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Nausea and vomiting of pregnancy and hyperemesis gravidarum.
Fejzo MS, Trovik J, Grooten IJ, Sridharan K, Roseboom TJ, Vikanes Å, Painter RC, Mullin PM. Fejzo MS, et al. Nat Rev Dis Primers. 2019 Sep 12;5(1):62. doi: 10.1038/s41572-019-0110-3. Nat Rev Dis Primers. 2019. PMID: 31515515 Review.
Nausea and vomiting of pregnancy (NVP) is a common condition that affects as many as 70% of pregnant women. Although no consensus definition is available for hyperemesis gravidarum (HG), it is typically viewed as the severe form of NVP and has been reported to occur …
Nausea and vomiting of pregnancy (NVP) is a common condition that affects as many as 70% of pregnant women. Although no consensus definition …
Placenta and appetite genes GDF15 and IGFBP7 are associated with hyperemesis gravidarum.
Fejzo MS, Sazonova OV, Sathirapongsasuti JF, Hallgrímsdóttir IB, Vacic V, MacGibbon KW, Schoenberg FP, Mancuso N, Slamon DJ, Mullin PM; 23andMe Research Team. Fejzo MS, et al. Nat Commun. 2018 Mar 21;9(1):1178. doi: 10.1038/s41467-018-03258-0. Nat Commun. 2018. PMID: 29563502 Free PMC article.
Hyperemesis gravidarum (HG), severe nausea and vomiting of pregnancy, occurs in 0.3-2% of pregnancies and is associated with maternal and fetal morbidity. ...While proving the casual roles of GDF15 and IGFBP7 in nausea and vomiting of pregnancy requires furth
Hyperemesis gravidarum (HG), severe nausea and vomiting of pregnancy, occurs in 0.3-2% of pregnancies and is associated with m
Analysis of GDF15 and IGFBP7 in Hyperemesis Gravidarum Support Causality.
Fejzo MS, Fasching PA, Schneider MO, Schwitulla J, Beckmann MW, Schwenke E, MacGibbon KW, Mullin PM. Fejzo MS, et al. Geburtshilfe Frauenheilkd. 2019 Apr;79(4):382-388. doi: 10.1055/a-0830-1346. Epub 2019 Feb 26. Geburtshilfe Frauenheilkd. 2019. PMID: 31000883 Free PMC article.
Objective Hyperemesis gravidarum, severe nausea and vomiting in pregnancy, occurs in up to 2% of pregnancies and leads to significant weight loss, dehydration, electrolyte imbalance, and ketonuria. ...In a recent GWAS, we showed that placentation, appetite, and cach …
Objective Hyperemesis gravidarum, severe nausea and vomiting in pregnancy, occurs in up to 2% of pregnancies and leads to sign …
Evidence GDF15 Plays a Role in Familial and Recurrent Hyperemesis Gravidarum.
Fejzo MS, Arzy D, Tian R, MacGibbon KW, Mullin PM. Fejzo MS, et al. Geburtshilfe Frauenheilkd. 2018 Sep;78(9):866-870. doi: 10.1055/a-0661-0287. Epub 2018 Sep 14. Geburtshilfe Frauenheilkd. 2018. PMID: 30258246 Free PMC article.
Introduction Hyperemesis gravidarum (HG), a pregnancy complication characterized by severe nausea and vomiting in pregnancy, occurs in up to 2% of pregnancies. ...Based on our findings, patients carrying GDF15 variants associated with GDF15 overexpress …
Introduction Hyperemesis gravidarum (HG), a pregnancy complication characterized by severe nausea and vomiting in pregnancy, o …
New Insight Into Hyperemesis Gravidarum and a Potential Role for GDF15.
Walker RG, Thompson TB. Walker RG, et al. Endocrinology. 2018 Jul 1;159(7):2698-2700. doi: 10.1210/en.2018-00439. Endocrinology. 2018. PMID: 29846562 Free PMC article.
Walker and Thompson provide a commentary on the study conducted by Fejzo et al. that identified a potential relationship between GDF15 and hyperemesis gravidarum....
Walker and Thompson provide a commentary on the study conducted by Fejzo et al. that identified a potential relationship between GDF15
Polyunsaturated Fatty Acids and Their Metabolites in Hyperemesis Gravidarum.
Lindberg R, Lindqvist M, Trupp M, Vinnars MT, Nording ML. Lindberg R, et al. Nutrients. 2020 Nov 4;12(11):3384. doi: 10.3390/nu12113384. Nutrients. 2020. PMID: 33158081 Free PMC article. Review.
However, there is limited knowledge on PUFAs and their metabolites in relation to hyperemesis gravidarum (HG), a pregnancy complication associated with nutritional deficiencies and excessive vomiting. ...The low number of retrieved records underlines the need for mo …
However, there is limited knowledge on PUFAs and their metabolites in relation to hyperemesis gravidarum (HG), a pregnancy com …
GDF15: A Hormone Conveying Somatic Distress to the Brain.
Lockhart SM, Saudek V, O'Rahilly S. Lockhart SM, et al. Endocr Rev. 2020 Aug 1;41(4):610-42. doi: 10.1210/endrev/bnaa007. Endocr Rev. 2020. PMID: 32310257 Free PMC article.
Circulating GDF15 levels are elevated in a range of human disease states, including various forms of cachexia, and GDF15-GFRAL antagonism is emerging as a therapeutic strategy for anorexia/cachexia syndromes. Metformin elevates circulating GDF15 chronically i …
Circulating GDF15 levels are elevated in a range of human disease states, including various forms of cachexia, and GDF15-GFRAL …
Associations of vomiting and antiemetic use in pregnancy with levels of circulating GDF15 early in the second trimester: A nested case-control study.
Petry CJ, Ong KK, Burling KA, Barker P, Goodburn SF, Perry JRB, Acerini CL, Hughes IA, Painter RC, Afink GB, Dunger DB, O'Rahilly S. Petry CJ, et al. Wellcome Open Res. 2018 Sep 21;3:123. doi: 10.12688/wellcomeopenres.14818.1. eCollection 2018. Wellcome Open Res. 2018. PMID: 30345390 Free PMC article.
We tested the hypothesis that circulating growth and differentiation factor 15 (GDF15) concentrations in early pregnancy, whose gene is implicated in hyperemesis gravidarum, are associated with nausea and vomiting. ...Given GDF15's site of action in th …
We tested the hypothesis that circulating growth and differentiation factor 15 (GDF15) concentrations in early pregnancy, whose gene …