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Nausea and vomiting of pregnancy and hyperemesis gravidarum.
Fejzo MS, Trovik J, Grooten IJ, Sridharan K, Roseboom TJ, Vikanes Å, Painter RC, Mullin PM. Fejzo MS, et al. Nat Rev Dis Primers. 2019 Sep 12;5(1):62. doi: 10.1038/s41572-019-0110-3. Nat Rev Dis Primers. 2019. PMID: 31515515 Review.
Although no consensus definition is available for hyperemesis gravidarum (HG), it is typically viewed as the severe form of NVP and has been reported to occur in 0.3-10.8% of pregnant women. ...Recent advances in the genetic study of NVP and HG suggest a placental c …
Although no consensus definition is available for hyperemesis gravidarum (HG), it is typically viewed as the severe form of NV …
Placenta and appetite genes GDF15 and IGFBP7 are associated with hyperemesis gravidarum.
Fejzo MS, Sazonova OV, Sathirapongsasuti JF, Hallgrímsdóttir IB, Vacic V, MacGibbon KW, Schoenberg FP, Mancuso N, Slamon DJ, Mullin PM; 23andMe Research Team. Fejzo MS, et al. Nat Commun. 2018 Mar 21;9(1):1178. doi: 10.1038/s41467-018-03258-0. Nat Commun. 2018. PMID: 29563502 Free PMC article.
Hyperemesis gravidarum (HG), severe nausea and vomiting of pregnancy, occurs in 0.3-2% of pregnancies and is associated with maternal and fetal morbidity. ...The genes implicated at these two loci are GDF15 and IGFBP7 respectively, both known to be involved i …
Hyperemesis gravidarum (HG), severe nausea and vomiting of pregnancy, occurs in 0.3-2% of pregnancies and is associated with m …
GDF15 linked to maternal risk of nausea and vomiting during pregnancy.
Fejzo M, Rocha N, Cimino I, Lockhart SM, Petry CJ, Kay RG, Burling K, Barker P, George AL, Yasara N, Premawardhena A, Gong S, Cook E, Rimmington D, Rainbow K, Withers DJ, Cortessis V, Mullin PM, MacGibbon KW, Jin E, Kam A, Campbell A, Polasek O, Tzoneva G, Gribble FM, Yeo GSH, Lam BYH, Saudek V, Hughes IA, Ong KK, Perry JRB, Sutton Cole A, Baumgarten M, Welsh P, Sattar N, Smith GCS, Charnock-Jones DS, Coll AP, Meek CL, Mettananda S, Hayward C, Mancuso N, O'Rahilly S. Fejzo M, et al. Nature. 2024 Jan;625(7996):760-767. doi: 10.1038/s41586-023-06921-9. Epub 2023 Dec 13. Nature. 2024. PMID: 38092039 Free PMC article.
GDF15, a hormone acting on the brainstem, has been implicated in the nausea and vomiting of pregnancy, including its most severe form, hyperemesis gravidarum (HG), but a full mechanistic understanding is lacking(1-4). ...We confirmed that higher GDF15 …
GDF15, a hormone acting on the brainstem, has been implicated in the nausea and vomiting of pregnancy, including its most severe form …
GDF15 Targeting for Treatment of Hyperemesis Gravidarum.
Thygerson J, Oyler D, Thomas J, Muse B, Brooks BD, Pullan JE. Thygerson J, et al. Medicines (Basel). 2024 Aug 30;11(7):17. doi: 10.3390/medicines11070017. Medicines (Basel). 2024. PMID: 39311313 Free PMC article.
Nausea and vomiting during pregnancy (NVP), particularly its severe form, Hyperemesis gravidarum (HG), affects up to 70% of pregnancies and significantly impacts the quality of life for those with the condition as well as generates a great economic burden, with annu …
Nausea and vomiting during pregnancy (NVP), particularly its severe form, Hyperemesis gravidarum (HG), affects up to 70% of pr …
Emerging Progress in Nausea and Vomiting of Pregnancy and Hyperemesis Gravidarum: Challenges and Opportunities.
Liu C, Zhao G, Qiao D, Wang L, He Y, Zhao M, Fan Y, Jiang E. Liu C, et al. Front Med (Lausanne). 2022 Jan 10;8:809270. doi: 10.3389/fmed.2021.809270. eCollection 2021. Front Med (Lausanne). 2022. PMID: 35083256 Free PMC article. Review.
Nausea and vomiting of pregnancy (NVP) is a common condition that affects up to 70% of pregnant women. Hyperemesis gravidarum (HG) is considered the serious form of NVP, which is reported in 0.3-10.8% of pregnant women. ...With the advance of precision medicine and …
Nausea and vomiting of pregnancy (NVP) is a common condition that affects up to 70% of pregnant women. Hyperemesis gravidarum …
Analysis of GDF15 and IGFBP7 in Hyperemesis Gravidarum Support Causality.
Fejzo MS, Fasching PA, Schneider MO, Schwitulla J, Beckmann MW, Schwenke E, MacGibbon KW, Mullin PM. Fejzo MS, et al. Geburtshilfe Frauenheilkd. 2019 Apr;79(4):382-388. doi: 10.1055/a-0830-1346. Epub 2019 Feb 26. Geburtshilfe Frauenheilkd. 2019. PMID: 31000883 Free PMC article.
Objective Hyperemesis gravidarum, severe nausea and vomiting in pregnancy, occurs in up to 2% of pregnancies and leads to significant weight loss, dehydration, electrolyte imbalance, and ketonuria. ...In a recent GWAS, we showed that placentation, appetite, and cach …
Objective Hyperemesis gravidarum, severe nausea and vomiting in pregnancy, occurs in up to 2% of pregnancies and leads to sign …
Whole-exome sequencing uncovers new variants in GDF15 associated with hyperemesis gravidarum.
Fejzo MS, MacGibbon KW, First O, Quan C, Mullin PM. Fejzo MS, et al. BJOG. 2022 Oct;129(11):1845-1852. doi: 10.1111/1471-0528.17129. Epub 2022 Mar 16. BJOG. 2022. PMID: 35218128 Free PMC article.
Whole-exome sequencing reveals placenta and vomiting hormone GDF15 most likely cause of Hyperemesis Gravidarum....
Whole-exome sequencing reveals placenta and vomiting hormone GDF15 most likely cause of Hyperemesis Gravidarum....
GDF15: A Hormone Conveying Somatic Distress to the Brain.
Lockhart SM, Saudek V, O'Rahilly S. Lockhart SM, et al. Endocr Rev. 2020 Aug 1;41(4):bnaa007. doi: 10.1210/endrev/bnaa007. Endocr Rev. 2020. PMID: 32310257 Free PMC article. Review.
Circulating GDF15 levels are elevated in a range of human disease states, including various forms of cachexia, and GDF15-GFRAL antagonism is emerging as a therapeutic strategy for anorexia/cachexia syndromes. Metformin elevates circulating GDF15 chronically i …
Circulating GDF15 levels are elevated in a range of human disease states, including various forms of cachexia, and GDF15-GFRAL …
Evidence GDF15 Plays a Role in Familial and Recurrent Hyperemesis Gravidarum.
Fejzo MS, Arzy D, Tian R, MacGibbon KW, Mullin PM. Fejzo MS, et al. Geburtshilfe Frauenheilkd. 2018 Sep;78(9):866-870. doi: 10.1055/a-0661-0287. Epub 2018 Sep 14. Geburtshilfe Frauenheilkd. 2018. PMID: 30258246 Free PMC article.
Introduction Hyperemesis gravidarum (HG), a pregnancy complication characterized by severe nausea and vomiting in pregnancy, occurs in up to 2% of pregnancies. ...Based on our findings, patients carrying GDF15 variants associated with GDF15 overexpress …
Introduction Hyperemesis gravidarum (HG), a pregnancy complication characterized by severe nausea and vomiting in pregnancy, o …
New Insight Into Hyperemesis Gravidarum and a Potential Role for GDF15.
Walker RG, Thompson TB. Walker RG, et al. Endocrinology. 2018 Jul 1;159(7):2698-2700. doi: 10.1210/en.2018-00439. Endocrinology. 2018. PMID: 29846562 Free PMC article.
Walker and Thompson provide a commentary on the study conducted by Fejzo et al. that identified a potential relationship between GDF15 and hyperemesis gravidarum....
Walker and Thompson provide a commentary on the study conducted by Fejzo et al. that identified a potential relationship between GDF15 …
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