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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1966 2
1967 2
1968 3
1971 1
1972 1
1973 4
1974 4
1975 1
1976 10
1977 5
1978 11
1979 25
1980 21
1981 31
1982 32
1983 41
1984 35
1985 51
1986 59
1987 53
1988 43
1989 61
1990 65
1991 64
1992 55
1993 64
1994 52
1995 51
1996 47
1997 41
1998 57
1999 50
2000 39
2001 37
2002 38
2003 44
2004 45
2005 31
2006 39
2007 50
2008 54
2009 72
2010 65
2011 64
2012 72
2013 67
2014 63
2015 56
2016 35
2017 41
2018 28
2019 21
2020 9
2021 17
2022 14
2023 15
2024 12
2025 15
2026 9

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1,983 results

Results by year

Filters applied: Meta-Analysis, Randomized Controlled Trial. Clear all
Page 1
Hydrochlorothiazide and Prevention of Kidney-Stone Recurrence.
Dhayat NA, Bonny O, Roth B, Christe A, Ritter A, Mohebbi N, Faller N, Pellegrini L, Bedino G, Venzin RM, Grosse P, Hüsler C, Koneth I, Bucher C, Del Giorno R, Gabutti L, Mayr M, Odermatt U, Buchkremer F, Ernandez T, Stoermann-Chopard C, Teta D, Vogt B, Roumet M, Tamò L, Cereghetti GM, Trelle S, Fuster DG. Dhayat NA, et al. N Engl J Med. 2023 Mar 2;388(9):781-791. doi: 10.1056/NEJMoa2209275. N Engl J Med. 2023. PMID: 36856614 Free article. Clinical Trial.
There was no relation between the hydrochlorothiazide dose and the occurrence of a primary end-point event (P = 0.66). Hypokalemia, gout, new-onset diabetes mellitus, skin allergy, and a plasma creatinine level exceeding 150% of the baseline level were more common among pa …
There was no relation between the hydrochlorothiazide dose and the occurrence of a primary end-point event (P = 0.66). Hypokalemia, g …
Chlorthalidone vs. Hydrochlorothiazide for Hypertension-Cardiovascular Events.
Ishani A, Cushman WC, Leatherman SM, Lew RA, Woods P, Glassman PA, Taylor AA, Hau C, Klint A, Huang GD, Brophy MT, Fiore LD, Ferguson RE; Diuretic Comparison Project Writing Group. Ishani A, et al. N Engl J Med. 2022 Dec 29;387(26):2401-2410. doi: 10.1056/NEJMoa2212270. Epub 2022 Dec 14. N Engl J Med. 2022. PMID: 36516076 Clinical Trial.
BACKGROUND: Whether chlorthalidone is superior to hydrochlorothiazide for preventing major adverse cardiovascular events in patients with hypertension is unclear. ...The mean age was 72 years. At baseline, hydrochlorothiazide at a dose of 25 mg per day had been pres …
BACKGROUND: Whether chlorthalidone is superior to hydrochlorothiazide for preventing major adverse cardiovascular events in patients …
Valsartan/hydrochlorothiazide: a review of its use in the management of hypertension.
Wagstaff AJ. Wagstaff AJ. Drugs. 2006;66(14):1881-901. doi: 10.2165/00003495-200666140-00011. Drugs. 2006. PMID: 17040120 Review.
Valsartan/hydrochlorothiazide is a fixed-dose (valsartan 80, 160 or 320mg plus hydrochlorothiazide 12.5 or 25mg) angiotensin II receptor blocker/diuretic drug combination indicated for the treatment of patients with essential hypertension not adequately controlled b …
Valsartan/hydrochlorothiazide is a fixed-dose (valsartan 80, 160 or 320mg plus hydrochlorothiazide 12.5 or 25mg) angiotensin I …
Chlorthalidone vs Hydrochlorothiazide and Kidney Outcomes in Patients With Hypertension: A Secondary Analysis of a Randomized Clinical Trial.
Ishani A, Hau C, Raju S, Wise JK, Glassman PA, Taylor AA, Ferguson RE, Cushman WC, Leatherman SM. Ishani A, et al. JAMA Netw Open. 2024 Dec 2;7(12):e2449576. doi: 10.1001/jamanetworkopen.2024.49576. JAMA Netw Open. 2024. PMID: 39656458 Free PMC article. Clinical Trial.
Veterans 65 years or older with hypertension who were taking hydrochlorothiazide were included. INTERVENTION: The Diuretic Comparison Project randomized 13 523 participants to continue hydrochlorothiazide or switch to chlorthalidone. ...There was no difference in th …
Veterans 65 years or older with hypertension who were taking hydrochlorothiazide were included. INTERVENTION: The Diuretic Comparison …
Meta-analysis of dose-response relationships for hydrochlorothiazide, chlorthalidone, and bendroflumethiazide on blood pressure, serum potassium, and urate.
Peterzan MA, Hardy R, Chaturvedi N, Hughes AD. Peterzan MA, et al. Hypertension. 2012 Jun;59(6):1104-9. doi: 10.1161/HYPERTENSIONAHA.111.190637. Epub 2012 Apr 30. Hypertension. 2012. PMID: 22547443 Free PMC article.
Potency series for diastolic BP, serum potassium, and urate were similar to those seen for systolic BP. Hydrochlorothiazide, chlorthalidone, and bendroflumethiazide have markedly different potency. This may account for differences in the antihypertensive effect between …
Potency series for diastolic BP, serum potassium, and urate were similar to those seen for systolic BP. Hydrochlorothiazide, chlortha …
Angiotensin II receptor antagonists alone and combined with hydrochlorothiazide: potential benefits beyond the antihypertensive effect.
Meredith PA. Meredith PA. Am J Cardiovasc Drugs. 2005;5(3):171-83. doi: 10.2165/00129784-200505030-00004. Am J Cardiovasc Drugs. 2005. PMID: 15901205 Review.
Most patients require combination therapy with two or more drugs to adequately control blood pressure to targets recommended by European and international guidelines. ARBs and the thiazide diuretic hydrochlorothiazide have complementary modes of action. Fixed-dose combinat …
Most patients require combination therapy with two or more drugs to adequately control blood pressure to targets recommended by European and …
Losartan with hydrochlorothiazide in the treatment of hypertension.
Schoenberger JA; Losartan Research Group. Schoenberger JA, et al. J Hypertens Suppl. 1995 Jul;13(1):S43-7. J Hypertens Suppl. 1995. PMID: 18800455 Clinical Trial.
The participants were randomly assigned to concomitant therapy once a day with: (1) 50 mg losartan and 6.25 mg hydrochlorothiazide, (2) 50 mg losartan and 12.5 mg hydrochlorothiazide, (3) 50 mg losartan alone, (4) 12.5 mg hydrochlorothiazide alone or (5) plac …
The participants were randomly assigned to concomitant therapy once a day with: (1) 50 mg losartan and 6.25 mg hydrochlorothiazide, ( …
Bioequivalence and Food Effect Assessment of Two Fixed-Dose Combination Formulations of Telmisartan-Hydrochlorothiazide Tablets in Chinese Healthy Subjects.
Hu M, Yang M, Zhang S, Li J, Pang H, Pei Y, Guo C, Wang X. Hu M, et al. Clin Transl Sci. 2025 May;18(5):e70228. doi: 10.1111/cts.70228. Clin Transl Sci. 2025. PMID: 40279189 Free PMC article. Clinical Trial.
This study assessed the bioequivalence and food effect of two fixed-dose combination (FDC) formulations of telmisartan-hydrochlorothiazide tablets (telmisartan 40 mg, hydrochlorothiazide 12.5 mg) in healthy Chinese subjects. ...The pharmacokinetic characteristics of …
This study assessed the bioequivalence and food effect of two fixed-dose combination (FDC) formulations of telmisartan-hydrochlorothiazid …
Oral combined hydrochlorothiazide and lisinopril vs nifedipine for postpartum hypertension: a comparative-effectiveness pilot randomized controlled trial.
Fishel Bartal M, Blackwell SC, Pedroza C, Lawal D, Amro F, Samuel J, Chauhan SP, Sibai BM. Fishel Bartal M, et al. Am J Obstet Gynecol. 2023 May;228(5):571.e1-571.e10. doi: 10.1016/j.ajog.2023.01.015. Epub 2023 Feb 12. Am J Obstet Gynecol. 2023. PMID: 36787814 Clinical Trial.
Participants were randomized to receive either combined hydrochlorothiazide and lisinopril therapy or nifedipine therapy after stratifying the participants by diagnosis (chronic hypertension vs hypertensive disorders of pregnancy). ...CONCLUSION: The results of the pilot t …
Participants were randomized to receive either combined hydrochlorothiazide and lisinopril therapy or nifedipine therapy after strati …
Effects of Hydrochlorothiazide and Metformin on Aquaresis and Nephroprotection by a Vasopressin V2 Receptor Antagonist in ADPKD: A Randomized Crossover Trial.
Kramers BJ, Koorevaar IW, van Gastel MDA, van Goor H, Hallows KR, Heerspink HL, Li H, Leonhard WN, Peters DJM, Qiu J, Touw DJ, Gansevoort RT, Meijer E. Kramers BJ, et al. Clin J Am Soc Nephrol. 2022 Apr;17(4):507-517. doi: 10.2215/CJN.11260821. Epub 2022 Mar 21. Clin J Am Soc Nephrol. 2022. PMID: 35314480 Free PMC article. Clinical Trial.
Urine volume decreased to 5.1 L/24 h (P<0.001) with hydrochlorothiazide and to 5.4 L/24 h (P<0.001) on metformin. During hydrochlorothiazide treatment, plasma copeptin (surrogate for vasopressin) decreased, quality of life improved, and several markers of kidn …
Urine volume decreased to 5.1 L/24 h (P<0.001) with hydrochlorothiazide and to 5.4 L/24 h (P<0.001) on metformin. During hyd …
1,983 results