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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1997 3
1999 3
2000 8
2001 2
2002 2
2003 4
2004 3
2005 4
2006 5
2007 4
2008 3
2009 7
2010 3
2011 3
2012 3
2013 3
2014 3
2015 3
2016 4
2017 2
2018 3
2019 1
2021 1
2022 1
2023 2
2024 0

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74 results

Results by year

Filters applied: Meta-Analysis, Randomized Controlled Trial. Clear all
Page 1
Heterogeneity in Blood Pressure Response to 4 Antihypertensive Drugs: A Randomized Clinical Trial.
Sundström J, Lind L, Nowrouzi S, Hagström E, Held C, Lytsy P, Neal B, Marttala K, Östlund O. Sundström J, et al. JAMA. 2023 Apr 11;329(14):1160-1169. doi: 10.1001/jama.2023.3322. JAMA. 2023. PMID: 37039792 Free PMC article. Clinical Trial.

The blood pressure response to different treatments varied considerably between individuals (P < .001), specifically for the choices of lisinopril vs hydrochlorothiazide, lisinopril vs amlodipine, candesartan vs hydrochlorothiazide, and candesartan

…

The blood pressure response to different treatments varied considerably between individuals (P < .001), specifically for the choices of l

…
Candesartan and hydrochlorothiazide in isolated systolic hypertension.
Wing LM, Arnolda LF, Upton J, Molloy D. Wing LM, et al. Blood Press. 2003;12(4):246-54. doi: 10.1080/08037050310014954. Blood Press. 2003. PMID: 14596362 Clinical Trial.
MAJOR FINDINGS: Compared with the placebo phase, clinic and ambulatory SBP was significantly reduced with both dose-adjusted candesartan and fixed-dose hydrochlorothiazide as monotherapy, the effect of candesartan being greater than that of hydrochlorothia …
MAJOR FINDINGS: Compared with the placebo phase, clinic and ambulatory SBP was significantly reduced with both dose-adjusted candesartan …
Pharmacokinetics of a new fixed-dose combination of candesartan cilexetil, hydrochlorothiazide, and rosuvastatin in healthy adult subjects.
Yerino GA, Feleder EC, Halabe EK, Diaz L, Sakson M, Iglesias M, Haddad T, Roldán E, Mondelo N. Yerino GA, et al. Int J Clin Pharmacol Ther. 2022 Apr;60(4):192-206. doi: 10.5414/CP204026. Int J Clin Pharmacol Ther. 2022. PMID: 35103587 Clinical Trial.
BACKGROUND: A fixed-dose combination (FDC) of candesartan cilexetil, hydrochlorothiazide and rosuvastatin (CC/HCTZ/RSV) has been developed to enhance patient compliance in the primary prevention of cardiovascular diseases. ...
BACKGROUND: A fixed-dose combination (FDC) of candesartan cilexetil, hydrochlorothiazide and rosuvastatin (CC/HCTZ/RSV) has be …
Efficacy of single-pill combination in uncontrolled essential hypertension: A systematic review and network meta-analysis.
Xie M, Tang T, Liang H. Xie M, et al. Clin Cardiol. 2023 Aug;46(8):886-898. doi: 10.1002/clc.24082. Epub 2023 Jul 11. Clin Cardiol. 2023. PMID: 37432701 Free PMC article. Review.
The results of the network meta-analysis showed that a total of 11 single-pill combination antihypertensive drugs were included, namely: Amlodipine/valsartan, Telmisartan/amlodipine, Losartan/HCTZ, Candesartan/HCTZ, Amlodipine/benazepril, Telmisartan/HCTZ, Valsartan/HCTZ, …
The results of the network meta-analysis showed that a total of 11 single-pill combination antihypertensive drugs were included, namely: Aml …
Hydrochlorothiazide compared to candesartan treatment increases adipose tissue gene expression and circulating levels of serum amyloid A in hypertensive patients.
Palming J, Jansson PA, Renström F, Johansson A, Johansson L, Karlsson C, Lind L, Eriksson JW. Palming J, et al. Horm Metab Res. 2011 May;43(5):319-24. doi: 10.1055/s-0031-1271695. Epub 2011 Feb 17. Horm Metab Res. 2011. PMID: 21332024 Clinical Trial.
In the MEDICA (MEchanisms for the DIabetes preventing effects of CAndesartan) study, 22 hypertensive, nondiabetic patients with abdominal obesity (10 men, 12 women) were randomized into 12-week treatment periods with candesartan, hydrochlorothiazide, and plac …
In the MEDICA (MEchanisms for the DIabetes preventing effects of CAndesartan) study, 22 hypertensive, nondiabetic patients with abdom …
Pharmacokinetic interaction study with fixed high dose combinations of candesartan cilexetil and hydrochlorothiazide.
Aberg JG, Olofsson B, Karlson BW. Aberg JG, et al. Int J Clin Pharmacol Ther. 2011 Dec;49(12):750-5. doi: 10.5414/cp201528. Int J Clin Pharmacol Ther. 2011. PMID: 22122817 Clinical Trial.
OBJECTIVE: Combination treatment with candesartan and hydrochlorothiazide (HCT) has been shown to provide the full additive antihypertensive effect of the components. ...CONCLUSION: There was no pharmacokinetic interaction found between the high doses of candesar …
OBJECTIVE: Combination treatment with candesartan and hydrochlorothiazide (HCT) has been shown to provide the full additive an …
Effects of losartan and candesartan monotherapy and losartan/hydrochlorothiazide combination therapy in patients with mild to moderate hypertension. Losartan Trial Investigators.
Manolis AJ, Grossman E, Jelakovic B, Jacovides A, Bernhardi DC, Cabrera WJ, Watanabe LA, Barragan J, Matadamas N, Mendiola A, Woo KS, Zhu JR, Mejia AD, Bunt T, Dumortier T, Smith RD. Manolis AJ, et al. Clin Ther. 2000 Oct;22(10):1186-203. doi: 10.1016/s0149-2918(00)83062-3. Clin Ther. 2000. PMID: 11110230 Clinical Trial.
OBJECTIVE: The goal of this multicenter, double-blind, randomized, parallel-group study was to compare the effects of losartan potassium (hereafter referred to as losartan), candesartan cilexitil (hereafter referred to as candesartan), and losartan/hydrochlorothi …
OBJECTIVE: The goal of this multicenter, double-blind, randomized, parallel-group study was to compare the effects of losartan potassium (he …
Comparative effects of candesartan and hydrochlorothiazide on blood pressure, insulin sensitivity, and sympathetic drive in obese hypertensive individuals: results of the CROSS study.
Grassi G, Seravalle G, Dell'Oro R, Trevano FQ, Bombelli M, Scopelliti F, Facchini A, Mancia G; CROSS Study. Grassi G, et al. J Hypertens. 2003 Sep;21(9):1761-9. doi: 10.1097/00004872-200309000-00027. J Hypertens. 2003. PMID: 12923410 Clinical Trial.
In contrast, HCTZ did not significantly affect MSNA and worsened insulin sensitivity, while achieving blood pressure reductions similar to those produced by candesartan cilexetil. CONCLUSIONS: These data provide evidence that, in obese hypertensive individuals, treatment w …
In contrast, HCTZ did not significantly affect MSNA and worsened insulin sensitivity, while achieving blood pressure reductions similar to t …
Combination therapy with candesartan cilexetil 32 mg and hydrochlorothiazide 25 mg provides the full additive antihypertensive effect of the components: A randomized, double-blind, parallel-group study in primary care.
Edes I; Multicentre Study Group. Edes I, et al. Clin Drug Investig. 2009;29(5):293-304. doi: 10.2165/00044011-200929050-00002. Clin Drug Investig. 2009. PMID: 19366271 Clinical Trial.
BACKGROUND AND OBJECTIVE: Fixed-combination tablets of candesartan (orally administered as the pro-drug candesartan cilexetil and hereafter referred to as candesartan) and hydrochlorothiazide (HCTZ) 8/12.5 mg and 16/12.5 mg are effective and well toler …
BACKGROUND AND OBJECTIVE: Fixed-combination tablets of candesartan (orally administered as the pro-drug candesartan cilexetil …
Efficacy and tolerability of candesartan cilexetil/hydrochlorothiazide and amlodipine in patients with poorly controlled mild-to-moderate essential hypertension.
Fogari R, Mugellini A, Derosa G; CANDIA (CANdesartan and DIuretic vs. Amlodipine in hypertensive patients) Study Group. Fogari R, et al. J Renin Angiotensin Aldosterone Syst. 2007 Sep;8(3):139-44. doi: 10.3317/jraas.2007.023. J Renin Angiotensin Aldosterone Syst. 2007. PMID: 17907102 Free article. Clinical Trial.
The antihypertensive efficacy and tolerability of combination therapy with candesartan cilexetil, 16 mg plus hydrochlorothiazide (CC/HCTZ), 12.5 mg was compared with that of amlodipine, in a multicentre, double-blind, randomised, parallel-group study in patients wit …
The antihypertensive efficacy and tolerability of combination therapy with candesartan cilexetil, 16 mg plus hydrochlorothiazide …
74 results