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Page 1
Postural Orthostatic Tachycardia Syndrome: Mechanisms and New Therapies.
Mar PL, Raj SR. Mar PL, et al. Annu Rev Med. 2020 Jan 27;71:235-248. doi: 10.1146/annurev-med-041818-011630. Epub 2019 Aug 14. Annu Rev Med. 2020. PMID: 31412221 Review.
The approach to the treatment of POTS centers on treating the underlying pathophysiologic mechanism. Stockings, abdominal binders, and vasoconstrictors are used to enhance venous return in partial neuropathic POTS. Exercise and volume expansion are the main treatmen …
The approach to the treatment of POTS centers on treating the underlying pathophysiologic mechanism. Stockings, abdominal binders, an …
Pathophysiology and management of postural orthostatic tachycardia syndrome (POTS): A literature review.
Ghazal M, Akkawi AR, Fancher A, Oundo E, Tanzeem H, Sajjad L, Briasoulis A. Ghazal M, et al. Curr Probl Cardiol. 2025 Mar;50(3):102977. doi: 10.1016/j.cpcardiol.2024.102977. Epub 2024 Dec 18. Curr Probl Cardiol. 2025. PMID: 39706392 Review.
Recent studies have identified three primary POTS phenotypes-hyperadrenergic, neuropathic, and hypovolemic-each requiring tailored management strategies. ...In hyperadrenergic POTS, excessive norepinephrine production or impaired reuptake leads …
Recent studies have identified three primary POTS phenotypes-hyperadrenergic, neuropathic, and hypovolemic-each requiring tail …
Randomized Trial of Ivabradine in Patients With Hyperadrenergic Postural Orthostatic Tachycardia Syndrome.
Taub PR, Zadourian A, Lo HC, Ormiston CK, Golshan S, Hsu JC. Taub PR, et al. J Am Coll Cardiol. 2021 Feb 23;77(7):861-871. doi: 10.1016/j.jacc.2020.12.029. J Am Coll Cardiol. 2021. PMID: 33602468 Free article. Clinical Trial.
OBJECTIVES: This study investigated the effect of ivabradine (selective blocker of the I(funny) channel in the sinoatrial node) on heart rate, quality of life (QOL), and plasma norepinephrine (NE) levels in patients with hyperadrenergic POTS defined by plasma …
OBJECTIVES: This study investigated the effect of ivabradine (selective blocker of the I(funny) channel in the sinoatrial node) on heart rat …
Hyperadrenergic Postural Tachycardia Syndrome: Clinical Biomarkers and Response to Guanfacine.
Okamoto LE, Urechie V, Rigo S, Abner JJ, Giesecke M, Muldowney JAS, Furlan R, Shibao CA, Shirey-Rice JK, Pulley JM, Diedrich A, Biaggioni I. Okamoto LE, et al. Hypertension. 2024 Nov;81(11):2237-2247. doi: 10.1161/HYPERTENSIONAHA.124.23035. Epub 2024 Aug 7. Hypertension. 2024. PMID: 39109428 Free PMC article.
BACKGROUND: A subset of patients with postural tachycardia syndrome (POTS) are thought to have a primary hyperadrenergic cause. We assessed clinical biomarkers to identify those that would benefit from sympatholytic therapy. METHODS: We measured sympathetic function …
BACKGROUND: A subset of patients with postural tachycardia syndrome (POTS) are thought to have a primary hyperadrenergic cause …
Long-Term Outcomes of Hyperadrenergic Orthostatic Hypotension.
Castro RA, Vernetti PM, Biaggioni I, Raj SR, Kaufmann H, Shibao CA. Castro RA, et al. Res Sq [Preprint]. 2023 Sep 11:rs.3.rs-3318273. doi: 10.21203/rs.3.rs-3318273/v1. Res Sq. 2023. Update in: Clin Auton Res. 2026 May 15. doi: 10.1007/s10286-026-01211-6. PMID: 37790494 Free PMC article. Updated. Preprint.
PURPOSE: Hyperadrenergic orthostatic hypotension is a subtype of orthostatic hypotension associated with elevated norepinephrine levels upon standing. ...METHODS: In this prospective observational study, 92 patients with orthostatic hypotension were recruited from t …
PURPOSE: Hyperadrenergic orthostatic hypotension is a subtype of orthostatic hypotension associated with elevated norepinephrine …
Clinical features of hyperadrenergic postural tachycardia syndrome in children.
Zhang Q, Chen X, Li J, Du J. Zhang Q, et al. Pediatr Int. 2014 Dec;56(6):813-816. doi: 10.1111/ped.12392. Epub 2014 Oct 15. Pediatr Int. 2014. PMID: 24862636
BACKGROUND: Hyperadrenergic postural tachycardia syndrome (POTS) is the main phenotype of POTS. The aim of this study was to present our single-center experience of hyperadrenergic POTS in children and adolescents. ...In a retrospective analysis …
BACKGROUND: Hyperadrenergic postural tachycardia syndrome (POTS) is the main phenotype of POTS. The aim of this study w …
Long-term outcomes of hyperadrenergic orthostatic hypotension.
Castro RA, Mehr PE, Vernetti PM, Mwesigwa N, Biaggioni I, Raj SR, Shehata E, Hackstadt AJ, Ding T, Kaufmann H, Shibao CA. Castro RA, et al. Clin Auton Res. 2026 May 15. doi: 10.1007/s10286-026-01211-6. Online ahead of print. Clin Auton Res. 2026. PMID: 42141334 No abstract available.
Postural tachycardia syndrome: a heterogeneous and multifactorial disorder.
Benarroch EE. Benarroch EE. Mayo Clin Proc. 2012 Dec;87(12):1214-25. doi: 10.1016/j.mayocp.2012.08.013. Epub 2012 Nov 1. Mayo Clin Proc. 2012. PMID: 23122672 Free PMC article. Review.
POTS manifests with symptoms of cerebral hypoperfusion and excessive sympathoexcitation. ...The aims of evaluation in patients with POTS are to exclude cardiac causes of inappropriate tachycardia; elucidate, if possible, the most likely pathophysiologic basis of pos …
POTS manifests with symptoms of cerebral hypoperfusion and excessive sympathoexcitation. ...The aims of evaluation in patients with …
Improvement of hyperadrenergic postural orthostatic tachycardia syndrome (POTS) with methylated B vitamins in the setting of a heterozygous COMT Val158Met polymorphism.
Mittal N, Portera A, Taub P. Mittal N, et al. BMJ Case Rep. 2021 Nov 11;14(11):e245012. doi: 10.1136/bcr-2021-245012. BMJ Case Rep. 2021. PMID: 34764114 Free PMC article.
A middle-aged woman was diagnosed with postural orthostatic tachycardia syndrome based on her clinical symptoms, elevated norepinephrine levels and positive tilt-table test. The patient was refractory to conventional treatment and improved only after she was treated with m …
A middle-aged woman was diagnosed with postural orthostatic tachycardia syndrome based on her clinical symptoms, elevated norepinephrine …
Distal sudomotor findings in postural tachycardia syndrome.
Peltier AC, Garland E, Raj SR, Sato K, Black B, Song Y, Wang L, Biaggioni I, Diedrich A, Robertson D. Peltier AC, et al. Clin Auton Res. 2010 Apr;20(2):93-9. doi: 10.1007/s10286-009-0045-y. Epub 2009 Dec 25. Clin Auton Res. 2010. PMID: 20035362 Free PMC article.
Postganglionic sudomotor deficits have been used to define a neurogenic postural tachycardia POTS subtype. Norepinephrine levels above 600 pg/ml have also been used to delineate patients with a hyperadrenergic state. ...No differences in autonomic tests or sp …
Postganglionic sudomotor deficits have been used to define a neurogenic postural tachycardia POTS subtype. Norepinephrine leve …
18 results