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1,309 results

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Page 1
Safety and Toxicology of Magnolol and Honokiol.
Sarrica A, Kirika N, Romeo M, Salmona M, Diomede L. Sarrica A, et al. Planta Med. 2018 Nov;84(16):1151-1164. doi: 10.1055/a-0642-1966. Epub 2018 Jun 20. Planta Med. 2018. PMID: 29925102 Free article. Review.
The biological and pharmacological activities of magnolol and honokiol have been extensively investigated. Here we review the safety and toxicological properties of magnolol and honokiol as pure substances or as components of concentrated MBE, including the potentia …
The biological and pharmacological activities of magnolol and honokiol have been extensively investigated. Here we review the safety …
Mitigation of honokiol on fluoride-induced mitochondrial oxidative stress, mitochondrial dysfunction, and cognitive deficits through activating AMPK/PGC-1alpha/Sirt3.
Wang D, Cao L, Zhou X, Wang G, Ma Y, Hao X, Fan H. Wang D, et al. J Hazard Mater. 2022 Sep 5;437:129381. doi: 10.1016/j.jhazmat.2022.129381. Epub 2022 Jun 16. J Hazard Mater. 2022. PMID: 35752048
The present study investigated the protective actions of honokiol on NaF-elicited cognitive deficits and elucidated the possible mechanism of honokiol-mediated protection. ...Further studies revealed that honokiol activated AMPK and upregulated the PGC-1alpha …
The present study investigated the protective actions of honokiol on NaF-elicited cognitive deficits and elucidated the possible mech …
Honokiol attenuates high glucose-induced peripheral neuropathy via inhibiting ferroptosis and activating AMPK/SIRT1/PGC-1alpha pathway in Schwann cells.
Hu M, Jiang W, Ye C, Hu T, Yu Q, Meng M, Sun L, Liang J, Chen Y. Hu M, et al. Phytother Res. 2023 Dec;37(12):5787-5802. doi: 10.1002/ptr.7984. Epub 2023 Aug 14. Phytother Res. 2023. PMID: 37580045
This study aimed to investigate the role of AMPK/SIRT1/PGC-1alpha axis in the protective effects of honokiol on DPN. The biochemical assay and JC-1 staining results demonstrated that honokiol reduced HG-induced oxidative stress and ferroptosis as well as mitochondri …
This study aimed to investigate the role of AMPK/SIRT1/PGC-1alpha axis in the protective effects of honokiol on DPN. The biochemical …
Honokiol: An anticancer lignan.
Rauf A, Patel S, Imran M, Maalik A, Arshad MU, Saeed F, Mabkhot YN, Al-Showiman SS, Ahmad N, Elsharkawy E. Rauf A, et al. Biomed Pharmacother. 2018 Nov;107:555-562. doi: 10.1016/j.biopha.2018.08.054. Epub 2018 Aug 13. Biomed Pharmacother. 2018. PMID: 30114639 Review.
Honokiol has inhibitory role on the proliferation, invasion and survival of cancer cells in in vitro as well as in vivo studies. ...It promotes the efficacy of several anticancer drugs and radiation tolerance. The derivatization of honokiol results in compounds with
Honokiol has inhibitory role on the proliferation, invasion and survival of cancer cells in in vitro as well as in vivo studies. ...I
Honokiol: A review of its pharmacological potential and therapeutic insights.
Rauf A, Olatunde A, Imran M, Alhumaydhi FA, Aljohani ASM, Khan SA, Uddin MS, Mitra S, Emran TB, Khayrullin M, Rebezov M, Kamal MA, Shariati MA. Rauf A, et al. Phytomedicine. 2021 Sep;90:153647. doi: 10.1016/j.phymed.2021.153647. Epub 2021 Jul 16. Phytomedicine. 2021. PMID: 34362632 Review.
BACKGROUND: Honokiol is a pleiotropic compound which been isolated from Magnolia species such as Magnolia grandiflora and Magnolia dealbata. ...PURPOSE: The objective of this review is to summarize the pharmacological potential and therapeutic insights of honokiol. …
BACKGROUND: Honokiol is a pleiotropic compound which been isolated from Magnolia species such as Magnolia grandiflora and Magnolia de …
The application prospects of honokiol in dermatology.
Li Y, Liang C, Zhou X. Li Y, et al. Dermatol Ther. 2022 Aug;35(8):e15658. doi: 10.1111/dth.15658. Epub 2022 Jun 28. Dermatol Ther. 2022. PMID: 35726011 Free PMC article. Review.
Honokiol is one of the natural extracts of Magnolia officinalis. It is a small molecule, lipophilic compound with extensive biological effects. ...As a small molecule fat-soluble compound, honokiol is suitable for external use. We reviewed the advantages and disadva
Honokiol is one of the natural extracts of Magnolia officinalis. It is a small molecule, lipophilic compound with extensive biologica
Honokiol and its analogues as anticancer compounds: Current mechanistic insights and structure-activity relationship.
Prasher P, Fatima R, Sharma M, Tynybekov B, Alshahrani AM, Ateşşahin DA, Sharifi-Rad J, Calina D. Prasher P, et al. Chem Biol Interact. 2023 Dec 1;386:110747. doi: 10.1016/j.cbi.2023.110747. Epub 2023 Oct 8. Chem Biol Interact. 2023. PMID: 37816447 Review.
The hydrophobicity of honokiol enables its rapid dissolution in lipids and the crossing of physiological barriers, including the blood-brain barrier and cerebrospinal fluid. ...In this review, we discuss the anticancer properties of honokiol....
The hydrophobicity of honokiol enables its rapid dissolution in lipids and the crossing of physiological barriers, including the bloo …
Activation of Sirtuin3 by honokiol ameliorates alveolar epithelial cell senescence in experimental silicosis via the cGAS-STING pathway.
Zhou Q, Yi G, Chang M, Li N, Bai Y, Li H, Yao S. Zhou Q, et al. Redox Biol. 2024 Aug;74:103224. doi: 10.1016/j.redox.2024.103224. Epub 2024 Jun 8. Redox Biol. 2024. PMID: 38865904 Free PMC article.
Silicosis was induced in mice via intratracheal instillation of crystalline silica particles, with honokiol administered intraperitoneally for 14 days. Silica-induced senescence in A549 cells was confirmed, and SIRT3 knockout and overexpression cell lines were generated. . …
Silicosis was induced in mice via intratracheal instillation of crystalline silica particles, with honokiol administered intraperiton …
Use of honokiol in lung cancer therapy: a mini review of its pharmacological mechanism.
Wang J, Mu HJ, Sun YL, Yuan B, Wang Y. Wang J, et al. J Asian Nat Prod Res. 2023 Nov;25(11):1029-1037. doi: 10.1080/10286020.2023.2193695. Epub 2023 Apr 3. J Asian Nat Prod Res. 2023. PMID: 37010929 Review.
Honokiol (3',5-di-(2-propenyl)-1,1'-biphenyl-2,2'-diol) is a biologically active natural product derived from Magnolia and has been shown to have excellent biological activities. ...In addition, honokiol combined with other chemotherapy drugs is also a way in which
Honokiol (3',5-di-(2-propenyl)-1,1'-biphenyl-2,2'-diol) is a biologically active natural product derived from Magnolia and has been s
Honokiol suppresses 2,6-dinitrochlorobenzene-induced atopic dermatitis in mice.
Lee JH, Im DS. Lee JH, et al. J Ethnopharmacol. 2022 May 10;289:115023. doi: 10.1016/j.jep.2022.115023. Epub 2022 Jan 21. J Ethnopharmacol. 2022. PMID: 35074454
Furthermore, the increase in lymph nodes sizes induced by DNCB treatment was reduced by honokiol administration. CONCLUSION: DNCB-induced atopic responses in the ears and lymph nodes were significantly suppressed by honokiol treatment. These results suggested that …
Furthermore, the increase in lymph nodes sizes induced by DNCB treatment was reduced by honokiol administration. CONCLUSION: DNCB-ind …
1,309 results