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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1936 1
1943 1
1945 1
1946 8
1947 6
1948 4
1949 6
1950 8
1951 10
1952 12
1953 7
1954 8
1955 18
1956 19
1957 24
1958 29
1959 43
1960 34
1961 47
1962 48
1963 44
1964 48
1965 27
1966 5
1967 11
1968 9
1969 22
1970 11
1971 17
1972 26
1973 26
1974 39
1975 295
1976 335
1977 382
1978 375
1979 406
1980 476
1981 575
1982 695
1983 868
1984 947
1985 1033
1986 1174
1987 1303
1988 1384
1989 1722
1990 1650
1991 1747
1992 1818
1993 1847
1994 2002
1995 2174
1996 2214
1997 2387
1998 2474
1999 2597
2000 2628
2001 2703
2002 2809
2003 2837
2004 3185
2005 3310
2006 3507
2007 3796
2008 3915
2009 4061
2010 4260
2011 4502
2012 4965
2013 5784
2014 6925
2015 7375
2016 7509
2017 7585
2018 8143
2019 8238
2020 7854
2021 7503
2022 5798
2023 5091
2024 5373
2025 5510
2026 2209

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152,379 results

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Page 1
The gut mycobiome of the Human Microbiome Project healthy cohort.
Nash AK, Auchtung TA, Wong MC, Smith DP, Gesell JR, Ross MC, Stewart CJ, Metcalf GA, Muzny DM, Gibbs RA, Ajami NJ, Petrosino JF. Nash AK, et al. Microbiome. 2017 Nov 25;5(1):153. doi: 10.1186/s40168-017-0373-4. Microbiome. 2017. PMID: 29178920 Free PMC article.
BACKGROUND: Most studies describing the human gut microbiome in healthy and diseased states have emphasized the bacterial component, but the fungal microbiome (i.e., the mycobiome) is beginning to gain recognition as a fundamental part of our microbiome. To date, …
BACKGROUND: Most studies describing the human gut microbiome in healthy and diseased states have emphasized the bacterial comp …
Global prevalence of human pegivirus-1 in healthy volunteer blood donors: a systematic review and meta-analysis.
Yang N, Dai R, Zhang X. Yang N, et al. Vox Sang. 2020 Apr;115(3):107-119. doi: 10.1111/vox.12876. Epub 2019 Dec 16. Vox Sang. 2020. PMID: 31845353
The aim of this systematic review and meta-analysis was to gather data from the literature to estimate the prevalence of HPgV-1 in healthy volunteer blood donors in the world. MATERIALS AND METHODS: We searched PubMed, EMBASE, Scopus and Google Scholar databases for …
The aim of this systematic review and meta-analysis was to gather data from the literature to estimate the prevalence of HPgV-1 in health …
Chemical warfare agent simulants for human volunteer trials of emergency decontamination: A systematic review.
James T, Wyke S, Marczylo T, Collins S, Gaulton T, Foxall K, Amlôt R, Duarte-Davidson R. James T, et al. J Appl Toxicol. 2018 Jan;38(1):113-121. doi: 10.1002/jat.3527. Epub 2017 Oct 9. J Appl Toxicol. 2018. PMID: 28990191 Free PMC article.
In such an event, emergency decontamination of affected casualties may need to be undertaken to reduce injury and possible loss of life. To ensure these methods are effective, human volunteer trials (HVTs) of decontamination protocols, using simulant contaminants, h …
In such an event, emergency decontamination of affected casualties may need to be undertaken to reduce injury and possible loss of life. To …
Anti-KIT monoclonal antibody CDX-0159 induces profound and durable mast cell suppression in a healthy volunteer study.
Alvarado D, Maurer M, Gedrich R, Seibel SB, Murphy MB, Crew L, Goldstein J, Crocker A, Vitale LA, Morani PA, Thomas LJ, Hawthorne TR, Keler T, Young D, Crowley E, Kankam M, Heath-Chiozzi M. Alvarado D, et al. Allergy. 2022 Aug;77(8):2393-2403. doi: 10.1111/all.15262. Epub 2022 Mar 3. Allergy. 2022. PMID: 35184297 Free PMC article. Clinical Trial.
Here we describe CDX-0159, an anti-KIT monoclonal antibody that potently suppresses MCs in human healthy volunteers. METHODS: CDX-0159-mediated KIT inhibition was tested in vitro using KIT-expressing immortalized cells and primary human mast cells. ... …
Here we describe CDX-0159, an anti-KIT monoclonal antibody that potently suppresses MCs in human healthy volunteers. ME …
Improved Diagnostic Criteria for Apical Hypertrophic Cardiomyopathy.
Hughes RK, Shiwani H, Rosmini S, Augusto JB, Burke L, Jiang Y, Pierce I, Joy G, Castelletti S, Orini M, Kellman P, Xue H, Lopes LR, Mohiddin S, Treibel T, Manisty C, Captur G, Davies R, Moon JC. Hughes RK, et al. JACC Cardiovasc Imaging. 2024 May;17(5):501-512. doi: 10.1016/j.jcmg.2023.07.012. Epub 2023 Oct 11. JACC Cardiovasc Imaging. 2024. PMID: 37831014 Free article.
OBJECTIVES: The authors aimed to define normal apical wall thickness thresholds in healthy subjects and use these to accurately identify ApHCM. METHODS: The following healthy subjects were recruited: healthy UK Biobank imaging substudy subjects (n = 4,112) an …
OBJECTIVES: The authors aimed to define normal apical wall thickness thresholds in healthy subjects and use these to accurately ident …
A TRPA1 inhibitor suppresses neurogenic inflammation and airway contraction for asthma treatment.
Balestrini A, Joseph V, Dourado M, Reese RM, Shields SD, Rougé L, Bravo DD, Chernov-Rogan T, Austin CD, Chen H, Wang L, Villemure E, Shore DGM, Verma VA, Hu B, Chen Y, Leong L, Bjornson C, Hötzel K, Gogineni A, Lee WP, Suto E, Wu X, Liu J, Zhang J, Gandham V, Wang J, Payandeh J, Ciferri C, Estevez A, Arthur CP, Kortmann J, Wong RL, Heredia JE, Doerr J, Jung M, Vander Heiden JA, Roose-Girma M, Tam L, Barck KH, Carano RAD, Ding HT, Brillantes B, Tam C, Yang X, Gao SS, Ly JQ, Liu L, Chen L, Liederer BM, Lin JH, Magnuson S, Chen J, Hackos DH, Elstrott J, Rohou A, Safina BS, Volgraf M, Bauer RN, Riol-Blanco L. Balestrini A, et al. J Exp Med. 2021 Apr 5;218(4):e20201637. doi: 10.1084/jem.20201637. J Exp Med. 2021. PMID: 33620419 Free PMC article. Clinical Trial.
Transient receptor potential cation channel member A1 (TRPA1) agonists are elevated in human asthmatic airways, and in rodents, TRPA1 is involved in the induction of airway inflammation and hyperreactivity. ...GDC-0334 inhibited TRPA1 function on airway smooth muscle and s …
Transient receptor potential cation channel member A1 (TRPA1) agonists are elevated in human asthmatic airways, and in rodents, TRPA1 …
Human volunteer study of the decontamination of chemically contaminated hair and the consequences for systemic exposure.
Collins S, James T, Southworth F, Davidson L, Williams N, Orchard E, Marczylo T, Amlôt R. Collins S, et al. Sci Rep. 2020 Nov 30;10(1):20822. doi: 10.1038/s41598-020-77930-1. Sci Rep. 2020. PMID: 33257756 Free PMC article.
Decontamination efficacy was evaluated using two chemical simulants, methyl salicylate (MeS) and benzyl salicylate (BeS) applied to and recovered from the hair of volunteers. Twenty-four-hour urinary MeS and BeS were measured as a surrogate for systemic bioavailability. .. …
Decontamination efficacy was evaluated using two chemical simulants, methyl salicylate (MeS) and benzyl salicylate (BeS) applied to and reco …
SLC6A19 inhibition facilitates urinary neutral amino acid excretion and lowers plasma phenylalanine.
Wobst HJ, Viader A, Muncipinto G, Hollibaugh R, van Kalken D, Burkhart CT, Cantin SM, Bates RM, Regimbald-Dumas Y, Gross L, Antalek MT, Zweig JE, Wu F, Rettenmaier TJ, Labenski MT, Pullen N, Blanchette HS, Henderson JL, Weng HH, Vaughn TA, Brown DG, Throup JP, Barrish JC. Wobst HJ, et al. JCI Insight. 2024 Nov 8;9(21):e182876. doi: 10.1172/jci.insight.182876. JCI Insight. 2024. PMID: 39513367 Free PMC article. Clinical Trial.
Here, we describe the characterization of the first small molecule SLC6A19 inhibitor to enter clinical development for the treatment of PKU.METHODSC57Bl/6J WT and Pahenu2 mice were dosed with an inhibitor of SLC6A19 to investigate the effects on urinary amino acids and plasma Phe …
Here, we describe the characterization of the first small molecule SLC6A19 inhibitor to enter clinical development for the treatment of PKU. …
Ethical Criteria for Improved Human Subject Protections in Phase I Healthy Volunteer Trials.
Walker RL, MacKay D, Waltz M, Lyerly AD, Fisher JA. Walker RL, et al. Ethics Hum Res. 2022 Sep;44(5):2-21. doi: 10.1002/eahr.500139. Ethics Hum Res. 2022. PMID: 36047278 Free PMC article.
Phase I healthy volunteer trials test the safety and tolerability of investigational pharmaceuticals. ...Monetary payments are used to incentivize enrollment and compensate participants for their time. Together, these features of phase I healthy volunteer …
Phase I healthy volunteer trials test the safety and tolerability of investigational pharmaceuticals. ...Monetary payments are …
152,379 results
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