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The use of hydroxyapatite toothpaste to prevent dental caries.
O'Hagan-Wong K, Enax J, Meyer F, Ganss B. O'Hagan-Wong K, et al. Odontology. 2022 Apr;110(2):223-230. doi: 10.1007/s10266-021-00675-4. Epub 2021 Nov 22. Odontology. 2022. PMID: 34807345 Free PMC article. Review.
Dissolution of hydroxyapatite from the tooth structure at low pH can lead to the irreversible destruction of enamel and dentin, which if left untreated can result in pain and tooth loss. Hydroxyapatite toothpastes contain hydroxyapatite particles in mi …
Dissolution of hydroxyapatite from the tooth structure at low pH can lead to the irreversible destruction of enamel and dentin, which …
Caries Etiology and Preventive Measures.
Meyer F, Schulze Zur Wiesche E, Amaechi BT, Limeback H, Enax J. Meyer F, et al. Eur J Dent. 2024 Jul;18(3):766-776. doi: 10.1055/s-0043-1777051. Epub 2024 Mar 31. Eur J Dent. 2024. PMID: 38555649 Free PMC article.
For efficient plaque removal/control, state-of-the-art toothpastes contain various active ingredients such as antimicrobial agents (e.g., chlorhexidine, stannous salts, and zinc salts), abrasives (e.g., calcium carbonate, calcium phosphates, and hydrated silica), surfactan …
For efficient plaque removal/control, state-of-the-art toothpastes contain various active ingredients such as antimicrobial agents (e …
Biomimetic hydroxyapatite and caries prevention: a systematic review and meta-analysis.
Limeback H, Enax J, Meyer F. Limeback H, et al. Can J Dent Hyg. 2021 Oct 1;55(3):148-159. eCollection 2021 Oct. Can J Dent Hyg. 2021. PMID: 34925515 Free PMC article.
Ovid MEDLINE (PubMed), Scopus, EMBASE, and Web of Science databases were searched using the following keywords: apatite, hydroxyapatite, caries, dental decay, dentin(e), enamel, toothpaste, dentifrice, mouthwash, gels, biofilm, (dental) plaque, ero(de, ded, s …
Ovid MEDLINE (PubMed), Scopus, EMBASE, and Web of Science databases were searched using the following keywords: apatite, hydroxyapatite …
Remineralization Strategies for Teeth with Molar Incisor Hypomineralization (MIH): A Literature Review.
Enax J, Amaechi BT, Farah R, Liu JA, Schulze Zur Wiesche E, Meyer F. Enax J, et al. Dent J (Basel). 2023 Mar 13;11(3):80. doi: 10.3390/dj11030080. Dent J (Basel). 2023. PMID: 36975577 Free PMC article. Review.
Furthermore, an additional search for studies focusing on using toothpaste/dentifrices for MIH management resulted in six studies, where three studies were on remineralization and three on reduction of sensitivity. ...In conclusion, calcium phosphates like CPP-ACP, …
Furthermore, an additional search for studies focusing on using toothpaste/dentifrices for MIH management resulted in six stud …
Caries-preventing effect of a hydroxyapatite-toothpaste in adults: a 18-month double-blinded randomized clinical trial.
Paszynska E, Pawinska M, Enax J, Meyer F, Schulze Zur Wiesche E, May TW, Amaechi BT, Limeback H, Hernik A, Otulakowska-Skrzynska J, Krahel A, Kaminska I, Lapinska-Antonczuk J, Stokowska E, Gawriolek M. Paszynska E, et al. Front Public Health. 2023 Jul 18;11:1199728. doi: 10.3389/fpubh.2023.1199728. eCollection 2023. Front Public Health. 2023. PMID: 37533523 Free PMC article. Clinical Trial.
The aim of this 18-month double-blinded, randomized, clinical trial was to compare the caries-preventing effect of a fluoride-free, hydroxyapatite toothpaste (test) and a toothpaste with sodium fluoride (1450 ppm fluoride; positive control) in adults. ...Acco …
The aim of this 18-month double-blinded, randomized, clinical trial was to compare the caries-preventing effect of a fluoride-free, hydro …
Clinical evidence of caries prevention by hydroxyapatite: An updated systematic review and meta-analysis.
Pawinska M, Paszynska E, Amaechi BT, Meyer F, Enax J, Limeback H. Pawinska M, et al. J Dent. 2024 Dec;151:105429. doi: 10.1016/j.jdent.2024.105429. Epub 2024 Oct 28. J Dent. 2024. PMID: 39471896 Free article.
More studies now show that hydroxyapatite is effective as an anti-caries active ingredient in the absence of fluoride. CLINICAL SIGNIFICANCE: As a sole active ingredient, considered safe if swallowed, hydroxyapatite is an ideal substitute for fluoride in toothpas …
More studies now show that hydroxyapatite is effective as an anti-caries active ingredient in the absence of fluoride. CLINICAL SIGNI …
The Potential of Hydroxyapatite Toothpaste to Prevent Root Caries: A pH-Cycling Study.
Amaechi BT, Phillips TS, Evans V, Ugwokaegbe CP, Luong MN, Okoye LO, Meyer F, Enax J. Amaechi BT, et al. Clin Cosmet Investig Dent. 2021 Jul 21;13:315-324. doi: 10.2147/CCIDE.S319631. eCollection 2021. Clin Cosmet Investig Dent. 2021. PMID: 34321930 Free PMC article.
PURPOSE: The effectiveness of a hydroxyapatite (HAP) toothpaste and a fluoride toothpaste in preventing root tissue demineralization (root caries) was compared using an established pH-cycling caries model. MATERIALS AND METHODS: Sixty dentin blocks were produ …
PURPOSE: The effectiveness of a hydroxyapatite (HAP) toothpaste and a fluoride toothpaste in preventing root tissue dem …
Do we have enough evidence to recommend hydroxyapatite toothpaste for preventing dental caries?
Gugnani N, Gugnani S. Gugnani N, et al. Evid Based Dent. 2025 Mar;26(1):38-39. doi: 10.1038/s41432-025-01123-w. Epub 2025 Feb 21. Evid Based Dent. 2025. PMID: 39984606
A COMMENTARY ON: Pawinska M, Paszynska E, Amaechi B T, Meyer F, Enax J, Limeback H Clinical evidence of caries prevention by hydroxyapatite: an updated systematic review and meta-analysis. ...The results also favored HAP toothpa …
A COMMENTARY ON: Pawinska M, Paszynska E, Amaechi B T, Meyer F, Enax J, Limeback H Clinical eviden …
The Whitening Efficacy of a Hydroxyapatite Toothpaste and a Blue Covarine Toothpaste: A Comparative In Vitro Study.
Enax J, Fandrich P, Schulze Zur Wiesche E, Amaechi BT. Enax J, et al. Dent J (Basel). 2025 Mar 26;13(4):143. doi: 10.3390/dj13040143. Dent J (Basel). 2025. PMID: 40277473 Free PMC article.
Background: There is high demand for white and healthy teeth. Therefore, various whitening toothpastes are commercially available. Hydroxyapatite and blue covarine are two ingredients used in whitening toothpaste formulations. ...The stain-removing efficacy w …
Background: There is high demand for white and healthy teeth. Therefore, various whitening toothpastes are commercially available. …
In vitro evaluation of the ability of nanohydroxyapatite toothpastes to enhance remineralization of enamel caries lesion.
Amaechi BT, Tan AI, Noureldin AAK, Kanthaiah K, Holladay E, Obiefuna AC, Vijayaraghavan M. Amaechi BT, et al. J Dent. 2025 Oct;161:106006. doi: 10.1016/j.jdent.2025.106006. Epub 2025 Jul 29. J Dent. 2025. PMID: 40744295 Free article.
The present study compared the efficacy of different hydroxyapatite-containing toothpastes in remineralizing early caries lesions. METHODS: Early enamel caries lesion were produced on one hundred and sixty bovine enamel blocks by 3-day demineralization using a multi …
The present study compared the efficacy of different hydroxyapatite-containing toothpastes in remineralizing early caries lesi …
25 results