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The ventral basal ganglia, a selection mechanism at the crossroads of space, strategy, and reward.
Humphries MD, Prescott TJ. Humphries MD, et al. Prog Neurobiol. 2010 Apr;90(4):385-417. doi: 10.1016/j.pneurobio.2009.11.003. Epub 2009 Nov 24. Prog Neurobiol. 2010. PMID: 19941931 Free article. Review.
The basal ganglia are often conceptualised as three parallel domains that include all the constituent nuclei. ...Dopamine's key role in learning is reviewed within the three current major computational frameworks; we also show that the shell-based basal ga …
The basal ganglia are often conceptualised as three parallel domains that include all the constituent nuclei. ...Dopamine's ke …
Insights into Parkinson's disease from computational models of the basal ganglia.
Humphries MD, Obeso JA, Dreyer JK. Humphries MD, et al. J Neurol Neurosurg Psychiatry. 2018 Nov;89(11):1181-1188. doi: 10.1136/jnnp-2017-315922. Epub 2018 Apr 17. J Neurol Neurosurg Psychiatry. 2018. PMID: 29666208 Free PMC article. Review.
For mechanisms, we review models that capture the effects of losing dopamine on basal ganglia function; for dynamics, we discuss models that have transformed our understanding of how beta-band (15-30 Hz) oscillations arise in the parkinsonian basal ganglia …
For mechanisms, we review models that capture the effects of losing dopamine on basal ganglia function; for dynamics, we discu …
Dopaminergic Control of the Exploration-Exploitation Trade-Off via the Basal Ganglia.
Humphries MD, Khamassi M, Gurney K. Humphries MD, et al. Front Neurosci. 2012 Feb 6;6:9. doi: 10.3389/fnins.2012.00009. eCollection 2012. Front Neurosci. 2012. PMID: 22347155 Free PMC article.
We first advance the idea of interpreting the basal ganglia output as a probability distribution function for action selection. Using computational models of the full basal ganglia circuit, we showed that, under this interpretation, the actions of dopa …
We first advance the idea of interpreting the basal ganglia output as a probability distribution function for action selection …
Transient and steady-state selection in the striatal microcircuit.
Tomkins A, Vasilaki E, Beste C, Gurney K, Humphries MD. Tomkins A, et al. Among authors: humphries md. Front Comput Neurosci. 2014 Jan 20;7:192. doi: 10.3389/fncom.2013.00192. eCollection 2013. Front Comput Neurosci. 2014. PMID: 24478684 Free PMC article.
Although the basal ganglia have been widely studied and implicated in signal processing and action selection, little information is known about the active role the striatal microcircuit plays in action selection in the basal ganglia-thalamo-cortical lo …
Although the basal ganglia have been widely studied and implicated in signal processing and action selection, little informati …
A probabilistic, distributed, recursive mechanism for decision-making in the brain.
Caballero JA, Humphries MD, Gurney KN. Caballero JA, et al. Among authors: humphries md. PLoS Comput Biol. 2018 Apr 3;14(4):e1006033. doi: 10.1371/journal.pcbi.1006033. eCollection 2018 Apr. PLoS Comput Biol. 2018. PMID: 29614077 Free PMC article.
Using it to simulate the random-dot-motion task, we demonstrate it quantitatively replicates the choice behaviour of monkeys, whilst predicting losses of otherwise usable information from MT. Its architecture maps to the recurrent cortico-basal-ganglia-thalamo-corti …
Using it to simulate the random-dot-motion task, we demonstrate it quantitatively replicates the choice behaviour of monkeys, whilst predict …
Network effects of subthalamic deep brain stimulation drive a unique mixture of responses in basal ganglia output.
Humphries MD, Gurney K. Humphries MD, et al. Eur J Neurosci. 2012 Jul;36(2):2240-51. doi: 10.1111/j.1460-9568.2012.08085.x. Eur J Neurosci. 2012. PMID: 22805068
High-frequency stimulation of the subthalamic nucleus (STN) within the basal ganglia is a main clinical target, but the physiological mechanisms of therapeutic STN DBS at the cellular and network level are unclear. ...We used our computational model of the complete …
High-frequency stimulation of the subthalamic nucleus (STN) within the basal ganglia is a main clinical target, but the physio …
Dopamine-modulated dynamic cell assemblies generated by the GABAergic striatal microcircuit.
Humphries MD, Wood R, Gurney K. Humphries MD, et al. Neural Netw. 2009 Oct;22(8):1174-88. doi: 10.1016/j.neunet.2009.07.018. Epub 2009 Jul 19. Neural Netw. 2009. PMID: 19646846 Free article. Review.
The striatum, the principal input structure of the basal ganglia, is crucial to both motor control and learning. It receives convergent input from all over the neocortex, hippocampal formation, amygdala and thalamus, and is the primary recipient of dopamine in the b …
The striatum, the principal input structure of the basal ganglia, is crucial to both motor control and learning. It receives c …
Is there a brainstem substrate for action selection?
Humphries MD, Gurney K, Prescott TJ. Humphries MD, et al. Philos Trans R Soc Lond B Biol Sci. 2007 Sep 29;362(1485):1627-39. doi: 10.1098/rstb.2007.2057. Philos Trans R Soc Lond B Biol Sci. 2007. PMID: 17428776 Free PMC article.
The search for the neural substrate of vertebrate action selection has focused on structures in the forebrain and midbrain, and particularly on the group of sub-cortical nuclei known as the basal ganglia. Yet, the behavioural repertoire of decerebrate and neonatal a …
The search for the neural substrate of vertebrate action selection has focused on structures in the forebrain and midbrain, and particularly …
A robot model of the basal ganglia: behavior and intrinsic processing.
Prescott TJ, Montes González FM, Gurney K, Humphries MD, Redgrave P. Prescott TJ, et al. Among authors: humphries md. Neural Netw. 2006 Jan;19(1):31-61. doi: 10.1016/j.neunet.2005.06.049. Epub 2005 Sep 8. Neural Netw. 2006. PMID: 16153803 Free article.
The existence of multiple parallel loops connecting sensorimotor systems to the basal ganglia has given rise to proposals that these nuclei serve as a selection mechanism resolving competitions between the alternative actions available in a given context. A strong t …
The existence of multiple parallel loops connecting sensorimotor systems to the basal ganglia has given rise to proposals that …
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