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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1975 3
1976 2
1978 1
1980 2
1981 2
1982 2
1983 3
1984 3
1985 3
1986 8
1987 6
1988 8
1989 13
1990 17
1991 18
1992 9
1993 11
1994 17
1995 15
1996 20
1997 16
1998 23
1999 11
2000 14
2001 20
2002 16
2003 27
2004 21
2005 17
2006 21
2007 22
2008 28
2009 37
2010 29
2011 29
2012 39
2013 45
2014 45
2015 26
2016 26
2017 20
2018 16
2019 14
2020 10
2021 12
2022 7
2023 5
2024 8
2025 8
2026 1

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722 results

Results by year

Filters applied: Meta-Analysis, Randomized Controlled Trial. Clear all
Page 1
Hydroxyethyl Starch for Fluid Management in Patients Undergoing Major Abdominal Surgery: A Systematic Review With Meta-analysis and Trial Sequential Analysis.
Pensier J, Deffontis L, Rollé A, Aarab Y, Capdevila M, Monet C, Carr J, Futier E, Molinari N, Jaber S, De Jong A. Pensier J, et al. Anesth Analg. 2022 Apr 1;134(4):686-695. doi: 10.1213/ANE.0000000000005803. Anesth Analg. 2022. PMID: 34854822
BACKGROUND: In critically ill patients, warnings about a risk of death and acute kidney injury (AKI) with hydroxyethyl starch (HES) solutions have been raised. However, HES solutions may yet have a role to play in major abdominal surgery. ...
BACKGROUND: In critically ill patients, warnings about a risk of death and acute kidney injury (AKI) with hydroxyethyl starch …
Use of hydroxyethyl starch in sepsis research: A systematic review with meta-analysis.
Johansen JR, Perner A, Brodtkorb JH, Møller MH. Johansen JR, et al. Acta Anaesthesiol Scand. 2021 Nov;65(10):1355-1364. doi: 10.1111/aas.13954. Epub 2021 Sep 1. Acta Anaesthesiol Scand. 2021. PMID: 34309830
BACKGROUND: After being used for more than a decade the use of hydroxyethyl starch (HES) 130/0.38-0.45 in clinical practice was discouraged because of serious adverse events including bleeding, acute kidney injury and death. ...PROTOCOL: Johansen JR, Perner A, Brodt …
BACKGROUND: After being used for more than a decade the use of hydroxyethyl starch (HES) 130/0.38-0.45 in clinical practice wa …
Hydroxyethyl starch 130/0.38-0.45 versus crystalloid or albumin in patients with sepsis: systematic review with meta-analysis and trial sequential analysis.
Haase N, Perner A, Hennings LI, Siegemund M, Lauridsen B, Wetterslev M, Wetterslev J. Haase N, et al. BMJ. 2013 Feb 15;346:f839. doi: 10.1136/bmj.f839. BMJ. 2013. PMID: 23418281 Free PMC article.
STUDY SELECTION: Eligible trials were randomised clinical trials comparing hydroxyethyl starch 130/0.38-0.45 with either crystalloid or human albumin in patients with sepsis. ...It seems unlikely that hydroxyethyl starch 130/0.38-0.45 provides overall …
STUDY SELECTION: Eligible trials were randomised clinical trials comparing hydroxyethyl starch 130/0.38-0.45 with either cryst …
Effect of hydroxyethyl starch on bleeding after cardiopulmonary bypass: a meta-analysis of randomized trials.
Navickis RJ, Haynes GR, Wilkes MM. Navickis RJ, et al. J Thorac Cardiovasc Surg. 2012 Jul;144(1):223-30. doi: 10.1016/j.jtcvs.2012.04.009. Epub 2012 May 9. J Thorac Cardiovasc Surg. 2012. PMID: 22578894 Free article.
Impacts of hydroxyethyl starch molecular weight and molar substitution were assessed. Randomized trials directly comparing different hydroxyethyl starch solutions were also included. ...None of these effects differed significantly between hydroxyeth …
Impacts of hydroxyethyl starch molecular weight and molar substitution were assessed. Randomized trials directly comparing dif …
Hydroxyethyl starch (HES) versus other fluid therapies: effects on kidney function.
Dart AB, Mutter TC, Ruth CA, Taback SP. Dart AB, et al. Cochrane Database Syst Rev. 2010 Jan 20;(1):CD007594. doi: 10.1002/14651858.CD007594.pub2. Cochrane Database Syst Rev. 2010. Update in: Cochrane Database Syst Rev. 2013 Jul 23;(7):CD007594. doi: 10.1002/14651858.CD007594.pub3. PMID: 20091640 Updated.
BACKGROUND: Hydroxyethyl starches (HES) are synthetic colloids commonly used for fluid resuscitation, yet controversy exists about their impact on kidney function. ...
BACKGROUND: Hydroxyethyl starches (HES) are synthetic colloids commonly used for fluid resuscitation, yet controversy exists about th …
Hydroxyethyl starch versus other fluids for non-septic patients in the intensive care unit: a meta-analysis of randomized controlled trials.
He B, Xu B, Xu X, Li L, Ren R, Chen Z, Xiao J, Wang Y, Xu B. He B, et al. Crit Care. 2015 Mar 19;19(1):92. doi: 10.1186/s13054-015-0833-9. Crit Care. 2015. PMID: 25886952 Free PMC article.
INTRODUCTION: Use of hydroxyethyl starch (HES) in septic patients is reported to increase the mortality and incidence of renal replacement therapy (RRT). ...
INTRODUCTION: Use of hydroxyethyl starch (HES) in septic patients is reported to increase the mortality and incidence of renal …
Association of hydroxyethyl starch administration with mortality and acute kidney injury in critically ill patients requiring volume resuscitation: a systematic review and meta-analysis.
Zarychanski R, Abou-Setta AM, Turgeon AF, Houston BL, McIntyre L, Marshall JC, Fergusson DA. Zarychanski R, et al. JAMA. 2013 Feb 20;309(7):678-88. doi: 10.1001/jama.2013.430. JAMA. 2013. PMID: 23423413
IMPORTANCE: Hydroxyethyl starch is commonly used for volume resuscitation yet has been associated with serious adverse events, including acute kidney injury and death. ...Clinical use of hydroxyethyl starch for acute volume resuscitation is not warrant …
IMPORTANCE: Hydroxyethyl starch is commonly used for volume resuscitation yet has been associated with serious adverse events, …
Comparative balanced salt solution and 6 % hydroxyethyl starch in goal-directed therapy for major abdominal surgery: A systematic review and meta-analysis.
Lu R, Kacha S, Phothikun N, Supphapipat A, Chittawatanarat K. Lu R, et al. Am J Surg. 2025 Jul;245:116355. doi: 10.1016/j.amjsurg.2025.116355. Epub 2025 Apr 19. Am J Surg. 2025. PMID: 40279860
Goal-directed fluid therapy (GDFT) improves postoperative outcomes in various surgeries, but the optimal fluid choice between balanced salt solutions (BSS) and hydroxyethyl starch (HES) remains debated. This meta-analysis compared postoperative outcomes of GDFT usin …
Goal-directed fluid therapy (GDFT) improves postoperative outcomes in various surgeries, but the optimal fluid choice between balanced salt …
Hydroxyethyl starch in sepsis.
Haase NR. Haase NR. Dan Med J. 2014 Jan;61(1):B4764. Dan Med J. 2014. PMID: 24393593 Free article. Clinical Trial.
BACKGROUND: Hydroxyethyl starch (HES) is a colloid that has been widely used for fluid resuscitation for decades. ...
BACKGROUND: Hydroxyethyl starch (HES) is a colloid that has been widely used for fluid resuscitation for decades. ...
722 results