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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1979 1
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1993 2
1994 1
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1997 3
1998 3
1999 2
2000 7
2001 9
2002 3
2003 6
2004 7
2005 6
2006 8
2007 11
2008 3
2009 8
2010 10
2011 19
2012 13
2013 30
2014 33
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584 results

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Page 1
The hyperarousal model of insomnia: a review of the concept and its evidence.
Riemann D, Spiegelhalder K, Feige B, Voderholzer U, Berger M, Perlis M, Nissen C. Riemann D, et al. Sleep Med Rev. 2010 Feb;14(1):19-31. doi: 10.1016/j.smrv.2009.04.002. Epub 2009 May 28. Sleep Med Rev. 2010. PMID: 19481481 Review.
Primary insomnia is defined as difficulties in falling asleep, maintaining sleep or non-restorative sleep accompanied by significantly impaired daytime functioning in the absence of a specific physical, mental or substance-related cause. The current review pr …
Primary insomnia is defined as difficulties in falling asleep, maintaining sleep or non-restorative sleep accompanied b …
Hyperarousal in insomnia disorder: Current evidence and potential mechanisms.
Dressle RJ, Riemann D. Dressle RJ, et al. J Sleep Res. 2023 Dec;32(6):e13928. doi: 10.1111/jsr.13928. Epub 2023 May 14. J Sleep Res. 2023. PMID: 37183177 Review.
Insomnia disorder is among the most frequent mental disorders, making research on its aetiology and pathophysiology particularly important. ...Besides being a state marker of insomnia, hyperarousal is considered crucial for the predisposition to ins …
Insomnia disorder is among the most frequent mental disorders, making research on its aetiology and pathophysiology particular …
Insomnia.
Buysse DJ. Buysse DJ. JAMA. 2013 Feb 20;309(7):706-16. doi: 10.1001/jama.2013.193. JAMA. 2013. PMID: 23423416 Free PMC article.
Insomnia is a risk factor for impaired function, development of other medical and mental disorders, and increased health care costs. ...The diagnosis of insomnia is established by a thorough history of sleep behaviors, medical and psychiatric problems, …
Insomnia is a risk factor for impaired function, development of other medical and mental disorders, and increased health care …
Brain mechanisms of insomnia: new perspectives on causes and consequences.
Van Someren EJW. Van Someren EJW. Physiol Rev. 2021 Jul 1;101(3):995-1046. doi: 10.1152/physrev.00046.2019. Epub 2020 Aug 13. Physiol Rev. 2021. PMID: 32790576 Free article. Review.
Further supported by the clear mental health risks conveyed by insomnia, the integrated findings suggest that the vulnerability to develop insomnia could rather be found in brain circuits regulating emotion and arousal than in circuits involved in circadian and home …
Further supported by the clear mental health risks conveyed by insomnia, the integrated findings suggest that the vulnerability to de …
Insomnia.
Paul AM, Salas RE. Paul AM, et al. Prim Care. 2024 Jun;51(2):299-310. doi: 10.1016/j.pop.2024.02.002. Epub 2024 Mar 13. Prim Care. 2024. PMID: 38692776 Review.
Sleep significantly impacts health. Insomnia, characterized by difficulty with sleep onset, maintenance, and subsequent daytime symptoms, is increasingly prevalent and increases the risk of other medical comorbidities. The pathophysiology involves h …
Sleep significantly impacts health. Insomnia, characterized by difficulty with sleep onset, maintenance, and sub …
The pathophysiology of insomnia.
Levenson JC, Kay DB, Buysse DJ. Levenson JC, et al. Chest. 2015 Apr;147(4):1179-1192. doi: 10.1378/chest.14-1617. Chest. 2015. PMID: 25846534 Free PMC article. Review.
Insomnia disorder is characterized by chronic dissatisfaction with sleep quantity or quality that is associated with difficulty falling asleep, frequent nighttime awakenings with difficulty returning to sleep, and/or awakening earlier in the morning than desi …
Insomnia disorder is characterized by chronic dissatisfaction with sleep quantity or quality that is associated with difficult …
Chronic insomnia, REM sleep instability and emotional dysregulation: A pathway to anxiety and depression?
Riemann D, Dressle RJ, Benz F, Spiegelhalder K, Johann AF, Nissen C, Hertenstein E, Baglioni C, Palagini L, Krone L, Perlis ML, Domschke K, Berger M, Feige B. Riemann D, et al. J Sleep Res. 2025 Apr;34(2):e14252. doi: 10.1111/jsr.14252. Epub 2024 May 29. J Sleep Res. 2025. PMID: 38811745 Free PMC article. Review.
It is suggested that this instability of rapid eye movement sleep is involved in the mismatch between subjective and objective measures of sleep in insomnia disorder. Furthermore, as rapid eye movement sleep has been linked in previous works to emotion …
It is suggested that this instability of rapid eye movement sleep is involved in the mismatch between subjective and objective measur …
The neurobiology, investigation, and treatment of chronic insomnia.
Riemann D, Nissen C, Palagini L, Otte A, Perlis ML, Spiegelhalder K. Riemann D, et al. Lancet Neurol. 2015 May;14(5):547-58. doi: 10.1016/S1474-4422(15)00021-6. Epub 2015 Apr 12. Lancet Neurol. 2015. PMID: 25895933 Review.
Chronic insomnia is defined by difficulties in falling asleep, maintaining sleep, and early morning awakening, and is coupled with daytime consequences such as fatigue, attention deficits, and mood instability. ...Family and twin studies confirm that chronic inso …
Chronic insomnia is defined by difficulties in falling asleep, maintaining sleep, and early morning awakening, and is coupled …
Hyperarousal and sleep reactivity in insomnia: current insights.
Kalmbach DA, Cuamatzi-Castelan AS, Tonnu CV, Tran KM, Anderson JR, Roth T, Drake CL. Kalmbach DA, et al. Nat Sci Sleep. 2018 Jul 17;10:193-201. doi: 10.2147/NSS.S138823. eCollection 2018. Nat Sci Sleep. 2018. PMID: 30046255 Free PMC article. Review.
In this report, we discuss evidence for hyperarousal in insomnia and explore the role of sleep reactivity. A trait characteristic, sleep reactivity is the degree to which stress disrupts sleep, manifesting as difficulty falling and staying aslee …
In this report, we discuss evidence for hyperarousal in insomnia and explore the role of sleep reactivity. A trait char …
The orexin story and orexin receptor antagonists for the treatment of insomnia.
Muehlan C, Roch C, Vaillant C, Dingemanse J. Muehlan C, et al. J Sleep Res. 2023 Dec;32(6):e13902. doi: 10.1111/jsr.13902. Epub 2023 Apr 22. J Sleep Res. 2023. PMID: 37086045 Review.
Insomnia is associated with an abnormal state of hyperarousal (increased somatic, cognitive, and cortical activation) and orexin has been identified as a key promotor of arousal and vigilance. ...This review provides an overview of the orexin history, the mechanism …
Insomnia is associated with an abnormal state of hyperarousal (increased somatic, cognitive, and cortical activation) and orex …
584 results