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408 results

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Page 1
(Ultra-)long-acting insulin analogues versus NPH insulin (human isophane insulin) for adults with type 2 diabetes mellitus.
Semlitsch T, Engler J, Siebenhofer A, Jeitler K, Berghold A, Horvath K. Semlitsch T, et al. Cochrane Database Syst Rev. 2020 Nov 9;11(11):CD005613. doi: 10.1002/14651858.CD005613.pub4. Cochrane Database Syst Rev. 2020. PMID: 33166419 Free PMC article.
In consequence, firm conclusions on the effect of interventions on patient-relevant outcomes cannot be drawn from the effect of these interventions on blood glucose concentration alone. In theory, the use of newer insulin analogues may result in fewer macrovascular and mic …
In consequence, firm conclusions on the effect of interventions on patient-relevant outcomes cannot be drawn from the effect of these interv …
Long-acting insulin analogues versus NPH insulin (human isophane insulin) for type 2 diabetes mellitus.
Horvath K, Jeitler K, Berghold A, Ebrahim SH, Gratzer TW, Plank J, Kaiser T, Pieber TR, Siebenhofer A. Horvath K, et al. Cochrane Database Syst Rev. 2007 Apr 18;(2):CD005613. doi: 10.1002/14651858.CD005613.pub3. Cochrane Database Syst Rev. 2007. Update in: Cochrane Database Syst Rev. 2020 Nov 9;11:CD005613. doi: 10.1002/14651858.CD005613.pub4. PMID: 17443605 Free article. Updated.
Pooling of studies by means of random-effects meta-analyses was performed. MAIN RESULTS: Six studies comparing insulin glargine to NPH (Neutral Protamine Hagedorn) insulin and two studies comparing insulin detemir to NPH insulin were identified. In the …
Pooling of studies by means of random-effects meta-analyses was performed. MAIN RESULTS: Six studies comparing insulin glargine to NP …
Human isophane or lente insulin? A double blind crossover trial in insulin dependent diabetes mellitus.
Gibb DM, Foot AB, May B, Parish H, Strang S, Grant DB, Dunger DB. Gibb DM, et al. Arch Dis Child. 1990 Dec;65(12):1334-7. doi: 10.1136/adc.65.12.1334. Arch Dis Child. 1990. PMID: 2270941 Free PMC article. Clinical Trial.
Fifty two children with insulin dependent diabetes mellitus were randomised to receive human isophane or lente insulin preparations in combination with soluble insulin in a double blind trial. ...Control assessed by glycated haemoglobin was sign …
Fifty two children with insulin dependent diabetes mellitus were randomised to receive human isophane or lente insul …
Human insulin-induced lipoatrophy.
Felner EI. Felner EI. J Pediatr. 2003 Apr;142(4):448. doi: 10.1067/mpd.2003.103. J Pediatr. 2003. PMID: 12712066 No abstract available.
A comparison of the pharmacokinetics of human protamine sodium insulin with human isophane insulin following subcutaneous injection in normal subjects.
Burke B, Andrews WJ, Hadden DR. Burke B, et al. Diabetes Res. 1987 Apr;4(4):163-7. Diabetes Res. 1987. PMID: 3304782 Clinical Trial.
The pharmacokinetics of human protamine sodium insulin 0.6 mg% were compared with those of human isophane zinc insulin using the glucose clamp technique. ...Plasma insulin and C-peptide concentrations were then measured over 24 hours. Aft …
The pharmacokinetics of human protamine sodium insulin 0.6 mg% were compared with those of human isophane zinc …
[Impact of human isophane insulin on the evaluation of beta cell functions].
Zhang M, Zhang L, Huang MJ, Xiong ZY, Guo D, An ZM. Zhang M, et al. Sichuan Da Xue Xue Bao Yi Xue Ban. 2008 Nov;39(6):989-91. Sichuan Da Xue Xue Bao Yi Xue Ban. 2008. PMID: 19253843 Chinese.
OBJECTIVE: To evaluate the beta cell functions with and without human Isophane insulin treatments. METHODS: Thirty patients with type 2 diabetes mellitus who followed the human Isophane insulin therapeutic regimen at bedtime were given 10 …
OBJECTIVE: To evaluate the beta cell functions with and without human Isophane insulin treatments. METHODS: Thirty pati …
Early morning glycaemia and the metabolic consequences of delaying breakfast/morning insulin. A comparison of continuous subcutaneous insulin infusion and multiple injection therapy with human isophane or human ultralente insulin at bedtime in insulin-dependent diabetics.
Haakens K, Hanssen KF, Dahl-Jørgensen K, Vaaler S, Torjesen P, Try K. Haakens K, et al. Scand J Clin Lab Invest. 1989 Nov;49(7):653-9. doi: 10.3109/00365518909091541. Scand J Clin Lab Invest. 1989. PMID: 2692136
We studied morning glycaemia and metabolic consequences of delaying morning insulin/breakfast in insulin-dependent diabetics on (i) continuous subcutaneous insulin infusion (CSII) (n = 27), (ii) multiple-injection therapy (MI) with human isophane …
We studied morning glycaemia and metabolic consequences of delaying morning insulin/breakfast in insulin-dependent diabetics o …
Split-mixed insulin regimen with human ultralente before supper and NPH (isophane) before breakfast in children and adolescents with IDDM.
Wolfsdorf JI, Laffel LM, Pasquarello C, Vernon A, Herskowitz RD. Wolfsdorf JI, et al. Diabetes Care. 1991 Nov;14(11):1100-6. doi: 10.2337/diacare.14.11.1100. Diabetes Care. 1991. PMID: 1797498 Clinical Trial.
We postulated that substituting human ultralente insulin for the presupper dose of intermediate-acting insulin would improve overnight glycemic control in children and adolescents with IDDM. RESEARCH DESIGN AND METHODS: This 6-mo double-blind crossover study …
We postulated that substituting human ultralente insulin for the presupper dose of intermediate-acting insulin would im …
A comparison of insulin detemir and neutral protamine Hagedorn (isophane) insulin in the treatment of diabetes: a systematic review.
Frier BM, Russell-Jones D, Heise T. Frier BM, et al. Diabetes Obes Metab. 2013 Nov;15(11):978-86. doi: 10.1111/dom.12106. Epub 2013 May 1. Diabetes Obes Metab. 2013. PMID: 23551900
The aim of this review is to summarize the clinical efficacy, tolerability and safety data of insulin detemir, and compare its use with that of neutral protamine Hagedorn (NPH) insulin in randomized controlled trials in people with type 1 or type 2 diabetes. ...Stud …
The aim of this review is to summarize the clinical efficacy, tolerability and safety data of insulin detemir, and compare its use wi …
Clinical pharmacology of human insulin.
Heinemann L, Richter B. Heinemann L, et al. Diabetes Care. 1993 Dec;16 Suppl 3:90-100. doi: 10.2337/diacare.16.3.90. Diabetes Care. 1993. PMID: 8299482 Review.
Nowadays, human insulin is used daily by millions of diabetic patients. The biological effect of human insulin is comparable to that of porcine insulin. However, after subcutaneous injection, pharmacological and clinical studies showed pharmacok …
Nowadays, human insulin is used daily by millions of diabetic patients. The biological effect of human insulin i …
408 results