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The Clinical Translation of alpha-humulene - A Scoping Review.
Dalavaye N, Nicholas M, Pillai M, Erridge S, Sodergren MH. Dalavaye N, et al. Planta Med. 2024 Aug;90(9):664-674. doi: 10.1055/a-2307-8183. Epub 2024 Apr 16. Planta Med. 2024. PMID: 38626911 Free PMC article. Review.
alpha-humulene, a sesquiterpene found in essential oils of various plant species, has garnered interest due to its potential therapeutic applications. ...Intraperitoneal administration of alpha-humulene (50 - 200 mg/kg) exhibited cannabimimetic properties through ca …
alpha-humulene, a sesquiterpene found in essential oils of various plant species, has garnered interest due to its potential therapeu …
Humulene Inhibits Acute Gastric Mucosal Injury by Enhancing Mucosal Integrity.
Yeo D, Hwang SJ, Song YS, Lee HJ. Yeo D, et al. Antioxidants (Basel). 2021 May 11;10(5):761. doi: 10.3390/antiox10050761. Antioxidants (Basel). 2021. PMID: 34064830 Free PMC article.
A rat model of hydrochloric acid (HCl)/ethanol-induced gastritis and human mast cells (HMC-1) were used to investigate the mucosal protective effect of alpha-humulene. alpha-Humulene significantly inhibited gastric lesions in HCl/ethanol-induced acute gastritis and …
A rat model of hydrochloric acid (HCl)/ethanol-induced gastritis and human mast cells (HMC-1) were used to investigate the mucosal protectiv …
Clove Essential Oil (Syzygium aromaticum L. Myrtaceae): Extraction, Chemical Composition, Food Applications, and Essential Bioactivity for Human Health.
Haro-González JN, Castillo-Herrera GA, Martínez-Velázquez M, Espinosa-Andrews H. Haro-González JN, et al. Molecules. 2021 Oct 22;26(21):6387. doi: 10.3390/molecules26216387. Molecules. 2021. PMID: 34770801 Free PMC article. Review.
Myrtaceae) is an aromatic plant widely cultivated in tropical and subtropical countries, rich in volatile compounds and antioxidants such as eugenol, beta-caryophyllene, and alpha-humulene. Clove essential oil has received considerable interest due to its wide application …
Myrtaceae) is an aromatic plant widely cultivated in tropical and subtropical countries, rich in volatile compounds and antioxidants such as …
Understanding and Engineering the Stereoselectivity of Humulene Synthase.
Schotte C, Lukat P, Deuschmann A, Blankenfeldt W, Cox RJ. Schotte C, et al. Angew Chem Int Ed Engl. 2021 Sep 6;60(37):20308-20312. doi: 10.1002/anie.202106718. Epub 2021 Aug 11. Angew Chem Int Ed Engl. 2021. PMID: 34180566 Free PMC article.
The non-canonical terpene cyclase AsR6 is responsible for the formation of 2E,6E,9E-humulene during the biosynthesis of the tropolone sesquiterpenoid (TS) xenovulene A. The structures of unliganded AsR6 and of AsR6 in complex with an in crystallo cyclized reaction product …
The non-canonical terpene cyclase AsR6 is responsible for the formation of 2E,6E,9E-humulene during the biosynthesis of the tropolone …
Humulene Diepoxides from the Australian Arid Zone Herb Dysphania: Assignment of Aged Hops Constituents.
Tan YP, Agnew-Francis KA, Hofmann J, Savchenko AI, Lafontaine SR, Boyle GM, Bernhardt PV, Fraser JA, Shellhammer TH, Williams CM. Tan YP, et al. Chemistry. 2020 Feb 3;26(7):1653-1660. doi: 10.1002/chem.201904420. Epub 2020 Jan 21. Chemistry. 2020. PMID: 31961021
Described herein, is the isolation and elucidation of two enantiomeric diastereomers of humulene diepoxide C from D. kalpari and D. rhadinostachya, of which unassigned diastereomers of humulene diepoxide C have been previously reported as components in beer brewed f …
Described herein, is the isolation and elucidation of two enantiomeric diastereomers of humulene diepoxide C from D. kalpari and D. r …
Engineering the oleaginous yeast Candida tropicalis for alpha-humulene overproduction.
Zhang L, Yang H, Xia Y, Shen W, Liu L, Li Q, Chen X. Zhang L, et al. Biotechnol Biofuels Bioprod. 2022 May 26;15(1):59. doi: 10.1186/s13068-022-02160-8. Biotechnol Biofuels Bioprod. 2022. PMID: 35619177 Free PMC article.
RESULTS: In this study, C. tropicalis was engineered for de novo synthesis of alpha-humulene from glucose. To improve alpha-humulene production, the codon-optimised alpha-humulene synthase gene and the entire endogenous farnesyl diphosphate synthesis pathway …
RESULTS: In this study, C. tropicalis was engineered for de novo synthesis of alpha-humulene from glucose. To improve alpha-humule …
Anti-inflammatory effects of alpha-humulene and beta-caryophyllene on pterygium fibroblasts.
Viveiros MMH, Silva MG, da Costa JGM, de Oliveira AG, Rubio C, Padovani CR, Rainho CA, Schellini SA. Viveiros MMH, et al. Int J Ophthalmol. 2022 Dec 18;15(12):1903-1907. doi: 10.18240/ijo.2022.12.02. eCollection 2022. Int J Ophthalmol. 2022. PMID: 36536965 Free PMC article.
AIM: To investigate the anti-inflammatory effects of the sesquiterpenes alpha-humulene and beta-caryophyllene on pterygium fibroblasts. METHODS: Primary cultures of pterygium fibroblasts were established. Third passage pterygium fibroblasts were exposed to alpha-humulen …
AIM: To investigate the anti-inflammatory effects of the sesquiterpenes alpha-humulene and beta-caryophyllene on pterygium fibroblast …
Effect of alpha-humulene incorporation on the properties of experimental light-cured periodontal dressings.
Rossato TCA, Alves T, Cuevas-Suárez CE, Rosa WLOD, Silva AFD, Piva E, ZANCHi CH, Lund RG. Rossato TCA, et al. Braz Oral Res. 2022 Jul 11;36:e091. doi: 10.1590/1807-3107bor-2022.vol36.0091. eCollection 2022. Braz Oral Res. 2022. PMID: 35830138 Free article.
In general, the cohesive strength values of materials decreased as the alpha-humulene concentration increased. All the experimental dressings showed antimicrobial activity against both bacteria tested. Cell viability results for the Ea, Ea1, Eb, and Eb1 groups showed moder …
In general, the cohesive strength values of materials decreased as the alpha-humulene concentration increased. All the experimental d …
Fermentative alpha-Humulene Production from Homogenized Grass Clippings as a Growth Medium.
Langsdorf A, Drommershausen AL, Volkmar M, Ulber R, Holtmann D. Langsdorf A, et al. Molecules. 2022 Dec 8;27(24):8684. doi: 10.3390/molecules27248684. Molecules. 2022. PMID: 36557817 Free PMC article.
Herein, we demonstrate the production of the sesquiterpene alpha-humulene with the versatile organism Cupriavidus necator pKR-hum on a growth medium from grass clippings. ...With the grass medium, 2 mg/L of alpha-humulene were produced compared to 10 mg/L with the L …
Herein, we demonstrate the production of the sesquiterpene alpha-humulene with the versatile organism Cupriavidus necator pKR-hum on …
Harnessing Yarrowia lipolytica Peroxisomes as a Subcellular Factory for alpha-Humulene Overproduction.
Guo Q, Shi TQ, Peng QQ, Sun XM, Ji XJ, Huang H. Guo Q, et al. J Agric Food Chem. 2021 Nov 24;69(46):13831-13837. doi: 10.1021/acs.jafc.1c05897. Epub 2021 Nov 9. J Agric Food Chem. 2021. PMID: 34751575
In this study, Yarrowia lipolytica was developed as a robust cell factory for alpha-humulene production. The peroxisome in Y. lipolytica was first engineered to boost the synthesis of the sesquiterpene alpha-humulene. By compartmentalization of the alpha-humulene …
In this study, Yarrowia lipolytica was developed as a robust cell factory for alpha-humulene production. The peroxisome in Y. lipolyt …
787 results

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