurine and GABA on hypothalamic and striatal dopamine metabolism.
Panula-Lehto E, Mäkinen M, Ahtee L. Panula-Lehto E, et al. Naunyn Schmiedebergs Arch Pharmacol. 1992 Jul;346(1):57-62. doi: 10.1007/BF00167571. Naunyn Schmiedebergs Arch Pharmacol. 1992. PMID: 1407006
To elucidate the effects of taurine on hypothalamic and striatal dopaminergic neurotransmission we compared its effects to those of gamma-aminobutyric acid (GABA) and homotaurine (a GABAA-receptor agonist) on hypothalamic and striatal concentrat …
To elucidate the effects of taurine on hypothalamic and striatal dopaminergic neurotransmission we compared its effects to those of gamma
The GABA and GABA-Receptor System in Inflammation, Anti-Tumor Immune Responses, and COVID-19.
Tian J, Kaufman DL. Tian J, et al. Biomedicines. 2023 Jan 18;11(2):254. doi: 10.3390/biomedicines11020254. Biomedicines. 2023. PMID: 36830790 Free PMC article. Review.
GABA and GABA(A)-receptors (GABA(A)-Rs) play major roles in neurodevelopment and neurotransmission in the central nervous system (CNS). ...The ability of GABA(A)-R agonists to limit both excessive immune responses and lung epithelial cell injury may un
GABA and GABA(A)-receptors (GABA(A)-Rs) play major roles in neurodevelopment and neurotransmission in the central nervo
GABA(A)-Receptor Agonists Limit Pneumonitis and Death in Murine Coronavirus-Infected Mice.
Tian J, Middleton B, Kaufman DL. Tian J, et al. Viruses. 2021 May 23;13(6):966. doi: 10.3390/v13060966. Viruses. 2021. PMID: 34071034 Free PMC article.
Many cells of the immune system express receptors for the neurotransmitter gamma-aminobutyric acid (GABA), and GABA-receptor (GABA-R) agonists have anti-inflammatory effects. ...Since GABA and homotaurine are safe for human …
Many cells of the immune system express receptors for the neurotransmitter gamma-aminobutyric acid (GABA), and …
Differential modulation of human GABA(C)-rho1 receptor by sulfur-containing compounds structurally related to taurine.
Ochoa-de la Paz LD, González-Andrade M, Pasantes-Morales H, Franco R, Zamora-Alvarado R, Zenteno E, Quiroz-Mercado H, Gonzales-Salinas R, Gulias-Cañizo R. Ochoa-de la Paz LD, et al. BMC Neurosci. 2018 Aug 3;19(1):47. doi: 10.1186/s12868-018-0448-6. BMC Neurosci. 2018. PMID: 30075755 Free PMC article.
This study aimed to determine if the dual action of taurine on GABA(C)-rho1R relates to its structure. To address this, we tested the ability of the structurally related compounds homotaurine, hypotaurine, and isethionic acid to modulate GABA(C)-rho1R. …
This study aimed to determine if the dual action of taurine on GABA(C)-rho1R relates to its structure. To address this, we tested the …
GABA(B) receptors and opioid mechanisms involved in homotaurine-induced analgesia.
Serrano MI, Serrano JS, Fernández A, Asadi I, Serrano-Martino MC. Serrano MI, et al. Gen Pharmacol. 1998 Mar;30(3):411-5. doi: 10.1016/s0306-3623(97)00279-6. Gen Pharmacol. 1998. PMID: 9510095
1. The involvement of GABA(B) receptors and opioid mechanisms in homotaurine-induced analgesia has been investigated in current models of nociception by using a GABA(B) receptor antagonist, morphine, and naloxone. ...These data imply that GABA(B) recep …
1. The involvement of GABA(B) receptors and opioid mechanisms in homotaurine-induced analgesia has been investigated in curren …
Future strategies of management of Alzheimer's Disease. The role of homotaurine.
Tsolaki M. Tsolaki M. Hell J Nucl Med. 2019 Jan-Apr;22 Suppl:82-94. Hell J Nucl Med. 2019. PMID: 30877726 Review.
In recent years, there has been a growing interest, supported by a large number of experimental, epidemiological and clinical studies, about the beneficial effects of some natural products in preventing various age-related pathologic conditions, including brain aging and neurodeg …
In recent years, there has been a growing interest, supported by a large number of experimental, epidemiological and clinical studies, about …
Locally infused taurine, GABA and homotaurine alter differently the striatal extracellular concentrations of dopamine and its metabolites in rats.
Ruotsalainen M, Majasaari M, Salimäki J, Ahtee L. Ruotsalainen M, et al. Amino Acids. 1998;15(1-2):117-34. doi: 10.1007/BF01345285. Amino Acids. 1998. PMID: 9871492
The extracellular dopamine concentration was elevated maximally 2.5-, 2- and 4-fold by taurine, GABA and homotaurine, respectively. At 150 mM concentration, at which the maximum effects occurred, homotaurine increased the extracellular dopamine more than taur …
The extracellular dopamine concentration was elevated maximally 2.5-, 2- and 4-fold by taurine, GABA and homotaurine, respecti …
144 results